112
13
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10638 |
BY27
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BY27 是一种具有强效性和选择性的 BET BD2 抑制剂(Ki:3.1 nM),具有抗癌活性,抑制 BRD2、BRD3、BRD4 和 BRDT 的 BD1/BD2,抑制肿瘤生长。 | |||
TP1333 |
Gap 27
|
Gap Junction Protein | Cytoskeletal Signaling |
Gap 27是一种合成的 connexin43 模拟肽,是一种间隙连接抑制剂。它与通往第二跨膜连接蛋白区段的第二细胞外环的一部分具有保守的序列同源性。 | |||
T13314 |
VTX-27
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
VTX-27 是蛋白激酶 C θ (PKC θ) 的一种选择性抑制剂,对 PKC θ 和 PKC δ 的 Ki 值分别为 0.08 nM 和 16 nM。 | |||
T18018 |
HS-27
|
Others; HSP | Cytoskeletal Signaling; Metabolism; Others |
HS-27 是一种荧光束缚的 Hsp90 抑制剂,SNX-5422 通过 PEG 接头束缚在异硫氰酸荧光素或 FITC 上。 HS-27 可用于“即看即治”模式。 | |||
T9612 |
Antibacterial agent 27
|
Anti-infection | Microbiology/Virology |
Antibacterial agent 27 是抗菌化合物,显示出有效的抗念珠菌活性。 | |||
T10591L |
(R)-BPO-27
|
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
(R)-BPO-27 是一种具有口服活性和高效性的 ATP 竞争性 CFTR 抑制剂(IC50:4 nM),可用于研究腹泻和多囊肾。 | |||
T77635 |
LSD1-IN-27
|
Histone Demethylase; PD-1/PD-L1 | Apoptosis; Cell Cycle/Checkpoint; Chromatin/Epigenetic; Immunology/Inflammation |
LSD1-IN-27 是一种高效的 LSD1 抑制剂 ,IC50 值为 13 nM。LSD1-IN-27 对胃癌细胞的干细胞性和迁移有抑制作用。LSD1-IN-27 对 BGC-823 和 MFC 细胞中 PD-L1 的表达有抑制作用。LSD1-IN-27 可增强对胃癌的 T 细胞免疫反应。 | |||
T10591 |
BPO-27 racemate
BPO-27 (racemate) |
CFTR; Autophagy | Autophagy; Membrane transporter/Ion channel |
BPO-27 racemate (BPO-27(racemate)) 是一种CFTR 抑制剂,IC50为8 nM。 | |||
T9989 |
AChE-IN-27
|
Others | Others |
AChE-IN-27是一种用于高通量测定的小分子。 | |||
T24804 |
SM27
SM-27,NSC-37204,SM 27,NSC37204 |
FGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
SM27 是一种成纤维细胞生长因子 2(FGF2) 抑制剂,具有抗血管生成活性,可用于研究肿瘤。 | |||
T22782 |
FGIN-1-27
|
Others | Others |
FGIN 1-27 是一种吲哚乙酰胺,是外周苯二氮卓受体的特异性的配体,Ki 为 5.0 nM。FGIN 1-27 可以透过血脑屏障。FGIN 1-27对异烟肼引起的抽搐发作具有抑制作用。 | |||
T78555 |
BRD4 Inhibitor-27
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
BRD4 Inhibitor-27 是一种有效的 BRD4 抑制剂,对 BRD4 BD1 和 BRD4 BD2 具有抑制作用, IC50 分别为 9.6 和 11.3 μM。BRD4 Inhibitor-27 具有抗癌活性,可用于研究乳腺癌。 | |||
T4344 |
ALW-II-41-27
Eph receptor tyrosine kinase inhibitor |
Ephrin Receptor | Tyrosine Kinase/Adaptors |
ALW-II-41-27 (Eph receptor tyrosine kinase inhibitor) 是一种 Eph 受体酪氨酸激酶抑制剂,可用于治疗癌症。 | |||
T77764 |
DC-Y13-27
|
Others | Others |
DC-Y13-27 是一种 DC-Y13 的衍生物,是一种有效的 YTHDF2 抑制剂 (KD: 37.9 μM)。DC-Y13-27 具有抗肿瘤活性,可增强放疗和免疫疗法对肿瘤的响应。 | |||
T38193L |
β-Endorphin (1-27) (human) acetate
β-Endorphin (1-27) (human) acetate(76622-84-9 Free base) |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
β-Endorphin (1-27) (human) acetate 存在于大脑垂体和下丘脑中,具有镇痛活性。 β-Endorphin (1-27) (human) acetate 是一种阿片受体激动剂,对 μ-阿片受体和 δ-阿片受体具有较好的亲和力。 | |||
T7265 |
HSP27 inhibitor J2
J2 |
HSP | Cytoskeletal Signaling; Metabolism |
HSP27 inhibitor J2 (J2) 是一种HSP27抑制剂,可显著增强 17-AAG 的抗增殖活性,并对顺铂诱导的肺癌细胞生长抑制具有敏感性。它显著诱导异常 HSP27 二聚体形成并抑制HSP27巨聚合物的产生,从而具有抑制HSP27的伴侣功能和降低细胞保护功能的作用。 | |||
TP1267L |
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base) |
