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Search Results for " nephropathy "

40

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T16695	Pyrintegrin	Integrin	Cytoskeletal Signaling
	Pyrintegrin 是一种 β1 整合素激动剂，也是 2,4-二取代的嘧啶，可促进胚胎干细胞存活。它可用作足细胞保护剂，能增强细胞-细胞外基质 (ECM) 粘附介导的整联蛋白信号传导，具有强大的成脂作用。
T16724	Razuprotafib AKB-9778	Phosphatase; Others	Metabolism; Others
	Razuprotafib (AKB-9778) 是一种 VE-PTP (HPTPß)催化活性的有效选择性抑制剂，抑制结构相关磷酸酶 PTP1B。除 HPTPη 和 HPTPγ 外，它对 VE-PTP 具有良好的选择性。它能够促进 TIE2 活化，增强 ANG1 诱导的 TIE2 活化，并刺激 TIE2 通路中信号分子的磷酸化。
T8408	GKT136901 AK120765	NADPH-oxidase; NADPH	Immunology/Inflammation; Metabolism
	GKT136901 (AK120765) 是选择性的和具有口服活性的 NADPH 氧化酶 NOX-1/4抑制剂，Ki 分别为 160 和 165 nM。它具有抗炎症活性。它也是一种选择性和直接的过氧亚硝酸清除剂。它可用于糖尿病肾病，中风和神经退行性疾病的研究。
T0476	Spironolactone 安体舒通,螺内酯,SC9420,Abbolactone	Glucocorticoid Receptor; Androgen Receptor; Autophagy	Autophagy; Endocrinology/Hormones
	Spironolactone (SC9420) 是一种可口服的醛固酮盐皮质激素受体拮抗剂，IC50值为 24 nM。它也是雄激素受体拮抗剂，促进足细胞自噬，IC50值为 77 nM。
T6542	Imidapril hydrochloride Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366	RAAS	Endocrinology/Hormones
	Imidapril hydrochloride (Tanapril) 是一种血管紧张素转换酶 (ACE) 抑制剂，具有抗高血压活性。
T28360	PF-00489791 PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817	PDE	Metabolism
	PF-00489791 (PF4634817) 是一种长效 PDE5 抑制剂，具有降血压活性，可用于研究糖尿病肾病。
T0358	Aminoguanidine hydrochloride Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine	NOS; NO Synthase	Immunology/Inflammation
	Aminoguanidine hydrochloride (Hydrazinecarboximidamide) 是二胺氧化酶抑制剂，也是一氧化氮合酶抑制剂，可用于糖尿病肾病的研究。
T14301	Apararenone MT-3995	Glucocorticoid Receptor	Endocrinology/Hormones
	Apararenone (MT-3995) 是一种新型的、非甾体类盐皮质激素受体 (mineralocorticoid receptor) 拮抗剂，正在开发用于糖尿病性肾病和非酒精性脂肪性肝炎的研究。
T6486	Enalapril Maleate MK-421 Maleate,Renitec Maleate,Glioten Maleate,MK-421 (maleate),Vasotec Maleate,马来酸依那普利	RAAS	Endocrinology/Hormones
	Enalapril Maleate (MK-421 Maleate) 一种是血管紧张素转化酶（ACE）抑制剂。
TP1978L	NFAT inhibitor, Cell Permeable aceate	Others	Others
	NFAT inhibitor, Cell Permeable aceate 是一种细胞可渗透的活化 T 细胞核因子 (NFAT) 抑制剂。可用于足细胞和糖尿病肾病的研究。
TP1761L	Handle region peptide, rat acetate Handle region peptide, rat acetate(749227-53-0 free base)	Others	Others
	Handle region peptide, rat acetate(749227-53-0 free base) 是一种肾素原受体拮抗剂，可抑制糖尿病肾病的进展并具有抗炎作用。
T24626	PF-249 PF-06685249,PF 06685249,PF06685249	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	PF-249 (PF-06685249) 是一种 β1 选择性 AMPK，对 AMPK α1β1γ1 的 EC50 为 12 nM，可用于糖尿病肾病的研究。
T0778	Phenacetin 非那西丁,Acetophenetidin	COX	Immunology/Inflammation; Neuroscience
	Phenacetin (Acetophenetidin) 是一种非阿片类解热化合物，可用于缓解疼痛的研究。它是一种选择性的COX-3抑制剂，能作为人肝微粒体和大鼠体内 CYP1A2 的探针。
T24270	KS370G KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide
	KS370G (Caffeic Acid Phenethyl Amide) 抑制 UUO 诱导的肾纤维化标志物表达。KS370G 是一种具有口服活性的降糖和心血管保护剂，可减少梗阻肾脏中胶原蛋白的沉积，并显著降低肾脏炎症趋化因子/粘附分子和单核细胞标志物的表达，改善压力过载小鼠心脏左室肥厚和功能。KS370G 可用于研究肾阻塞性肾病。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T27090	CRX-526
	CRX-526, a TLR4 antagonist, protects against advanced diabetic nephropathy.
T16502	PF-3882845	Others	Others
	PF-3882845 also binds to the progesterone receptor (the binding IC50: 310 nM). PF-3882845 is a remarkably high affinity selective and orally efficacious mineralocorticoid receptor (MR binding IC50=2.7 nM) antagonist for hypertension and nephropathy.
