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23

抑制剂 & 化合物

12

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1808	Bak BH3
	This peptide, generated from the BH3 domain of Bak (Flu-BakBH3), has been shown to have high-affinity binding to a surface pocket of the Bcl-XL protein that is required for its death antagonist function.
T80029	Bak BH3 (72-87), TAMRA-labeled
	BakBH3 (72-87), TAMRA-labeled，是一种具有生物活性的肽类化合物。
T4215	TCS-PIM-1-4a 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a	Apoptosis; Pim	Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling
	TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂，可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系，IC50值为 0.8 μM 至 40 μM。
T23771	BAK2-66 BAK2 66
	BAK2-66 is a selective antagonist of the dopamine D3 receptor.
T23861	CAY10526 CAY-10526,BTH,CAY 10526	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	CAY10526 (BTH) 是 mPGES-1 的选择性抑制剂，可抑制 NF-κB 信号通路。
T124107	Bakuchalcone
	Bakuchalcone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124107。
T125549	12-Hydroxyisobakuchiol
	12-Hydroxyisobakuchiol 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125549。
T77034	Inbakicept N-803
	Inbakicept (ALT-803) 是一种 IL-15超激动剂，由 IL-15突变体和 IL-15Rα-Fc 融合体组成。Inbakicept 可放大抗 CD20单抗介导的 NK 细胞反应和抗体依赖性细胞毒性 (ADCC)。INbakicept 也增加 NK 细胞的脱粒或 IFNγ 的产生。
TP1724L	PUMA BH3 acetate PUMA BH3 acetate(PUMA BH3 Free base)	BCL	Apoptosis
	PUMA BH3 acetate (PUMA BH3 Free base) 是一种 p53 凋亡阳性调节因子 (PUMA) BH3 结构域多肽，可作为 Bak 的直接激活剂，Kd 为 26 nM。
T14846	Bz 423 BZ48	Apoptosis; BCL	Apoptosis
	Bz 423 是一种有效的免疫调节剂，通过激活 Bax 和 Bak 来诱导线粒体外膜通透和细胞色素 c 释放来诱导细胞凋亡。Bz 423 在狼疮小鼠模型中显示出部分活性。
T2099	ABT-737	Mitophagy; BCL; Autophagy	Apoptosis; Autophagy
	ABT737 是 BH3 模拟物，是Bcl-2、Bcl-xL 和Bcl-w 抑制剂，EC50分别为 30.3 nM、78.7 nM 和 197.8 nM。它诱导自噬，有研究急性髓系白血病的潜力。它还诱导 BCL-2/BAX 复合物的破坏和 BAK 依赖性。
T83751	PUMA BH3 (human) TFA
	PUMA BH3是一个由p53上调凋亡调节器(PUMA)的BH3域组成的肽，并激活促凋亡蛋白Bak。PUMA BH3与Bak结合（在HEPES和CHAPS缓冲液中的Kds分别为290和26 nM），诱导Bak同源寡聚化和Bak介导的膜透性增加。
T28117	MSN-50 MSN50,MSN 50
	MSN-50, an inhibitor of Bax and Bak oligomerization, inhibits liposome permeabilization, prevents genotoxic cell death and promotes neuroprotection.
T16155	MSN-125	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	MSN-125 effectively inhibits Bax/Bak-mediated apoptosis in HCT-116, BMK Cells, and primary cortical neurons protect primary neurons against glutamate excitotoxicity. MSN-125 is an effective Bax and Bak oligomerization inhibitor. MSN-125 prevents mitochond
TP1712	PUMA BH3 (TFA)
	PUMA BH3 (TFA) is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.
T75980	PUMA BH3 TFA
	PUMA BH3 (TFA) 是一种 p53 正向凋亡调控因子 (PUMA) BH3 结构域多肽，作为Bak 的直接激活剂，Kd 值为 26 nM。
T32344	JY-1-106 JY-1 106,JY-1106
	JY-1-106 is a BH3 α-helix mimetic, inducing apoptosis in a subset of cancer cells (lung cancer, colon cancer and mesothelioma) by disrupting Bcl-xL and Mcl-1 protein-protein interactions with Bak.
T79242	Mcl-1 inhibitor 16
	Mcl-1 inhibitor16 (Compound 9)为基于铂的线粒体靶向性Mcl-1抑制剂。该化合物通过诱导Bax/Bak依赖的细胞凋亡(apoptosis)，展现出对癌细胞的作用，可以单独使用或与ABT-199联合应用，表现出抗肿瘤活性。
T76073	BH3 hydrochloride
	BH3 hydrochloride是一种能够穿透血脑屏障的多肽，其机制是通过直接激活促凋亡蛋白Bax/Bak或中和抗凋亡Bcl-2家族蛋白(Bcl-2、Bcl-XL、Bcl-w、mcl1和A-1)，从而诱导细胞凋亡。这一作用是通过与BH3结构域的结合实现的。
T26789	BH3I-2' BH3I2',BH3I 2'
	BH3I-2' is a cell-permeable BH3 mimetic. BH3I-2' induces apoptosis by specifically preventing BH3 domain-mediated interactions between pro-apoptotic and anti-apoptotic members of the Bcl-2 family, thereby blocking the interaction between Bcl-x and Bak BH3 by targeting the Bcl-x binding pocket.
TP1724	PUMA BH3
	PUMA BH3 is a p53 upregulated modulator of apoptosis (PUMA) BH3 domain peptide, acts as a direct activator of Bak, with a Kd of 26 nM.This is a PUMA BH3 domain peptide. PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome C releas
T29060	UNBS-1450 UNBS 1450,UBS1450,UBS-1450,UBS 1450
	UNBS-1450 is a sodium channel antagonist. UNBS-1450 is a hemi-synthetic cardenolide derived from 2″-oxovorusharin, it is effective against various cancer cell types with an excellent differential toxicity. At low nanomolar concentrations, UNBS-1450 induce
T80224	Bid BH3 (80-99)
	Bid BH3 (80-99) 是一种具有促凋亡功能的生物活性肽，属于BCL-2蛋白家族中的"BH3仅限"(BOPS)亚群。作为第一个能够结合并激活Bcl-2、Bax和Bak的BOP，Bid扮演引发细胞凋亡的关键角色。它通过从细胞质迁移到线粒体膜来失活Bcl-2或激活Bax。特别地，在N末端位置的谷氨酰胺(Q)或谷氨酸(E)，会自然转化为pGlu形式，其疏水性γ-内酰胺环被认为有助于增强肽针对胃肠道蛋白酶的稳定性。焦谷氨酰肽通常被划分为这类生物活性肽的一个常见子集，并且在HPLC分析中，作为评估肽纯度的重要指标被考虑在内。

