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抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T6055	Quisinostat 奎诺司他,JNJ-26481585	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat (JNJ-26481585) 是一种高效的，具有口服活性的 pan-HDAC 抑制剂，对 HDAC1、HDAC2、HDAC4、HDAC10、HDAC11 作用的 IC50值范围为 0.11-0.64 nM。它在成神经细胞瘤中能诱导自噬，具有广泛的抗肿瘤活性。
T12477	Uzansertib phosphate INCB053914 phosphate	Pim	Chromatin/Epigenetic; JAK/STAT signaling
	Uzansertib phosphate (INCB053914 phosphate) 是一种可口服的 ATP 竞争性泛-PIM 激酶抑制剂，对多种血液肿瘤细胞系具有广泛的抗增殖活性，对 PIM1、PIM2 和 PIM3 的 IC50分别为 0.24 、30 和 0.12 nM。
T6079	NVP-ADW742 ADW742,ADW,GSK 552602A	Apoptosis; IGF-1R	Apoptosis; Tyrosine Kinase/Adaptors
	NVP-ADW742 (ADW) 是一种具有口服活性，选择性的IGF-1R 酪氨酸激酶抑制剂，IC50为 0.17 μM。它抑制胰岛素受体，IC50为 2.8 μM，在肿瘤细胞中诱导多效性抗增殖/促凋亡。
T12574	PTC299 Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate	VEGFR; Dehydrogenase	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	PTC299 ((4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate) 是一种口服活性的 VEGFA mRNA 翻译抑制剂，可选择性地抑制转录后水平的 VEGF 蛋白合成。它还是二氢乳酸脱氢酶 (DHODH) 的有效抑制剂，可研究血液系统恶性肿瘤。
T6865	Quisinostat dihydrochloride Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl	Apoptosis; HDAC; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Quisinostat dihydrochloride (JNJ26854165(Quisinostat) 2HCl) 是一种有口服活性，高效的 pan-HDAC 抑制剂，具有广泛的抗肿瘤活性。它对 HDAC1、HDAC2、HDAC4、HDAC10和HDAC11 的IC50值分别为 0.11 nM、0.33 nM、0.64 nM、0.46 nM 和 0.37 nM。
T10436	AZD4573	CDK	Cell Cycle/Checkpoint
	AZD4573 是一种有效的选择性 CDK9 抑制剂，IC50值小于 4 nM，可以用于治疗血液系统恶性肿瘤的研究。
T1601	Lomustine CCNU,NSC 79037,洛莫司汀	Apoptosis; Others; DNA Alkylator/Crosslinker; DNA Alkylation; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Others
	Lomustine (NSC-79037) 是一种具有抗肿瘤活性的 DNA 烷化剂。
T17028	Tefinostat CHR-2845	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Tefinostat (CHR-2845) 是一种有效的单核细胞/巨噬细胞靶向组蛋白脱乙酰酶 (HDAC) 抑制剂。 Tefinostat 可被胞内酯酶人羧酸酯酶-1 (hCE-1) 裂解成活性酸 CHR-2847。Tefinostat 具有抗肿瘤活性，可用于研究白血病和晚期血液系统恶性肿瘤。
T77385	Idactamab INT-001
	Idactamab (INT-001) 是一种人氨基酸转运蛋白 ASCT2 的单克隆抗体。
T20798	Fluindione LM123,LM 123,LM-123
	Fluindione is a hematologic drug.
T25364	Efegatran LY 294468,LY294468,LY-294468
	Efegatran is a hematologic agent and platelet aggregation inhibitor.
T11544	HDACs/mTOR Inhibitor 1	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1.2 nM, and >500 nM for HDAC1, HDAC6, mTOR and PI3Kα).
T27558	HT1042 HT 1042,HT-1042
	HT1042 is an inhibitor of the β5i component of the 20S proteasome complex, it is used to aid in the treatment of inflammatory diseases, autoimmune and hematologic malignancies.
T39090	Uzansertib INCB053914
	Uzansertib (INCB053914) is a potent ATP-competitive pan-PIM kinase inhibitor. It exhibits exceptional inhibitory activity against PIM1, PIM2, and PIM3 with IC50 values of 0.24 nM, 30 nM, and 0.12 nM, respectively. Furthermore, Uzansertib demonstrates significant anti-proliferative effects against an assorted range of hematologic tumor cell lines.
T81461	Pidilizumab CT-011,MDV9300	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	Pidilizumab (CT-011) 是一种人源化 IgG1k 抗PD-1单克隆抗体，作为DLL1 拮抗剂，展现了对血液恶性肿瘤研究的应用潜力。
