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Search Results for " cytotoxin "

68

抑制剂 & 化合物

15

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T14349	Auristatin F	Microtubule Associated	Cytoskeletal Signaling
	Auristatin F 是一种有效的微管抑制剂和血管损伤剂。 Auristatin F 可用于抗体-药物偶联物。
T14348	Auristatin E	Microtubule Associated	Cytoskeletal Signaling
	Auristatin E 通过阻断微管蛋白的聚合来抑制细胞分裂。它是一种细胞毒性微管蛋白修饰剂，具有强效和选择性抗肿瘤活性。它是一种 MMAE 类似物，是抗体-药物偶联物中的细胞毒素。
T38889	Thailanstatin A
	Thailanstatin A 是真核 RNA 剪接抑制剂，IC50为650 nM，通过非共价结合到剪接体的 U2 snRNA 亚复合物的 SF3b 亚单位发挥作用。Thailanstatin A 对多种癌细胞系的抑制显示 nM 级别的 IC50。它与 Trastuzumab 上的赖氨酸结合，可产生“无连接子” ADC。
T15141	DM4 Ravtansine,美登素 DM4	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	DM4 (Ravtansine)可用于制备抗体药物偶联物，是抗微管蛋白剂。它抑制细胞分裂。
T11120	Duocarmycin TM	DNA Alkylation; Antibiotic	DNA Damage/DNA Repair; Microbiology/Virology
	Duocarmycin TM 是一种有抗肿瘤活性的抗生素，也是一种 DNA 烷化剂。
T16557	PNU-159682	Topoisomerase	DNA Damage/DNA Repair
	PNU-159682 是蒽环类新霉素的代谢产物，是一种 DNA 拓扑异构酶 II 抑制剂，具有出色的细胞毒性。
T3256	MMAF 一甲基澳瑞他汀 F,MonoMethyl auristatin F	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	MMAF (MonoMethyl auristatin F) 是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂，用作抗肿瘤药物和抗体偶联药物的细胞毒性成分。
T8003	Methotrexate disodium	Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Methotrexate disodium 是一种叶酸类似物代谢抑制剂，具有免疫抑制剂和抗肿瘤特性，用于类风湿关节炎和研究多种癌症。
T12081	MMAF-OMe Monomethyl auristatin F methyl ester
	MMAF-OMe (Monomethyl auristatin F methyl ester) 是一种抗微管蛋白剂，能够抑制 MDAMB435/5T4，MDAMB361DYT2，MDAMB468 和 Raji (5T4-) 这四种肿瘤细胞，IC50值分别为 0.056 nM，0.166 nM，0.183 nM 和 0.449 nM。它也是ADC 细胞毒素。
T14858	Calicheamicin Calicheamicin γ1,卡奇霉素	Others	Others
	Calicheamicin (Calicheamicin γ1) 是肿瘤抗生素，可引起DNA 双链断裂，抑制DNA 合成。
T11249L	Dxd Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase	DNA Damage/DNA Repair
	Dxd (OQM5SD32BQ) 是一种有效的DNA 拓扑异构酶 I 抑制剂，IC50值为 0.31 μM，用作HER2靶向ADC 的偶联药物。
T21408	DM1-SMe DM1-SSMe	Microtubule Associated	Cytoskeletal Signaling
	DM1-SMe (DM1-SSMe) 是美登木素微管的有效抑制剂。 DM1-SMe 的效力是母体药物美登素的 3 至 10 倍，在一组人类肿瘤细胞系中，DM1-SMe 的 IC50 为 0.003 至 0.01 nM。
T6897	Monomethyl auristatin E 一甲基澳瑞他汀E,Vedotin,MMAE	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Monomethyl auristatin E (MMAE) 是海兔毒素 10 的合成衍生物，是一种抗有丝分裂剂，通过阻断微管蛋白的聚合来抑制细胞分裂，并且还具有抑制抗体-药物偶联物的活性。
T1910	Ansamitocin P 3' Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'	Microtubule Associated	Cytoskeletal Signaling
	Ansamitocin P 3' (Maytansinol butyrate) 是一种具有抗肿瘤活性的抗体-药物偶联细胞毒素。
T4677	MMAD Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10	Microtubule Associated	Cytoskeletal Signaling
	MMAD (Demethyldolastatin 10) 是一种有效的微管蛋白抑制剂，是抗体药物偶联物中的一种毒素有效载荷。
T1992	Mertansine DM1,Maytansinoid DM1	Microtubule Associated	Cytoskeletal Signaling
	Mertansine (DM1) 是一种微管蛋白抑制剂，也是一种抗体可缀合的美登木素生物碱。它通过连接体连接到单克隆抗体上，形成抗体偶联药物。