Others | Others |
CEF27, Epstein-Barr Virus BRLF-1 lytic 148-156 acetate(254110-79-7 free base) 对应于 BRLF1 的氨基酸 148-156。 BRLF1 是一种转录激活因子,可直接与一些 Epstein-Barr 病毒 (EBV) 裂解基因启动子中的富含 GC 的基序结合。 | |||
T81436 |
PNC-27
|
||
PNC-27, 为含有HDM-2结合域的抗癌肽,展现出抗肿瘤活性,适用于急性骨髓性白血病研究。 | |||
T36998 |
7β,27-dihydroxy Cholesterol
7β,27-DHC,7β,27-dihydroxy Cholesterol |
||
7β,27-dihydroxy Cholesterol is an oxysterol and agonist of retinoic acid receptor-related orphan receptor γ (RORγ) and RORγt. [1] It activates RORγ- or RORγt-dependent signaling with EC50 values of 691 and 1,045 nM, respectively, in reporter assays using HEK293T cells expressing the recombinant human receptors. 7β,27-dihydroxy Cholesterol is selective for RORγ and RORγt over a panel of eight additional nuclear receptors at 30 µM. It increases IL-17A production in Th17-polarized isolated hum... | |||
T70502 |
AZ-27
|
||
AZ-27 is a respiratory syncytial virus inhibitor which differentially inhibits different polymerase activities at the promoter. | |||
T63121 |
Anticancer agent 27
|
||
Anticancer agent 27 是一种有希望的治疗癌症候选者,值得进一步开发。 | |||
T82996 |
Antiviral agent 27
|
||
Antiviralagent 27 (Compound 12) 表现出针对 Ebola 病毒的活性,其半抑制浓度(EC50)为 14 nM。 | |||
T61190 | Tubulin inhibitor 27 | ||
Tubulin inhibitor 27 (DYT-1) 是一种微管蛋白聚集 (tubulin polymerisation) 抑制剂,IC50为 25.6 μM。Tubulin inhibitor 27 具有抗血管生成活性和抗肿瘤活性。 | |||
T80213 |
BMAP-27
|
||
BMAP-27,抗菌肽,具有破坏微生物膜完整性的能力。由于其膜透化效应,BMAP-27对细菌和癌细胞均展现出抑制作用。 | |||
T79812 |
BTK-IN-27
|
BTK | Angiogenesis; Tyrosine Kinase/Adaptors |
BTK-IN-27(示例8)作为一种BTK抑制剂,具有高效的IC50值为0.2 nM。在TMD8细胞中,该化合物展现出显著的抗增殖能力,IC50值低于5 nM。BTK-IN-27适用于癌症、淋巴瘤、白血病及免疫性疾病研究领域。 | |||
T61209 | HDAC-IN-27 | ||
HDAC-IN-27 是一种有效的口服活性HDACI 类选择性抑制剂,对 HDAC1-3 的 IC50值范围为 0.43 至 3.01 nM。抗急性髓系白血病 (AML) 活性。 | |||
T79237 |
α-Glucosidase-IN-27
|
Glucosidase | Metabolism |
α-Glucosidase-IN-27(化合物8l)是一种有效的α-glucosidase抑制剂,其IC50值为25.78 μM。该化合物有望用于研究2型糖尿病(D2M)。 | |||
T79110 |
JAK-IN-27
|
JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells |
JAK-IN-27(化合物1)是JAK家族激酶的口服有效抑制剂,对TYK2、JAK1和JAK3的IC50分别为3.0 nM、7.7 nM和629.6 nM。此外,JAK-IN-27能够抑制Jurkat细胞内由IFN-α2B诱导的STAT3磷酸化,其IC50为23.7 nM。 | |||
T72086 |
Questiomycin A derivatives 27
|
||
Questiomycin A derivatives 27 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T72086。 | |||
T82117 |
ICMT-IN-27
|
||
ICMT-IN-27(化合物64)作为ICMT抑制剂,具有0.1 μM的IC50值。 | |||
T79485 |
IRAK4-IN-27
|
IRAK | Immunology/Inflammation; NF-κB |
IRAK4-IN-27(Compound 22)为高效选择性IRAK4抑制剂,具IC50值8.7 nM。该化合物能够抑制含MYD88L265P突变的DLBCL细胞系生长并促进其细胞凋亡(apoptosis),适用于弥漫大B细胞淋巴瘤(DLBCL)的研究。 | |||
T61129 |
Tubulin polymerization-IN-27
|
||
Tubulin polymerization-IN-27 (compound 5j) is an inhibitor of tubulin polymerization. It has the ability to halt the cell cycle specifically at the G2/M phase and also induce apoptosis [1]. | |||
T62546 |
ALK5-IN-27
|
||
ALK5-IN-27 (Compound EX-04) 是一种 ALK-5 的有效抑制剂 (IC50≤10 nM)。ALK5-IN-27 对 ALK-2 也具有抑制作用。 | |||
T81488 |
PHI-27 (rat)
|
||
