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33

抑制剂 & 化合物

14

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T3934	Isavuconazonium sulfate	Antifungal	Microbiology/Virology
	Isavuconazonium sulfate 是一种口服活性抗真菌药，是活性三唑类抗真菌药物 Isavuconazole 的前药，可用于侵袭性曲霉菌病和毛霉菌病。
T9211	Mito-LND Mito-Loidamine	OXPHOS; Reactive Oxygen Species; Mitochondrial Metabolism; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Mito-LND (Mito-Loidamine) 是一种有口服活性和靶向线粒体的氧化磷酸化抑制剂。它抑制线粒体生物能，刺激活性氧的形成，并诱导肺癌细胞自噬细胞死亡。
T5519	Bivalirudin BG-8967,比伐卢定,Hirulog-1	Thrombin	Proteases/Proteasome
	Bivalirudin (BG-8967) 是一种直接凝血酶(thrombin)抑制剂，是一种肽类抗凝剂，可在侵入性心脏病，特别是在经皮冠状动脉介入中用于抗凝。
T14322	ARP-100 MMP-2 Inhibitor III	MMP	Proteases/Proteasome
	ARP-100 (MMP-2 Inhibitor III) 是选择性基质金属蛋白酶MMP-2抑制剂 (IC50=12 nM)。它对 MMP-1 (>50 μM)，MMP-3 (4.5 μM)，MMP-7 (>50 μM) 和MMP-9 (0.2 μM) 的抑制活性较小。它与 MMP-2 的 S1＇口袋相互作用，并在体外对基质胶的侵袭模型中显示抗侵袭特性。
T1898	RKI-1447 RKI1447	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	RKI-1447 是一种高效的ROCK1和ROCK2的小分子抑制剂，IC50值分别为14.5和6.2 nM。
T21483	Tricaine methanesulfonate 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222	Others	Others
	Tricaine methanesulfonate (MS-222) 常用于固定鱼的标记和运输，并能抑制入侵过程中的感觉系统。
T17239	VU0155069 CAY10593	Phospholipase	Metabolism
	VU0155069 在 transwell 试验中强烈抑制几种癌细胞系的侵袭性迁移。 VU0155069 是一种选择性磷脂酶 D1 抑制剂（体外 IC50：46 nM）。
T25384	Erbulozole R-55104,R55104,R 55104	Microtubule Associated	Cytoskeletal Signaling
	Erbulozole (R 55104) 是一种有效的合成微管抑制剂，具有抗侵袭、抗肿瘤和放射增敏活性，可诱发 Wernicke 脑病样神经毒性。
T64695	IR-808 MHI-148
	IR-808 (MHI-148) 是一种近红外菁染料，可用于无创癌症成像、诊断和成像引导光热治疗。
T9912	Trastuzumab	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Trastuzumab 是人源化单克隆抗体，以高亲和力与HER2选择性结合，可用于 HER2 阳性转移性乳腺癌和 HER2 阳性胃癌的研究。
TQ0223	Lusutrombopag 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta	Thrombin; Thrombopoietin Receptor	Immunology/Inflammation; Proteases/Proteasome
	Lusutrombopag (Mulpleta) 是一种口服生物可利用的小分子血小板生成素 (TPO) 受体激动剂，用于选择性侵入性手术前患有血小板减少症的慢性肝病的患者。
T60952	Fluridone EL-171	Others	Others
	Fluridone (EL-171) 是一种有效的合成脱落酸 (ABA) 的抑制剂，抑制 AchnFAR 和 TF 基因的表达，减少伯醇的形成。Fluridone 常作为水生除草剂用于控制入侵植物，也被用来控制水螅和欧亚水螅等物种。
T30040	Amphocil Amphotericin B cholesteryl sulfate
	Amphocil is used to treat patients with invasive fungal infection.
T40861	Nerindocianine
	Nerindocianine is a hydrophilic, fluorescent diagnostic contrast agent that is predominantly metabolized by the kidneys, enabling non-invasive, intraoperative ureteral imaging.
T68425	Saracatinib difumarate
	Saracatinib difumarate is an orally available dual-specific inhibitor of Src and Abl with anti-invasive and anti-tumor activities.
T25925	p-DDAP pDDAP,p-Dodecylaminophenol
	p-DDAP is an anti-invasive agent that acts by significantly suppressing cell invasion, and the activity and mRNA expression of matrix metalloproteinase-9 (MMP-9).
T11325	Frondoside A	Others	Others
	possesses anticancer, anti-invasive, anti-metastasis, anti-angiogenic and pro-apoptosis properties with high safety.Frondoside A, a natural glycoside extracted from the sea cucumber, Cucumaria frondosa,
T70703	DK-139
	DK-139 is an inhibitor of NF-kappaB-mediated GROalpha expression, suppressing the TNFalpha-induced invasive capability of MDA-MB-231 human breast cancer cells.
T69769	BDP8900
	BDP8900 is a potent and selective MRCK inhibitor, reducing substrate phosphorylation. BDP8900 leads to morphological changes in cancer cells along with inhibition of their motility and invasive character.
