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Search Results for " osteogenic "

19

抑制剂 & 化合物

13

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T37603L	Osteogenic Growth Peptide (10-14) acetate Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base)	Src	Angiogenesis; Tyrosine Kinase/Adaptors
	Osteogenic Growth Peptide (10-14) acetate (Osteogenic Growth Peptide) 是一种 Src 抑制剂，是一种有效的有丝分裂原和促成骨和造血因子。Osteogenic Growth Peptide (10-14) acetate 负责与 OGP 受体结合并激活细胞内 Gi 蛋白激酶信号通路。
TP1820L	Osteogenic Growth Peptide, OGP acetate Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)	Others	Others
	Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base) 是一种短的、天然存在的 14 聚体生长因子肽，存在于血清中，浓度为 μM。成骨生长肽 OGP 是局部骨髓损伤全身成骨反应机制的关键因素。
T37603	Osteogenic Growth Peptide (10-14)
	YGFGG, C-terminal pentapeptide fragment of the osteogenic growth peptide (OGP), (H-8640), showed the full spectrum of OGP-like bioactivities. It has attracted considerable interest as bone anabolic agent and hematopoietic stimulator.
TP1820	Osteogenic Growth Peptide, OGP
	Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations. Osteogenic growth peptide OGP is a key factor in the mechanism of the systemic osteogenic response to local bone marrow injury
T4205	AG-494 Tyrphostin AG-494,AG 494,Tyrphostin B48	EGFR; CDK	Angiogenesis; Cell Cycle/Checkpoint; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	AG-494 (Tyrphostin B48) 是一种高效、选择性的 EGFR 酪氨酸激酶抑制剂，IC50为0.7 μM。它阻断 Cdk2 的激活并抑制 EGF 依赖的 DNA 合成。它抑制 EGFR、ErbB2、HER1-2 和 PDGF-R 的自磷酸化，IC50为 1.1、39、45 和 6 μM。
T19389	L-Ascorbic acid 2-phosphate magnesium 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁	Phosphatase; Phosphorylase	Metabolism
	L-Ascorbic acid 2-phosphate magnesium (2-Phospho-L-ascorbic acid magnesium) 是长效的维生素 C 衍生物，能够以刺激胶原蛋白的表达和形成。它提高成骨细胞分化过程中 hASC 中的碱性磷酸酶特性和 runx2A 的表达。它能够以作为培养基补充人脂肪干细胞的成骨分化。
T7358	YK11 (17ALPHA,20E)-17,20-[(1-甲氧基乙亚基)二(氧基)]-3-氧代-19-去甲孕甾-4,20-二烯-21-羧酸甲酯	Androgen Receptor	Endocrinology/Hormones
	YK11 是雄激素受体部分激动剂，当使用浓度为 0.1 μM 时，可激活过表达雄激素受体的 HEK293 细胞中的雄激素受体转录活性，具有成骨活性。
T67855	ISX-3	Others	Others
	ISX-3 是有效的促成骨剂和抗脂肪生成剂。ISX-3 可以增加 PPARγ 的表达。ISX-3 可用于研究骨质减少和骨质疏松症。
T35694	OD36 OD 36,OD 36 hydrochloride,OD-36	ALK; RIP kinase	Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	OD36 是一种选择性强效 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 可抑制 ALK2 信号传导和成骨分化（KD：37 nM），并能与 ALK2 激酶 ATP 袋有效结合。
T61301	Chromenone 1	TGF-beta/Smad	Stem Cells
	Chromenone 1 是一种有效的成骨骨形态发生蛋白(BMP)增强剂，其通过诱导显著的非激酶依赖的负TGFβ反馈，独特地增强了核BMP-Smad信号输出。
T19390	L-Ascorbic acid 2-phosphate 维生素C磷酸酯,2-Phospho-L-ascorbic acid	Others	Others
	L-ascorbic acid 2-phosphate can be used as a culture medium supplement for the osteogenic differentiation of human adipose stem cells (hASCs). L-ascorbic acid 2-phosphate increases alkaline phosphatase (ALP) activity and expression of runx2A in hASCs during the osteogenic differentiation. L-ascorbic acid 2-phosphate is a long-acting vitamin C derivative that can stimulate collagen formation and expression.
T124960	Avenacoside B	Others	Others
	Avenacoside B 可从燕麦中提取，具有抗线虫活性，可增强成骨活性。
T76798	Bimekizumab
	Bimekizumab (Anti-Human IL17A/IL-17F Recombinant Antibody) 是一种人源化单克隆抗体，可选择性中和 IL-17A 和 IL-17F。这两种细胞因子都能够促进成骨的人骨膜衍生细胞 (hPDC) 分化。因此，Bimekizumab 的应用，可以阻断炎症驱动的成骨分化。
T31124	CW 008 CW-008,CW008
	CW 008 is an activator of the cAMP/PKA/CREB pathway. It promotes osteogenic differentiation of human bone marrow derived mesenchymal stem cells in vitro and increases bone mass and bone volume density in ovariectomized mice.
T81406	Preptin (rat)
	Preptin 在剂量依赖的方式下刺激胎鼠原代成骨细胞和成骨样细胞系的增殖，影响表现在细胞数量和DNA合成上。
T82851	BMP2-derived peptide
	BMP2-derived peptide为BMP-2第73至92位氨基酸序列的功能性基序，具有促进骨髓基质细胞(BMSCs)成骨分化及骨再生的作用。
T82929	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG 促进骨化作用。该化合物适用于研究成骨缺陷或骨矿物质密度（BMD）降低相关疾病，如骨质疏松症。
T61424	OD36 hydrochloride OD 36 hydrochloride,OD-36 hydrochloride	ALK; RIP kinase	Angiogenesis; Apoptosis; NF-κB; Tyrosine Kinase/Adaptors
	OD36 hydrochloride (OD-36 hydrochloride) 是一种强效的 RIPK2 抑制剂，IC50 为 5.3 nM。OD36 hydrochloride 是一种大环抑制剂，可与 ALK2 激酶 ATP 口袋有效结合，能有效拮抗突变 ALK2 信号传导和成骨分化。OD36 hydrochloride 靶向作用于 ALK2，KD 为 37 nM。
T83848	VnP-16 TFA
	VnP-16是一种合成肽段，对应vitronectin的氨基酸270-281，vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时，能促进人类成骨细胞的附着和扩散，此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内，VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。

