71
27
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T27102 |
CV-6209
|
||
CV-6209 is a potent antagonist of the platelet-activating factor (PAF) receptor. | |||
T10159 |
48740 RP
RP-48740,RP-55778,RP 55779,RP 55778 |
PAFR; Platelet aggregation | GPCR/G Protein; Others |
48740 RP (RP 55779) 是血小板活化因子的拮抗剂。 | |||
T14007 |
PAF-AN-1
|
PAFR | GPCR/G Protein |
PAF-AN-1是一种新型有效的血小板激活因子受体 (PAF) 拮抗剂,参与研究过敏性死亡。 | |||
T28740 |
SDZ-62-434
SDZ 62 434,SDZ62434 |
Platelet aggregation | Others |
SDZ-62-434 是一种血小板活化因子抑制剂,具有抗肿瘤活性,抑制静止的瑞士 3T3 细胞中 bombesin 和血小板衍生生长因子诱导的 DNA 合成,可用于研究白血病、人异种移植结直肠癌和肺癌。 | |||
T28607 |
Rocepafant
LAU 8080,LAU8080,BN 50730,LAU-8080,BN50730,BN-50730 |
Platelet aggregation | Others |
Rocepafant (LAU8080) 是一种血小板活化因子(PAF)拮抗剂,可减轻新生大鼠缺氧缺血性脑损伤。Rocepafant 抑制肿瘤坏死因子-Afa 介导的小鼠 L929 肿瘤细胞的细胞毒性。 | |||
T15338 |
Foropafant
SR27417,福罗帕泛 |
Others; Platelet aggregation | Others |
Foropafant (SR27417) 是一种高效和特异性的血小板活化因子 (PAF) 受体拮抗剂 (Ki: 57 pM)。 Foropafant 有效抑制 PAF 诱导的兔和人血小板聚集。 | |||
T16751 |
Rilapladib
SB 659032 |
Phospholipase | Metabolism |
Rilapladib (SB 659032) 是 Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) 的选择性抑制剂 (IC50 = 230 pM) 和血小板活化因子受体的拮抗剂。 | |||
T70084 |
Dersalazine
Dersalazine Free Base |
IL Receptor; Platelet aggregation | Immunology/Inflammation; Others |
Dersalazine (Dersalazine Free Base) 是血小板活化因子抑制剂,通过下调 IL-17表达,在不同啮齿动物型结肠炎中发挥肠道抗炎活性,对溃疡性结肠炎患者具有潜在疗效。 | |||
T77638 |
BIRM 271
|
Phospholipase; LTR | Immunology/Inflammation; Metabolism |
BIRM 271 是一种新型花生四烯酸释放抑制剂,可阻断白三烯B4和人中性粒细胞中的血小板活化因子生物合成。BIRM 271 和 BIRM 270 属于对映异构体,对白三烯B4 的产生有抑制作用,IC50 为40 nM。 | |||
T19686 |
SCH-37370
乙酰地氯雷他定 |
Platelet aggregation | Others |
SCH-37370 是一种有效且具有口服活性的血小板活化因子和组胺双重拮抗剂。 Sch 37370 阻断 [3H]pyrilamine 与大鼠脑膜中组胺-H1 受体的结合。 Sch 37370 选择性地抑制 PAF 诱导的人血小板聚集(IC50:0.6 mM),并且还与 PAF 竞争与人肺膜制剂中特定位点的结合(IC50:1.2 mM)。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T67959 |
Pirodomast
|
Thrombin; Serine Protease | Proteases/Proteasome |
Pirodomast 是血栓素 A(TXA2)合成酶抑制剂。Pirodomast 能抑制白三烯(LT)D4、C4、E4 的形成和血栓素 B2(TXB2)的活性,但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物,在体外可抑制胰蛋白酶的蛋白水解活性,在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应,抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。 | |||
T26876 |
BN 52111
BN-52111,BN52111 |
||
BN 52111 is a platelet activating factor antagonist. | |||
T24321 |
L 668750
|
||
L 668750 is an inhibitor of platelet-activating factor. | |||
T32457 |
L 653150
L-653150,L653150 |
||
L 653150 is an antagaonist of platelet-activating factor. | |||
T26022 |
R 75317
R-75317,R75317 |
||
R 75317 is a Platelet-activating factor (PAF) antagonist. | |||
T13103 |
TCV-309 chloride
|
Others | Others |
TCV-309 chloride is an antagonist of platelet activating factor (PAF). | |||
T28081 |
(Rac)-Modipafant
UK-74505,Modipafant racemate,UK74505,UK 74505 |
||
Modipafant racemate is a potent and specific oral platelet activating factor (PAF) receptor antagonist. | |||
T27370 |
FR106969
FR-106969,FR 106969 |