T71965	KRIBB3
	KRIBB3 is novel and potent microtubule inhibitor with potential anticancer activity. KRIBB3 has anti-migratory and anti-invasive activities in MDA-MB-231 cells. KRIBB3 inhibits tumor cell migration and invasion by blocking protein kinase C-dependent phosphorylation of Hsp27 through its direct binding to Hsp27.
T35368	N-butyl-N-(4-hydroxybutyl) nitrosamine 4-Hydroxybutylbutylnitrosamine,N-Nitrosobutylbutanolamine,OH-BBN,N-butyl-N-(4-hydroxybutyl) nitrosamine,BBN,N-Butyl-N-(4-hydroxybutyl)nitrosamine,4-(Butylnitrosamino)-1-butanol	Others	Others
	N-butyl-N-(4-hydroxybutyl) nitrosamine (N-Nitrosobutylbutanolamine) (BBN, OH-BBN) 是一种模型化合物，可诱导膀胱中的高级别侵袭性肿瘤。
T74959	Antifungal agent 41
	Antifungal agent 41 (compound B01) 是一种抗真菌剂。Antifungal agent 41 在体内外表现出对白假丝酵母菌的抗性。Antifungal agent 41 可以用于侵袭性真菌感染的研究。
TD0087L	Sulfo-Cy5.5 Trifluoroacetate	Others	Others
	Sulfo-Cy5.5 Trifluoroacetate 是一种氰基染料，非常适用于无创体内近红外成像，适用于需要低荧光背景的应用。
T11314	Fosmanogepix APX001,E1211	Others	Others
	Fosmanogepix (APX001) is a first-in-class, orally available broad-spectrum antifungal agent. It acts as an N-phosphonooxymethyl prodrug that undergoes rapid and complete metabolism by systemic alkaline phosphatases. This metabolism leads to the formation of the active moiety, APX001A. Fosmanogepix (APX001), with its ability to target the highly conserved Gwt1 fungal enzyme, holds great potential for the development of treatments against invasive fungal infections.
T79789	DT-6	TGF-beta/Smad	Stem Cells
	DT-6为一有效TGF-β1抑制剂，能够抑制M2巨噬细胞诱导的上皮至间质转化(Epithelial-Mesenchymal Transition, EMT)及癌细胞侵袭性迁移，可用于癌症相关疾病研究。
T74956	Chitin synthase inhibitor 10
	Chitin synthase inhibitor 10为一种高效的几丁质合酶(CHS)抑制剂，具有0.11 mM的IC50，表现出显著的CHS抑制活性。作为抗真菌剂，该化合物对包括C. albicans和C. neoformans在内的耐药真菌变体有效，适合用于侵袭性真菌感染(IFI)研究。
T80591	Efungumab
	Efungumab为一种单克隆抗体，对抗真菌(fungal)活性。该化合物通过与HSP90结合，抑制对真菌生存必需的构象变化。Efungumab主要用于侵袭性念珠菌感染(IC)的研究。
T72569	Cathepsin L/S-IN-1
	CathepsinL/S-IN-1 是 Cathepsin L 和 Cathepsin S 的双重抑制剂，IC50分别为 4.10 μM 和 1.79 μM。CathepsinL/S-IN-1 对胰腺癌 BxPC-3 和 PANC-1 细胞具有显著的抗转移和侵袭作用。
T69269	DMGF
	DMGF, also known as 7,7-dimethoxyagastisfavone, is a biflavonoid isolated from Taxus × media cv. Hicksii. DMGF induces apoptotic and autophagic cell death. DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). MGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization DMGF may be further developed to...
T63077	Chitin synthase inhibitor 12
	Chitin synthase inhibitor 12 是一种几丁质合酶 (CHS) 抑制剂，具有优异的 CHS 抑制作用 (IC50: 0.16 mM)。Chitin synthase inhibitor 12 也是一种广谱抗真菌剂，对耐药真菌变体（如 C. albicans、C. neoformans）具有抗性。Chitin synthase inhibitor 12 能够用于研究侵袭性真菌感染 (IFIs)。
T75363	Fluorescein Di-β-D-Glucuronide
	Fluorescein Di-β-D-Glucuronide 作为一款荧光探针，以其非侵入性的优势被广泛应用于裸鼠肠道细菌β-葡萄糖醛酸酶（βG）活性成像研究中。该探针通过成像技术有效揭示了肠道细菌β-葡萄糖醛酸酶在体内外的活性，进而为特定细菌β-葡萄糖醛酸酶抑制剂的药效学评估提供了重要工具。
T62090	(Rac)-Tanomastat
	Rac)-Tanomastat ((Rac)-BAY 12-9566) 是 Tanomastat 的外消旋体。其中 Tanomastat (BAY 12-9566) 是一种口服具有活力的、含锌羧基的非肽联苯基质金属蛋白酶(MMPs)抑制剂，能够抑制 MMP-2 (Ki: 11 nM)、MMP-3 (Ki: 143 nM)、MMP-9 (Ki: 301 nM)、MMP-13 (Ki: 1470 nM)。在几种实验性肿瘤模型中，Tanomastat 表现出抗侵袭和抗转移作用。
T30783	CDy9 CDy 9,CDy-9
	CDy9 is a highly selective fluorescent probe for the detection and isolation of mESC using fluorescence microscopy and flow cytometry. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities. CD

