31
6
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1476 |
Pramipexole
SND 919,普拉克索 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pramipexole (SND 919) 是能够透过血脑屏障的 D2 型多巴胺受体的选择性激动剂,对 D2 型受体、D2、D3、D4亚型受体的Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM。它可用于研究帕金森综合症和腿多动综合征。 | |||
T6951 |
Pramipexole dihydrochloride hydrate
Pramipexole 2HCl Monohydrate,普拉克索盐酸盐水合物,Mirapex,普拉克索 |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Pramipexole dihydrochloride hydrate (Mirapex) 是选择性的,具有血脑屏障 (BBB) 渗透性的 D2 型多巴胺受体激动剂,对 D2 型受体、D2、D3、D4亚型受体的 Ki 分别为 2.2 nM、3.9 nM、0.5 nM、1.3 nM,可用于研究帕金森综合症和腿多动综合征。 | |||
T70470 |
CM-352
|
MMP | Proteases/Proteasome |
CM-352是一种金属蛋白酶抑制剂,可减少脑损伤并改善脑出血大鼠模型的功能恢复。 | |||
T12269 |
NUCC-390
|
CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
NUCC-390 是新型的选择性小分子 CXCR4 receptor 受体激动剂。NUCC-390 可以诱导 CXCR4 受体的内化,作用方式与 AMD3100相反。NUCC-390 在动物模型中,有助于神经退行性变后神经功能恢复。 | |||
T8860 |
DSRM-3716
|
Androgen Receptor | Endocrinology/Hormones |
DSRM-3716 是选择性的SARM1 NADase 抑制剂,IC50为 75 nM,相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。 | |||
T50050 |
2,3-dihydroxy-3-methylbutanoic acid
|
Others | Others |
2,3-dihydroxy-3-methylbutanoic acid 是支链氨基酸亮氨酸的天然代谢产物。它通过激活mTOR 信号通路发挥作用,促进新肌肉蛋白的合成,减少现有蛋白质的分解,从而增加肌肉质量,改善运动后的恢复。 | |||
T8887 |
2'MeO6MF
|
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
2'MeO6MF 是可透过血脑屏障的α2β1γ2L 和所有含α1的GABAA 受体的正变构调节剂。它也可以直接激活α2β2/3和α2β2/3γ2L GABAA 受体。它具有抗焦虑和促进安定作用。它可提供神经保护作用并改善功能恢复,还可抑制中风诱发的炎症反应。 | |||
T28866 |
Stemazole
|
Apoptosis | Apoptosis |
Stemazole 是一种新型小分子人类干/祖细胞增殖激活剂 ,可促进人类胚胎干细胞的存活并保持干性 ,促进少突胶质细胞前体细胞在体外的存活。Stemazole 能显著提高细胞存活率和克隆形成数,并呈剂量依赖性,降低细胞凋亡率,促进运动功能障碍的恢复和髓鞘的修复。Stemazole 可作为脱髓鞘疾病的治疗剂,促进OPC 体外存活和体内再生。 | |||
T21185 |
CEP03
CEP 03,CEP-03 |
||
CEP03 enhances EC/EPC proliferation, tubelike formation, and wound-healing efficiency, leading to promote angiogenesis and significantly improve blood flow perfusion recovery in the ischemic hind limbs of mice. | |||
T71601 | CU-2010 | ||
CU-2010 is a synthetic serine protease inhibitor with antifibrinolytic and anticoagulant properties. CU-2010 dose-dependently reduces postoperative blood loss and improves postischemic recovery after cardiac surgery in a canine model. | |||
T39890 |
8-Bromo-AMP
8-Bromoadenosine 5'-monophosphate,8-Bromo-AMP,8-Bromoadenylicacid |
||
8-Bromo-AMP, also known as 8-Bromoadenosine 5'-monophosphate, is a membrane permeable cAMP analogue. It enhances cardiac recovery from ischemia and reperfusion by elevating ATP, ADP, and total adenine nucleotide concentrations. | |||
T33019 |
LY-79771 free base
LY 79771,LY79771,LY-79771 |
||
LY-79771 is a phenylethanolamine anti-obesity agent, which can effectively prevent fat recovery after energy deprivation. | |||
T82798 |
C3bot(154-182) TFA
|
||
C3bot(154-182) TFA 是C3 肽类化合物,能够通过促进脊髓损伤后下行纤维束的再生,增强其修复效能。此外,C3bot(154-182) TFA 或许能够促进中枢神经系统损伤后的轴突保护与修复,并有助于功能性恢复。 | |||
T25312 |
Detajmium
Tachmalcor |
||
Detajmium 是一种抗心律失常的化合物。它是一种钠(+)通道阻断药物,从使用依赖性钠通道阻断中恢复时间极长。 | |||
T63004 |
NUCC-390 dihydrochloride
|
||
NUCC-390 dihydrochloride 是新型的选择性小分子CXCR4receptor 受体激动剂。NUCC-390 dihydrochloride 可以诱导CXCR4受体的内化,作用方式与 AMD3100 相反。NUCC-390 dihydrochloride 在动物模型中,有助于神经退行性变后神经功能恢复。 | |||
T71398 |
RO5126946
|
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RO5126946 is a Novel α7 nicotinic acetylcholine receptor-positive allosteric modulator. RO5126946 allosterically modulates α7nAChR activity. RO5126946 increased acetylcholine-evoked peak current and delayed current decay but did not affect the recovery of α7nAChRs from desensitization. In addition, RO5126946's effects were absent when nicotine-evoked currents were completely blocked by coapplication of the α7nAChR-selective antagonist methyl-lycaconitine. | |||
