Powder: -20°C for 3 years | In solvent: -80°C for 1 year
N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) 是基于硝酮的自由基清除剂,可形成一氧化氮自旋加合物。它可以穿透血脑屏障,抑制 COX2的催化活性,有 ROS 清除、抗炎、神经保护、抗衰老和抗糖尿病的作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
25 mg | ¥ 353 | 现货 | ||
50 mg | ¥ 497 | 现货 | ||
100 mg | ¥ 747 | 现货 | ||
200 mg | ¥ 1,170 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 317 | 现货 |
产品描述 | N-tert-butyl-α-Phenylnitrone ((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) inhibits COX2 catalytic activity. N-tert-butyl-α-Phenylnitrone((Z)-N-benzylidene-2-Methylpropan-2-aMine oxide) possesses potent reactive oxygen species scavenging, anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic activities, and can penetrate the blood-brain barrier. |
体外活性 | Treatment of 25-100 μM N-tert-butyl-α-Phenylnitrone significantly reduces 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH)-induced intracellular ROS accumulation. N-tert-butyl-α-Phenylnitrone also attenuates AAPH-induced cytotoxicity, matrix degradation, and apoptosis, inhibiting AAPH-induced ERK/MAPK pathway activation[1]. |
体内活性 | In C57Bl/6 mice induced by lipopolysaccharide (LPS), intraperitoneal injection of 100 mg/kg N-tert-butyl-α-Phenylnitrone twice a day (on gestational day 8) abolishes LPS-induced lipid peroxidation, nitrate tyrosine residue levels and GSH depletion, and reduces the incidence of external malformations[2]. |
别名 | (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide, N-叔丁基-α-苯基硝酮 |
分子量 | 177.24 |
分子式 | C11H15NO |
CAS No. | 3376-24-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 50 mg/Ml(282.10 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 5.6421 mL | 28.2103 mL | 56.4207 mL | 141.0517 mL |
5 mM | 1.1284 mL | 5.6421 mL | 11.2841 mL | 28.2103 mL | |
10 mM | 0.5642 mL | 2.821 mL | 5.6421 mL | 14.1052 mL | |
20 mM | 0.2821 mL | 1.4105 mL | 2.821 mL | 7.0526 mL | |
50 mM | 0.1128 mL | 0.5642 mL | 1.1284 mL | 2.821 mL | |
100 mM | 0.0564 mL | 0.2821 mL | 0.5642 mL | 1.4105 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
N-tert-butyl-α-Phenylnitrone 3376-24-7 Immunology/Inflammation Neuroscience ROS COX neuroprotective adducts inhibit Cyclooxygenase ERK Inhibitor Scavenger (Z)-N-benzylidene-2-Methylpropan-2-aMine oxide N-叔丁基-α-苯基硝酮 spin BBB N tert butyl α Phenylnitrone N-benzylidene-2-Methylpropan-2-aMine Oxide iNOS N-tert-butyl-alpha-Phenylnitrone nitroxide antioxidant N-tert-butyl-a-Phenylnitrone Reactive Oxygen Species MAPK NtertbutylαPhenylnitrone inhibitor