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49

抑制剂 & 化合物

6

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Cat. No. Product Name Target Signaling Pathways
T3434 BAY1217389

Kinesin Cytoskeletal Signaling
BAY1217389 是一种有效的选择性单极纺锤体 1 (MPS1) 激酶抑制剂 ,IC50值小于10 nM。
T16130 Mps1-IN-3

Kinesin Cytoskeletal Signaling
Mps1-IN-3 是一种有效的选择性 MPS1 激酶抑制剂,IC50值为 50 nM。
T1839 Mps1-IN-2

Kinesin; PLK Cell Cycle/Checkpoint; Cytoskeletal Signaling
Mps1-IN-2 是一种 ATP 竞争性Mps1/Plk1选择性双重抑制剂,对 Mps1 的IC50和Kd 值分别为 145 和 12 nM,对 Plk1 的Kd 值为 61 nM。
T2689 AZ3146

AZ 3146

Kinesin Cytoskeletal Signaling
AZ3146 是一种选择性 Mps1 抑制剂,IC50为 35 nM。
T2313 MPI-0479605

Apoptosis; Kinesin Apoptosis; Cytoskeletal Signaling
MPI0479605 是一种选择性的,ATP 竞争性的 Mps1抑制剂,IC50值为 1.8 nM。
T12237 NMS-P715

Casein Kinase; Kinesin; MELK; MAPK Cytoskeletal Signaling; MAPK; Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
NMS-P715 是一种 ATP 竞争性MPS1选择性抑制剂,IC50值为 182 nM。
T8487 Empesertib

BAY 1161909

Kinesin Cytoskeletal Signaling
Empesertib (BAY 1161909) 是一种口服有效的Mps1抑制剂,IC50值小于1 nM,具有潜在的抗肿瘤活性。
T14765 BOS-172722

Kinesin Cytoskeletal Signaling
BOS-172722 是一种单极纺锤体 1 (MPS1) 检查点抑制剂,对MPS1 (1 mM ATP) 和P-MPS1 的IC50值分别为 11 nM 和 63 nM。它可研究多种乳腺癌。
T8492 BO-264

Apoptosis; FGFR Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
BO-264 是一种有口服活性的转化酸性卷曲螺旋 3 抑制剂,可特异性阻断 FGFR3-TACC3融合蛋白的功能。它诱导纺锤体检查点依赖的有丝分裂阻滞,DNA 损伤和细胞凋亡,具有广谱抗肿瘤活性。
T2241 Alisertib

MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸

Apoptosis; Aurora Kinase; Autophagy Apoptosis; Autophagy; Cell Cycle/Checkpoint; Chromatin/Epigenetic
Alisertib (MLN 8237) 是一种口服活性和选择性的Aurora A 激酶抑制剂,IC50值为 1.2 nM。它通过靶向白血病细胞中的AKT/mTOR/AMPK/p38途径诱导其凋亡和自噬,具有抗肿瘤活性。
T2255 SB-743921 hydrochloride

SB743921 HCl,SB743921

Kinesin; KSP Cell Cycle/Checkpoint; Cytoskeletal Signaling
SB-743921 hydrochloride (SB743921 HCl) 是一种有效的驱动蛋白纺锤体蛋白 KSP 抑制剂,Ki 值为 0.1 nM。
T9682 AZD-4877

AZD4877

Apoptosis; Kinesin Apoptosis; Cytoskeletal Signaling
AZD-4877 是一种高效的纺锤体驱动蛋白 (Eg5) 抑制剂,对其 IC50 值为 2 nM。 AZD-4877 是 Ispinesib 的另一种构型, 能够抑制细胞有丝分裂,诱导形成单极纺锤体表型,介导细胞凋亡(Apoptosis)。 AZD-4877 具有抗肿瘤活性,对循环外周血单核细胞 (PBMC)有抑制作用。
T9831 MKC-1

Ro-31-7453

Apoptosis; Akt; Microtubule Associated; mTOR Apoptosis; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
MKC-1 (Ro-31-7453) 是一种口服生物可利用的小分子双吲哚基马来酰亚胺细胞周期抑制剂,具有潜在的抗肿瘤活性。
T5699 SSE15206