化合物

Isavuconazonium sulfate

Cat.No: T3934

Target: Antifungal

Cat.No: T9211

Synonym: Mito-Loidamine

Target: OXPHOS, Reactive Oxygen Species, Mitochondrial Metabolism, Autophagy

Cat.No: T5519

Synonym: BG-8967,比伐卢定,Hirulog-1

Target: Thrombin

Cat.No: T14322

Synonym: MMP-2 Inhibitor III

Target: MMP

Cat.No: T1898

Synonym: RKI1447

Target: ROCK

Tricaine methanesulfonate

Cat.No: T21483

Synonym: 3-氨基苯甲酸乙酯甲基磺酸盐,MS-222

Target: Others

Cat.No: T17239

Synonym: CAY10593

Target: Phospholipase

Cat.No: T25384

Synonym: R-55104,R55104,R 55104

Target: Microtubule Associated

Cat.No: T64695

Synonym: MHI-148

Cat.No: T9912

Target: EGFR

Cat.No: TQ0223

Synonym: 芦曲泊帕,鲁索曲波帕,S-888711,Mulpleta

Target: Thrombin, Thrombopoietin Receptor

Cat.No: T60952

Synonym: EL-171

Target: Others

Cat.No: T30040

Synonym: Amphotericin B cholesteryl sulfate

Cat.No: T40861

Saracatinib difumarate

Cat.No: T68425

Cat.No: T25925

Synonym: pDDAP,p-Dodecylaminophenol

Cat.No: T11325

Target: Others

Cat.No: T70703

Cat.No: T69769

Cat.No: T71965

N-butyl-N-(4-hydroxybutyl) nitrosamine

Cat.No: T35368

Synonym: 4-Hydroxybutylbutylnitrosamine,N-Nitrosobutylbutanolamine,OH-BBN,N-butyl-N-(4-hydroxybutyl) nitrosamine,BBN,N-Butyl-N-(4-hydroxybutyl)nitrosamine,4-(Butylnitrosamino)-1-butanol

Target: Others

Antifungal agent 41

Cat.No: T74959

Sulfo-Cy5.5 Trifluoroacetate

Cat.No: TD0087L

Target: Others

Cat.No: T11314

Synonym: APX001,E1211

Target: Others

Cat.No: T79789

Target: TGF-beta/Smad

Chitin synthase inhibitor 10

Cat.No: T74956

Cat.No: T80591

Cathepsin L/S-IN-1

Cat.No: T72569

Cat.No: T69269

Chitin synthase inhibitor 12

Cat.No: T63077

Fluorescein Di-β-D-Glucuronide

Cat.No: T75363

(Rac)-Tanomastat

Cat.No: T62090

Cat.No: T30783

Synonym: CDy 9,CDy-9

Cat. No.	Product Name	Target	Signaling Pathways
T5834	Myrcene	Others	Others
	Myrcene 是具有可挥发性的芳香族化合物，对 TNFα 诱导的 NF-κB 具有抑制作用，且具有抗侵袭的能力。
T13509	4-Vinylphenol	Apoptosis; Endogenous Metabolite	Apoptosis; Metabolism
	4-Vinylphenol 是酒中乳酸菌对香豆酸和阿魏酸的代谢产物，在白花蛇舌草中发现。 4-Vinylphenol 在体内诱导细胞凋亡。
T8193	α-Thujone Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮	Apoptosis; Reactive Oxygen Species; GABA Receptor; AChR; Parasite; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; NF-κB