T69990	Ruboxistaurin mesylate monohydrate
	Ruboxistaurin mesylate monohydrate is a PKC beta inhibitor potentially for the treatment of diabetic nephropathy and diabetic macular edema. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/Smad and GRAP pathways. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin inhibits retinal neovascularization via suppression of phosphorylation of ERK1/2 and Akt.
T27743	KRH-594 free acid WK14922K,WK-1492,WK-14922K,WK1492
	KRH-594 is a potent, specific and insurmountable AT1 receptor antagonist. KRH-594 ameliorates hyperlipidaemia and nephropathy in diabetic spontaneously hypertensive rats. KRH-594 prevents end-organ damage in stroke-prone spontaneously hypertensive/Izm ra
T70059	ALT-946 HCl
	ALT-946 HCl is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
T68794	ALT-946 free base
	ALT-946 free base is an inhibitor of advanced glycation that has been shown to improve severe nephropathy in the diabetic transgenic (mREN-2)27 rat.
T3689L	Ruboxistaurin mesylate LY-333531,LY333531,LY 333531,LY-333531 Mesylate
	Ruboxistaurin is a PKC beta inhibitor. Ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes. Ruboxistaurin attenuates diabetic nephropathy via modulation of TGF-β1/
T38829	Lademirsen RG-012,SAR339375
	Lademirsen (SAR339375; RG-012) is a highly specific antisense oligonucleotide (ASO) targeting miR-21 . Lademirsen has the potential for Alport nephropathy research.
T10536	BI 703704	Others	Others
	BI 703704 是一种有效的可溶性鸟苷酸环化酶(sGC)激活剂，可抑制 ZSF1 大鼠的糖尿病肾病的进展。
T71450	Ilacirnon sodium
	Ilacirnon sodium is a potent CCR2 antagonist that may be useful in the treatment of renal diseases including Focal Segmental Glomerulosclerosis and Diabetic Nephropathy.
TP1761	Handle region peptide, rat
	Handle region peptide, rat, functions as a prorenin receptor antagonist, effectively inhibiting the development of diabetic nephropathy while also exhibiting anti-inflammatory properties specifically within the eye.
T38646	GKT136901 hydrochloride GKT136901 hydrochloride
	GKT136901 hydrochloride is a powerful, selective, and orally active inhibitor of NADPH oxidase (NOX1/4). It exhibits K i values of 160 nM and 165 nM against NOX1 and NOX4, respectively. Additionally, GKT136901 hydrochloride demonstrates selectivity and direct scavenging ability towards peroxynitrite. This compound finds utility in studying diabetic nephropathy, stroke, neurodegeneration, and possesses anti-inflammatory properties.
T31109	CTP-499
	CTP499, a selective PDE inhibitor, and the deuterium-containing agent is an HDX analogue and a metabolite of hexantheobromine that slows the progression of type 2 diabetic nephropathy in patients with macroalbuminuria.
T83428	1-Myristoyl-3-chloropropanediol
	1-Myristoyl-3-chloropropanediol 是一种MCPD (3-一氯丙二醇) 脂肪酸酯。慢性口服该化合物可导致肾病、小管增生和腺瘤形成，在大鼠中也观察到生育能力下降，不育发生率增加，以及免疫功能受到抑制。
T39063	Azilsartan mepixetil
