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Search Results for " isoquinoline "

20

抑制剂 & 化合物

19

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T11600	IBR2 Isoquinoline	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	IBR2（Isoquinoline）是一种针对RAD51的强效特异性抑制剂，通过干预RAD51多聚体形成，加速蛋白酶体介导的RAD51蛋白降解，抑制癌细胞生长并诱导凋亡。实验证明在抑制RAD51介导的DNA双链断裂修复方面有效。
T60109	Protein kinase inhibitor H-7 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine	PKC	Chromatin/Epigenetic; Cytoskeletal Signaling
	Protein kinase inhibitor H-7 (5-(2-methylpiperazine-1-sulfonyl)isoquinoline) 是有效的蛋白激酶 C (PKC) 和环核苷酸依赖性蛋白激酶抑制剂，抑制 PKC 的 Ki 值为 6 μM。
T8921	M-31850 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-	Others	Others
	M-31850 (1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-) 是一种竞争性的 β-己糖胺酶选择性抑制剂，能够抑制人HexA (IC50:6.0 µM) 及HexB (IC50:3.1 µM)。它还能够竞争性抑制 β-N-acetyl-D-hexosaminidaseOfHex2 (Ki:2.5 µM)。
T32227	Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide
	Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide is a bioactive chemical.
T60186	(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide	Discoidin Domain Receptor (DDR)	Tyrosine Kinase/Adaptors
	MitoBloCK-6 是一种有效的 Erv1/ALR 抑制剂，IC50 分别为 900 nM 和 700 nM。MitoBloCK-6 还抑制 Erv2 (IC50=1.4 μM)。MitoBloCK-6 可通过细胞色素 c 的释放诱导 hESCs 细胞凋亡。
T7042	1,5-Isoquinolinediol	PARP	Chromatin/Epigenetic; DNA Damage/DNA Repair
	1,5-Isoquinolinediol 是一种多聚（ADP-核糖）合成酶抑制剂，对PARP1的IC50值为 0.39 µM。它用于研究 PARP1 在 DNA 修复和氧化应激诱导的细胞死亡中的作用。
T64998	1-Hydroxyisoquinoline
	1-Hydroxyisoquinoline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64998，CAS号为 491-30-5。
T66594	2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid
	2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66594，CAS号为 851784-82-2。
T67325	6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride
	6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T67325，CAS号为 2048273-58-9。
T64999	5-Hydroxyisoquinoline
	5-Hydroxyisoquinoline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T64999，CAS号为 2439-04-5。
T66649	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline
	(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T66649，CAS号为 118864-75-8。
T8860	DSRM-3716	Androgen Receptor	Endocrinology/Hormones
	DSRM-3716 是选择性的SARM1 NADase 抑制剂，IC50为 75 nM，相较于其他 NAD+加工酶、受体和转运蛋白具有选择性。DSRM-3716显示出强大的轴突保护作用。
T30858	CH 102 Chinoin 102,CH-102,CH102,Chinoin-102
	CH 102 is an isoquinoline derivative that inhibits platelet aggregation.
T32590	Lauformine
	Lauformine is a isoquinoline alkaloid.
T32546	Lamellarin H Lamellarine H
	Lamellarin H is a benzo-isoquinoline-coumarin.
T68887	Octaverine hydrochloride
	Octaverine hydrochloride is an isoquinoline derivative that has shown inhibition of HIV (human immunodeficiency virus) reverse transcriptase.
T23918	Cularine
	Cularine is an isoquinoline alkaloid from the Fumariaceae family. It displays non-specific antispasmodic activity on guinea-pig and human airways.
T33282	Memotine HCl UK-237101,UK-2371,UK 237101,UK 2371,UK2371
	Memotine HCl has antiviral activity against respiratory tract infection and is used as a therapeutic agent for acute respiratory diseases. It is also a memo fracture in the form of hydrochloride, an isoquinoline, with anti-myxovirus and paramyxovirus acti
T35459	Glycyl H-1152 hydrochloride
	Two Rho-associated kinases (ROCK), ROCK-I and ROCK-II, act downstream of the G protein Rho to regulate cytoskeletal stability. The ROCKs play important roles in diverse cellular functions including cell adhesion and proliferation, smooth muscle contraction, and stem cell renewal. Glycyl-H-1152 is a selective and potent ROCK inhibitor (IC50 = 11.8 nM for ROCK-II). It is a glycylated isoquinoline compound derived from the therapeutically-important ROCK inhibitor HA-1077 (Fasudil) and exhibits bett...
T75238	YS-49 monohydrate
	YS-49 (单水合物) 作为PI3K/Akt（RhoA的下游靶点）的激活剂，有效降低3-甲基胆碱处理的细胞中RhoA/PTEN的活性。此外，YS-49通过促进血红素加氧酶（HO-1）的表达，抑制血管紧张素II（Ang II）诱导的血管平滑肌细胞（VSMC）增殖。作为一种异喹啉化合物生物碱，YS-49因激活心脏β-adrenoceptors而显示出显著的正性肌力效应。