T69589 |
PX-316
|
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PX-316 is a AKT inhibior. PX-316, when administered intraperitoneally to mice at 150 mg/kg, inhibits Akt activation in HT-29 human tumor xenografts up to 78% at 10 h with recovery to 34% at 48 h. PX-316 has antitumor activity against early human MCF-7 breast cancer and HT-29 colon cancer xenografts in mice. PX-316 formulated in 20% hydroxypropyl-beta-cyclodextrin for intravenous administration is well tolerated in mice and rats with no hemolysis and no hematological toxicity. Thus, PX-316 is the... | |||
T60792 | NMDA receptor antagonist-3 | ||
NMDA receptor antagonist-3 是NMDA 受体的拮抗剂。NMDA receptor antagonist-3 在 SH-SY5Y 和人脂肪间充质干细胞中具有显著的回收率(40.0 %,100 μM)和安全的毒理学特性。 | |||
T71559 | Melanotan II acetate | ||
Melanotan II acetate is an agonist of melanocortin receptor 1 (MC1R), MC3R, MC4R, and MC5R. It has been shown to improve recovery of sciatic nerve function after mechanical injury and increase cisplatin-induced decreases in sensory nerve conduction velocity. Melanotan II acetate increases oxygen consumption and protein levels of uncoupling protein 1 (UCP1) in brown adipose tissue homogenates and decreases food intake, body weight, and serum levels of leptin, glucose, insulin, and cholesterol. | |||
T80420 |
TAT-NEP1-40 acetate
|
Apoptosis | Apoptosis |
TAT-NEP1-40 acetate 是促进脑卒中后轴突再生和功能恢复的候选分子。该化合物能够抵御PC12细胞的氧和葡萄糖剥夺(OGD)损伤,并促进神经突生长。它通过抑制神经元凋亡(apoptosis)作用,保护大脑免受缺血再灌注伤害,并能有效传递至大鼠的脑内。 | |||
T62137 | ANKRD22-IN-1 | ||
ANKRD22-IN-1 是一种 ANKRD22 的有效抑制剂。ANKRD22-IN-1 能够促进胃肠黏膜上皮干细胞的扩增,进而可以间接激活 Wnt 经典通路,对体内受损胃肠黏膜组织的恢复有益。 | |||
T83963 |
Z-DEVD-FMK Caspase-3 Inhibitor
|
||
Z-DEVD-FMK Caspase-3 Inhibitor 是一种可渗透细胞膜的、不可逆的 caspase-3/CPP32 抑制剂,能够抑制肿瘤细胞的凋亡。在动物体内,它在大鼠发作后的海马区具有神经保护作用,且显著减少创伤后的细胞凋亡,并在诱发的大鼠创伤性脑损伤之前和之后改善神经学恢复情况。 | |||
T38282 |
C22 Glucosylceramide (d18:1/22:0)
|
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C22 Glucosylceramide (d18:1/22:0) is an endogenous glucosylceramide. Glucosylceramides are major constituents of skin lipid membranes where they play a role in maintaining the water permeability barrier. They are precursors in the synthesis of lactosylceramide , as well as oligoglycolipids and gangliosides. Phospholipase A2 (PLA2) type XIIA knockdown increases C22 glucosylceramide (d18:1/22:0) expression in rat brain. It is also increased in the brain, but not the liver or spinal cord, of mice f... | |||
TP1989 |
NEP(1-40)
Nogo-66 (1-40) |
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Peptide fragment corresponding to residues 1 - 40 of Nogo-66, the domain of the myelin protein Nogo that inhibits axonal outgrowth. Acts as a competitive antagonist at the Nogo-66 receptor (NgR); blocks Nogo-66- and CNS myelin-induced inhibition of axonal | |||
T71228 | Adaprolol maleate | ||
Adaprolol maleate is a beta-blocker and opthalmic which may be used in the treatment of Glaucoma or other ailments of the eye. Adaprolol has marked electrophysiologic effects. Its major action was on sinus node; it prolonged the basic sinus cycle length and had significant effect on intrinsic automaticity as reflected by the prolonged corrected sinus node recovery time and sinuatrial conduction time. There was, also, direct effect on atrial function and AV nodal function. Adaprolol prolonged the... | |||