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
SSE15206 是一种克服多药耐药性的微管聚合抑制剂,其在 HCT116 细胞中的 GI50值为 197 nM。由于癌细胞中纺锤体形成不完整,导致 G2/M 停滞,有丝分裂异常。
T2103 Ispinesib

伊匹尼塞,伊斯平斯,CK0238273,SB-715992

Apoptosis; Kinesin; KSP Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling
Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂,具有抗肿瘤特性。
TQ0318 Filanesib

ARRY-520,ARRY 520

KSP Cell Cycle/Checkpoint
Filanesib (ARRY 520) 是一种选择性的驱动蛋白纺锤体蛋白(KSP)的抑制剂(IC50 = 6 nM),具有强大的抗增殖活性。
TQ0318L ARRY 520 hydrochloride

KSP Cell Cycle/Checkpoint
ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡,并具有有效的抗增殖活性。
T2090 Lexibulin

CYT-997

Apoptosis; Reactive Oxygen Species; Microtubule Associated Apoptosis; Cytoskeletal Signaling; Immunology/Inflammation; Metabolism; NF-κB
Lexibulin (CYT-997) 是一种微管蛋白聚集强效抑制剂,可诱导细胞凋亡,并诱导 GC 细胞中的线粒体ROS 生成。它对多种癌细胞的 IC50 值为 10-100n M,在体内外具有高细胞毒性和血管增生阻断作用。
T2511 Plinabulin

普那布林,NPI-2358

Microtubule Associated Cytoskeletal Signaling
Plinabulin (NPI-2358) 是一种抗微管蛋白解聚肿瘤细胞的血管破坏剂,选择性地靶向并结合到微管蛋白的秋水仙碱结合位点,从而中断微管动力学的平衡。它对人肿瘤细胞系具有抑制作用,对 HT-29 细胞系的IC50值为 9.8 nM。
T36816 S-trityl-L-Cysteine

STLC

Kinesin Cytoskeletal Signaling
S-Trityl-L-cysteine 是别构驱动蛋白Eg5的选择性抑制剂。rityl-L-cysteine 抑制基础 ATPase 活性的IC50为 1 μM,抑制微管激活的 ATPase 活性的IC50为 140 nM。S-Trityl-L-cysteine 显示出抗肿瘤活性。
T28694 SB-743921 free base

SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921

SB-743921, a kinesin spindle protein (KSP) inhibitor, is used potentially for the treatment of non-Hodgkin's lymphoma (NHL).
T23865 CCT-271850

MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77

CCT-271850 is an inhibitor of the spindle checkpoint function of Monospindle 1.
T21321 MK-0731

MK-0731, a synthetic small molecule with potential antineoplastic activity, selectively inhibits kinesin spindle protein (KSP), leading to the inhibition of mitotic spindle assembly, induction of cell cycle arrest during the mitotic phase and apoptosis in
T73229 Mps1-IN-4

Mps1-IN-4,一种针对Monopolar spindle 1 (Mps1)的选择性抑制剂,展现出抗增殖特性,适用于癌症领域的研究。
T25418 Filanesib TFA

Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA

Filanesib (ARRY-520) targets the kinesin spindle protein (KSP) with potential antineoplastic activity. ARRY-520 specifically inhibits KSP (kinesin-5 or Eg5), resulting in activation of the spindle assembly checkpoint, induction of cell cycle arrest during
T38710 JH295

JH295 is a highly potent and selective inhibitor of NIMA-related kinase 2 (Nek2), exhibiting irreversible inhibition activity with an IC 50 value of 770 nM. This compound effectively inhibits cellular Nek2 using the alkylation of Cys22. Importantly, JH295 does not exhibit any inhibitory effects toward Cdk1, Aurora B, or Plk1, which are kinases involved in mitotic processes. Furthermore, JH295 has no impact on bipolar spindle assembly or the spindle assembly checkpoint mechanism.
T68743 AZD4877 HCl