化合物

Cat.No: T11600

Synonym: Isoquinoline

Target: DNA/RNA Synthesis

Protein kinase inhibitor H-7

Cat.No: T60109

Synonym: 5-(2-methylpiperazine-1-sulfonyl)isoquinoline,蛋白激酶抑制剂H-7,1-(5-Isoquinolinylsulfonyl)-2-methylpiperazine

Target: PKC

Cat.No: T8921

Synonym: 1H-Benz[de]isoquinoline-1,3(2H)-dione, 2,2'-(iminodi-2,1-ethanediyl)bis-

Target: Others

Isoquinoline, 5,5'-oxybis(decahydro-2-ethyl-, dihydrobromide

Cat.No: T32227

(S)-4-methyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-2-(pyrimidin-5-yl)-1,2,3,4-tetrahydroisoquinoline-7-carboxamide

Cat.No: T60186

Target: Discoidin Domain Receptor (DDR)

1,5-Isoquinolinediol

Cat.No: T7042

Target: PARP

1-Hydroxyisoquinoline

Cat.No: T64998

2-(tert-Butoxycarbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid

Cat.No: T66594

6,7-Dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline hydrochloride

Cat.No: T67325

5-Hydroxyisoquinoline

Cat.No: T64999

(S)-1-Phenyl-1,2,3,4-tetrahydroisoquinoline

Cat.No: T66649

Cat.No: T8860

Target: Androgen Receptor

Cat.No: T30858

Synonym: Chinoin 102,CH-102,CH102,Chinoin-102

Cat.No: T32590

Cat.No: T32546

Synonym: Lamellarine H

Octaverine hydrochloride

Cat.No: T68887

Cat.No: T23918

Cat.No: T33282

Synonym: UK-237101,UK-2371,UK 237101,UK 2371,UK2371

Glycyl H-1152 hydrochloride

Cat.No: T35459

YS-49 monohydrate

Cat.No: T75238

Cat. No.	Product Name	Target	Signaling Pathways
TN1584	Dihydropalmatine ZINC689644,2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline,二氢巴马汀	Others	Others
	Dihydropalmatine (2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline) 是一种来源于小檗根和茎皮的天然产物。
T8187	Tetrahydroepiberberine	Others; Influenza Virus; Antifungal	Microbiology/Virology; Others
	Tetrahydroepiberberine 是从Corydalis impatiens(Pall) 中分离得到的一种异喹啉生物碱，具有抗真菌和选择性抑制 PI-3 病毒活性的作用。
T5S1895	Norisoboldine Laurelliptine,去甲异波尔定,(+)-Laurelliptine	MAPK; Adenosine Receptor	GPCR/G Protein; MAPK; Neuroscience
	Norisoboldine ((+)-Laurelliptine) 是一种可口服的芳基烃受体激动剂，是乌药中主要的异喹啉类生物碱，可用于类风湿性关节炎和溃疡性结肠炎的研究。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T3933	Jatrorrhizine Yatrorizine,neprotin,药根碱	MAO; 5-HT Receptor; Antibacterial; AChE	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Jatrorrhizine (neprotin) 是一种从黄连中分离得到的生物碱，具有抗菌、抗氧化、抗疟原虫和神经保护活性。它通过抑制 uptake-2 transporter 的活性减少血清素和去甲肾上腺素的摄取。它是一种有口服活性的乙酰胆碱酯酶制剂。
T4912	Jatrorrhizine chloride 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride	Others; 5-HT Receptor; OCT; Antibacterial; AChE	GPCR/G Protein; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Others
	Jatrorrhizine chloride (Neprotine chloride) 是从黄连中分离得到的生物碱，具有神经保护、抗菌、抗氧化和抗疟原虫活性。它通过抑制摄取2转运蛋白的活性减少血清素和去甲肾上腺素的摄取。它是具有口服活性的乙酰胆碱酯酶抑制剂。
T2874	Tetrahydroberberine 四氢小檗碱,Tetrahydroberberine THB,Canadine	Dopamine Receptor; 5-HT Receptor	GPCR/G Protein; Neuroscience
	Tetrahydroberberine (Canadine) THB 是一种异喹啉类生物碱，从延胡索中分离得到，对 D2和5-HT1A 受体 uM 级亲和力。
T2718	Palmatine chloride	Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others
	Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，并改善 DSS 诱发的结肠炎。
T5S1099	Liensinine	Apoptosis; Mitophagy; Others; Autophagy	Apoptosis; Autophagy; Others
	Liensinine 是一种自噬/线粒体自噬抑制剂。Liensinine 是从芙蕖种子胚中提取的，一种主要的异喹啉生物碱，具抗心律不齐、抗高血压、抗肺纤维化、血管平滑肌松弛等广泛的生物活性。
T2917	Tetrahydropalmatine hydrochloride 延胡索乙素盐酸盐,1-Tetrahydropalmitine HCl,Gindarine hydrochloride,盐酸延胡乙素	Others; Dopamine Receptor	GPCR/G Protein; Neuroscience; Others
	Tetrahydropalmatine hydrochloride (Gindarine hydrochloride) 通过抑制大鼠杏仁核的多巴胺释放来抑制癫痫发作，可用于缓解疼痛的研究。
T5S2360	Corydaline Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline	P450; Virus Protease; Opioid Receptor; AChE	Endocrinology/Hormones; GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Corydaline (Corydalin) 是从 Corydalis yanhusuo 提取的一种异喹啉生物碱，是一种新型促动力植物药的主要活性成分之一。它促进胃排空和小肠转运，促进胃的调节，具有抗乙酰胆碱酯酶、抗过敏和镇痛活性。
T4S1102	Liensinine diperchlorate 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate	Mitophagy; Others; Autophagy	Autophagy; Others
	Liensinine Diperchlorate 是从芙蕖种子胚中提取的一种异喹啉生物碱。它通过阻断自噬小体-溶酶体融合来抑制晚期自噬，具有抗心律不齐、抗高血压、抗肺纤维化和血管平滑肌松弛等生物学活性。
T83234	8-Demethoxycephatonine
	8-Demethoxycephatonine是从Menispermaceae科植物Sinomenium acutum中分离出的一种异喹啉生物碱。
T83255	7(R)-7,8-Dihydrosinomenine
	7(R)-7,8-Dihydrosinomenine是从青藤中分离出的异喹啉生物碱，具备抗破骨细胞活性。
T83410	2,3,5,6-Tetramethoxyaporphine
	2,3,5,6-Tetramethoxyaporphine 是阿扑啡碱类化合物，具有止咳作用并具药用价值，可从黄角罂粟（Glaucium flavum Cr.，罂粟科）中提取。
T32329	Juzirine
	Juzirine is a member of the class of benzylisoquinolines. Benzylisoquinolines are organic compounds containing an isoquinoline to which a benzyl group is attached. Juzirine, practically insoluble (in water), is a very weakly acidic compound (based on its
T81159	Sibiricine
	Sibiricine（Compound 8），一种从Corydalis crispa药用植物提取的异喹啉类生物碱，对于LPS诱导的THP-1细胞产生的TNF-α显示出显著的抗炎效果。
T73640	Pancratistatin
	Pancratistatin 是一种异喹啉生物碱，可以从蜘蛛兰 Hymenocallis littoralis 中分离。Pancratistatin 诱导人黑素瘤细胞凋亡。Pancratistatin 可用于神经母细胞瘤、白血病、和乳腺癌的研究。
T75433	Norisoboldine hydrochloride
	Norisoboldine hydrochloride是一种口服活性天然芳基烃受体(AhR)激动剂，作为林参中的主要异喹啉类生物碱，适用于类风湿性关节炎和溃疡性结肠炎的研究。

