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N-(α-Linolenoyl) Tyrosine

N-(α-Linolenoyl) Tyrosine

产品编号 T38222   CAS 259143-19-6

Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.

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N-(α-Linolenoyl) Tyrosine Chemical Structure
N-(α-Linolenoyl) Tyrosine, CAS 259143-19-6
规格 价格/CNY 货期 数量
5 mg ¥ 1,240 35日内发货
10 mg ¥ 2,320 35日内发货
50 mg ¥ 9,690 35日内发货
100 mg ¥ 16,900 35日内发货
千万补贴 助力科研
BCA蛋白浓度测定试剂盒限时半价
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产品目录号及名称: N-(α-Linolenoyl) Tyrosine (T38222)
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产品描述 Certain chronic neurologic disorders, such as Parkinson's disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons. N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier. In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson's therapeutic agent.
分子量 441.6
分子式 C27H39NO4
CAS No. 259143-19-6

存储

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year

溶解度

DMF: 30 mg/mL

PBS (pH 7.2): 1 mg/mL

Ethanol: 30 mg/mL

DMSO: 30 mg/mL

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Keywords

N-(α-Linolenoyl) Tyrosine 259143-19-6 N (α Linolenoyl) Tyrosine N(αLinolenoyl) Tyrosine N-(a-Linolenoyl) Tyrosine N-(alpha-Linolenoyl) Tyrosine Inhibitor inhibitor inhibit

 

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