AZD4877 is a synthetic kinesin spindle protein (KSP) inhibitor with potential antineoplastic activity. KSP inhibitor AZD4877 selectively inhibits microtubule motor protein KSP (also called kinesin-5 or Eg5), which may result in the inhibition of mitotic spindle assembly; activation of the spindle assembly checkpoint; induction of cell cycle arrest during the mitotic phase; and cell death in tumor cells that are actively dividing. Because KSP is not involved in postmitotic processes, such as neur...
T37050 MPS1/TTK Inhibitor

MPS1/TTK Inhibitor

MPS1/TTK inhibitor is an inhibitor of monopolar spindle 1 (MPS1/TTK; IC50 = 5.8 nM), a kinase involved in mitotic spindle checkpoint signaling that is overexpressed in certain cancerous tumors. It inhibits MPS1 phosphorylation of kinetochore scaffold 1 (KNL1) and increases the rate of mitosis and the number of cells entering anaphase within 15 minutes, indicating MPS1 checkpoint inhibition, when used at a concentration of 100 nM. MPS1/TTK inhibitor (50 and 100 nM) increases the number of missegr...
T14906 CCT251455

Kinesin Cytoskeletal Signaling
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T17007 TC-Mps1-12

Kinesin Cytoskeletal Signaling
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
T71232 Alisertib sodium hydrate

Alisertib sodium hydrate is a salt of Alisertib --- an inhibitor of Aurora A kinase with potential antineoplastic activity. Alisertib binds to and inhibits Aurora A kinase, which may result in disruption of the assembly of the mitotic spindle apparatus, disruption of chromosome segregation, and inhibition of cell proliferation.
T10373 (R)-Filanesib

(R)-ARRY-520

Others Others
(R)-Filanesib is the R-enantiomer of ARRY-520. (R)-Filanesib is a synthetic kinesin spindle protein (KSP) inhibitor (IC50: 6 nM).
T71082 DW532

DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca...
T72757 TTK inhibitor 3

TTK inhibitor 3 是一种有效的选择性TTK(一种必需的纺锤体组装检查点酶)抑制剂,其IC50值为 3.0 nM。
T73195 EAPB 02303

EAPB 02303 是一种微管破坏剂和抑制剂。EAPB 02303 诱导有丝分裂停止和纺锤体组装损伤。因此,EAPB 02303 诱导细胞凋亡 (apoptosis) 并表现出抗肿瘤活性。EAPB 02303 在较低浓度下也表现出与紫杉醇 的强协同作用。
T73483 RMS-07

RMS-07 是 Monopolar Spindle Kinase 1 (MPS1/TTK)的共价抑制剂,其 IC50值为 13.1 nM。RMS-07靶向激酶结构域的半胱氨酸。
T25025 ALB-109564 dihydrochloride

ALB-109564 dihydrochloride 是长春碱生物碱的半合成衍生物,是一种微管蛋白抑制剂和抗肿瘤药物。它与微管蛋白单体结合并抑制微管的形成,导致有丝分裂纺锤体组装的破坏和肿瘤细胞停滞在细胞周期的G2/M 期。
T37063 Laulimalide

Microtubule stabilizing agent. Potent inhibitor of cellular proliferation in cancer cell lines (IC50 reported to be 3-30 nM, dependent on cell line used). Causes cells to arrest in the prometaphase of the cell cycle, prevents formation of bipolar spindle and increases kinetochore tension in preformed spindles. Pryor et al (2002) The microtubule stabilizing agent laulimalide does not bind in the taxoid site, kills cells resistant to PacT. and epothilones, and may not require its epoxide moiety fo...
T61061 JH295 hydrate

JH295 hydrate 通过 Cys22 烷基化从而抑制细胞Nek2,它是有效的,不可逆和选择性的NIMA 相关激酶 2 (Nek2)抑制剂 (IC50 = 770 nM)。JH295 hydrate 对有丝分裂激酶 Cdk1,Aurora B 或 Plk1 不具有活性,不干扰双极纺锤体组件或纺锤体组件检查点。
T68686 DAP-81

DAP-81 is a diaminopyrimidine derivative that targets PLKs, destabilizing kinetochore microtubules. Other spindle tubules are stabilized, resulting in monopolar mitotic spindles. In vitro, DAP-81 inhibits Plk1 at an IC50 of 0.9 nM. DAP-81 is currently in ongoing preclinical evaluations.
T70095 Mps1-IN-1 dihydrochloride

