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Search Results for " multidrug-resistant "

64

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11888	LtaS-IN-1	Others; Antibacterial	Microbiology/Virology; Others
	LtaS-IN-1 是多药耐药粪肠球菌中脂磷壁酸合成的有效抑制剂，可改变细胞壁形态。 LtaS-IN-1 对抗肠球菌属 28 菌株，MIC 值从 0.5 μg/mL 到 64 μg/mL 不等。 LtaS-IN-1 抑制菌株 E1630 和 E1590，MIC 值为 0.5 μg/mL。
T4989	Fosfomycin Tromethamine	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin tromethamine 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T6685	Sulbactam sodium 舒巴坦钠,CP-45899-2	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam sodium (CP-45899-2) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂。它具有抗菌活性，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。
T3131	Fosfomycin calcium Phosphomycin calcium salt,Fosmicin,磷霉素钙	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin calcium (Phosphomycin calcium salt) 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药细菌。
T1631	Sulbactam CP45899,舒巴坦,舒巴坦酸	Antibacterial; Antibiotic	Microbiology/Virology
	Sulbactam (CP45899) 是一种竞争性、不可逆的 β-内酰胺酶抑制剂，抑制耐多药不动杆菌-鲍曼不动杆菌复合物。它具有抗菌活性。
T10460	Batabulin 巴他布林,T138067	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Batabulin (T138067) 是一种抗肿瘤剂，可与 β-微管蛋白同种型的子集共价且选择性地结合，从而破坏微管聚合。它影响细胞形态并导致细胞周期停滞，最终诱导细胞凋亡。
T22330	Fenamic acid N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid	Chloride channel	Membrane transporter/Ion channel
	Fenamic acid (N-Phenylanthranilic acid) 是氯通道阻滞剂。
T10378	Artelinic acid	Others	Others
	Artelinic acid, a derivative of Artemisinin, is an antimalarial drug for the treatment of multidrug-resistant strains of Plasmodium falciparum.
T9982	PU23	MRP	Immunology/Inflammation
	PU 23 是一种多药抗性蛋白4(MRP4)的抑制剂。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T9830	GSK2556286 GSK286	Antibacterial	Microbiology/Virology
	GSK2556286 (GSK286) 是一种具有口服活性的结核分枝杆菌 (M. tuberculosis) 抑制剂。GSK2556286 对人巨噬细胞 (macrophages) 生长具有抑制作用，IC50值为 0.07 μM。GSK2556286对多重耐药 (MDR) 或广泛耐药 (XDR) 和药物敏感 (DS) 结核分枝杆菌均有效。
T15409	GNF179	Parasite	Microbiology/Virology
	GNF179 是8,8-二甲基 IP 类似物。它表现出对多药耐药菌株 W2 的效力，具有良好的体外代谢稳定性和体内口服生物相容性。
T12343	Benzquinamide BZQ,P2647,Benzoquinamide	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Benzquinamide (P2647) 是一种具有抗癌活性的止吐剂, 抑制p糖蛋白介导的药物外排，增强多重耐药细胞中抗癌药物的细胞毒性。Benzquinamide 对 α2A, α2B, 以及α2C 肾上腺素能受体（α2-AR）的 Ki值分别为 1,365, 691 和 545 nM。
T35610	2,5-dimethyl Celecoxib	Apoptosis; Wnt/beta-catenin; Prostaglandin Receptor	Apoptosis; Cytoskeletal Signaling; GPCR/G Protein; Immunology/Inflammation; Stem Cells
	2,5-dimethyl Celecoxib 是塞来昔布衍生物和微粒体前列腺素 E 合酶 1 (mPGES-1) 的靶向抑制剂，mPGES-1 是炎症介质 PGE2 合成途径中的关键酶。
T33683	NITD-304 NITD304
	NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates.
T27712	KAR425 KAR-425,KAR 425
	KAR425 is a bipyrrole tambjamines. KAR425 has antimalarial activity against multidrug-resistant P. yoelii in mice.
T70546	HI-346
	HI-346 is a potent inhibitor of multidrug-resistant human immunodeficiency virus-1 (HIV-1).
T68404	Azidopine
	Azidopine is a photoactive dihydropyridine channel blocker which may also act as a multidrug resistant (MDR) modulator.
T14780	BRD9185	Dehydrogenase	Metabolism
	BRD9185 is an inhibitor of Dihydroorotate dehydrogenase (DHODH) with an EC50 of 16 nM against multidrug-resistant blood-stage parasites in vitro.
