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34

抑制剂 & 化合物

23

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T23046	N-tert-butyl-α-Phenylnitrone (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮	ROS; COX	Immunology/Inflammation; Neuroscience
	N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) 是基于硝酮的自由基清除剂，可形成一氧化氮自旋加合物。它可以穿透血脑屏障，抑制 COX2的催化活性，有 ROS 清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。
T2103	Ispinesib 伊匹尼塞,伊斯平斯,CK0238273,SB-715992	Apoptosis; Kinesin; KSP	Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling
	Ispinesib (SB-715992) 是一种选择性可逆的驱动蛋白纺锤体蛋白抑制剂，具有抗肿瘤特性。
T8455	Spinorphin	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Spinorphin 是一种脑非肽降解酶抑制剂，能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶和脑非肽酶。它可用于研究疼痛的缓解。
T60512	Haspin-IN-3	Haspin Kinase	Cell Cycle/Checkpoint
	Haspin-IN-3是一种有效的haspin抑制剂，IC50为 14 nM。Haspin-IN-3 具有抗癌活性。
T35060	VinSpinIn Vinnie's Spindlin Inhibitor,TD020824a
	VinSpinIn is a probe for the Spin family proteins.
T126235	Planispine A
	Planispine A 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T126235。
T80530	Spinoxin SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13	Potassium Channel	Membrane transporter/Ion channel
	Spinoxin是一种从Heterometrus spinifer蝎子毒液中提取的神经毒素，由34个氨基酸残基组成，通过4个二硫桥交联。它能有效抑制Kv1.3钾通道（IC50= 63 nM），是研发诊断及治疗自身免疫性疾病和癌症策略时的潜在分子靶点。
T35594	Cuspin-1
	The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Ra...
T125714	Tinospin E
	Tinospin E 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125714，CAS号为 1582321-96-7。
T60477	Haspin-IN-1
	Haspin-IN-1 (compound 2a) 是一种haspin（单倍体生殖细胞特异性核蛋白激酶）抑制剂，IC50值为 119 nM。Haspin-IN-1 还抑制CLK1、DYRK1A 和 CDK9，IC50分别为 221 nM 、916.3 nM 和406.8 nM。Haspin-IN-1具有开发新型抗癌药物的潜力[1]。
T60394	Haspin-IN-2
	Haspin-IN-2 (compound 4) 是一种有效的选择性的 haspin 抑制剂，IC50为 50 nM。Haspin-IN-1 还抑制 CLK1和DYRK1A，IC50分别为 445 nM 和 917 nM。
T126533	Spinacetin 3-gentiobioside
	Spinacetin 3-gentiobioside 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126533，CAS号为 101021-29-8。
T28960	Thaspine HCl Thaspine,Thaspine HCl, NSC 135784,NSC-135784,NSC135784
	Thaspine is a potent topoisomerase IB inhibitor. Taspine downregulates VEGF expression and inhibits proliferation of vascular endothelial cells through PI3 kinase and MAP kinase signaling pathways.
T125312	Verbaspinoside
	Verbaspinoside 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125312，CAS号为 221014-58-0。
T26947	Caprospinol SP 233,SP233,SP-233
	Caprospinol inhibits β-Amyloid (Aβ) protein neurotoxicity.
T75597	Loxosceles Spiniceps Venom
	Loxosceles Spiniceps Venom 是一种可以从Loxosceles Spiniceps 中获得的毒液。Loxosceles 蜘蛛的毒液是一种复杂的毒素混合物，富含蛋白质、糖蛋白和低分子质量多肽。目前已鉴定出几种蛋白类，包括类虾蛋白酶金属蛋白酶、低分子杀虫肽、抑制剂半胱氨酸结肽 (ICK) 和磷脂酶 D。其中独特的酶，鞘磷脂酶 D 负责坏死的发展。
T78002	Spinorphin TFA LVV-hemorphin-4 TFA
	Spinorphin TFA是一种脑啡肽降解酶抑制剂，能够抑制氨基肽酶、二肽基氨基肽酶III、血管紧张素转换酶以及脑非肽酶，常用于缓解疼痛研究中。
T123977	Isospinosin
	Isospinosin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123977。
T36207	Methylspinazarin
	Methylspinazarin is a naphthoquinone bacterial metabolite that has been found in Streptomyces and is an inhibitor of catechol O-methyltransferase (COMT; IC50 = 0.8 μg/ml).1 It is selective for COMT over tyrosine hydroxylase, DOPA decarboxylase, and dopamine-β-hydroxylase at 100 μg/ml. Methylspinazarin decreases blood pressure in spontaneously hypertensive rats when administered at a dose of 50 mg/kg. \|1. Chimura, H., Sawa, T., Takita, T., et al. Methylspinazarin and dihydromethylspinazarin, gate...
T125257	α-Spinasterone
	α-Spinasterone 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T125257。
T35059	VinSpinIC Vinnie's Spindlin Inactive Control,TD020826a
	VinSpinIC is an inactive control for VinSpinIn.
T19750	Spinosad Factor D
	Spinosad Factor D is a naturally derived fermentation product. It is used as a pesticide against many different insects.