PHI-27 (rat) 为含27个氨基酸的肽类化合物,主要应用于肽激素和其它活性肽的研究识别。 | |||
T61308 | Antifungal agent 27 | ||
Antifungal agent 27 (compound 7) is a chemical compound possessing antifungal properties. It exhibits moderate antibacterial activity and weak antifungal activity against MRSA and C. albicans SS5314, with minimal inhibitory concentration (MIC) values of 8 and 32 μg/mL, respectively [1]. | |||
T78728 |
SP27
|
PROTACs | PROTAC |
SP27为一种选择性PROTAC,专一地降解PLK4,具有19.5 nM的DC50。该化合物主要应用于乳腺癌研究。 | |||
T78936 |
Antimalarial agent 27
|
Parasite | Microbiology/Virology |
Antimalarial agent 27 (compound 11a) 是一款针对恶性疟原虫有效的抗疟疾化合物,展现出优异的抑制能力(IC50=0.37 μM)。其机制主要通过抑制目标疟原虫中的DXR (1-脱氧-D-木糖-5-磷酸还原酶),以达成较高抑制效果(IC50=0.11 μM)。 | |||
T126295 |
Antibiotic JBIR 27
|
||
Antibiotic JBIR 27 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126295,CAS号为 1172094-65-3。 | |||
T83146 |
ALK-IN-27
|
||
ALK-IN-27(化合物1)是一种有效的ALK抑制剂,展现出抗肿瘤活性。在Ba/F3 CLIP1-LTK细胞中,ALK-IN-27的IC50为2.7 nM。 | |||
T37206 |
CCK (27-33) (non-sulfated)
|
||
CCK (27-33) is a C-terminal fragment of CCK , a peptide hormone found in the intestine and brain that stimulates digestion, mediates satiety, and is involved in anxiety. Non-sulfated CCK (27-33) inhibits binding of [3H]naloxone in rat cerebellum membranes (IC50 = 4 uM) and inhibits electrically-stimulated contraction of isolated guinea pig ileum (IC50 = 17 uM), an effect that can be reversed by naloxone. Unlike sulfated CCK (27-33), the non-sulfated form does not reduce exploratory behavior in m... | |||
T81489 |
PHI-27 (porcine)
|
||
PHI-27 (porcine)是由27个氨基酸组成的肽类化合物,主要用于探索肽激素及其他活性肽。 | |||
T75095 | STING agonist-27 | ||
STINGagonist-27 (CF509) 是一种非核苷酸小分子 STING 激动剂。STINGagonist-23 激活 STING,表现出抗 SARS-CoV 系列的活性。 | |||
T79289 |
Antiproliferative agent-27
|
Apoptosis | Apoptosis |
Antiproliferative agent-27 (化合物 11) 作为一种有效的抗增殖剂,可显著降低肿瘤细胞的集落数量并诱导细胞凋亡,显示出在癌症研究中的应用潜力。 | |||
T62901 |
VEGFR-2-IN-27
|
||
VEGFR-2-IN-27 (compound 7a) 是一种 VEGFR-2 的高效抑制剂 (IC50: 14.8 nM),能够用于抗癌研究。 | |||
T61141 | Antitubercular agent-27 | ||
Antitubercular agent-27 (compound 1) 是一种有效的抗结核药剂,IC50值为 3.2 μM,MICb> 值为 7.8 μM,IC90值为 7.0 μM。Antitubercular agent-27 对结核分枝杆菌 H37Rv 的耐药分离株显示出抗分枝杆菌活性。Antitubercular agent-27 显示出有效的细胞内抗分枝杆菌活性和低细胞毒性。 | |||
T76245 |
CKLF1-C27
|
||
CKLF1-C27 是 CKLF1 的 C 末端肽,与CCR4受体结合并激活ERK1/2通路。CKLF1-C27 可以通过竞争CCR4受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进HUVECs 增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。 | |||
T79117 |
Menin-MLL inhibitor 27
|
Epigenetic Reader Domain | Chromatin/Epigenetic |
Menin-MLL inhibitor 27 是一种化合物,它能有效抑制Menin-MLL之间的相互作用,对于研究癌症具有潜在价值,尤其是在急性骨髓性白血病方面。 | |||
T38193 |
β-Endorphin (1-27) (human) (trifluoroacetate salt)
|
||
β-Endorphin (1-27) is an endogenous peptide that binds to μ-, δ-, and κ-opioid receptors (Kis = 5.31, 6.17, and 39.82 nM, respectively, in COS-1 cells expressing rat receptors). It binds to rat and mouse brain membrane preparations (IC50s = 1.1 and 5.7 nM, respectively) and induces chemotaxis of human monocytes in vitro when used at a concentration of 1 nM. Intracerebroventricular administration of β-endorphin (1-27) increases the latency to tail withdrawal in response to thermal stimulation in ... | |||