T38778	DB2115 tertahydrochloride DB2115 tertahydrochloride
	DB2115 (tertahydrochloride) is a powerful inhibitor of the myeloid master regulator PU.1. With significant potential in cancer research, particularly hematologic cancers like leukemia, as well as other conditions linked to PU.1 dysfunction, DB2115 (tertahydrochloride) offers promising avenues of study.
T63497	PI3Kδ/γ-IN-1
	PI3Kδ/γ-IN-1 是选择性的 PI3Kδ/γ 有效抑制剂，能够用于血液系统恶性肿瘤的治疗。
T38857	SBP-0636457 SBI-0636457,SB1-0636457,SBP-0636457
	SBP-0636457 (SB1-0636457) is a SMAC mimetic and an inhibitor of inhibitor of apoptosis (IAP) proteins. It specifically binds to the BIR-domains of IAP proteins with a Ki value of 0.27 μM. SBP-0636457 holds potential for research in the fields of solid tumors and hematologic cancers.
T60706	LP-284
	LP-284 可杀死实体瘤。LP-284 是一种有效的 DNA 烷化剂，可用于 DNA 修复受损的血液癌症研究，例如，套细胞淋巴瘤 (MCL) 。
T76732	CC-90002
	CC-90002 是一种人源化抗 CD47 单克隆抗体 (mAb)。CC-90002 与 CD47 具有高亲和力，具有亚纳摩尔 Kd 值。CC-90002 可用于血液系统恶性肿瘤和实体瘤的研究。
T70802	Duvelisib hydrate
	Duvelisib, also known as IPI-145 and INK-1197, is an orally bioavailable, highly selective and potent small molecule inhibitor of the delta and gamma isoforms of phosphoinositide-3 kinase (PI3K) with potential immunomodulating and antineoplastic activities. Upon administration, PI3K delta/gamma inhibitor IPI 145 prevents the activation of the PI3K delta/gamma-mediated signaling pathways which may lead to a reduction in cellular proliferation in PI3K delta/gamma-expressing tumor cells. Unlike oth...
T61524	Tubulin/HDAC-IN-1
	Tubulin/HDAC-IN-1 is a compound that functions as a dual inhibitor for tubulin and HDAC-IN-1. It achieves this by interacting with tubulin through CH/π interaction and with HDAC8 through hydrogen bond interaction. This compound effectively inhibits tubulin polymerization and selectively targets HDAC8 with an IC50 of 150 nM. Additionally, Tubulin/HDAC-IN-1 demonstrates cytotoxicity against various human cancer cells, induces cell cycle arrest in the G2/M phase, and triggers cell apoptosis. This c...
T82994	Anzurstobart BMS-986351,CC-95251
	Anzurstobart (CC-95251; BMS-986351) 是具有高亲和力的SIRPα全人源单克隆抗体，能够阻断CD47与SIRPα的结合。联合应用抗体利妥昔单抗时，Anzurstobart能增强巨噬细胞在共培养模型中对DLBCL细胞系的吞噬作用，显示出在实体和血液恶性肿瘤研究中的应用潜力。
T77115	Plamotamab
	Plamotamab (XmAb-13676) 是一种人源双特异性抗体(bsAb)，目标是CD3和CD20，通过招募细胞毒性T细胞以消灭CD20+表达的肿瘤细胞。在体内，Plamotamab诱导了轻微的血液学反应(MR)并有效促进肿瘤消退。
T79171	Bcl-2-IN-11
	Bcl-2-IN-11（compound 6）是高效选择性的Bcl-2抑制剂，具有0.9 nM的IC50。相对于Bcl-xl，其抑制作用较弱（IC50 > 1000 nM）。该化合物主要用于研究因Bcl-2家族蛋白过量表达引起的多种癌症，尤其适用于急性淋巴性白血病等恶性血液疾病。同时，Bcl-2-IN-11可以减少由Bcl-xl抑制相关的副作用，例如减少血小板。
T37419	Zetomipzomib
	KZR-616, a first-in-class inhibitor of the immunoproteasome, selectively targets the LMP7 (IC50: 39/57 nM=hLMP7/mLMP7) and LMP2 (IC50: 131/179 nM=hLMP7/mLMP7) subunits of the immunoproteasome. KZR-616 has the potential for the research of multiple autoimmune diseases[1][2]. KZR-616 also inhibits MECL-1 subunit (IC50=623 nM) and constitutive proteasome β5 subunit (IC50=688 nM). KZR-616 maintains LMP7 and LMP2 selective inhibition in MOLT-4 cells. KZR-616 (250 nM) shows a comparable cytokine inhib...