||
FR106969 is a platelet activating factor antagonist isolated from fungus with anti-inflammatory activity. | |||
T33466 | Modipafant | ||
Modipaafant is a potent dihydropyridine PAF (platelet activating factor) antagonist. | |||
T28359 |
PF 10040
PF-10040,PF10040 |
||
PF 10040 is an antagonist of platelet activating factor (PAF). | |||
T27821 |
Lexipafant
ISV-611,GR-167089,DO-6,BB-882,DO6,BB882 |
||
Lexipafant is a platelet-activating factor (PAF) receptor antagonist. | |||
T16874 |
Setipafant
BN-50727,司替帕泛,LAU-0901 |
Others | Others |
Setipafant is an antagonist of the platelet-activating factor. | |||
T28564 |
Ro 19-1400
Ro19-1400,Ro-19-1400 |
||
Ro 19-1400, a platelet-activating factor antagonist, directly inhibits immunoglobulin E-dependent mediator release. | |||
T26874 |
BN 50341
BN50341,BN-50341 |
||
BN 50341 is an inhibitor of antithrombotic platelet activating factor. | |||
T28720 |
Sch 44643
Sch44643,Sch-44643 |
||
Sch 44643 is an antagonist of platelet activating factor with oral activity. | |||
T24314 |
L 659989
L659,989,L 659,989,L-659,989,L659989,L-659989 |
||
L 659989 is an antagonist of the Platelet-activating factor receptor. | |||
T71075 | BN 50726 | ||
BN 50726 is a platelet activating factor inhibitor; antagonizes PAF receptor binding. | |||
T16768 | Ro-24-4736 | Others | Others |
Ro 24-4736 is an effective and selective platelet-activating factor antagonist. | |||
T15188 | E-6123 | Others | Others |
E-6123 is an antagonist of platelet-activating factor (PAF) receptor. | |||
T71428 | Mocoht bromide | ||
Mocoht bromide is new antagonists of platelet activating factor. | |||
T27101 |
CV-3988
CV 3988,CV3988 |
||
CV-3988 is a specific antagonist of PAF-R (platelet-activating factor receptor)(Ki = 0.872 μM). | |||
T10844 | CMI-392 | Others | Others |
CMI-392 is a dual 5-lipoxygenase inhibitor and platelet-activating factor (PAF) receptor antagonist (IC50s: 100 and 10 nM). | |||
T13369 |
YM-264
|
Others | Others |
YM-264 is a selective and orally active antagonist of platelet-activating factor (PAF) (pKi value of 8.85 for rabbit platelet membranes). | |||
T26072 | Rhazimine | ||
Rhazimine is an indole alkaloid. It is a dual inhibitor of arachidonic acid metabolism and platelet activating factor-induced platelet aggregation. | |||
T24305 |
L 651142
L651,142,L651142,L-651,142,L 651,142,L-651142 |
||
L 651142 is a weak inhibitor of the platelet-activating factor receptor. It is also binding to polymorphonuclear leukocytes. | |||
T24586 |
PAFAH1b2
PAFAH-1-b-2,3-IN-P11,3INP11,3 IN P11,PAFAH 1 b 2 |
||
PAFAH1b2 is a selective platelet-activating factor acetylhydrolases 1b2 and 1b3 inhibitor that acts by impairing cancer cell survival. | |||
T27035 |
CL-184005
CL184005,CL 184005 |
||
CL-184005 is a platelet activating factor (PAF) inhibitor. CL-184005 interferes with tumor necrosis factor synthesis. CL-184005 also dreases Spleen-associated tumor necrosis factor protein. | |||
T71614 |
FR 900452
|