	α-Thujone 是一种从西方金钟柏精油中分离出来的单萜，可穿透血脑屏障。它是 GABAA 受体的可逆调节剂，在抑制 GABA 诱导的电流时，它的 IC50为 21 μM。它诱导 ROS 依赖性细胞毒性，还诱导细胞凋亡和自噬。它具有抗伤害，抗肿瘤、杀虫和驱虫活性。
T5S0689	Demethylwedelolactone 去甲蟛蜞菊内酯,去甲基蟛蜞内酯	Serine Protease	Proteases/Proteasome
	Demethylwedelolactone 是一种分离自 Eclipta alba 中的 coumestan 天然产物。它能抑制乳腺癌细胞的移动和侵袭，是一种有效的trypsin 抑制剂(IC50:3.0 μM)。
T13741	Isoviolanthin 异佛莱心苷,异佛来心苷	Others	Others
	Isoviolanthin 是一种黄酮类苷类化合物，提取自铁皮石斛叶中。它能减少 TGF-β1 处理的 HCC 细胞的迁移和入侵能力，对正常细胞没有毒性影响，对转移性肝癌晚期具有潜在的研究价值。
T2787	Picroside I 6'-Cinnamoylcatalpol,胡黄连苦苷I	MMP; STAT	JAK/STAT signaling; Proteases/Proteasome; Stem Cells
	Picroside I (6'-Cinnamoylcatalpol) 是胡黄连的一种天然产物，是有肝脏保护作用的代谢成分，可用于哮喘研究，有减轻炎症作用，还下调 pSTAT6 和 GATA3 表达。
T5S0055	Chelidonine Helidonine,Khelidonin,白屈菜碱,Stylophorin	Apoptosis; Others; Influenza Virus	Apoptosis; Microbiology/Virology; Others
	Chelidonine (Stylophorin) 是白屈菜中的一种异喹啉生物碱，有抗肿瘤和抗病毒作用。它可导致细胞周期 G2/M 停滞，诱导 caspase 依赖和非依赖性的细胞凋亡。
T3S0737	Flavokawain A 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A	Apoptosis; p38 MAPK	Apoptosis; MAPK
	Flavokawain A (Flavokavain A) 是 kava 提取物中的查耳酮，是一种抗癌试剂，具有抗肿瘤活性。它通过 Bax 蛋白依赖和线粒体依赖的凋亡途径诱导细胞凋亡，有潜力用于膀胱癌的相关研究。
T4S1551	Cinnamaldehyde Cinnamic Aldehyde,肉桂醛	HIF	Angiogenesis; Chromatin/Epigenetic
	Cinnamaldehyde (Cinnamic Aldehyde) 具有解热作用。它是镇静剂。它抑制MDA-MB-435S 细胞的侵袭能力与下调miR-27a 的表达有关。它诱导活性氧的产生，发挥血管扩张和抗癌作用。它似乎是一种有希望的候选药物，可作为与 5-氟尿嘧啶 (5-FU) 和奥沙利铂 (OXA) 这两种用于 CRC 治疗的化疗药物联合治疗的辅助剂。其作用的可能机制可能涉及药物代谢基因的调节。它在抑制黑色素瘤的发生和发展方面具有一定的作用，其作用机制可能表现为抑制VEGF 和HIF-α的表达，从而使血管模拟和黑色素瘤细胞新生血管的形成，促进肿瘤的生长。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T12403	Penitrem A	Others	Others
	Penitrem A is a selective antagonist of BK channel with antiproliferative and anti-invasive activities against multiple malignancies.
TN1867	Licoricidin	MMP; VEGFR; ROS	Angiogenesis; Immunology/Inflammation; Proteases/Proteasome; Tyrosine Kinase/Adaptors
	Licoricidin, is a potent anti-metastatic agent, which can markedly inhibit the metastatic and invasive capacity of malignant prostate cancer cells.
TN1881	Lucidenic acid C 赤芝酸 C,赤芝酸C	MMP	Proteases/Proteasome
	Lucidenic acid C has anti-invasive effect, it shows significant inhibitory effects on PMA-induced MMP-9 activity and invasion of HepG(2 )cells.
T16035	Meleagrin	Others	Others
	Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities.