	Azilsartan mepixetil is a potent angiotensin II receptor antagonist with enhanced efficacy and prolonged duration of action. It exhibits more prominent and sustained effects in lowering blood pressure and heart rate, while maintaining a high level of safety. Furthermore, Azilsartan mepixetil demonstrates optimal protective efficacy for cardiovascular and renal functions. Hence, it holds promise for the research and treatment of hypertension, chronic heart failure, and diabetic nephropathy.
T10684L	Carnostatine hydrochloride SAN9812 hydrochloride	Others	Others
	Carnostatine hydrochloride (SAN9812 hydrochloride) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine hydrochloride 可用于治疗糖尿病性肾病 (DN) 。
T12419L	PF-04634817	CCR	Immunology/Inflammation; Microbiology/Virology
	PF-0463481 is safe and well-tolerated and has the potential for the study of diabetic nephropathy. PF-0463481 is an effective and orally active dual CCR2/CCR5 antagonist. It also has comparable human and rodent CCR2 potency (rat IC50=20.8 nM). PF-0463481
T78612	APPA	Apoptosis	Apoptosis
	APPA为一种醛糖还原酶抑制剂，能够抑制大鼠多元醇途径，有效预防细胞凋亡及链脲佐菌素引发的糖尿病症状，显示出对糖尿病肾病(DN)研究的应用潜力。
T78657	Azilsartan mepixetil potassium QR-01019K
	Azilsartan mepixetil potassium (QR-01019K)，是一种高效安全的血管紧张素 II 受体拮抗剂，展现出卓越的持久降压效应以及显著且持续的降心率功能，有望用于治疗高血压、慢性心力衰竭和糖尿病肾病。
T10684	Carnostatine SAN9812	Others	Others
	Carnostatine (SAN9812) 是一种有效的选择性肌肽酶 1 (CN1) 抑制剂，对人重组 CN1 的Ki 值为 11 nM。Carnostatine 可用于治疗糖尿病性肾病 (DN) 。
T71065	Quinapril-d5
	Quinapril-d5 is intended for use as an internal standard for the quantification of quinapril by GC- or LC-MS. Quinapril is a prodrug form of the angiotensin converting enzyme (ACE) inhibitor quinaprilat. In vivo, quinapril reduces mean arterial pressure in renal hypertensive and spontaneously hypertensive rats. It inhibits angiotensin I-induced pressor responses in normotensive rats and dogs. Quinapril prevents left ventricular heart failure in CHF 14.6 cardiomyopathic hamsters. Formulations con...
T69523	BMS-681
	BMS-681 is an orthosteric antagonist of chemokine receptor 2 (CCR2) that forms a ternary complex with CCR2 and its allosteric antagonist, CCR2-RA-[R]. Together, the complex inhibits chemokine binding with BVMS-681 in the orthosteric pocket and CCR2-RA-[R] in the intracellular allosteric G-protein binding site. When chemokine binding is inhibited, modulation responses implicated in several inflammatory and neurodegenerative diseases, including atherosclerosis, multiple sclerosis, asthma, neuropat...
T36622	Angiotensin I/II (1-6) (TFA)
	Angiotensin I/II (1-6) TFA is a chemical compound comprising amino acids 1-6. It is derived from the Angiotensin I/II peptide, which is formed by the cleavage of the precursor angiotensinogen by renin. The resulting Angiotensin I is then hydrolyzed by angiotensin-converting enzyme (ACE) to produce biologically active Angiotensin II. Angiotensin II has been extensively studied for its potential applications in the treatment of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Neph...
T83125	AMPK-α1β1γ1 activator 1	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	AMPK-α1β1γ1激活剂1 (M1) 是一个衍生于Indole-3-carcinoma的酰基葡萄糖醛酸代谢AMPK激活剂，专一性地针对人类β1亚型，表现出38.1nM的EC50值。该化合物能够直接结合至人AMPK α1β1γ1亚型，适用于糖尿病肾病的相关研究。
T62005	Imidapril
	Imidapril (TA-6366 free base) 是口服有效的血管紧张素转换酶（ACE）和MMP-9抑制剂。Imidapril 通过抑制血管紧张素 I 向血管紧张素 II 转化从而降低总外周阻力和血压。Imidapril 在高血压、1 型糖尿病、肾病和慢性心力衰竭中有研究价值。