||
FR 900452 is a platelet activating factor antagonist from fermentatiion products of Streptomyces phaeofaciens. | |||
T26877 |
BN 52115
BN-52115,BN52115 |
||
BN 52115, a platelet activating factor antagonist, has been found to inhibit in vivo bronchopulmonary alteration. | |||
T26767 |
Benafentrine dimaleate
Benafentrine |
||
Benafentrine dimaleate is a platelet activating factor receptor (PAFR) antagonists and phosphodiesterase (PDE) 3/4 inhibitors. | |||
T25787 |
Me-Indoxam
Methyl indoxam,Methyl-indoxam |
||
Me-Indoxam is an inhibitor of sPLA2. It has no effect on arachidonic acid release and platelet activating factor synthesis. | |||
T71159 |
F-0401
|
||
F-0401 is a novel calcium antagonist with platelet-activating factor-antagonistic action. | |||
T71427 | N-(5-((2-Methylene-3-(((octadecylamino)carbonyl)oxy)propoxy)carbonyl)pentyl)pyridinium | ||
N-(5-((2-Methylene-3-(((octadecylamino)carbonyl)oxy)propoxy)carbonyl)pentyl)pyridinium is a platelet activating factor antagonist. | |||
T28243 |
Ono 6240
Ono-6240,Ono6240 |
||
Ono 6240 is an antagonist of platelet-activating factor. Ono 6240 prevents airway eosinophilia by inhibiting production of IL-2 and IL-5. | |||
T29308 |
Lyso-PAF C-16
|
||
Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor. | |||
T14300 |
Apafant
WEB 2086,阿帕泛 |
Others | Others |
Apafant is a potent antagonist of platelet-activating factor (PAF), inhibits PAF binding to human PAF receptors(Ki : 9.9 nM). | |||
T10873 |
CP-96486
|
Others | Others |
CP-96486 is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor (Kis: 20 and 24 nM). | |||
T10872 |
CP-96021 hydrochloride
|
Others | Others |
CP-96021 hydrochloride is a potent and orally active antagonist of leukotriene D4 (LTD4)/platelet activating factor receptor (Kis: 34 nM and 37 nM). | |||
T68185 | U 66985 | ||
U 66985 is a Platelet-activating factor (PAF) receptor antagonist that inhibit the electrophysiological effects of PAF. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8288 |
14-Deoxyandrographolide
去氧穿心莲内酯,14-去氧穿心莲内酯 |
Apoptosis; Others | Apoptosis; Others |
14-Deoxyandrographolide 是穿心莲中的一种天然产物,是一种钙通道阻断剂,具有保肝功效。它通过诱导 TNFRSF1A 的释放,使肝细胞对 TNF-α 介导的凋亡脱敏。 | |||
TN4222 |
Homoeriodictyol 7-O-β-D-glucoside
高圣草素-7-O-Β-D-葡萄糖苷,Homoeriodictyol 7-O-glucoside |
Others; Platelet aggregation | Others |
Homoeriodictyol 7-O-β-D-glucoside (Homoeriodictyol 7-O-glucoside) 是 Viscum coloratum(Kom.)Nakai 的天然产物。Homoeriodictyol 7-O-β-D-glucoside 是血小板活化因子 (PAF) 的拮抗剂。 | |||
TN1873 |
Lirinidine
|
Others | Others |
Lirinidine 是一种分离自L. tulipifera 叶片生物碱,具有抗氧化 (antioxidant) 和抗癌作用。它在体外表现出中等的铁还原能力和较小的自由基清除能力,可用于研究化妆品。 | |||
TN2322 |
Yangambin
|
Calcium Channel; PAFR | GPCR/G Protein; Membrane transporter/Ion channel; Metabolism |
Yangambin 是从诸如番荔枝科植物中分离出来的呋喃木脂素,是选择性PAF 受体拮抗剂,通过调控Ca2+通道抑制 Ca2+流入,导致 [Ca2+]i 在血管平滑肌细胞和随后的外周血管舒张中减少,具有降压作用。 | |||
TN3520 | Bisdethiobis(methylthio)gliotoxin | PAFR | GPCR/G Protein |