化合物

Osteogenic Growth Peptide (10-14) acetate

Cat.No: T37603L

Synonym: Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base)

Target: Src

Osteogenic Growth Peptide, OGP acetate

Cat.No: TP1820L

Synonym: Osteogenic Growth Peptide, OGP acetate(132996-61-3 free base)

Target: Others

Osteogenic Growth Peptide (10-14)

Cat.No: T37603

Osteogenic Growth Peptide, OGP

Cat.No: TP1820

Cat.No: T4205

Synonym: Tyrphostin AG-494,AG 494,Tyrphostin B48

Target: EGFR, CDK

L-Ascorbic acid 2-phosphate magnesium

Cat.No: T19389

Synonym: 2-Phospho-L-ascorbic acid magnesium,维生素C磷酸酯镁,维生素 C 磷酸酯镁

Target: Phosphatase, Phosphorylase

Cat.No: T7358

Synonym: (17ALPHA,20E)-17,20-[(1-甲氧基乙亚基)二(氧基)]-3-氧代-19-去甲孕甾-4,20-二烯-21-羧酸甲酯

Target: Androgen Receptor

Cat.No: T67855

Target: Others

Cat.No: T35694

Synonym: OD 36,OD 36 hydrochloride,OD-36

Target: ALK, RIP kinase

Cat.No: T61301

Target: TGF-beta/Smad

L-Ascorbic acid 2-phosphate

Cat.No: T19390

Synonym: 维生素C磷酸酯,2-Phospho-L-ascorbic acid

Target: Others

Cat.No: T124960

Target: Others

Cat.No: T76798

Cat.No: T31124

Synonym: CW-008,CW008

Cat.No: T81406

BMP2-derived peptide

Cat.No: T82851

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG

Cat.No: T82929

OD36 hydrochloride

Cat.No: T61424

Synonym: OD 36 hydrochloride,OD-36 hydrochloride

Target: ALK, RIP kinase

Cat.No: T83848

Cat. No.	Product Name	Target	Signaling Pathways
TN1124	Neoeriocitrin	AChE	Neuroscience
	Neoeriocitrin 是一种有效的乙酰胆碱酯酶抑制剂，分离于自百日草，在 MC3T3-E1 中显示出对增殖和成骨分化的活性。
TN7036	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide (Macamide Impurity 14) 是一种从玛卡中分离得到的玛卡酰胺。它能够激活典型的Wnt/β‐catenin 信号通路，诱导间充质干细胞成骨分化和随后的骨形成，可用于研究骨质疏松症。
T2185	L-Ascorbic acid 2-phosphate trisodium L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐	Reactive Oxygen Species; c-Met/HGFR; Endogenous Metabolite	Immunology/Inflammation; Metabolism; NF-κB; Tyrosine Kinase/Adaptors
	L-Ascorbic acid 2-phosphate trisodium (Sodium ascorbyl phosphate) 是长效的维生素 C 衍生物，能够刺激胶原蛋白的表达和形成。Sodium L-ascorbyl-2-phosphate 提高成骨细胞分化过程中 hASC 中的碱性磷酸酶活性和 runx2A 的表达，因此，能够促进人脂肪干细胞的成骨分化。
T5S0836	Isoastragaloside II 黄芪甲苷VII,Astrasieversianin VII	Others	Others
	Isoastragaloside II (Astrasieversianin VII) 是一种是从黄芪毛状根培养分离得到的黄芪甲苷。
T3808	Icariside I 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I	Others	Others
	Icariside I (Lcariside I) 是一种 Icarlin 的代谢产物，具有调节骨重塑的作用，可用于研究骨质疏松。
T3925	Astragaloside I 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Astragaloside I (Cyclosieversioside B) 是从黄芪中分离得到天然产物。它可通过 Wnt/β-catenin 信号通路刺激成骨细胞分化，可用于成骨活性研究。
T3924	Astragaloside II 黄芪皂苷 II,Astrasieversianin VIII	TGF-beta/Smad	Stem Cells
	Astragaloside II (Astrasieversianin VIII) 是一种分离自黄芪中的天然化合物。
TN1918	Medicarpin 美迪紫檀素	Apoptosis; BCL; ROS; JNK	Apoptosis; Immunology/Inflammation; MAPK
	Medicarpin 是从紫花苜蓿中分离出的一种类黄酮。它通过调节 P-gp 介导的药物外流，诱导白血病 P388 细胞凋亡并克服多药耐药性。