T1485	Methotrexate NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377	Apoptosis; Dehydrogenase; DNA/RNA Synthesis; Antifolate	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Methotrexate (WR19039) 是一种叶酸类似物，一种二氢叶酸还原酶 DHFR 的抑制剂。Methotrexate 具有抗代谢、抗肿瘤和免疫抑制等活性，常用于类风湿关节炎和多种肿瘤的研究。
T10459	Banoxantrone dihydrochloride AQ4N dihydrochloride,AZD1689 2HCl	NOS	Immunology/Inflammation
	Banoxantrone dihydrochloride (AQ4N dihydrochloride) 是一种新型缺氧细胞毒素，通过 iNOS 依赖机制选择性地杀死缺氧细胞。
T41248	Thiocolchicine	Microtubule Associated	Cytoskeletal Signaling
	Thiocolchicine 是一种有效的微管蛋白聚合抑制剂，IC50 为 2.5 µM，Ki 为 0.7 µM。 Thiocolchicine 诱导细胞凋亡。 Thiocolchicine 可用作 ADC 技术中的 ADC 细胞毒素。
T3615	Evofosfamide 艾伏磷酰胺,TH-302	Apoptosis; Others	Apoptosis; Others
	Evofosfamide (TH-302) 是一种缺氧激活前药，在缺氧 (N2) 和常氧 (21% O2) 环境下，IC50分别为 10 μM 和 1000 μM。
T10972	DC4	Others	Others
	DC4 can be used to synthesize antibody-drug conjugate (ADC), which is an ADC cytotoxin. DC4 can be used for targeted therapy of tumors.
T77889	NH2-methylpropanamide-Exatecan TFA	Topoisomerase	DNA Damage/DNA Repair
	NH2-methylpropanamide-Exatecan (TFA) 为对异丁酰胺进行修饰的Exatecan，属于ADC毒素（ADC Cytotoxin），应用于ADC合成中。该化合物作为DNA拓扑异构酶I（topoisomerase I）抑制剂，具有2.2 μM（0.975 μg/mL）的IC50，适用于癌症研究。
T33700	NLP 1 NLP-1,NLP1,2-Nlp-3
	NLP 1 is a DNA intercalating hypoxic cell radiosensitizer and cytotoxin.
T30104	Apratoxin A
	Apratoxin A is a potent cytotoxin isolated from the marine cyanobacterium Lyngbya majuscula Harvey ex Gomont.
T19300	Duocarmycin Analog	DNA Alkylation	DNA Damage/DNA Repair
	Duocarmycin Analog is used as an DNA alkylator and ADC cytotoxin. Duocarmycin Analog is an analog of Duocarmycin.
T30105	Apratoxin B
	Apratoxin B is a potent cytotoxin.
T32136	ICT2700 de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700
	ICT2700 is a potent cytotoxin selectively by CYP1A1 as a tumor-selective treatment for human bladder cancers.
T18292	Mal-PEG4-VC-PAB-DMEA-PNU-159682	Others	Others
	Mal-PEG4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate designed for antibody-drug conjugate (ADC) therapy. It combines the ADC linker, Mal-PEG4-VC-PAB, with the potent ADC cytotoxin, DMEA-PNU-159682. The cytotoxin, DMEA-PNU-159682, is derived from metabolites of nemorubicin (MMDX) found in liver microsomes, as well as the ADC cytotoxin PNU-159682[1].
T17802	DBCO-PEG4-VC-PAB-DMEA-PNU-159682	Others	Others
	DBCO-PEG4-VC-PAB-DMEA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), comprises the ADC linker DBCO-PEG4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. The cytotoxin includes metabolites of nemorubicin (MMDX) from liver microsomes and the ADC cytotoxin PNU-159682[1].
T39582	2',3'-cGAMP-C2-SH 2',3'-cGAMP-C2-SH
	2', 3'-cGAMP-C2-SH is a ADC cytotoxin.
T12813L	Seco-Duocarmycin SA	DNA Alkylation	DNA Damage/DNA Repair
	Seco-Duocarmycin SA is a highly potent DNA alkylator used as an ADC cytotoxin.
T30106	Apratoxin C
	Apratoxin C is a cyanobacterial cyclodepsipeptide as a potent cytotoxin.
T13658	DMEA-PNU-159682	Others	Others