Mps1-IN-1 dihydrochloride 是一种有效的,ATP 竞争性 Mps1激酶抑制剂,IC50为 367 nM。Mps1-IN-1 dihydrochloride 抑制 Mps1有丝分裂激酶活性并沉默纺锤体组装检查点 (SAC) 功能。Mps1-IN-1 dihydrochloride 降低癌细胞和“正常”细胞的活力。
T68428 ZK-Thiazolidinone

ZK-Thiazolidinone, also known as TAL, is an ATP-competitive inhibitor of PLK1. In vitro, ZK-Thiazolidinone counteracts the role of Plk1 in previously established functions, notably, sister chromatid separation, centrosome maturation, and bipolar spindle assembly. In vivo, ZK-Thiazolidinone selectively inhibits PLK1 and causes a prometaphase-like mitotic (G2–M) arrest. ZK-Thiazolidinone inhibits human PLK1 (IC50, 19± 12 nM) and various human and mouse tumor cell lines (IC50, 0.2–1.3 μM). ZK-Thiaz...
T71556 MK-1496

MK1496 is a n orally bioavailable Polo-like kinase 1 (Plk1) inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor MK1496 selectively inhibits Plk1, inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a n...
T78138 SIC5-6

Others Others
SIC5-6为一强效Separase抑制剂,此酶为大型半胱氨酸蛋白酶,关键参与有丝分裂与减数分裂中染色体分离,DNA损伤修复,中心体分离与复制,以及纺锤体稳定与伸长。Separase在众多实体瘤高表达,成为潜在的化疗靶标。
T68273 BNC105P

BNC105P is a benzofuran-based vascular disrupting agent (VDA) prodrug with potential anti-vascular and antineoplastic activities. Upon administration vascular disrupting agent BNC105P, the disodium phosphate ester of BNC105, is rapidly converted to BNC105; in activated endothelial cells, BNC105 binds to tubulin and inhibits its polymerization, which may result in a blockage of mitotic spindle formation, cell cycle arrest, and disruption of the tumor vasculature. Hypoxic conditions ensue, deprivi...
T38428 Alisertib sodium

MLN 8237 sodium

Alisertib sodium (MLN 8237) is a potent and specific inhibitor (IC50 = 1.2 nM) of Aurora A kinase, an enzyme involved in cell division. By binding to Aurora A kinase, Alisertib sodium disrupts the formation of the mitotic spindle and causes abnormal cell division. At the molecular level, it acts on the AKT/mTOR/AMPK/p38 pathway, leading to the induction of apoptosis and autophagy in leukemic cells. This compound exhibits significant antitumor activity.
T78125 PVZB1194

Kinesin Cytoskeletal Signaling
PVZB1194是一种联苯型激酶Eg5(亦称KIF11)抑制剂,与细胞周期相关,可以通过抑制Eg5的ATP酶活性导致细胞周期阻滞和细胞凋亡,从而显现抗癌潜力。该化合物与α4/α6变抗袋结合,展现ATP竞争性活性。
T62148 NW 1028

NW 1028 是一种 VCP/p97 的有效抑制剂。NW 1028 能够选择性作用于 p97 的 ND1L 结构域,抑制依赖于 p97 的报告基因的降解。NW 1028 能够良好的结合 ND1L (Kd: 100 nM) 和全长 p97 (Kd: 285 nM)。NW 1028 对细胞有丝分裂纺锤体具有调节作用。
T36199 AZD 1152 (hydrochloride)

AZD 1152 is an orally bioavailable prodrug of AZD 1152-HQPA, a selective inhibitor of Aurora kinase B (IC50= 0.36 nM).1AZD 1152 is converted to AZD 1152-HQPA in plasma. Inhibition of Aurora B results in disruption of spindle checkpoint functions and chromosome alignment, resulting in inhibition of cytokinesis followed by apoptosis.2,3AZD 1152 inhibits tumor xenograft growthin vivo.4,5 1.Mortlock, A.A., Foote, K.M., Heron, N.M., et al.Discovery, synthesis, and in vivo activity of a new class of p...