化合物

Cat.No: T16695

Target: Integrin

Cat.No: T16724

Synonym: AKB-9778

Target: Phosphatase, Others

Cat.No: T8408

Synonym: AK120765

Target: NADPH-oxidase, NADPH

Cat.No: T0476

Synonym: 安体舒通,螺内酯,SC9420,Abbolactone

Target: Glucocorticoid Receptor, Androgen Receptor, Autophagy

Imidapril hydrochloride

Cat.No: T6542

Synonym: Novaloc,Imidapril HCl,盐酸咪达普利,Tanapril,TA-6366

Target: RAAS

Cat.No: T28360

Synonym: PF-4634817,PF 4634817,PF00489791,PF 00489791,PF4634817

Target: PDE

Aminoguanidine hydrochloride

Cat.No: T0358

Synonym: Imino semicarbazide,Pimagedine hydrochloride,CP-12009-18 tartrate,Hydrazinecarboximidamide,肼甲酰亚胺酰胺一氯化氢（氨基胍盐酸盐）,氨基胍盐酸盐,Guanyl hydrazine,Pimagedine

Target: NOS, NO Synthase

Cat.No: T14301

Synonym: MT-3995

Target: Glucocorticoid Receptor

Enalapril Maleate

Cat.No: T6486

Synonym: MK-421 Maleate,Renitec Maleate,Glioten Maleate,MK-421 (maleate),Vasotec Maleate,马来酸依那普利

Target: RAAS

NFAT inhibitor, Cell Permeable aceate

Cat.No: TP1978L

Target: Others

Handle region peptide, rat acetate

Cat.No: TP1761L

Synonym: Handle region peptide, rat acetate(749227-53-0 free base)