T26180	Sdz 280 446 Sdz 280,446,Sdz 280-446
	Sdz 280 446 is one of the most active cyclopeptolide of many resistance-modifying agents in restoring rhodamine-123 retention within multidrug-resistant P388 cells.
T26413	A 30312 A-30312,A30312
	A 30312 is a fused indole, which overcomes multidrug resistance in P388/Adr cells in vitro. It potentiates the cytotoxicity of the antitumor drugs Adriamycin, vincristine and vinblastine in multidrug-resistant cells with no effect on drug-sensitive parent P388 cells.
T12991	SPR206	Others	Others
	SPR206 is a polymyxin analogue and an important class of antibiotic for the treatment of bacterial infections due to multidrug resistant Gram-negative pathogen.
T71458	Epetraborole
	Epetraborole is a potent and selective leucyl-tRNA synthetase inhibitor. Epetraborole was in development for the treatment of infections caused by multidrug-resistant Gram-negative pathogens.
T39230	Contezolid acefosamil MRX-4,Contezolid acefosamil
	Contezolid acefosamil (MRX-4), an orally active prodrug, is metabolized into Contezolid (MRX-I), an oxazolidinone derivative with potent in vitro efficacy against multidrug-resistant Gram-positive bacteria, including MRSA.
T11445	GNF179 (Metabolite) GNF179 Metabolite	Others	Others
	GNF179 Metabolite, the derivative of GNF179—an optimized 8,8-dimethyl IP analog—demonstrates significant potency (4.8 nM against the multidrug-resistant W2 strain) alongside in vitro metabolic stability and in vivo oral bioavailability.
T76501	Defensin HNP 4
	Defensin HNP 4，一种由11个氨基酸组成的HNP-41-11的片段，对多药耐药及非耐药菌株均显示出抑制效果。
T68209	Kopsoffinol
	Kopsoffinol is a bisindole alkaloid that has been shown to have in vitro growth inhibitory activity against human PC-3, HCT-116, MCF-7, and A549 cells and moderate effects in reversing multidrug-resistance in vincristine-resistant human KB cells.
T69388	PD 0305970
	PD 0305970 is new bacterial gyrase and topoisomerase inhibitor that possess outstanding in vitro and in vivo activities against a wide spectrum of bacterial species including quinolone- and multidrug-resistant gram-positive and fastidious organism groups.
T80283	cOB1 phermone
	cOB1 pheromone是一种细菌性信息素，其对多重耐药粪肠球菌V583表现出有效抑制作用。
T62627	Antibacterial agent 69
	Antibacterial agent 69 是一种新型结构抗菌调节剂，并被用来对抗致命的耐多药细菌感染 (MICs: 2.978 μM)。
T78717	Topoisomerase inhibitor 2	Topoisomerase	DNA Damage/DNA Repair
	Topoisomerase inhibitor2(18C)为针对细菌拓扑异构酶的抑制剂，展现出对多重耐药革兰氏阴性菌的强效广谱活性。
TP2286	Quinupristin (mesylate) (120138-50-3 free base) Quinupristin (mesylate)	Others	Others
	Quinupristin is a streptogramin antibiotic. Streptogramins, a class of antibiotics, is effective in the treatment of vancomycin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus, which are two of the most rapidly growing strains of mul
T39296	DS86760016
	DS86760016 is a highly effective inhibitor of leucyl-tRNA synthetase (LeuRS), demonstrating potent activity against multidrug-resistant (MDR) Gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, and Pseudomonas aeruginosa. Notably, DS86760016 effectively inhibits LeuRS enzymes derived from Escherichia coli, Pseudomonas aeruginosa, and Acinetobacter baumannii, exhibiting IC50 values of 0.38 μM, 0.62 μM, and 0.16 μM, respectively.
T69305	Milataxel
	Milataxel is an orally bioavailable taxane with potential antineoplastic activity. Upon oral administration, milataxel and its major active metabolite M-10 bind to and stabilize tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, milataxel appears to be a poor substrate for the multidrug resistance (MDR) membrane-associated P-glycoprotein (P-gp) ...
T76244	Amp1EP9
	Amp1EP9为一抗菌肽，作为开发有效无毒抗菌活性分子的强大工具，具备针对多重耐药细菌感染进行研究的潜力。
T39983	SPR206 acetate
	SPR206 acetate is a polymyxin analog that exhibits antibiotic activity against Gram-negative pathogens, including multidrug-resistant (MDR) variants. By interacting with the outer membrane of the bacterium, SPR206 acetate effectively combats bacterial infections. Notably, SPR206 acetate demonstrates significant efficacy with minimum inhibitory concentration (MIC) values of 0.125 mg/L against Pseudomonas aeruginosa Pa14 and Acinetobacter baumannii NCTC13301.
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
T80535	AMPR-22
	AMPR-22 是一种具有抗菌作用的肽类化合物，能够与细菌膜结合并诱导透化作用，对 MDR 菌株引起的败血症小鼠模型表现出有效的对抗性。
T73095	PNU-101603
	PNU-101603 是Sutezolid 的亚砜代谢物。PNU-101603 单独使用或与SQ109 联用均展现了出色的抗分枝杆菌 (MTB) 活性，以及抗药敏和耐多药结核病活性。
T83758	SAAP 148 TFA Synthetic Antimicrobial and Antibiofilm Peptide 148
	SAAP 148是一种抗菌肽。在体外，它对多种耐多药的细菌有活性。在体内，SAAP 148（0.125-2% w/w）能减少小鼠A. baumannii或耐甲氧西林金黄色葡萄球菌（MRSA）感染模型中皮肤菌落形成单位（CFUs）的数量。
T78732	BO-1
	BO-1是一种苯甲酸酯类抗菌活性化合物。它能够抑制多重耐药金黄色葡萄球菌，同时与环丙沙星等抗生素显示协同效应。此外，BO-1可逆转该菌株的耐药性，并在小鼠体内降低IL-6及C反应蛋白的水平。
T61170	Antibacterial agent 96
	Antibacterial agent 96 (compound 4k) 是一种有效的抗菌剂。Antibacterial agent 96 对药物敏感和耐多药的结核分枝杆菌 (M.tuberculosis)显示出抗结核活性。Antibacterial agent 96 对 HepG2 和 Vero 细胞有毒性。
T72678	P-gp inhibitor 4
	P-gp inhibitor 4 是一种选择性的 P-glycoprotein 调节剂，EC50值为 94 nM。P-gp inhibitor 4 增加药物通过胃肠道屏障的能力，恢复 doxorubicin 在耐药癌细胞中的毒性。
T62786	HDAC1-IN-3
	HDAC1-IN-3 是一种 Pf HDAC1 的有效抑制剂。HDAC1-IN-3 在野生型和耐多药寄生虫菌株中均具有抗疟作用。HDAC1-IN-3 对寄生虫所有生命周期表现出明显的体内杀伤效果。
T69480	Sagopilone
	Sagopilone is a fully synthetic low-molecular-weight epothilone with potential antineoplastic activity. Sagopilone binds to tubulin and induces microtubule polymerization while stabilizing microtubules against depolymerization, which may result in the inhibition of cell division, the induction of G2/M arrest, and apoptosis. The agent is not a substrate for the P-glycoprotein (P-gp) efflux pump and so may exhibit activity in multidrug-resistant (MDR) tumors. The epothilone class of metabolites wa...
T73120	MptpB-IN-1
	MptpB-IN-1 是一种有效的、具有口服活性的 MptpB 抑制剂。结核分枝杆菌蛋白-酪氨酸-磷酸酶 B (MptpB) 是一种分泌的毒力因子，可破坏宿主的抗菌活性。MptpB-IN-1 可降低耐多药结核分枝杆菌的存活率和感染负担。
T67948	OY-101
	OY-101为口服生效的特异性P-glycoprotein(P-gp)抑制剂。该化合物可增强耐药性肿瘤的敏感性，并有效逆转多药耐药现象。相较于Tetrandrine，OY-101在水溶性、细胞毒性以及逆转活性方面均表现出改进。
T76219L	MDP1 acetate
	MDP1 acetate为一种基于蜂毒肽(melittin)的衍生肽，能够破坏革兰氏阳性及革兰氏阴性细菌的膜完整性，进而通过膜损伤机制杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌及铜绿假单胞菌等耐多药(MDR)与标准菌株表现出显著的抗菌活性。
T74591	Ceftaroline fosamil (hydrate)(acetate)
	Ceftaroline fosamil hydrate acetate 是一种高效的头孢菌素类抗生素(antibiotic)，对多种病原体有广谱活性，特别是针对革兰氏阳性病原体，如耐甲氧西林金黄色葡萄球菌(MRSA)和耐多药肺炎链球菌，以及常见的革兰氏阴性微生物。此外，Ceftaroline fosamil hydrate acetate 在治疗复杂皮肤及皮肤结构感染(cSSSIs)和社区获得性肺炎(CABP)方面表现出显著的抗感染活性。
T76219	MDP1
	MDP1是一种源自蜂毒肽(melittin)的衍生肽，具有破坏革兰氏阳性及阴性细菌膜完整性的能力，能够通过膜损伤方式杀灭细菌。该化合物对金黄色葡萄球菌、大肠杆菌以及铜绿假单胞菌的耐多药(MDR)和参考菌株显示出高度的抗菌活性。

化合物

Cat.No: T11888

Target: Others, Antibacterial

Fosfomycin Tromethamine

Cat.No: T4989

Target: Antibacterial, Antibiotic

Sulbactam sodium

Cat.No: T6685

Synonym: 舒巴坦钠,CP-45899-2

Target: Antibacterial, Antibiotic

Fosfomycin calcium

Cat.No: T3131

Synonym: Phosphomycin calcium salt,Fosmicin,磷霉素钙

Target: Antibacterial, Antibiotic

Cat.No: T1631

Synonym: CP45899,舒巴坦,舒巴坦酸

Target: Antibacterial, Antibiotic

Cat.No: T10460

Synonym: 巴他布林,T138067

Target: Apoptosis, Microtubule Associated

Cat.No: T22330

Synonym: N-苯基邻氨基苯甲酸,2-Anilinobenzoic acid,Diphenylamine-2-carboxylic acid,2-(Phenylamino)benzoic acid,N-Phenylanthranilic acid

Target: Chloride channel

Cat.No: T10378

Target: Others

Cat.No: T9982

Target: MRP

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Cat.No: T9830

Synonym: GSK286

Target: Antibacterial

Cat.No: T15409

Target: Parasite

Cat.No: T12343

Synonym: BZQ,P2647,Benzoquinamide

Target: Adrenergic Receptor

2,5-dimethyl Celecoxib

Cat.No: T35610

Target: Apoptosis, Wnt/beta-catenin, Prostaglandin Receptor

Cat.No: T33683

Synonym: NITD304

Cat.No: T27712

Synonym: KAR-425,KAR 425

Cat.No: T70546

Cat.No: T68404

Cat.No: T14780

Target: Dehydrogenase

Cat.No: T26180

Synonym: Sdz 280,446,Sdz 280-446

Cat.No: T26413

Synonym: A-30312,A30312

Cat.No: T12991

Target: Others

Cat.No: T71458

Contezolid acefosamil

Cat.No: T39230

Synonym: MRX-4,Contezolid acefosamil

GNF179 (Metabolite)

Cat.No: T11445

Synonym: GNF179 Metabolite

Target: Others

Cat.No: T76501

Cat.No: T68209

Cat.No: T69388

Cat.No: T80283

Antibacterial agent 69

Cat.No: T62627

Topoisomerase inhibitor 2

Cat.No: T78717

Target: Topoisomerase

Quinupristin (mesylate) (120138-50-3 free base)

Cat.No: TP2286

Synonym: Quinupristin (mesylate)

Target: Others

Cat.No: T39296

Cat.No: T69305

Cat.No: T76244

Cat.No: T39983

Cat.No: T70808

Cat.No: T80535

Cat.No: T73095

Cat.No: T83758

Synonym: Synthetic Antimicrobial and Antibiofilm Peptide 148

Cat.No: T78732

Antibacterial agent 96

Cat.No: T61170

P-gp inhibitor 4

Cat.No: T72678

Cat.No: T62786

Cat.No: T69480

Cat.No: T73120

Cat.No: T67948

Cat.No: T76219L

Ceftaroline fosamil (hydrate)(acetate)

Cat.No: T74591

Cat.No: T76219

Cat. No.	Product Name	Target	Signaling Pathways
T8262	Fosfomycin sodium Fosfomycin Disodium,磷霉素钠	Antibacterial; Antibiotic	Microbiology/Virology
	Fosfomycin sodium 是一种能透过血脑屏障的广谱抗生素，不可逆地抑制细胞壁合成的早期阶段。它对多种细菌具有杀菌活性，包括耐多药、广泛耐药和耐全药的细菌。
T1589	D-Cycloserine RO-1-9213,D-环丝氨酸	Others; Antibacterial; Antibiotic; iGluR	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	D-Cycloserine (RO-1-9213) 是一种抗生素，靶向细菌细胞壁肽聚糖生物合成酶。它是一种NMDA 部分激动剂，可以改善认知功能，可研究耐多药结核病。
T5757	Loganetin	Antibacterial	Microbiology/Virology
	Loganetin 是无毒的天然产物，来源于Cornus officinalis Sieb. et Zucc.，可用于耐多药革兰氏阴性菌感染的研究。
TN1342	8-Epidiosbulbin E acetate 8-表黄药子素E乙酸酯	Anti-infection; Antibacterial	Microbiology/Virology
	8-Epidiosbulbin E acetate 是从 Dioscorea bulbifera L.中发现的呋喃类化合物，对耐多药细菌具有广谱的质粒治疗活性。
T5A2455	Arenobufagin 沙蟾毒精,沙蟾毒经	Others	Others
	Arenobufagin 是一种蟾蜍甾烯，从蟾蜍毒液中提取得到，具有抗癌活性。
TN4221	Homoembelin 2,5-dihydroxy-3-nonyl-1,4-benzoquinone	Antibacterial	Microbiology/Virology
	Homoembelin (2,5-dihydroxy-3-nonyl-1,4-benzoquinone) 是来自 E. ribes 和 C. monocarpus 的色素，具有抗菌效果，可用于耐多药细菌感染的研究。
T2S0271	Voacamine 老刺木胺,Voacanginine	Cannabinoid Receptor; P-gp	GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Voacamine (Voacanginine) 是非洲马铃果中的一种吲哚生物碱，可抑制多药耐药肿瘤细胞中的 P-糖蛋白作用，具有强效的大麻素 CB1受体拮抗活性。
T2S1120	Ganoderenic acid B	P-gp	Membrane transporter/Ion channel; Neuroscience
	Ganoderenic acid B 是一种从Ganoderma lucidum 中提取的天然产物，可以通过抑制ABCB1的转运功能，增强化疗药物对ABCB1介导的耐多药癌细胞的细胞毒性来发挥作用。
T2S0410	Euphorbia factor L1 Euphorbiasteroid,大戟因子L1,大戟因子 L1	Apoptosis; P-gp	Apoptosis; Membrane transporter/Ion channel; Neuroscience
	Euphorbia factor L1 (Euphorbiasteroid) 可降低 Bcl-2，PI3K，AKT 和 mTOR 蛋白和 mRNA 水平，上调 caspase-9 and caspase-3 蛋白水平。它可诱导自噬，具有抗癌、抗脂肪生成、抗破骨细胞生成和多重耐药调节作用。
TN4962	Scholaricine	Others	Others
	Scholaricine reverses multidrug resistance in vincristine-resistant KB cells.
TN5114	Taxinine	P-gp	Membrane transporter/Ion channel; Neuroscience
	Taxinine and Taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells.
TN1522	Combretol	Antifection	Microbiology/Virology
	Combretol has leishmanicidal activity, it showed moderate activity (growth inhibition 87.3 and 73.0 %, respectively, at 50 μM) against a multidrug-resistant L. tropica line. Combretol also shows weakly active cytotoxic activity.
T12518	Polymyxin B1 硫酸多粘 B1	Others	Others
	Polymyxin B1 is a potent antimicrobial lipopeptide first derived from Bacilus polymyxa. Polymyxin B1 has the potential for multidrug-resistant Gram-negative bacterial infections treatment.
TN1165	(Rac)-Myrislignan 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟	Others	Others
	1-(3,4-Dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol shows anti-staphylococcal activity against a total of five multidrug-resistant (MDR) and methicillin-resistant Staphylococcus aureus strains and the minimum inhibitory concentrations (MIC
TN3077	5,5'-Dimethoxylariciresinol 4-O-glucoside 5,5'-二甲氧基落叶松脂素4-O-葡萄糖苷	Others	Others
	5,5'-Dimethoxylariciresinol-4'-O-beta-D-glucoside is shown to effectively enhance chemosensitivity of resistant cells, which makes it may be a suitable candidate for potential multidrug resistance (MDR)-reversing agents.
TN5113	Taxinine B	Others	Others
	Taxinine and taxinine B can inhibit the drug transport by P-glycoprotein in multidrug-resistant cells. Taxinine B shows stronger inhibitory effects than acetylsalicylic acid (ASA) on platelet aggregation induced by arachidonic acid (AA).
T79943	6-C-Methylquercetin-3,4'-dimethyl ether	Antibiotic	Microbiology/Virology
	6-C-Methylquercetin-3,4'-dimethyl etheris 是一种黄酮醇衍生物，提取自Bauhinia thonningii Schum叶。本化合物对多重耐药的革兰氏阴性细菌及耐甲氧西林金黄色葡萄球菌（MRSA）表现出抗菌活性。
T72735	Coleon-U-quinone
	Coleon-U-quinone 是一种有效的P-gp 抑制剂。Coleon-U-quinone 能抑制癌细胞活力，能提高多药耐药肿瘤细胞对Doxorubicin 的敏感性。
T36815	Chevalone C
	Chevalone C is a meroterpenoid fungal metabolite originally isolated from E. chevalieri. It is active against M. tuberculosis H37Ra (MIC = 6.3 μg/ml) and is cytotoxic to BC1 human breast cancer cells (IC50 = 8.7 μg/ml). Chevalone C inhibits the growth of multidrug-resistant isolates of E. coli, S. aureus, and E. faecium in a disc diffusion assay when used at a concentration of 15 μg/disc. It also induces cell death in HCT116 colorectal carcinoma cells.
T35754	Aszonapyrone A
	Aszonapyrone A is a meroditerpene fungal metabolite that has been found in Neosartorya and has diverse biological activities.1,2,3 It inhibits the growth of MCF-7, NCI H460, and A375-C5 cancer cells (GI50s = 13.6, 11.6, and 10.2 μM, respectively).1 Aszonapyrone A is active against multidrug-resistant isolates of S. aureus, E. faecalis, and E. faecium (MICs = 8, 16, and 16 μg/ml, respectively) and inhibits S. aureus biofilm formation.2 It is also active against P. falciparum in vitro (IC50 = 1.34...
TN5530	Volkensiflavone Talbotaflavone	Others	Others
	Volkensiflavone (Talbotaflavone) 是一种天然产物，存在于黄芪和藤黄中。它具有植物代谢物的作用,是一种次生代谢产物。Volkensiflavone 是一种双类黄酮，属于羟黄酮和羟黄酮。Volkensiflavone 可以作为佐剂用于过表达外排泵的多药耐药金黄色葡萄球菌的抗生素治疗。
TN3438	Arborinine	HCV Protease; Antifection	Microbiology/Virology; Proteases/Proteasome
	Arborinine shows mild in vitro antibacterial activity, it possesses moderate levels of anti-hepatitis C virus(HCV) activities with the IC50 values being 6.4 ± 0.7 ug/ml. Arborinine shows antifeedant activity against Spodoptera frugiperda. Arborinin shows
TN5153	Torilin	MMP; ERK; IκB/IKK; p38 MAPK; NF-κB; Tyrosinase; Reductase; DNA/RNA Synthesis; JNK	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Endocrinology/Hormones; MAPK; Metabolism; NF-κB; Proteases/Proteasome
	Torilin 是一种睾酮5α还原酶抑制剂，它（IC50=31.7+/-4.23μM）对5α还原酶的抑制作用强于α-亚麻酸（IC50=160.3+/-24.62μM），但弱于非那雄胺（IC50=0.38+/-0.06μM）。Torilin 具有免疫调节、肝脏保护和抗炎特性，它通过限制 TAK1介导的 MAP 激酶和 NF-βB 活化来抑制炎症，它可以减轻关节炎的严重程度，改变 dLN 或关节中的白细胞活化，并恢复血清和脾细胞细胞因子失衡。托利林抑制α-黑素细胞刺激激素激活的 B16黑色素瘤细胞中的黑色素生成，IC（50）值为25μM。Torilin 对枯草芽孢杆菌 ATCC 6633孢子和营养细胞表现出优异的抗菌活性。Torilin 在体内和体外都具有强大的抗血管生成活性，它可能通过抑制肿瘤侵袭来抑制肿瘤发生，逆转癌细胞的多药耐药性，它可以增强阿霉素、长春碱、紫杉醇和秋水仙碱对多药耐药 KB-V1和 MCF7/ADR 细胞的细胞毒性。
T38330	Collinin
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Fosfomycin sodium

Cat.No: T8262

Synonym: Fosfomycin Disodium,磷霉素钠

Target: Antibacterial, Antibiotic

Cat.No: T1589

Synonym: RO-1-9213,D-环丝氨酸

Target: Others, Antibacterial, Antibiotic, iGluR

Cat.No: T5757

Target: Antibacterial

8-Epidiosbulbin E acetate

Cat.No: TN1342

Synonym: 8-表黄药子素E乙酸酯

Target: Anti-infection, Antibacterial

Cat.No: T5A2455

Synonym: 沙蟾毒精,沙蟾毒经

Target: Others

Cat.No: TN4221

Synonym: 2,5-dihydroxy-3-nonyl-1,4-benzoquinone

Target: Antibacterial

Cat.No: T2S0271

Synonym: 老刺木胺,Voacanginine

Target: Cannabinoid Receptor, P-gp

Ganoderenic acid B

Cat.No: T2S1120

Target: P-gp

Euphorbia factor L1

Cat.No: T2S0410

Synonym: Euphorbiasteroid,大戟因子L1,大戟因子 L1

Target: Apoptosis, P-gp

Cat.No: TN4962

Target: Others

Cat.No: TN5114

Target: P-gp

Cat.No: TN1522

Target: Antifection

Cat.No: T12518

Synonym: 硫酸多粘 B1

Target: Others

(Rac)-Myrislignan

Cat.No: TN1165

Synonym: 1-(3,4-dimethoxyphenyl)-2-(4-allly-2,6-dimethoxyphenoxy)propan-1-ol,rac-myrislignan,ALPHA-[1-[2,6-二甲氧基-4-(2-丙烯-1-基)苯氧基]乙基]-4-羟

Target: Others

5,5'-Dimethoxylariciresinol 4-O-glucoside

Cat.No: TN3077

Synonym: 5,5'-二甲氧基落叶松脂素4-O-葡萄糖苷

Target: Others

Cat.No: TN5113

Target: Others

6-C-Methylquercetin-3,4'-dimethyl ether

Cat.No: T79943

Target: Antibiotic

Coleon-U-quinone

Cat.No: T72735

Cat.No: T36815

Cat.No: T35754

Volkensiflavone

Cat.No: TN5530

Synonym: Talbotaflavone

Target: Others

Cat.No: TN3438

Target: HCV Protease, Antifection

Cat.No: TN5153

Target: MMP, ERK, IκB/IKK, p38 MAPK, NF-κB, Tyrosinase, Reductase, DNA/RNA Synthesis, JNK

Cat.No: T38330

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