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27

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T40351	MHY-1685	mTOR	PI3K/Akt/mTOR signaling
	MHY-1685是一种哺乳动物雷帕霉素靶蛋白(mTOR)抑制剂及衰老抑制剂，通过调节自噬作用能够使衰老的hCSCs恢复活力。
T11383	GDP366	Survivin	Apoptosis
	GDP366 有效且特异性地抑制 survivin 和 Op18 的表达。 GDP366 增加染色体不稳定性，并通过抑制端粒酶活性诱导细胞衰老。
T36010	p38 MAPK Inhibitor	p38 MAPK	MAPK
	p38 MAPK Inhibitor 是p38 MAPK 激酶的有效抑制剂（IC50＝ 35 nM）。p38 MAPK Inhibitor 抑制癌基因RAS 诱导的衰老。
T71832	CTX-0124143	Histone Acetyltransferase	Chromatin/Epigenetic
	CTX-0124143 是一种组蛋白乙酰转移酶抑制剂，对 KAT6A 的 IC50 值为 1.0μM。CTX-0124143 可用于研究细胞衰老。
T1923	BRD4770	Histone Methyltransferase	Chromatin/Epigenetic
	BRD4770 是组蛋白甲基转移酶G9a 抑制剂，可激活共济失调毛细血管扩张突变途径并诱导细胞衰老。它可抑制H3K9的二甲基和三甲基化，EC50为 5 µM。
T78393	C12FDG 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside
	C12FDG (5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside) 作为一种亲脂性用于检测β-半乳糖活性的绿色荧光底物，是一种衰老标志物，常与流式细胞仪连用。
T79903	Sirtuin-1 inhibitor 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Sirtuin-1 inhibitor 1 是一种针对去乙酰化酶-1（Sirtuin-1）的抑制剂，可用于研究机体的衰老和细胞的死亡。
T12040	Milademetan RAIN-32,DS-3032,DS3032b	Mdm2; Others	Apoptosis; Others
	Milademetan (DS-3032) 是一种具有口服活性和有效性的 MDM2 抑制剂，具有抗肿瘤活性，诱导 G1 细胞周期阻滞、衰老和凋亡。Milademetan 可用于研究急性髓系白血病和实体肿瘤。
T3317	SZL P1-41	Apoptosis; Others; E1/E2/E3 Enzyme	Apoptosis; Others; Ubiquitination
	SZL P1-41 是 Skp2 抑制剂，可以阻止 Skp2-Skp1 复合物的组装。它选择性地抑制 Skp2 SCF E3 连接酶活性，还在体内外抑制 Skp2 介导的 p27 和 Akt 泛素化。它通过触发细胞衰老和抑制糖酵解来抑制 Y 细胞和 Y 干细胞的存活，有抗肿瘤作用。
T26872	BMVC4 BMVC 4,BMVC-4
	BMVC4 is a G-quadruplex stabilizer. BMVC4 induces senescence by activation of pathways of response to DNA damage that was independent of its telomerase inhibitory activity.
T41151	K34c
	K34c is a potent and selective α5β1 integrin inhibitor (IC50 = 3.1 nM). K34c inhibits cell survival and migration, inhibits p53-dependent senescence induced by Temozolomide or Ellipticine and promotes apoptosis in U87MG cells. K34c also prevents TGFβ-induced infiltrationin vivoand reduces cell adhesion on fibronectin.
T83432	1-DCP
	1-DCP 是一种抑制果实成熟和衰老作用中乙烯功能的有效乙烯拮抗剂。
T74590	Boanmycin
	Boanmycin 是一种具有抗肿瘤活性的抗生素，可以诱导细胞衰老、凋亡 (apoptosis)。
T61848	Rosiglitazone potassium
	Rosiglitazone (BRL 49653) potassium is a potent and selective PPARγ agonist (EC 50: 60 nM, Kd: 40 nM), administered orally. It also serves as an activator of TRPC5 (EC 50: 30 μM) and an inhibitor of TRPM3. This compound, widely used in research, has shown promise in investigating obesity, diabetes, senescence, and ovarian cancer [1] [2] [4] [7].