T80544 |
PTPσ Inhibitor, ISP
|
Phosphatase | Metabolism |
PTPσ Inhibitor, ISP 结合并抑制重组人PTPσ的信号传导,具有穿透细胞膜的能力,有助于缓解CSPG介导的脊髓损伤模型中轴突的生长抑制。该抑制剂能增强LPC引起的脊髓脱髓鞘损伤的髓鞘再生,并在MS动物模型中促进OPC的迁移、分化、髓鞘形成及功能恢复。 | |||
T80418 |
TAT-NEP1-40
|
Apoptosis | Apoptosis |
TAT-NEP1-40是一种能够穿透血脑屏障的多肽。它能够保护PC12细胞不受缺氧和葡萄糖剥夺(OGD)所致的损伤,同时促进神经突的生长。此外,TAT-NEP1-40通过阻断缺血性脑损伤中的细胞凋亡,对缺血后的神经功能恢复具有积极作用。该化合物适用于中枢神经系统损伤,特别是中风后的轴突再生与功能恢复方面的研究。 | |||
T35494 | (±)11(12)-EET | ||
(±)11(12)-EET is a fully racemic version of the R/S enantiomeric forms biosynthesized from arachidonic acid by cytochrome P450 enzymes.[1][2][3[]A higher proportion of 11(R),12(S)-EET is produced by the CYP450 isoforms CYP2C23 and CYP2C24 while CYP2B2 produces a higher proportion of 11(S),12(R)-EET.[3]11(12)-EET has been shown, along with 8(9)-EET to play a role in the recovery of depleted calcium pools in cultured smooth muscle cells[4] It also inhibits basolateral 18-pS potassium channels in t... | |||
T71966 |
PD-128763
|
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PD-128763 is a selective inhibitor of poly(ADP-ribose) polymerase. PD-128763 has an IC50 value against the purified enzyme approximately 50X lower than 3-aminobenzamide (3-AB), a widely used specific inhibitor of the enzyme. Exposure of exponentially growing cells to a noncytotoxic concentration (0.5 mM) of PD 128763 for 2 h immediately following X irradiation increased their radiation sensitivity, modifying both the shoulder and the slope of the survival curve. When recovery from sublethal dama... | |||
T37297 | Ru360 | ||
Ru360, an oxygen-bridged dinuclear ruthenium amine complex, is a selective mitochondrial calcium uptake inhibitor. Ru360 potently inhibits Ca2+ uptake into mitochondria with an IC50 of 0.184 nM. Ru360 binds to mitochondria with high affinity (Kd of 0.34 nM). Ru360 has antiarrhythmic and cardioprotective effects[1][2]. Ru360 permeates slowly into the cell, and specifically inhibits mitochondrial calcium uptake in intact cardiomyocytes and in isolated heart. 1 μm Ru360 is taken up by myocardial ce... | |||
T23800 |
BI-9627 hydrochloride
BIX Hydrochloride,BIX HCl |
||
BIX HCl is a sodium-hydrogen exchange type 1 inhibitor. |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2916 |
Patchouli alcohol
百秋李醇,Patchouli camphor,Patchoulol,(-)-Patchouli Alcohol,广藿香醇 |
Antibacterial; Antifungal | Microbiology/Virology |
Patchouli alcohol (Patchoulol) 是一种从广藿香中提取的天然三环倍半萜,有抗幽门螺杆菌和抗炎活性。 | |||
T5S0018 |
Betulonic acid
路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid |
Parasite; HSV | Microbiology/Virology |
Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物,具有抗肿瘤,抗炎,抗寄生虫和抗病毒的活性。 | |||
T5294 |
(S)-Leucic acid
L-alpha-羟基异己酸,L-LEUCIC ACID,Hydroxyisocaproic acid,(S)-2-羟基-4-甲基戊酸,(S)-(−)-2-Hydroxyisocaproic acid |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Leucic acid (Hydroxyisocaproic acid) 是氨基酸代谢物。 | |||
T4840 |
3-Hydroxybenzoic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
3-Hydroxybenzoic acid 是内源性代谢产物的一种。 | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T4439 |
sn-Glycero-3-phosphocholine
Choline Alfoscerate,甘磷酸胆碱,Glycerophosphocholine,Glycerophosphorylcholine,Alpha-GPC,Choline glycerophosphate,L-α-GPC |
Endogenous Metabolite; AChE | Metabolism; Neuroscience |
sn-Glycero-3-phosphocholine (Choline glycerophosphate) 是脑磷脂生物合成的前体,能够提高胆碱在神经组织中的生物利用度。它对认知功能有显著影响,同时具有良好的耐受性和安全性,因此能够用于阿尔茨海默病和痴呆症的研究。 |