Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ARRY 520 hydrochloride 是一种驱动蛋白纺锤体蛋白 (KSP) 抑制剂。它通过凋亡诱导细胞死亡,并具有有效的抗增殖活性。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 628 | 现货 | ||
5 mg | ¥ 1,550 | 现货 | ||
10 mg | ¥ 2,460 | 现货 | ||
25 mg | ¥ 4,390 | 现货 | ||
50 mg | ¥ 6,260 | 现货 | ||
100 mg | ¥ 8,580 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 1,790 | 现货 |
产品描述 | ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity. |
体外活性 | ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1]. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors[1].ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells[1]. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2]. ARRY 520 is able to induce caspase-2 activation[3]. ARRY 520 is cytotoxic in Type II EOC cells[3]. |
体内活性 | ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model[3]. |
分子量 | 456.94 |
分子式 | C20H23ClF2N4O2S |
CAS No. | 1385020-40-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/mL (109.42 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 2.1885 mL | 10.9424 mL | 21.8847 mL | 54.7118 mL |
5 mM | 0.4377 mL | 2.1885 mL | 4.3769 mL | 10.9424 mL | |
10 mM | 0.2188 mL | 1.0942 mL | 2.1885 mL | 5.4712 mL | |
20 mM | 0.1094 mL | 0.5471 mL | 1.0942 mL | 2.7356 mL | |
50 mM | 0.0438 mL | 0.2188 mL | 0.4377 mL | 1.0942 mL | |
100 mM | 0.0219 mL | 0.1094 mL | 0.2188 mL | 0.5471 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
ARRY 520 hydrochloride 1385020-40-5 Cell Cycle/Checkpoint KSP ARRY 520 Hydrochloride ARRY-520 Hydrochloride ARRY520 Hydrochloride Inhibitor inhibitor inhibit