化合物

BAY1217389
Cat.No: T3434
Synonym:
Target: Kinesin
Mps1-IN-3
Cat.No: T16130
Synonym:
Target: Kinesin
Mps1-IN-2
Cat.No: T1839
Synonym:
Target: Kinesin, PLK
AZ3146
Cat.No: T2689
Synonym: AZ 3146
Target: Kinesin
MPI-0479605
Cat.No: T2313
Synonym:
Target: Apoptosis, Kinesin
NMS-P715
Cat.No: T12237
Synonym:
Target: Casein Kinase, Kinesin, MELK, MAPK
Empesertib
Cat.No: T8487
Synonym: BAY 1161909
Target: Kinesin
BOS-172722
Cat.No: T14765
Synonym:
Target: Kinesin
BO-264
Cat.No: T8492
Synonym:
Target: Apoptosis, FGFR
Alisertib
Cat.No: T2241
Synonym: MLN 8237,4-[[9-氯-7-(2-氟-6-甲氧基苯基)-5H-嘧啶并[5,4-D][2]苯并氮杂卓-2-基]氨基]-2-甲氧基苯甲酸
Target: Apoptosis, Aurora Kinase, Autophagy
SB-743921 hydrochloride
Cat.No: T2255
Synonym: SB743921 HCl,SB743921
Target: Kinesin, KSP
AZD-4877
Cat.No: T9682
Synonym: AZD4877
Target: Apoptosis, Kinesin
MKC-1
Cat.No: T9831
Synonym: Ro-31-7453
Target: Apoptosis, Akt, Microtubule Associated, mTOR
SSE15206
Cat.No: T5699
Synonym:
Target: Apoptosis, Microtubule Associated
Ispinesib
Cat.No: T2103
Synonym: 伊匹尼塞,伊斯平斯,CK0238273,SB-715992
Target: Apoptosis, Kinesin, KSP
Filanesib
Cat.No: TQ0318
Synonym: ARRY-520,ARRY 520
Target: KSP
ARRY 520 hydrochloride
Cat.No: TQ0318L
Synonym:
Target: KSP
Lexibulin
Cat.No: T2090
Synonym: CYT-997
Target: Apoptosis, Reactive Oxygen Species, Microtubule Associated
Plinabulin
Cat.No: T2511
Synonym: 普那布林,NPI-2358
Target: Microtubule Associated
S-trityl-L-Cysteine
Cat.No: T36816
Synonym: STLC
Target: Kinesin
SB-743921 free base
Cat.No: T28694
Synonym: SB743921,SB-921,SB921,SB-743921,GSK-743921,GSK-921
Target:
CCT-271850
Cat.No: T23865
Synonym: MPS1-IN-77,MPS1IN77,CCT271850,CCT 271850,MPS1 IN 77
Target:
MK-0731
Cat.No: T21321
Synonym:
Target:
Mps1-IN-4
Cat.No: T73229
Synonym:
Target:
Filanesib TFA
Cat.No: T25418
Synonym: Filanesib trifluoroacetic acid,ARRY-520 TFA,ARRY 520 TFA,ARRY520 TFA
Target:
JH295
Cat.No: T38710
Synonym:
Target:
AZD4877 HCl
Cat.No: T68743
Synonym:
Target:
MPS1/TTK Inhibitor
Cat.No: T37050
Synonym: MPS1/TTK Inhibitor
Target:
CCT251455
Cat.No: T14906
Synonym:
Target: Kinesin
TC-Mps1-12
Cat.No: T17007
Synonym:
Target: Kinesin
Alisertib sodium hydrate
Cat.No: T71232
Synonym:
Target:
(R)-Filanesib
Cat.No: T10373
Synonym: (R)-ARRY-520
Target: Others
DW532
Cat.No: T71082
Synonym:
Target:
TTK inhibitor 3
Cat.No: T72757
Synonym:
Target:
EAPB 02303
Cat.No: T73195
Synonym:
Target:
RMS-07
Cat.No: T73483
Synonym:
Target:
ALB-109564 dihydrochloride
Cat.No: T25025
Synonym:
Target:
Laulimalide
Cat.No: T37063
Synonym:
Target:
JH295 hydrate
Cat.No: T61061
Synonym:
Target:
DAP-81
Cat.No: T68686
Synonym:
Target:
Mps1-IN-1 dihydrochloride
Cat.No: T70095
Synonym:
Target:
ZK-Thiazolidinone
Cat.No: T68428
Synonym:
Target:
MK-1496
Cat.No: T71556
Synonym:
Target:
SIC5-6
Cat.No: T78138
Synonym:
Target: Others
BNC105P
Cat.No: T68273
Synonym:
Target:
Alisertib sodium
Cat.No: T38428
Synonym: MLN 8237 sodium
Target:
PVZB1194
Cat.No: T78125
Synonym:
Target: Kinesin
NW 1028
Cat.No: T62148
Synonym:
Target:
AZD 1152 (hydrochloride)
Cat.No: T36199
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
TN7041 (-)-Epipodophyllotoxin