化合物

Cat.No: T6055

Synonym: 奎诺司他,JNJ-26481585

Target: Apoptosis, HDAC, Autophagy

Uzansertib phosphate

Cat.No: T12477

Synonym: INCB053914 phosphate

Target: Pim

Cat.No: T6079

Synonym: ADW742,ADW,GSK 552602A

Target: Apoptosis, IGF-1R

Cat.No: T12574

Synonym: Emvododstat,(4-chlorophenyl) (1S)-6-chloro-1-(4-methoxyphenyl)-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylate

Target: VEGFR, Dehydrogenase

Quisinostat dihydrochloride

Cat.No: T6865

Synonym: Quisinostat 2HCl,Quisinostat (JNJ-26481585) 2HCl,JNJ26854165(Quisinostat) 2HCl,JNJ-26481585 2HCl

Target: Apoptosis, HDAC, Autophagy

Cat.No: T10436

Target: CDK

Cat.No: T1601

Synonym: CCNU,NSC 79037,洛莫司汀

Target: Apoptosis, Others, DNA Alkylator/Crosslinker, DNA Alkylation, Autophagy

Cat.No: T17028

Synonym: CHR-2845

Target: HDAC

Cat.No: T77385

Synonym: INT-001

Cat.No: T20798

Synonym: LM123,LM 123,LM-123

Cat.No: T25364

Synonym: LY 294468,LY294468,LY-294468

HDACs/mTOR Inhibitor 1

Cat.No: T11544

Target: HDAC

Cat.No: T27558

Synonym: HT 1042,HT-1042

Cat.No: T39090

Synonym: INCB053914

Cat.No: T81461

Synonym: CT-011,MDV9300

Target: PD-1/PD-L1

DB2115 tertahydrochloride

Cat.No: T38778

Synonym: DB2115 tertahydrochloride

Cat.No: T63497

Cat.No: T38857

Synonym: SBI-0636457,SB1-0636457,SBP-0636457

Cat.No: T60706

Cat.No: T76732

Duvelisib hydrate

Cat.No: T70802

Tubulin/HDAC-IN-1

Cat.No: T61524

Cat.No: T82994

Synonym: BMS-986351,CC-95251

Cat.No: T77115

Cat.No: T79171

Cat.No: T37419

Cat. No.	Product Name	Target	Signaling Pathways
T3S0209	Vincristine	ERK; p38 MAPK; NF-κB; Akt; JNK; mTOR	Cytoskeletal Signaling; MAPK; NF-κB; PI3K/Akt/mTOR signaling
	Vincristine 与微管蛋白结合并抑制微管的形成，从而抑制癌细胞的有丝分裂。 Vincristine 可用作微管去稳定剂，用于研究治疗血液系统癌症，如白血病和淋巴瘤以及儿童肉瘤的相关研究。

天然产物

Cat.No: T3S0209

Target: ERK, p38 MAPK, NF-κB, Akt, JNK, mTOR

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