	DMEA-PNU-159682 (molecule D12) is an ADC cytotoxin molecule, including neomycin (MMDX) metabolites from liver microsomes and effective ADC cytotoxin PNU-159682.
T40191	17-GMB-APA-GA
	17-GMB-APA-GA, a potent HSP90 inhibitor, is an ADC cytotoxin commonly employed for studying latent T. gondii infection.
T12813	(S)-Seco-Duocarmycin SA	Others	Others
	(S)-Seco-Duocarmycin SA is a DNA alkylator, acts as a ADC cytotoxin for antibody-drug conjugates.
T10640	C-11	Others	Others
	C-11 is a tubulin inhibitor and acts as an ADC cytotoxin with cytotoxicity for carcinoma cell lines.
T38430	Tubulysin IM-2
	Tubulysin IM-2 is an ADC Cytotoxin and tubulin binder used as anti-microtubule toxins .
T63713	Mytoxin B
	Mytoxin B 是一种大环内脂，作用与 LY294002 相似，也是一种 ADC 细胞毒素 (ADC cytotoxin)。Mytoxin B 能够利用 PI3K/Akt 通路，进而诱导细胞凋亡 (apoptosis)。
T19254	Cyclooctyne-O-NHS ester	Others	Others
	Cycloctyne-O-NHS ester is a derivative of cyclooctyne, which will seriously damage HEK293 cells and be used as ADC cytotoxin.
T60321	Tubulysin IM-3
	Tubulysin IM-3 是ADC 细胞毒素 (ADC Cytotoxin)，也是一种微管蛋白结合剂。Tubulysin IM-3 可用作抗微管毒素 (anti-microtubule toxins)。
T39138	Muscotoxin A
	Muscotoxin A is an ADC cytotoxin with lipopeptide properties that effectively permeabilizes mammalian cell membranes, ultimately inducing necrotic cell death.
T17740	Cyclooctyne-O-PFP ester	Others	Others
	Cyclooctyne-O-PFP ester is a used as an ADC cytotoxin, which connects antibody and linker[1].
T18302	Mal-Phe-C4-VC-PAB-DMEA-PNU-159682	Others	Others
	Mal-Phe-C4-VC-PAB-DMEA-PNU-159682 is a drug-linker conjugate utilized in antibody-drug conjugate (ADC) therapy. It comprises the ADC linker Mal-Phe-C4-VC-PAB and the potent ADC cytotoxin DMEA-PNU-159682. DMEA-PNU-159682 encompasses metabolites of nemorubicin (MMDX) derived from liver microsomes, as well as the ADC cytotoxin PNU-159682[1].
T19523	PNU-159682 carboxylic acid	Others	Others
	PNU-159682 carboxylic acid is a potent ADCs cytotoxin,PNU-159682 carboxylic acid has protein fold and diverse functions.
T18246	Mal-C2-Gly3-EDA-PNU-159682	Others	Others
	Mal-C2-Gly3-EDA-PNU-159682, a drug-linker conjugate for antibody-drug conjugates (ADC), combines the cleavable ADC linker Mal-C2-Gly3-EDA with the potent ADC cytotoxin PNU-159682.
T74177	Modified MMAF
	Modified MMAF 是一种用于构建 Antibody-drug Conjugate (ADC) 的 ADC 细胞毒素，适用于癌症靶向研究。
T73947	Tubulysin IM-1
	Tubulysin IM-1 是 ADC 细胞毒素 (ADC Cytotoxin)，也是一种微管蛋白结合剂，用作抗微管毒素 (anti-microtubule toxins)。
T77852	INX-SM-56
	INX-SM-56是一种用于合成抗VISTA抗体活性分子偶联物的cytotoxin。VISTA代指含V区域免疫球蛋白的T细胞活化抑制因子。
T82382	Fmoc-MMAF-OMe
	Fmoc-MMAF-OMe，一种具有Fmoc保护基团的抗癌剂和微管蛋白聚合抑制剂，其活性成分MMAF作为经典抗体偶联药物（ADCs）中的细胞毒性（ADC Cytotoxin）组分。
T18304	Mal-VC-PAB-ABAEP-Azonafide	Others	Others
	Mal-VC-PAB-ABAEP-Azonafide, an ADC (antibody-drug conjugate) linker-drug conjugate, demonstrates potent antitumor activity. It incorporates Azonafide, a cytotoxin, connected through the ADC linker Mal-VC-PAB[1].