化合物

Cat.No: TP1808

Bak BH3 (72-87), TAMRA-labeled

Cat.No: T80029

Cat.No: T4215

Synonym: 5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a

Target: Apoptosis, Pim

Cat.No: T23771

Synonym: BAK2 66

Cat.No: T23861

Synonym: CAY-10526,BTH,CAY 10526

Target: Prostaglandin Receptor

Cat.No: T124107

12-Hydroxyisobakuchiol

Cat.No: T125549

Cat.No: T77034

Synonym: N-803

PUMA BH3 acetate

Cat.No: TP1724L

Synonym: PUMA BH3 acetate(PUMA BH3 Free base)

Target: BCL

Cat.No: T14846

Synonym: BZ48

Target: Apoptosis, BCL

Cat.No: T2099

Target: Mitophagy, BCL, Autophagy

PUMA BH3 (human) TFA

Cat.No: T83751

Cat.No: T28117

Synonym: MSN50,MSN 50

Cat.No: T16155

Target: Akt

Cat.No: TP1712

Cat.No: T75980

Cat.No: T32344

Synonym: JY-1 106,JY-1106

Mcl-1 inhibitor 16

Cat.No: T79242

BH3 hydrochloride

Cat.No: T76073

Cat.No: T26789

Synonym: BH3I2',BH3I 2'

Cat.No: TP1724

Cat.No: T29060

Synonym: UNBS 1450,UBS1450,UBS-1450,UBS 1450

Bid BH3 (80-99)