T131395	Spinosine
	Spinosine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T131395。
T22739	DMPO 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide	Others	Others
	DMPO (5,5-Dimethyl-1-pyrroline N-oxide) 是一种细胞渗透性亲水自旋诱捕剂，可用于超氧化物检测。
T5363	Tempo 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy	Free radical scavengers; Reactive Oxygen Species; DNA/RNA Synthesis; Mitochondrial Metabolism	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction
	Tempo (2,2,6,6-Tetramethylpiperidinooxy) 可用作自由基清除剂、有机合成中的试剂和电子自旋共振光谱中的结构探针。它可在催化循环中使超氧化物歧化，也可诱导DNA 链断裂。
T65636	BIS-TRIS propane BTP	Others	Others
	BIS-TRIS propane (BTP) 是镍基和钴基自旋团簇的新型多齿配体，是一种金属螯合剂。Bis-tris propane 常作为两性离子缓冲液使用，可用于PCR、蛋白质结晶研究和MgATPase 酶活力研究。
T24654	PPT
	PPT is a modulator of water-heme interactions of CYP2C9d and CYP125A1 in low-spin P450 complexes.
T36026	DEPMPO 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide
	DEPMPO is a phosphorylated derivative of the widely used DMPO spin trap. It has been reported to produce spin adducts with increased stability particularly for the adduct of superoxide. [1] [2] [3] DEPMPO displays a detectable spin adduct signal at a concentration as low as 1 mM, as compared to 5 mM for DMPO.[3] A significant advantage of using DEPMPO in trapping superoxide radical is that the decomposition of DEPMPO/O2 - does not produce the OH adduct, which can be a drawback when using DMPO....
T35948	4-carboxy TEMPO
	4-carboxy TEMPO is a nitroxide and spin label. Nitroxides such as 4-carboxy TEMPO react with reactive oxygen species (ROS) and can be used with electron spin resonance (ESR) spectroscopy to monitor ROS production in vivo., It has also been used to study flavin-photosensitized damage in inner mitochondrial membranes.
T21079	Decafluorobenzophenone Perfluorobenzophenone
	Decafluorobenzophenone is used in the synthesis of fluorinated acridones and acridines. Decafluorobenzophenone alcoholic solution generates radical anion and ketyl which can be studied by electron spin resonance spectra. It undergoes photolysis to form ke
T35968	Nitrosobenzene
	Nitrosobenzene is a spin trap that has been used in the study of oxidative DNA damage and nitroso-compound-induced respiratory burst in neutrophils.
T36027	DEPMPO-biotin
	DEPMPO is a nitrone that is used to spin trap reactive O-, N-, S-, and C-centered radicals and allow their characterization when used in association with electron spin resonance. It is noted for the stability of adducts formed. DEPMPO can be used in vitro or in vivo, as it crosses lipid bilayer membranes and is a good trapping agent in biological systems. DEPMPO-biotin is a biotinylated form of DEPMPO which retains the outstanding persistency of its adducts. The biotin moiety offers an effective...
T36501	CYPMPO RR 071
	CYPMPO is a free radical spin trap with excellent trapping capabilities toward hydroxyl and superoxide radicals in biological and chemical systems. Decay of the superoxide adduct of CYPMPO proceeds in an apparent first order fashion with half-lives of 15 and 51 minutes in a UV-illuminated hydrogen peroxide solution and a hypoxanthine/xanthine oxidase system, respectively. CYPMPO traps superoxide radicals generated by bovine neutrophils as effectively as DEPMPO.[1] The high melting point (126°C),...
T35655	2,6-Dichloropurine-9-β-D-riboside
	2,6-Dichloropurine-9-β-D-riboside is a building block.1,2It has been used in the synthesis of photoaffinity probes for nucleotide binding sites in proteins. 1.Wower, J., Hixson, S.S., Sylvers, L.A., et al.Synthesis of 2,6-diazido-9-(β-D-ribofuranosyl)purine 3',5'-bisphosphate: Incorporation into transfer RNA and photochemical labeling of Escherichia coli ribosomesBioconjug. Chem.5(2)158-161(1994) 2.Seiter, M.S., Bauer, M.P., Bogel, P.D., et al.Synthesis of novel spin-labeled photoaffinity deriva...