T64705 |
PHI 27 (human) trifluoroacetate
|
||
PHI 27 (human) trifluoroacetate 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T64705。 | |||
T79367 |
CDK9-IN-27
|
CDK | Cell Cycle/Checkpoint |
CDK9-IN-27(Compound 6a)是一款针对CDK9的抑制剂,其IC50s为0.424 μM。该化合物可诱导细胞凋亡(apoptosis)及S期细胞周期停滞,并对HepG2、HCT-116及MCF-7细胞系展现出细胞毒性,其IC50s介于10.31至40.34 μM之间。CDK9-IN-27主要应用于癌症相关研究领域。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8301 |
Amaranth
Acid Red 27,酸性红 27 |
Others | Others |
Amaranth (Acid Red 27) 是一种阴离子染料, 可应用到天然和合成纤维、皮革、纸张及苯酚-甲醛树脂。它是一种暗红色至紫色的偶氮染料,可用作食品染料和化妆品。 | |||
TN1222 |
26-Deoxyactein
27-Deoxyactein,脱氧升麻烃,23-epi-26-Deoxyactein,27-脱氧升麻亭 |
NOS; CDK; NO Synthase | Cell Cycle/Checkpoint; Immunology/Inflammation |
23-epi-26-Deoxyactein (27-Deoxyactein) 是一种黑升麻中的主要成分,能够阻止 TCDD 诱导的成骨细胞的损伤。它对 AhR,CYP1A1 和 ERK 的水平升高具有抑制作用。 | |||
TQ0274 |
27-Hydroxycholesterol
27-羟基胆固醇,5,25R-胆甾烯-3BETA,26-二醇,25(R)-27-hydroxy Cholesterol |
Estrogen/progestogen Receptor; Liver X Receptor | Endocrinology/Hormones; Metabolism |
27-Hydroxycholesterol (25(R)-27-hydroxy Cholesterol) 是一种有效的、选择性的雌激素受体调节剂和肝X 受体激动剂。 | |||
T35647 |
4-oxo-27-TBDMS Withaferin A
|
||
4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.References1. Perestelo, N.R., Llanos, G.G., Reyes, C.P., et al. Expanding the chemical space of wi... | |||
TN1230 |
27-O-acetyl-withaferin A
27-O-乙酰基-醉茄素A |
Others | Others |
27-O-acetyl-withaferin A is a natural product | |||
T83041 |
Antimicrobial agent-27
|
||
Antimicrobial agent-27 (compound 4),一种齐墩烷型三萜酰化衍生物,源自匙羹藤 (Gymnema sylvestre) 的分离提取。 | |||
T75490 | 27-O-(tert-Butyldimethylsilyl)withaferin A | ||
27-O-(tert-Butyldimethylsilyl)withaferin A (compound 9a) 为一种天然茄内酯类化合物,具备诱导细胞凋亡 (apoptosis) 的能力。该化合物对人类癌细胞系HeLa、A-549、MCF-7以及正常Vero细胞展现出抗增殖活性。 | |||
T83571 |
(22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide
|
||
(22R)-27-Hydroxy-1-oxowitha-2,5,24-trienolide(睡茄内酯),这种化合物为天然产物,可从盐生植物Datura stramonium的地上部分分离得到。 | |||
T38892 |
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid
|
||
3,11,15,23-Tetraoxo-27ξ-lanosta-8,16-dien-26-oic acid, a lanostane-type triterpenoid, is extracted from Antrodia camphorate. | |||
T81952 |
Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo-
|
||
Lanosta-7,9(11),23,25(27)-tetraen-26-oic acid, 23,27-epoxy-3-oxo- 是一种从土津皮 (山楝的根皮) 提取的羊毛甾烷型化合物。 | |||
T1276 |
Danofloxacin mesylate
甲磺酸达氟沙星,CP 76136-27 |
DNA/RNA Synthesis; Antibacterial; Antibiotic | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Danofloxacin mesylate (CP 76136-27) 是一种兽医用氟喹诺酮类抗菌素。 | |||
T37177 |
Norcholic Acid
|
||
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4 | |||
T35779 |
Oosporein
|
||
Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |