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Search Results for " metabolic disease "

40

抑制剂 & 化合物

6

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T9491	Pyraclostrobin	Antibacterial; Antifungal	Microbiology/Virology
	Pyraclostrobin 是一种球果苷杀菌剂，可诱导 3T3-L1 细胞内甘油三酯的积累，还可抑制真菌和哺乳动物细胞的线粒体复合物 III 。
T9609	GRK5-IN-2	GRK	GPCR/G Protein
	GRK5-IN-2 是基于吡啶的双环化合物，抑制 G 蛋白偶联受体激酶 5 。它调节胰岛素的表达和/或释放，在代谢疾病中有研究价值。
T2216	Entacapone OR-611,恩他卡朋	Transferase	Metabolism
	Entacapone (OR-611) 是可逆的、具有口服活性的、外周作用的儿茶酚-O-甲基转移酶抑制剂。它对大鼠脑、红细胞和肝脏 COMT 有抑制作用。它对 COMT 的选择性优于其他儿茶酚胺代谢酶。它抑制 FTO 去甲基化活性，可用于研究代谢紊乱。它可用于研究帕金森病。
T12931	SLC13A5-IN-1	Stearoyl-CoA Desaturase (SCD)	Metabolism
	SLC13A5-IN-1 是柠檬酸钠协同转运蛋白 (SLC13A5)选择性抑制剂，在 HepG2 细胞中阻断 14C-柠檬酸盐摄取的 IC50 : 0.022 μM。
T31611	Eldacimibe WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147	Acyltransferase	Metabolism
	Eldacimibe (WAY-ACA-147) 是一种ACAT2抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，研究动脉粥样硬化和高胆固醇血症。
T6112	Doxercalciferol TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2	Others	Others
	Doxercalciferol (TSA 840) 是一种维生素 D2 类似物，是一种维生素 D 受体激活剂，能够阻碍肾病的进程。
T13230	TXNIP-IN-1	Others	Others
	TXNIP-IN-1 是硫氧还蛋白-硫氧还蛋白相互作用蛋白复合物抑制剂。它在 TXNIP-TRX 复合物相关代谢紊乱的糖尿病、心血管疾病或炎症疾病方面有研究的价值。
T60150	(1S,2R)-Alicapistat	Cysteine Protease	Proteases/Proteasome
	(1S,2R)-Alicapistat ((1S,2R)-ABT-957) is a highly efficient, orally active compound that selectively inhibits human calpains 1 and 2, with promising implications for Alzheimer's disease (AD) therapy [1]. This compound effectively addresses the metabolic liability associated with carbonyl reduction, while demonstrating potent inhibition of calpain 1 with an IC50 value of 395 nM [2].
T31992	Granotapide	CETP	Metabolism
	Granotapide 是一种微粒体甘油三酯转移蛋白（MTP）抑制剂，治疗和而预防动脉硬化，冠状动脉疾病，代谢综合征，肥胖，糖尿病，糖尿病前期和高血压。
T63016	Nrf2 activator-4	Reactive Oxygen Species; Nrf2	Immunology/Inflammation; Metabolism; NF-κB
	Nrf2 activator-4 是一种具有口服活性的 Nrf2 激活剂（EC50: 0.63 μM），对小神经胶质细胞中活性氧的产生有抑制作用，用于治疗人类代谢功能障碍相关的脂肪肝病。
T27245L	Eflucimibe L0081,F-12511	Acyltransferase	Metabolism
	Eflucimibe (L0081) 是一种酰基辅酶A：胆固醇酰基转移酶抑制剂，可用于治疗心血管疾病和内分泌与代谢疾病，可用于研究动脉粥样硬化和高脂血症。
T111959	IFB-088 acetate
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T61743	PPARγ agonist 2
	PPARγ agonist 2 is a highly effective compound that acts as a partial agonist for PPARγ. It exhibits significant potential for utilization in metabolic disease research [1].
T83533	(R)-Monlunabant (R)-MRI-1891	Cannabinoid Receptor	GPCR/G Protein
	(R)-Monlunabant ((R)-MRI-1891)为CB1受体调节剂，应用于肥胖及代谢病研究领域。
T63818	Omesdafexor
	Omesdafexor 是 FXR 激动剂，能够用于研究肝病或代谢性炎症引起的疾病。
T35886	L-hydroxy Arginine (acetate)
	L-hydroxy Arginine is a substrate for nitric oxide synthase in the catabolism of L-arginine to form nitric oxide. It has been used as a biomarker for reduced nitric oxide formation in patients with cardiovascular disease and metabolic syndrome.
T79161	PROTAC PTPN2 degrader-2 TFA	Phosphatase	Metabolism
	PROTACPTPN2 degrader-2（例187B）TFA 作为PTPN2降解剂，展现出对癌症及代谢性疾病研究的潜在效用。
T19370	Impurity of Doxercalciferol	Others	Others
	Impurity of Doxercalciferol is an impurity of doxercalciferol, which is a synthetic analog of ergocalciferol. Impurity of Doxercalciferol used as a drug for secondary hyperparathyroidism and metabolic bone disease, and it suppresses parathyroid synthesis
T40059	Nicotinamide riboside tartrate
	Nicotinamide riboside tartrate (NRT) is an oral NAD+ precursor that raises NAD+ levels, activates SIRT1 and SIRT3, and serves as a vitamin B3 (niacin) source. NRT also improves oxidative metabolism and protects against metabolic abnormalities induced by a high-fat diet. Furthermore, NRT mitigates cognitive decline in a transgenic mouse model of Alzheimer's disease.
T78093	Cisd2 agonist 1	Others	Others
	Cisd2 agonist 1 (Compound 4q)为一种EC50值为34 nM的Cisd2激动剂，可增强Cisd2表达并改善非酒精性脂肪肝疾病（NAFLD）的病理改变，同时具备良好的代谢稳定性，适用于NAFLD研究。
T40060	Nicotinamide riboside malate
	Nicotinamide riboside malate is an orally active NAD+ precursor that elevates NAD+ levels and stimulates the activity of SIRT1 and SIRT3. Functioning as a vitamin B3 (niacin) source, it augments oxidative metabolism and provides protection against metabolic abnormalities induced by a high-fat diet. Additionally, Nicotinamide riboside malate mitigates cognitive decline in a genetically modified mouse model of Alzheimer's disease.
T17231	Vicagrel	Others	Others
	Vicagrel 是一种有效的、具有口服活性抗血小板化合物，通过不可逆地抑制 P2Y12 受体，降低代谢失活，增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。
T73434	BI-2081
	BI-2081是一种GPR40 (FFAR1)部分激动剂，具有EC50值为4 nM。该化合物能诱导葡萄糖依赖性胰岛素释放，并降低血浆中葡萄糖含量，适用于研究代谢疾病，尤其是2型糖尿病。
T74797	MAO-B-IN-20
	MAO-B-IN-20 (Compound C14) 是一种有效的 MAO-B 抑制剂，IC50为 0.037 μM。MAO-B-IN-20 表现出良好的代谢稳定性和脑血屏障渗透性。MAO-B-IN-20 可用于帕金森病的研究。
T75009	PPARγ/GR modulator 1
	PPARγ/GR modulator 1 是一种口服活性的 PPARγ和糖皮质激素受体 (GR) 的双动激动剂，Ki 值分别为 3.3 和 33.6 μM。PPARγ/GR modulator 1 可用于研究代谢疾病，例如糖尿病。
T75150	GIP/GLP-1 dual receptor agonist-1
	GIP/GLP-1 dual receptor agonist-1 (化合物 4) 是一种 GIP/GLP-1双受体激动剂。GIP/GLP-1 dual receptor agonist-1 可用于代谢紊乱和脂肪肝病，包括非酒精性脂肪性肝炎 (NASH)、非酒精性脂肪性肝病 (NAFLD) 的研究。
T79226	AMPK activator 11	Mitochondrial Metabolism	Metabolism
	AMPK activator11 是一种抗肿瘤活性纳米级化合物，有效针对多种CRC。通过激活AMPK及上调OXPHOS（mitochondrial metabolism），该化合物能选择性抑制RKO异种移植物生长，应用于肿瘤和代谢性疾病研究领域。
T79684	5-HT6R antagonist 1	5-HT Receptor	GPCR/G Protein; Neuroscience
	5-HT6R antagonist 1（Compound 8）是一款具有突出代谢稳定性的5-HT6R拮抗剂（Ki: 5 nM），能有效抑制血小板聚集，并可逆转由MK-801引起的大鼠记忆障碍。此化合物在阿尔茨海默病（AD）的研究中有潜在应用价值。
T73231	RR-RJW100
	RR-RJW100是RJW100的对映异构体之一，后者为核受体肝受体同源物1(LRH-1)和类固醇生成因子1(SF-1)的激动剂。相比于另一对映异构体SS-RJW100，RR-RJW100展现出更强的LRH-1激活能力。此化合物在调节代谢稳态方面具有潜力，因而在糖尿病、肝病以及炎症性肠病等疾病的研究中有所应用。
T79321	nSMase2-IN-1	Phospholipase	Metabolism
	nSMase2-IN-1是一款口服活性的nSMase2抑制剂，具有0.13 ± 0.06 μM的IC50。该化合物在肝脏微粒体内具有良好的代谢稳定性，口服给药后获得较高的脑血浆比值，适用于神经系统疾病研究。
T79716	c-ABL-IN-5	Bcr-Abl	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	c-ABL-IN-5是一种选择性c-Abl抑制剂，具有神经保护功能。该化合物显示出血脑屏障渗透性、代谢稳定性和优良的药物动力学特性。经[18F]标记的c-ABL-IN-5（化合物[18F]3）可用作PET示踪剂，以评估疾病改善的功效。此外，c-ABL-IN-5适用于帕金森病（PD）等神经退行性疾病的研究。
T37717	Galactosylcerebrosides (non-hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T37716	Galactosylcerebrosides (hydroxy)
	Galactosylcerebrosides are glycosphingolipids that contain a galactose attached to a ceramide acylated with a hydroxy or non-hydroxy fatty acid. They are metabolic precursors to sulfatides , found primarily in nerve tissues, and are the main glycosphingolipids in the central nervous system. Galactosylcerebrosides are involved in a multitude of cellular processes including cell agglutination, cellular signaling in glycosynapses, cellular development, and activation of T cells. They accumulate in ...
T62052	AMPK activator 6
	AMPK activator 6 (Compound GC) 可降低 HepG2 和 3T3-L1 细胞中的脂质含量并激活AMPK 通路。AMPK activator 6 对血清中甘油三酯 (TG)、总胆固醇 (TC)、低密度脂蛋白-C (LDL-C) 和其他生化指标的增加有显著的抑制作用。AMPK activator 6 在非酒精性脂肪肝（NAFLD）和代谢综合征中有研究价值。
T78649	MAO-B-IN-4	Monoamine Oxidase	Neuroscience
	MAO-B-IN-4（Compound 26）是一款口服活性MAO-B选择性可逆抑制剂，IC50为9 nM。它展现出优良的代谢稳定性和血脑屏障渗透能力，以及在安全性方面的良好特性。此外，MAO-B-IN-4在大鼠及小鼠中表现出显著的抗抑郁效果，并在星形胶质细胞中具有神经保护作用，适用于阿尔茨海默病相关的研究。
T38222	N-(α-Linolenoyl) Tyrosine
	Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precurs...
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...
T35816	ZLY032
	ZLY032 is a dual agonist of free fatty acid receptor 1 (FFAR1/GPR40; EC50= 68 nM in a FLIPR assay) and peroxisome proliferator-activated receptor δ (PPARδ; EC50= 102 nM in a reporter assay).1It is selective for FFAR1 and PPARδ over PPARα and PPARγ (EC50s = >10 μM for both). ZLY032 (40 mg/kg, twice per day) reduces blood glucose levels in an oral glucose tolerance test and decreases plasma total cholesterol and triglyceride levels in theob/obmouse model of metabolic disease.2It reduces hepatic st...
T37631	tetranor-12(S)-HETE
	12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran...
T36176	AMK (hydrochloride)
	AMK is an active metabolite of the neurohormone melatonin .1,2,3,4It is formed from melatoninviathe metabolic intermediate AFMK that is then deformylated by catalase or formamidase.5,6AMK scavenges singlet oxygenin vitrowhen used at a concentration of 200 μM.1It inhibits the epinephrine- and arachidonic acid-induced production of prostaglandin E2and PGD2in ovine seminal vesicle microsomes in a concentration- and time-dependent manner, as well as LPS-induced increases in COX-2 levels in RAW 264.7...

化合物

Cat.No: T9491

Target: Antibacterial, Antifungal

Cat.No: T9609

Target: GRK

Cat.No: T2216

Synonym: OR-611,恩他卡朋

Target: Transferase

Cat.No: T12931

Target: Stearoyl-CoA Desaturase (SCD)

Cat.No: T31611

Synonym: WAY-ACA-147,UNII-4PBL76O2G8,ANA 147,ACA 147

Target: Acyltransferase

Doxercalciferol

Cat.No: T6112

Synonym: TSA 840,度骨化醇,Hectorol,1.alpha.-Hydroxyvitamin D2,1α-hydroxyvitamin D2

Target: Others

Cat.No: T13230

Target: Others

(1S,2R)-Alicapistat

Cat.No: T60150

Target: Cysteine Protease

Cat.No: T31992

Target: CETP

Nrf2 activator-4

Cat.No: T63016

Target: Reactive Oxygen Species, Nrf2

Cat.No: T27245L

Synonym: L0081,F-12511

Target: Acyltransferase

IFB-088 acetate

Cat.No: T111959

PPARγ agonist 2

Cat.No: T61743

(R)-Monlunabant

Cat.No: T83533

Synonym: (R)-MRI-1891

Target: Cannabinoid Receptor

Cat.No: T63818

L-hydroxy Arginine (acetate)

Cat.No: T35886

PROTAC PTPN2 degrader-2 TFA

Cat.No: T79161

Target: Phosphatase

Impurity of Doxercalciferol

Cat.No: T19370

Target: Others

Nicotinamide riboside tartrate

Cat.No: T40059

Cisd2 agonist 1

Cat.No: T78093

Target: Others

Nicotinamide riboside malate

Cat.No: T40060

Cat.No: T17231

Target: Others

Cat.No: T73434

Cat.No: T74797

PPARγ/GR modulator 1

Cat.No: T75009

GIP/GLP-1 dual receptor agonist-1

Cat.No: T75150

AMPK activator 11

Cat.No: T79226

Target: Mitochondrial Metabolism

5-HT6R antagonist 1

Cat.No: T79684

Target: 5-HT Receptor

Cat.No: T73231

Cat.No: T79321

Target: Phospholipase

Cat.No: T79716

Target: Bcr-Abl

Galactosylcerebrosides (non-hydroxy)

Cat.No: T37717

Galactosylcerebrosides (hydroxy)

Cat.No: T37716

AMPK activator 6

Cat.No: T62052

Cat.No: T78649

Target: Monoamine Oxidase

N-(α-Linolenoyl) Tyrosine

Cat.No: T38222

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

Cat.No: T35816

tetranor-12(S)-HETE

Cat.No: T37631

AMK (hydrochloride)

Cat.No: T36176

Cat. No.	Product Name	Target	Signaling Pathways
T4733	Sucrose D(+)-Sucrose,D-(+)-Saccharose,蔗糖	Others; Endogenous Metabolite	Metabolism; Others
	Sucrose (D-(+)-Saccharose) 是一种二糖，由果糖和葡萄糖组成。Sucrose 能够应用于一些动物模型，包括代谢性疾病、偏食、肥胖、糖尿病等。
T5623	Bisphenol A	Others; Endogenous Metabolite	Metabolism; Others
	Bisphenol A 是酚类内源性代谢合成物，广泛用于环氧树脂和聚碳酸酯塑料的生产。它是生殖、发育和全身毒性物质，常被归类为内分泌干扰物。它与许多疾病有关，包括呼吸系统疾病、心血管疾病、糖尿病、肾脏疾病、肥胖和生殖障碍。
T5253	3-Methyladipic acid	Others; Endogenous Metabolite	Metabolism; Others
	3-Methyladipic acid 是 ω 氧化途径的终产物。它是植烷酸分解代谢的代谢物。
T0256	Citric acid trilithium salt tetrahydrate Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate	Dehydrogenase; GSK-3; HIF/HIF Prolyl-Hydroxylase; Antibacterial; GluR	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling; Stem Cells
	Citric acid trilithium salt tetrahydrate (Lithium citrate tribasic tetrahydrate) 是一种用于治疗精神疾病的药物。它也是一种医药和建筑材料, 可用于氨基酸定量分析时的梯度洗脱。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
TN4670	Norlichexanthone	Antibacterial; Parasite	Microbiology/Virology
	Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力，例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。它具有抗菌和抗疟活性，对枯草芽孢杆菌有很强的活性，IC50范围为1-5uM，对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用，IC50为20.95±1.56uM。

天然产物

Cat.No: T4733

Synonym: D(+)-Sucrose,D-(+)-Saccharose,蔗糖

Target: Others, Endogenous Metabolite

Cat.No: T5623

Target: Others, Endogenous Metabolite

3-Methyladipic acid

Cat.No: T5253

Target: Others, Endogenous Metabolite

Citric acid trilithium salt tetrahydrate

Cat.No: T0256

Synonym: Lithium citrate tribasic tetrahydrate,柠檬酸三锂盐四水合物,Trilithium citrate tetrahydrate

Target: Dehydrogenase, GSK-3, HIF/HIF Prolyl-Hydroxylase, Antibacterial, GluR

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Norlichexanthone

Cat.No: TN4670

Target: Antibacterial, Parasite

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