T71034	Bizelesin
	Bizelesin is a synthetic cyclopropylpyrroloindole antineoplastic antibiotic. Bizelesin binds to the minor groove of DNA and induces interstrand cross-linking of DNA, thereby inhibiting DNA replication and RNA synthesis. Bizelesin also enhances p53 and p21 induction and triggers G2/M cell-cycle arrest, resulting in cell senescence without apoptosis.
T37865	9(S)-HOTrE
	9(S)-HOTrE is a monohydroxy polyunsaturated fatty acid produced by the action of 5-lipoxygenase on α-linolenic acid. 9(S)-HOTrE is predominantly localized in cellular ester lipids of Glechoma hederacea leaves and is partially released during artificial dehydration. The biological role of 9(S)-HOTrE in G. hederacea leaves is still undetermined, but it may play a role in natural senescence. 9(S)-HOTrE is an inhibitor of spore germination and germ tube elongation of rice blast fungus with ED50 valu...
T77767	GLF16
	GLF16 是一种亲水性荧光 SBB 类似物，可有效识别衰老。它可以使用流式细胞术和活细胞分选来快速检测衰老细胞。 GLF16 适用于各种生物材料中单细胞水平的衰老细胞群的体内鉴定、分离和下游表征。
T73634	Milademetan tosylate hydrate
	Milademetan (DS-3032) tosylate hydrate，一种特异性、具口服活性的MDM2抑制剂，主要研究用途包括急性髓系白血病和实体肿瘤。它能诱导G1细胞周期阻滞、衰老和凋亡。
T31573	DPX-3778
	DPX-3778 is the triethanolamine salt of 3-(p-chlorophenyl)-6-methoxy-s-triazine-2,4(1H,3H) dione, at concentrations of 0.124-2.48 μM enhanced ca. 4-5-fold the proliferation of tobacco (Nicotiana tabacum L. cv. Wisconsin 38) callus cultured in the presence
T78344	Pectinase
	果胶酶(Pectinase)为水解果胶的酶混合物，广泛存在于微生物与高等植物中。该酶涉及细胞壁代谢，并影响细胞生长、衰老、果实成熟及发病与脱落过程。
T75714	Decapeptide-12
	Decapeptide-12，一个小型寡肽，作为tyrosinase的抑制剂，通过与tyrosinase的C末端残基相互作用(Kd: 61.1 μM)发挥作用。作为mushroom tyrosinase的竞争性抑制剂(IC50: 40 µM)，Decapeptide-12有效上调SIRT的转录水平，并能减少黑色素细胞中的黑色素含量，适用于黑色素生成、衰老和炎症的研究。
T82420	FAK-IN-12	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	FAK-IN-12（Compound 12S）为FAK抑制剂，具有47 nM的IC50值。该化合物对MGC-803、HCT-116及KYSE30细胞系的增殖具有抑制作用（IC50值分别为0.24、0.45、0.44 μM），并可诱导细胞凋亡和细胞衰老。
T81154	SIRT1 activator 1	Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair
	SIRT1 activator1(compound 3)，作为海洋化合物xyloallenoide a的衍生物，最初从红树林真菌Xylaria sp中分离获得。该化合物在斑马鱼模型中展现了促进血管生成的活性，并且能够通过提升SIRT1的表达水平以及调节AMPK/Akt信号通路，来防护人类内皮祖细胞(hEPC)免受血管老化的影响。
T36618	Rupatadine
	Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu...