Apoptosis Apoptosis
(-)-Epipodophyllotoxin 是一种从八角莲中分离的癌细胞抗增殖剂,在 HeLa 细胞和 MCF-7 细胞中的GI50值分别为 0.36 和 0.24 μM。它可在体外抑制有丝分裂纺锤体组装。
T1270 Vincristine sulfate

Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱

Apoptosis; Microtubule Associated Apoptosis; Cytoskeletal Signaling
Vincristine sulfate (Leurocristine sulfate) 是一种抗肿瘤长春花生物碱。在细胞周期的 S 期不可逆地与微管(Ki: 85 nM) 和纺锤体蛋白结合,并干扰有丝分裂纺锤体的形成。
T0190 Vinorelbine

长春瑞宾,KW-2307 base

Microtubule Associated Cytoskeletal Signaling
Vinorelbine (KW-2307 base) 是一种半合成的长春花生物碱。它与微管蛋白结合并阻止有丝分裂纺锤体的形成,导致中期肿瘤细胞生长停滞。
T22455 Vindesine sulfate

DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS

Others Others
Vindesine sulfate (Desacetyl Vinblastine amide) 是一种长春花生物碱,它是长春碱的合成衍生物,与有丝分裂纺锤体的微管蛋白结合,导致微管结晶和有丝分裂停滞或细胞死亡。
T1121 Podofilox

鬼臼毒素,Podophyllotoxin,(+)-Shikonin

Microtubule Associated; Topoisomerase Cytoskeletal Signaling; DNA Damage/DNA Repair
Podofilox ((+)-Shikonin) 是从八角莲中分离的一种木脂素,是微管组装和 DNA 拓扑异构酶 II 抑制剂。它对皮肤和粘膜有很强的刺激性,具有角质溶解作用,可用于治疗疣和角化病,具有潜在的抗肿瘤特性。
T32055 Hemiasterlin

NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin

Hemiasterlin is a cytotoxic peptide that acts by inducing mitotic arrest and abnormal spindle formation.

天然产物

(-)-Epipodophyllotoxin
Cat.No: TN7041
Synonym:
Target: Apoptosis
Vincristine sulfate
Cat.No: T1270
Synonym: Leurocristine,22-Oxovincaleukoblastine sulfate,Leurocristine sulfate,硫酸长春新碱
Target: Apoptosis, Microtubule Associated
Vinorelbine
Cat.No: T0190
Synonym: 长春瑞宾,KW-2307 base
Target: Microtubule Associated
Vindesine sulfate
Cat.No: T22455
Synonym: DVA,Desacetylvinblastine amide,硫酸长春地辛,DAVA,Desacetyl Vinblastine amide,VDS
Target: Others
Podofilox
Cat.No: T1121
Synonym: 鬼臼毒素,Podophyllotoxin,(+)-Shikonin
Target: Microtubule Associated, Topoisomerase
Hemiasterlin
Cat.No: T32055
Synonym: NSC 695242,NSC-695242,Milnamide B,NSC695242,(-)-Hemiasterlin
Target:
TargetMol Loading
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