天然产物

Dihydropalmatine

Cat.No: TN1584

Synonym: ZINC689644,2,3,9,10-tetramethoxy-6,8-dihydro-5H-isoquinolino[2,1-b]isoquinoline,二氢巴马汀

Target: Others

Tetrahydroepiberberine

Cat.No: T8187

Target: Others, Influenza Virus, Antifungal

Cat.No: T5S1895

Synonym: Laurelliptine,去甲异波尔定,(+)-Laurelliptine

Target: MAPK, Adenosine Receptor

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T3933

Synonym: Yatrorizine,neprotin,药根碱

Target: MAO, 5-HT Receptor, Antibacterial, AChE

Jatrorrhizine chloride

Cat.No: T4912

Synonym: 盐酸药根碱,Yatrorhizine chloride,Neprotine chloride

Target: Others, 5-HT Receptor, OCT, Antibacterial, AChE

Tetrahydroberberine

Cat.No: T2874

Synonym: 四氢小檗碱,Tetrahydroberberine THB,Canadine

Target: Dopamine Receptor, 5-HT Receptor

Palmatine chloride

Cat.No: T2718

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Cat.No: T5S1099

Target: Apoptosis, Mitophagy, Others, Autophagy

Tetrahydropalmatine hydrochloride

Cat.No: T2917

Synonym: 延胡索乙素盐酸盐,1-Tetrahydropalmitine HCl,Gindarine hydrochloride,盐酸延胡乙素

Target: Others, Dopamine Receptor

Cat.No: T5S2360

Synonym: Corydalin,紫堇碱,延胡索甲素,(+)-Corydaline

Target: P450, Virus Protease, Opioid Receptor, AChE

Liensinine diperchlorate

Cat.No: T4S1102

Synonym: 莲心碱高氯酸盐,莲心碱二高氯酸盐,Liensinine-Perchlorate

Target: Mitophagy, Others, Autophagy

8-Demethoxycephatonine

Cat.No: T83234

7(R)-7,8-Dihydrosinomenine

Cat.No: T83255

2,3,5,6-Tetramethoxyaporphine

Cat.No: T83410

Cat.No: T32329

Cat.No: T81159

Cat.No: T73640

Norisoboldine hydrochloride

Cat.No: T75433

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