天然产物

Cat.No: T5834

Target: Others

Cat.No: T13509

Target: Apoptosis, Endogenous Metabolite

Cat.No: T8193

Synonym: Thujone,ALPHA-(-)-THUJONE,α-侧柏酮,(-)-α-侧柏酮

Target: Apoptosis, Reactive Oxygen Species, GABA Receptor, AChR, Parasite, Autophagy

Demethylwedelolactone

Cat.No: T5S0689

Synonym: 去甲蟛蜞菊内酯,去甲基蟛蜞内酯

Target: Serine Protease

Cat.No: T13741

Synonym: 异佛莱心苷,异佛来心苷

Target: Others

Cat.No: T2787

Synonym: 6'-Cinnamoylcatalpol,胡黄连苦苷I

Target: MMP, STAT

Cat.No: T5S0055

Synonym: Helidonine,Khelidonin,白屈菜碱,Stylophorin

Target: Apoptosis, Others, Influenza Virus

Cat.No: T3S0737

Synonym: 2'-羟基-4,4',6'-三甲氧基查耳酮,Flavokavain A

Target: Apoptosis, p38 MAPK

Cat.No: T4S1551

Synonym: Cinnamic Aldehyde,肉桂醛

Target: HIF

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Cat.No: T12403

Target: Others

Cat.No: TN1867

Target: MMP, VEGFR, ROS

Lucidenic acid C

Cat.No: TN1881

Synonym: 赤芝酸 C,赤芝酸C

Target: MMP

Cat.No: T16035

Target: Others

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