Bisdethiobis(methylthio)gliotoxin is a platelet activating factor (PAF) antagonist. | |||
T25983 |
Prehispanolone
LC 5504,LC5504,LC-5504 |
||
Prehispanolone is a platelet activating factor antagonist from Chinese medicinal herb Leonurus heterophyllus. | |||
TN5045 | Spiradine F | PAFR | GPCR/G Protein |
Spiradine F can significantly inhibit platelet-activating factor(PAF)-induced platelet aggregation in a concentration-dependent manner. | |||
TN4821 |
Pregomisin
|
PAFR | GPCR/G Protein |
Pregomisin shows platelet-activating factor (PAF) antagonistic activity and the IC 50 value is 4.8x10(-5) M. | |||
TN4367 |
Kadsurin A
|
PAFR | GPCR/G Protein |
Kadsurin A 具有抗血小板活化因子活性。 | |||
TN1654 |
Futoquinol
|
Others; ROS; PAFR | GPCR/G Protein; Immunology/Inflammation; Others |
Futoquinol is an anti-platelet activating factor principle from the stem part of Piper futokadsura (Piperaceae), the Chinese drug haifengteng. | |||
T13716 | (+)-Guaiacin | Others | Others |
(+)-Guaiacin is a compound isolated from the bark of Machilus wangchiana Chun. It shows potent in vitro activities against the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs) induced by platelet-activating factor (PAF). | |||
TN4795 |
Piperenone
|
PAFR | GPCR/G Protein |
Piperenone is an insect antifeeding substance. It has anti-platelet-activating factor(PAF) activities, is a PAF-acether antagonist. | |||
T68233 |
Kadsurenone
|
||
Kadsurenone is a platelet-activating factor receptor antagonist from Chinese herbal plant, haifenteng. It is a useful and promising treatment strategy for breast cancer bone metastases by blocking the PAF/PTAFR signaling pathway. | |||
TN4794 |
Pinusolidic acid
|
PAFR | GPCR/G Protein |
Pinusolidic acid shows a potent inhibitory effect on platelet activating factor (PAF) binding to rabbit platelets (IC50 = 2.3 x 10(-5) M, 7.48 +/- 2.11 micrograms/ml). | |||
TN6056 |
Zanthobungeanine
8-Methoxy-N-methylflindersine |
||
Zanthobungeanine has anti-inflammatory activity, it shows moderate NO production inhibitory activity with an IC50 value of 37.26 mg /L.It shows obviously inhibitoryactivity to platelet aggregation caused by platelet-activating factor (PAF). Zanthobungeani | |||
TN2763 |
2-Hydroxy-3-methoxybenzoic acid glucose ester
|
PAFR | GPCR/G Protein |
2-Hydroxy-3-methoxybenzoic acid glucose ester shows a potent antagonistic activity against platelet activating factor (PAF), it can prevent the mice from the PAF-induced death at a dose of 300 micrograms/mouse. | |||
T79948 |
Kadsurenin B
|
||
Kadsurenin B为PAF(platelet-activating factor)拮抗剂,展现出神经保护作用。该化合物在药理学领域显示出广泛的研究潜力,包括抗菌、抗炎、神经保护、抗氧化、抗血小板聚集、细胞毒性和抗寄生虫等效能。 | |||
T3P2855 | Chamigrenal | EGFR; NOS; PAFR; COX; Prostaglandin Receptor | Angiogenesis; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; Neuroscience; Tyrosine Kinase/Adaptors |
β-Chamigrenal has anti-inflammatory activity, it has inhibitory effects on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production in RAW 264.7 macrophages. Chamigrenal shows platelet-activating factor antagonistic activity and the IC(50) | |||