化合物

Cat.No: T12854

Target: NAMPT

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T40351

Target: mTOR

Cat.No: T11383

Target: Survivin

p38 MAPK Inhibitor

Cat.No: T36010

Target: p38 MAPK

Cat.No: T71832

Target: Histone Acetyltransferase

Cat.No: T1923

Target: Histone Methyltransferase

Cat.No: T78393

Synonym: 5-Dodecanoylaminofluorescein di-β-D-Galactopyranoside

Sirtuin-1 inhibitor 1

Cat.No: T79903

Target: Sirtuin

Cat.No: T12040

Synonym: RAIN-32,DS-3032,DS3032b

Target: Mdm2, Others

Cat.No: T3317

Target: Apoptosis, Others, E1/E2/E3 Enzyme

Cat.No: T26872

Synonym: BMVC 4,BMVC-4

Cat.No: T41151

Cat.No: T83432

Cat.No: T74590

Rosiglitazone potassium

Cat.No: T61848

Cat.No: T71034

Cat.No: T37865

Cat.No: T77767

Milademetan tosylate hydrate

Cat.No: T73634

Cat.No: T31573

Cat.No: T78344

Cat.No: T75714

Cat.No: T82420

Target: FAK

SIRT1 activator 1

Cat.No: T81154

Target: Sirtuin

Cat.No: T36618

Cat. No.	Product Name	Target	Signaling Pathways
T3768	Epifriedelanol 表木栓醇,Epifriedelinol	Others	Others
	Epifriedelanol (Epifriedelinol) 是一种分离自 Ulmus davidiana 根皮中的三萜类化合物，具有抗肿瘤作用，可以减缓人原始细胞的衰老。
T0591	D-Galactose D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose	Endogenous Metabolite	Metabolism
	D-Galactose (Alpha-D-galactose) 是一种天然的己糖，是葡萄糖的C-4差向异构体。
TL0005	3,5-O-Dicaffeoylquinic acid Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid	Others	Others
	3,5-O-Dicaffeoylquinic acid (Isochlorogenic Acid A) 能够改善由三甲基锡诱导的学习和记忆缺陷。
T19320	FAPy-adenine	Others	Others
	FAPy-adenine is an oxidized DNA base.Adenine is on the rise in the brains of people with Alzheimer's disease.Nucleoside oxidation is a biochemical marker for tumors, senescence and neurodegenerative diseases.
T64533	Ceramide (Egg, Chicken)	Apoptosis	Apoptosis
	Ceramide (Egg, Chicken)在鞘脂的合成代谢和分解代谢途径中起主要作用。Ceramide (Egg, Chicken)刺激许多细胞分化，生长抑制，细胞衰老和凋亡。
T79991	Condurango glycoside A
	Condurango glycoside A 作为p53激活剂，能够促进ROS的生成并且上调p53的表达。此外，Condurango glycoside A 还能够诱导HeLa细胞发生与DNA损伤相关的凋亡及过早老化。
TN3719	Cristacarpin	p38 MAPK; ROS; CDK; Antifection; p53	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation; MAPK; Microbiology/Virology
	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-lethal reactive oxygen species (ROS) generation and which eventually terminates by triggering s
TN3968	Epifriedelanol acetate	Others	Others
	Epifriedelanol exhibits antibacterial activities. It also can reduce cellular senescence in human primary cells and may be used to develop dietary supplements or cosmetics that modulate tissue aging or aging-associated diseases. Epifriedelanol and friedel
T4752	1-Aminocyclopropane-1-carboxylic acid 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC	Endogenous Metabolite; NMDAR	Metabolism; Neuroscience
	1-Aminocyclopropane-1-carboxylic acid (ACC) 是内源性代谢产物的一种。

天然产物

Cat.No: T3768

Synonym: 表木栓醇,Epifriedelinol

Target: Others

Cat.No: T0591

Synonym: D-(+)-Galactose,alpha-D-半乳糖,D-半乳糖,D-Galactopyranose,Alpha-D-galactose

Target: Endogenous Metabolite

3,5-O-Dicaffeoylquinic acid

Cat.No: TL0005

Synonym: Isochlorogenic Acid A,(-)-3,5-二咖啡酰奎宁酸,(-)-3,5-Dicaffeoyl quinic acid,3,5-Dicaffeoylquinic Acid

Target: Others

Cat.No: T19320

Target: Others

Ceramide (Egg, Chicken)

Cat.No: T64533

Target: Apoptosis

Condurango glycoside A

Cat.No: T79991

Cat.No: TN3719

Target: p38 MAPK, ROS, CDK, Antifection, p53

Epifriedelanol acetate

Cat.No: TN3968

Target: Others

1-Aminocyclopropane-1-carboxylic acid

Cat.No: T4752

Synonym: 1-Aminocyclopropanecarboxylic acid,1-氨基环丙烷羧酸,1-Amino-1-carboxycyclopropane,ACC

Target: Endogenous Metabolite, NMDAR

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