化合物

Cat.No: T14349

Target: Microtubule Associated

Cat.No: T14348

Target: Microtubule Associated

Thailanstatin A

Cat.No: T38889

Cat.No: T15141

Synonym: Ravtansine,美登素 DM4

Target: Others, Microtubule Associated

Cat.No: T11120

Target: DNA Alkylation, Antibiotic

Cat.No: T16557

Target: Topoisomerase

Cat.No: T3256

Synonym: 一甲基澳瑞他汀 F,MonoMethyl auristatin F

Target: Others, Microtubule Associated

Methotrexate disodium

Cat.No: T8003

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Cat.No: T12081

Synonym: Monomethyl auristatin F methyl ester

Cat.No: T14858

Synonym: Calicheamicin γ1,卡奇霉素

Target: Others

Cat.No: T11249L

Synonym: Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ

Target: Topoisomerase

Cat.No: T21408

Synonym: DM1-SSMe

Target: Microtubule Associated

Monomethyl auristatin E

Cat.No: T6897

Synonym: 一甲基澳瑞他汀E,Vedotin,MMAE

Target: Apoptosis, Microtubule Associated

Ansamitocin P 3'

Cat.No: T1910

Synonym: Maytansinol butyrate,Ansamitocin P-3,安丝菌素P-3,Antibiotic C 15003P3'

Target: Microtubule Associated

Cat.No: T4677

Synonym: Monomethylauristatin D,Demethyldolastatin 10,单甲基澳瑞他汀 D,Monomethyl Dolastatin 10