Target: Others

Cat.No: T24626

Synonym: PF-06685249,PF 06685249,PF06685249

Target: AMPK

Cat.No: T0778

Synonym: 非那西丁,Acetophenetidin

Target: COX

Cat.No: T24270

Synonym: KS-370-G,KS 370 G,Caffeic Acid Phenethyl Amide

MTP 131 acetate

Cat.No: T35689

Target: Others

Cat.No: T27090

Cat.No: T16502

Target: Others

Ruboxistaurin mesylate monohydrate

Cat.No: T69990

KRH-594 free acid

Cat.No: T27743

Synonym: WK14922K,WK-1492,WK-14922K,WK1492

Cat.No: T70059

ALT-946 free base

Cat.No: T68794

Ruboxistaurin mesylate

Cat.No: T3689L

Synonym: LY-333531,LY333531,LY 333531,LY-333531 Mesylate

Cat.No: T38829

Synonym: RG-012,SAR339375

Cat.No: T10536

Target: Others

Ilacirnon sodium

Cat.No: T71450

Handle region peptide, rat

Cat.No: TP1761

GKT136901 hydrochloride

Cat.No: T38646

Synonym: GKT136901 hydrochloride

Cat.No: T31109

1-Myristoyl-3-chloropropanediol

Cat.No: T83428

Azilsartan mepixetil

Cat.No: T39063

Carnostatine hydrochloride

Cat.No: T10684L

Synonym: SAN9812 hydrochloride

Target: Others

Cat.No: T12419L

Target: CCR

Cat.No: T78612

Target: Apoptosis

Azilsartan mepixetil potassium

Cat.No: T78657

Synonym: QR-01019K

Cat.No: T10684

Synonym: SAN9812

Target: Others

Cat.No: T71065

Cat.No: T69523

Angiotensin I/II (1-6) (TFA)

Cat.No: T36622

AMPK-α1β1γ1 activator 1

Cat.No: T83125

Target: AMPK

Cat.No: T62005

Cat. No.	Product Name	Target	Signaling Pathways
T14002	12-Ketodeoxycholic acid	Endogenous Metabolite	Metabolism
	12-Ketodeoxycholic acid 是一种胆汁酸，由肾脏代谢产生。它是肾脏损伤的标志物。
TN1644	Flavanomarein	Others	Others
	Flavanomarein 是Coreopsis tinctoria Nutt 的主要黄酮类化合物，对糖尿病性肾病具有保护作用。它具有很好的抗氧化，降糖，降压和降血脂作用。
TN1471	Cassiaside C 决明子苷C,Toralactone 9-O-β-D-gentiobioside	Others; Endogenous Metabolite	Metabolism; Others
	Cassiaside C (Toralactone 9-O-β-D-gentiobioside) 是一种萘酚类化合物，从决明子种子中分离得到，对晚期糖基化终产物 (AGE) 的形成具有抑制作用。
T6S1367	Procyanidin B2 原花青素 B2,Proanthocyanidin B2	Reactive Oxygen Species; NOD	Immunology/Inflammation; Metabolism; NF-κB
	Procyanidin B2 (Proanthocyanidin B2) 是天然黄酮类物质，具有抗肿瘤，抗氧化等活性。
TL0001	dencichine L-Dencichin,ODAP,Dencichin,三七素	Others; HIF/HIF Prolyl-Hydroxylase	Chromatin/Epigenetic; Metabolism; Others
	Dencichine (ODAP) 是抑制从三七中分到的非蛋白氨基酸，可抑制 HIF-prolyl hydroxylase-2 的活性。
TN3391	alpha-Spinasterol acetate	Others	Others
	alpha-Spinasterol has a significant therapeutic potential to modulate the development and/or progression of diabetic nephropathy.
T83562	(2R)-Flavanomarein
	(2R)-Flavanomarein为Coreopsis tinctoria Nutt的黄酮主要成分，具备糖尿病性肾病防护功能。该化合物展现出显著的抗氧化、降血糖、降血压及降低血脂的活性。
T80631	Esculin sesquihydrate	p38 MAPK	MAPK
	Esculin sesquihydrate为荧光香豆素葡萄糖苷类化合物，源自灰树皮有效成分。该化合物可经MAPK信号通路改善实验性糖尿病肾病(DN)的认知障碍，并具有抗氧化应激及抗炎效应。

天然产物

12-Ketodeoxycholic acid

Cat.No: T14002

Target: Endogenous Metabolite

Cat.No: TN1644

Target: Others

Cat.No: TN1471

Synonym: 决明子苷C,Toralactone 9-O-β-D-gentiobioside

Target: Others, Endogenous Metabolite

Cat.No: T6S1367

Synonym: 原花青素 B2,Proanthocyanidin B2

Target: Reactive Oxygen Species, NOD

Cat.No: TL0001

Synonym: L-Dencichin,ODAP,Dencichin,三七素

Target: Others, HIF/HIF Prolyl-Hydroxylase

alpha-Spinasterol acetate

Cat.No: TN3391

Target: Others

(2R)-Flavanomarein

Cat.No: T83562

Esculin sesquihydrate

Cat.No: T80631

Target: p38 MAPK

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