化合物

N-tert-butyl-α-Phenylnitrone

Cat.No: T23046

Synonym: (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide,N-叔丁基-α-苯基硝酮

Target: ROS, COX

Cat.No: T2103

Synonym: 伊匹尼塞,伊斯平斯,CK0238273,SB-715992

Target: Apoptosis, Kinesin, KSP

Cat.No: T8455

Target: Opioid Receptor

Cat.No: T60512

Target: Haspin Kinase

Cat.No: T35060

Synonym: Vinnie's Spindlin Inhibitor,TD020824a

Cat.No: T126235

Cat.No: T80530

Synonym: SPX,α-KTx6.13,Potassium channel toxin alpha-KTx 6.13

Target: Potassium Channel

Cat.No: T35594

Cat.No: T125714

Cat.No: T60477

Cat.No: T60394

Spinacetin 3-gentiobioside

Cat.No: T126533

Cat.No: T28960

Synonym: Thaspine,Thaspine HCl, NSC 135784,NSC-135784,NSC135784

Cat.No: T125312

Cat.No: T26947

Synonym: SP 233,SP233,SP-233

Loxosceles Spiniceps Venom

Cat.No: T75597

Spinorphin TFA

Cat.No: T78002

Synonym: LVV-hemorphin-4 TFA

Cat.No: T123977

Methylspinazarin

Cat.No: T36207

α-Spinasterone

Cat.No: T125257

Cat.No: T35059

Synonym: Vinnie's Spindlin Inactive Control,TD020826a

Spinosad Factor D

Cat.No: T19750

Cat.No: T131395

Cat.No: T22739

Synonym: 5,5-二甲基-1-吡咯啉-N-氧化物,5,5-Dimethyl-1-pyrroline N-oxide

Target: Others

Cat.No: T5363

Synonym: 2,2,6,6-四甲基哌啶氧化物,2,2,6,6-Tetramethylpiperidinooxy

Target: Free radical scavengers, Reactive Oxygen Species, DNA/RNA Synthesis, Mitochondrial Metabolism