T79950 |
Piperulin A
|
||
Piperulin A,作为一种有效的PAFR抑制剂,其通过抑制兔血小板质膜上PAFR的特异性结合,展现出其功能,IC50值为7.3 μM。 | |||
TN1815 | Kadsulignan L | HBV; PAFR | GPCR/G Protein; Microbiology/Virology |
Kadsulignan L shows in vitro antiviral effects on hepatitis B virus. It also shows moderate platelet-activating factor (PAF) antagonistic activities with the IC50 value of 2.6 x 10(-5) M. | |||
TL0014 | Pinusolide | ERK; p38 MAPK; Calcium Channel; Lipoxygenase; PAFR; Caspase; JNK; AMPK | Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling; Proteases/Proteasome |
Pinusolide is a platelet activating factor ( PAF) antagonist, it may prove of therapeutic value in the treatment of hypotension, it has antileukemic potential, and could be used to treat neurodegenerative diseases. Pinusolide attenuates blockade of insulin signaling by enhancing IRS-1 tyrosine phosphorylation by the activating the AMPK pathway, indicates the targeting of AMPK represents a new therapeutic strategy for hyperglycemia-induced insulin resistance and type 2 diabetes. | |||
TN4088 |
Futoenone
|
PAFR | GPCR/G Protein |
Futoenone and a series of its derivatives have shown inhibitory activities against matrix metalloproteinases, the molecular modelings of these compounds indicate the preferred binding of the P2' site of the enzymes. Neolignan derivative compounds of the 2,4-diaryl-1,3-dithiolane and futoenone variety exhibit both platelet activating factor receptor(PAF)and 5-lipoxygenase antagonist activity. | |||
TN5414 |
Wallichinine
|
||
Wallichinine shows inhibitory activity on platelet aggregation caused by platelet activating factor (PAF). Wallichinine with ABCB1 presents valuable clues for the development of novel MDR reversal reagents from natural products, wallichinine can significa | |||
T38015 |
Herquline A
|
||
Herquline A is an alkaloid fungal metabolite originally isolated from P. herquei. It inhibits cell death induced by influenza A strain A/PR/8/34 in MDCK cells with an IC50 value of 10 μg/ml and inhibits viral replication in a plaque assay in a concentration-dependent manner. Herquline A also inhibits platelet aggregation induced by ADP and platelet-activating factor (PAF) in vitro (IC50s = 180 and 240 μM, respectively). | |||
TN3161 |
6-Deoxyjacareubin
|
Antioxidant; PAFR; Platelet aggregation; Antifection | GPCR/G Protein; Microbiology/Virology; Others; oxidation-reduction |
6-Deoxyjacareubin 具有有效的抗氧化和抗真菌活性。 6-Deoxyjacareubin 抑制血小板活化因子 (PAF) 受体,IC50 为 29.0 microM,可用于天然 PAF 受体拮抗剂的研究。 | |||
TN4664 |
Norarmepavine
|
Others | Others |
N-norarmepavine shows significant cytotoxic activities against HL-60 carcinoma cell line with inhibitory ratios of 51.43% at concentration of 1 x 10(-5) M. Norarmepavine shows inhibition against Trypanosoma cruzi. D-(+)- N-norarmepavine exhibits significa | |||
T38330 |
Collinin
|
||
Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a... |