T6S1966	Curculigoside Curculigoside A,仙茅苷	Antioxidant; NF-κB; JAK; STAT	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells
	Curculigoside (Curculigoside A) 是仙茅中的主要皂苷，具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径，具有抗关节炎作用。
TN6568	Glycinol
	Glycinol enhances osteogenic differentiation and attenuates the effects of age on mesenchymal stem cells, it could as a potential preventive or treatment for osteoporosis. Glycinol also has antidiuretic activity.
TN3215	7,4'-Dihydroxy-8-methylflavan	Others	Others
	7,4'-Dihydroxy-8-methylflavan can significantly promote mesenchymal stem cells (MSCs) osteogenic differentiation by increasing the levels of alkaline phosphatase (ALP) activity. 7,4'-Dihydroxy-8-methylflavan also has free radical scavenging properties.
T14368	Azadirachtin B	Others	Others
	Azadirachtin B, a limonoid derived from the seed kernels of Azadirachta indica, exhibits a broad spectrum of biochemical activities, including insecticidal, nematocidal, anticancer, anti-inflammatory, antiviral, and osteogenic effects. It is effective against the Epstein-Barr virus early antigen (EBV-EA), enhances alkaline phosphatase (ALP) activity, and promotes osteoblast differentiation[1][2][3].
TN4999	Serratenediol	BCL; PARP; Caspase	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
	Serratenediol demonstrates strong inhibitory effects on the Epstein-Barr virus early antigen (EBV-EA) activation without showing any cytotoxicity, its effects being stronger than that of a representative control, oleanolic acid. Serratenediol can promote

天然产物

Cat.No: TN1124

Target: AChE

N-(3-Methoxybenzyl)-(9Z,12Z,15Z)-octadecatrienamide

Cat.No: TN7036

Synonym: (9Z,12Z,15Z)-N-[(3-Methoxyphenyl)methyl]-9,12,15-octadecatrienamide,间-甲氧基苄基-亚麻酰胺,Macamide Impurity 14

Target: Wnt/beta-catenin

L-Ascorbic acid 2-phosphate trisodium

Cat.No: T2185

Synonym: L-抗坏血酸-2-磷酸三钠盐（维生素C）,L-Ascorbic acid 2-phosphate trisodium salt,Sodium L-ascorbyl-2-phosphate,Sodium ascorbyl phosphate,2-Phospho-L-ascorbic acid trisodium salt,Sodium ascorbyl monophosphate,L-抗坏血酸-2-磷酸三钠盐

Target: Reactive Oxygen Species, c-Met/HGFR, Endogenous Metabolite

Isoastragaloside II

Cat.No: T5S0836

Synonym: 黄芪甲苷VII,Astrasieversianin VII

Target: Others

Cat.No: T3808

Synonym: 淫羊藿次苷I,Lcariside I,Icariin I,Icarisid I

Target: Others

Astragaloside I

Cat.No: T3925

Synonym: 黄芪皂苷I,Cyclosieversioside B,Astrasieversianin IV

Target: Wnt/beta-catenin

Astragaloside II

Cat.No: T3924

Synonym: 黄芪皂苷 II,Astrasieversianin VIII

Target: TGF-beta/Smad

Cat.No: TN1918

Synonym: 美迪紫檀素

Target: Apoptosis, BCL, ROS, JNK

Cat.No: T6S1966

Synonym: Curculigoside A,仙茅苷

Target: Antioxidant, NF-κB, JAK, STAT

Cat.No: TN6568

7,4'-Dihydroxy-8-methylflavan

Cat.No: TN3215

Target: Others

Cat.No: T14368

Target: Others

Cat.No: TN4999

Target: BCL, PARP, Caspase

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