Cat.No: T80224

Cat. No.	Product Name	Target	Signaling Pathways
T3400	Bakuchiol	p38 MAPK; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; MAPK
	Bakuchiol 是一种从补骨脂种子中提取的植物雌激素，具有抗肿瘤和抗蠕虫特性，以及细胞毒活性和抗菌活性。
TWS1977	Kamebakaurin 尾叶香茶菜丙素,Kamebakaurine	NF-κB	NF-κB
	Kamebakaurin (Kamebakaurine) 是一种提取自Isodon japonicus 中的天然产物，是一种NF-κB 的抑制剂，能够抑制 p50 的 DNA 结合活性。
TN3483	Bakkenolide D	IL Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities.
T2S0606	Bakkenolide A	IL Receptor; IκB/IKK; GSK-3; TNF; Akt; Caspase; PI3K; HDAC	Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells
	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related signaling pathways.
TN3485	Bakkenolide III	Others	Others
	Bakkenolide III may have cytotoxicity.
TN2562	1-Oxobakkenolide S	Others	Others
	1-Oxobakkenolide S 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2562，CAS号为 18456-02-5。
TN3484	Bakkenolide Db	Others	Others
	Bakkenolide Db may have cytotoxicity.
TN3486	Bakkenolide IIIa	ERK; BCL; IκB/IKK; NF-κB; Akt	Apoptosis; Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Bakkenolide IIIa has antioxidant, and neuroprotective effects, it protects against cerebral damage by inhibiting AKT and ERK1/2 activation and inactivated NF-ÎºB signaling.
TN2945	3-Hydroxybakuchiol	ATPase; Caspase	Apoptosis; Membrane transporter/Ion channel; Proteases/Proteasome
	3-Hydroxybakuchiol exerts cytotoxic and anti-proliferative effects on the TA3/Ha mouse mammary adenocarcinoma cell line and induces a decrease in the mitochondrial transmembrane potential, the activation of caspase-3, the opening of the mitochondrial perm
TN3482	Bakkenolide B	NOS; COX	Immunology/Inflammation; Neuroscience
	Bakkenolide B has suppressive properties for allergic and inflammatory responses and may be utilized as a potent agent for the treatment of asthma.
T6S0052	Chelerythrine Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine	Apoptosis; BCL; PKC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Cytoskeletal Signaling
	Chelerythrine (Broussonpapyrine) 是一种天然生物碱，为有效、选择性的 Ca2+/磷脂依赖性PKC 拮抗剂，IC50值为 0.7 μM。它具有抗肿瘤、抗糖尿病、抗炎的活性。它抑制BclXL-Bak BH3肽结合，IC50为 1.5 μM，并从 BclXL 取代了 Bax。它诱导细胞凋亡和自噬。
TN3244	7-O-Methyleucomol	Others	Others
	7-O-Methyleucomol is a natural product from Eucomis bicolor Bak.

天然产物

Cat.No: T3400

Target: p38 MAPK, DNA/RNA Synthesis, Autophagy

Cat.No: TWS1977

Synonym: 尾叶香茶菜丙素,Kamebakaurine

Target: NF-κB

Bakkenolide D

Cat.No: TN3483

Target: IL Receptor, Histamine Receptor

Bakkenolide A

Cat.No: T2S0606

Target: IL Receptor, IκB/IKK, GSK-3, TNF, Akt, Caspase, PI3K, HDAC

Bakkenolide III

Cat.No: TN3485

Target: Others

1-Oxobakkenolide S

Cat.No: TN2562

Target: Others

Bakkenolide Db

Cat.No: TN3484

Target: Others

Bakkenolide IIIa

Cat.No: TN3486

Target: ERK, BCL, IκB/IKK, NF-κB, Akt

3-Hydroxybakuchiol

Cat.No: TN2945

Target: ATPase, Caspase

Bakkenolide B

Cat.No: TN3482

Target: NOS, COX

Cat.No: T6S0052

Synonym: Toddalin,Broussonpapyrine,白屈菜红碱,Cheleritrine

Target: Apoptosis, BCL, PKC, Autophagy

7-O-Methyleucomol

Cat.No: TN3244

Target: Others

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