BIS-TRIS propane

Cat.No: T65636

Synonym: BTP

Target: Others

Cat.No: T24654

Cat.No: T36026

Synonym: 5-(Diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide

4-carboxy TEMPO

Cat.No: T35948

Decafluorobenzophenone

Cat.No: T21079

Synonym: Perfluorobenzophenone

Cat.No: T35968

Cat.No: T36027

Cat.No: T36501

Synonym: RR 071

2,6-Dichloropurine-9-β-D-riboside

Cat.No: T35655

Cat. No.	Product Name	Target	Signaling Pathways
T21495	Spinosyn A	Others	Others
	Spinosyn A 是聚酮化合物衍生的大环内酯，来自多刺甘蔗多孢菌。Spinosyn A 是有效的杀虫剂。
T3S2325	Ardisiacrispin A 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin	HSV	Microbiology/Virology
	Ardisiacrispin A (Deglucocyclamin) 是一种常见的三萜皂苷，来自于紫金牛属物种。它与来自紫金牛属的 A. crenata 中的一些三萜皂苷具有相似的生物学特性，如对肿瘤细胞具有细胞毒活性、免疫调节和抗病毒活性。
T6S2227	Spinosin 斯皮诺素,Flavoayamenin	Others	Others
	Spinosin (Flavoayamenin) 是一种具有神经保护作用的 C-糖苷类黄酮，从 Zizyphus jujube 种子分离得到，能够激活 Nrf2/HO-1 通路，并抑制 Aβ1-42的产生和聚合。
T9076	Spinosad	Others	Others
	Spinosad 是在土壤细菌 S. spinosa 中发现的一种杀虫剂，是大环内酯多杀菌素 A 和多杀菌素 D 的混合物，可作为昆虫烟碱乙酰胆碱酯酶受体 (nAChRs) 的激动剂。它具有优良的环境和哺乳动物毒理学特征，以及杀灭幼虫的活性。
T37298	Spinacine	Endogenous Metabolite	Metabolism
	Spinacine 是人内源性代谢产物。
TN1377	α-Spinasterol Α-波菜甾醇,alpha-Spinasterol,菠甾醇	COX; Antibacterial; TRP/TRPV Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	α-Spinasterol 是一种从Spinacia oleracea 分离的瞬时受体电位香草酸 1 拮抗剂，具有抗菌、抗炎、抗抑郁、抗氧化和抗伤害作用。它抑制COX-1和COX-2活性，IC50值分别为 16.17 μM 和 7.76 μM。
T5S2228	6‴-Feruloylspinosin 6'''-Feruloylspinosin,6-阿魏酰斯皮诺素	NF-κB	NF-κB
	6‴-Feruloylspinosin (6'''-Feruloylspinosin) 是一种类黄酮，分离自 Ziziphus jujuba 种子中。在大鼠海马神经元中，它能透过血脑屏障，增强 GABAAα1、GABAAα5、GABABR1 的 mRNA 表达。
TN5123	Taxuspine W	Others	Others
	Taxuspine W is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc.
TN5122	Taxuspine B	Others	Others
	Taxuspine B is a natural product from the Japanese yew Taxus cuspidata Sieb. et Zucc.
TN3256	7beta-Acetoxytaxuspine C	Others	Others
	7beta-Acetoxytaxuspine C is a natural product from Taxus canadensis.
TN2797	20-Deacetyltaxuspine X	Others	Others
	20-Deacetyltaxuspine X 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2797，CAS号为 284672-76-0。
TN6667	Spinacetin
	Spinacetin has anti-inflammatory effects, it weakly inhibited nitric oxide production and reduced prostaglandin E2 levels to different extents. It shows the activities in preventing inflammatory processes, which might be at least partially attributed to t
TN1397	Ardisiacrispin B	Others	Others
	Ardisiacrispin B displays cytotoxic effects in multi-factorial drug resistant cancer cells via ferroptotic and apoptotic cell death.
TN1223	23-Hydroxylongispinogenin (3BETA,4ALPHA,16BETA)-齐墩果-12-烯-3,16,23,28-四醇,23-羟基龙吉苷元	Others	Others
	23-Hydroxylongispinogenin is a natural product
T32864	Longispinogenin
	Longispinogenin is a triterpenetriol fatty acid ester isolated from Trichocereus chilensis.
TN2754	2-Deacetyltaxuspine X	Others	Others
	2-Deacetyltaxuspine X 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2754，CAS号为 259678-73-4。
TMA1799	alpha-Spinasterol glucoside	Others	Others
	alpha-Spinasterol glucoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TMA1799，CAS号为 1745-36-4。
TN5124	Taxuspine X	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxuspine X may have p-glycoprotein inhibitory activity.
T81116	Spinasaponin E
	Spinasaponin E 是一种具有研究潜力的化合物，适用于探索炎性疾病的治疗机制。
TN5478	3"-O-Desmethylspinorhamnoside
	3"-O-Desmethylspinorhamnoside 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5478，CAS号为 2220243-41-2。
TN5100	Taspine	ERK; EGFR; BCL; VEGFR; MAPK; Akt	Angiogenesis; Apoptosis; Cytoskeletal Signaling; JAK/STAT signaling; MAPK; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Taspine shows antitumor activity by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo, it can inhibit growth and induce apoptosis of HUVEC in a dose-dependent manner, it has shown meaningful angiogenesis activity. Taspine exhibi
TN5148	Tinospinoside C	Others	Others
	Tinospinoside C shows inhibitory activities of NO production with the IC(50) value of 218 uM.
TN3391	alpha-Spinasterol acetate	Others	Others
	alpha-Spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.

天然产物

Cat.No: T21495

Target: Others

Ardisiacrispin A

Cat.No: T3S2325

Synonym: 百两金素,Saxifragifolin B,LTS-4,Deglucocyclamin

Target: HSV

Cat.No: T6S2227

Synonym: 斯皮诺素,Flavoayamenin

Target: Others

Cat.No: T9076

Target: Others

Cat.No: T37298

Target: Endogenous Metabolite

α-Spinasterol

Cat.No: TN1377

Synonym: Α-波菜甾醇,alpha-Spinasterol,菠甾醇

Target: COX, Antibacterial, TRP/TRPV Channel

6‴-Feruloylspinosin

Cat.No: T5S2228

Synonym: 6'''-Feruloylspinosin,6-阿魏酰斯皮诺素

Target: NF-κB

Cat.No: TN5123

Target: Others

Cat.No: TN5122

Target: Others

7beta-Acetoxytaxuspine C

Cat.No: TN3256

Target: Others

20-Deacetyltaxuspine X

Cat.No: TN2797

Target: Others

Cat.No: TN6667

Ardisiacrispin B

Cat.No: TN1397

Target: Others

23-Hydroxylongispinogenin

Cat.No: TN1223

Synonym: (3BETA,4ALPHA,16BETA)-齐墩果-12-烯-3,16,23,28-四醇,23-羟基龙吉苷元

Target: Others

Longispinogenin

Cat.No: T32864

2-Deacetyltaxuspine X

Cat.No: TN2754

Target: Others

alpha-Spinasterol glucoside

Cat.No: TMA1799

Target: Others

Cat.No: TN5124

Target: P-gp

Spinasaponin E

Cat.No: T81116

3"-O-Desmethylspinorhamnoside

Cat.No: TN5478

Cat.No: TN5100

Target: ERK, EGFR, BCL, VEGFR, MAPK, Akt

Tinospinoside C

Cat.No: TN5148

Target: Others

alpha-Spinasterol acetate

Cat.No: TN3391

Target: Others

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