Target: Microtubule Associated

Cat.No: T1992

Synonym: DM1,Maytansinoid DM1

Target: Microtubule Associated

Cat.No: T1485

Synonym: NCI-C04671,WR19039,Amethopterin,甲氨蝶呤,CL14377

Target: Apoptosis, Dehydrogenase, DNA/RNA Synthesis, Antifolate

Banoxantrone dihydrochloride

Cat.No: T10459

Synonym: AQ4N dihydrochloride,AZD1689 2HCl

Target: NOS

Cat.No: T41248

Target: Microtubule Associated

Cat.No: T3615

Synonym: 艾伏磷酰胺,TH-302

Target: Apoptosis, Others

Cat.No: T10972

Target: Others

NH2-methylpropanamide-Exatecan TFA

Cat.No: T77889

Target: Topoisomerase

Cat.No: T33700

Synonym: NLP-1,NLP1,2-Nlp-3

Cat.No: T30104

Duocarmycin Analog

Cat.No: T19300

Target: DNA Alkylation

Cat.No: T30105

Cat.No: T32136

Synonym: de OH CPI MI,deOHCPIMI,de-OH-CPI-MI,ICT 2700,ICT-2700

Mal-PEG4-VC-PAB-DMEA-PNU-159682

Cat.No: T18292

Target: Others

DBCO-PEG4-VC-PAB-DMEA-PNU-159682

Cat.No: T17802

Target: Others

2',3'-cGAMP-C2-SH

Cat.No: T39582

Synonym: 2',3'-cGAMP-C2-SH

Seco-Duocarmycin SA

Cat.No: T12813L

Target: DNA Alkylation

Cat.No: T30106

DMEA-PNU-159682

Cat.No: T13658

Target: Others

Cat.No: T40191

(S)-Seco-Duocarmycin SA

Cat.No: T12813

Target: Others

Cat.No: T10640

Target: Others

Cat.No: T38430

Cat.No: T63713

Cyclooctyne-O-NHS ester

Cat.No: T19254

Target: Others

Cat.No: T60321

Cat.No: T39138

Cyclooctyne-O-PFP ester

Cat.No: T17740

Target: Others

Mal-Phe-C4-VC-PAB-DMEA-PNU-159682

Cat.No: T18302

Target: Others

PNU-159682 carboxylic acid

Cat.No: T19523

Target: Others

Mal-C2-Gly3-EDA-PNU-159682

Cat.No: T18246

Target: Others

Cat.No: T74177

Cat.No: T73947

Cat.No: T77852

Cat.No: T82382

Mal-VC-PAB-ABAEP-Azonafide

Cat.No: T18304

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T16016	Maytansinol 美登醇,Ansamitocin P-0	Apoptosis; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用，用于果蝇和人类癌细胞。
T0968	Paclitaxel Taxol,紫杉醇,NSC 125973	Apoptosis; Microtubule Associated; Autophagy	Apoptosis; Autophagy; Cytoskeletal Signaling
	Paclitaxel (Taxol) 属于天然产物，是一种微管聚合物稳定剂。Paclitaxel 具有抗肿瘤活性；通过诱导有丝分裂停滞、细胞凋亡、细胞自噬等，导致细胞死亡。
T5868	Methyl indole-3-carboxylate 吲哚-3-甲酸甲酯,Methyl 3-indolecarboxylate,3-吲哚甲酸甲酯	Others; Antibacterial	Microbiology/Virology; Others
	Methyl indole-3-carboxylate (Methyl 3-indolecarboxylate) 是一种从Sorangium cellulosumSoce895 菌株中分离出来的天然产物。它对革兰氏阳性诺卡氏菌的MIC 值为 33.3 μg/mL。
T1511	Daunorubicin hydrochloride Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin	Apoptosis; DNA/RNA Synthesis; Topoisomerase; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Daunorubicin hydrochloride (Rubidomycin hydrochloride) 是一种蒽环类氨基糖苷类抗肿瘤药物，可抑制 DNA 复制和修复以及 RNA 和蛋白质合成。
T1123	Camptothecin NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT	Apoptosis; Influenza Virus; Topoisomerase; Antibiotic; Antifungal	Apoptosis; DNA Damage/DNA Repair; Microbiology/Virology
	Camptothecin (CPT) 属于生物碱类天然产物，是一种 DNA 拓扑异构酶 I (Topo I) 的抑制剂 (IC50=679 nM)，具有特异性。Camptothecin 具有抗肿瘤活性，可以诱导细胞凋亡。
TP1180	Dolastatin 10 尾海兔素10,NSC 376128,DLS 10	Microtubule Associated	Cytoskeletal Signaling
	Dolastatin 10 (DLS 10) 是一种多肽，可以抑制微管蛋白聚合，显示除抗有丝分裂的活性。
T1703	SN-38 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38	DNA/RNA Synthesis; Topoisomerase; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	SN-38 (NK012) 是 DNA 拓扑异构酶 I (Topo I) 抑制剂 Irinotecan 的活性代谢产物，可以抑制 DNA 和 RNA 合成 (IC50=0.077/1.3 μM)。SN-38 具有抗肿瘤活性，可以诱导细胞自噬。
T1020	Doxorubicin hydrochloride Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127	Apoptosis; Mitophagy; HBV; HIV Protease; Topoisomerase; Antibacterial; Antibiotic; AMPK; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Doxorubicin hydrochloride (Adriamycin) 属于蒽环类抗生素，是人类 DNA 拓扑异构酶 I/II 抑制剂 (IC50=0.8/2.67 μM)。Doxorubicin hydrochloride 具有细胞毒性和抗肿瘤活性。Doxorubicin hydrochloride 可降低 AMPK 及其下游靶蛋白乙酰辅酶 A 羧化酶的磷酸化，还可诱导凋亡和自噬。
T5749	10-Deacetyl-7-xylosyl paclitaxel 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物，具有改进的药理特性和更高的水溶性，用于治疗癌症。
T1456	Doxorubicin Hydroxydaunorubicin,阿霉素,Adriamycin	Topoisomerase; AMPK	Chromatin/Epigenetic; DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
	Doxorubicin (Adriamycin) 是一种有细胞毒性的蒽环类抗生素，具有肿瘤化疗作用。它抑制DNA 拓扑异构酶 I 和拓扑异构酶 II，IC50分别为0.8 μM 和2.67 μM，从而抑制 DNA 复制。它下调AMPK 的基础磷酸化以及下游 acetyl-CoA 羧化酶。它诱导凋亡和自噬。
T4918	DL-Glyceraldehyde Glyceric aldehyde,DL-甘油醛晶体	Reductase	Endocrinology/Hormones; Metabolism
	DL-Glyceraldehyde (Glyceric aldehyde) 是由酶甘油醛脱氢酶的作用产生的，该酶使用 NADP 作为辅因子将甘油转化为甘油醛。它是一种高活性化合物，可以修饰和交联蛋白质。
TN1338	7Beta-Hydroxycholesterol	LDL; Calcium Channel; MAPK	MAPK; Membrane transporter/Ion channel; Metabolism
	7beta-Hydroxycholesterol, a major cytotoxin in oxidized LDL, induces Ca(2+) oscillations, MAP kinase activation and apoptosis in human aortic smooth muscle cells.
T73915	Luisol A
	Luisol A 是一种芳香族四醇，是链霉菌属的河口海洋放线菌的主要代谢产物。Luisol A 是一种蒽醌抗生素类似物，是 ADC 细胞毒素 (ADC Cytotoxin)。
T39562	γ-Amanitin
	γ-Amanitin an ADC cytotoxin and isolated from the mushroom. γ-Amanitin inhibits RNA polymerase II and disrupts synthesis of mRNA. γ-Amanitin shows similar effects to α-Amanitin and β-Amanitin.
T35782	Swinholide A MK-7684	Antifungal	Microbiology/Virology
	Swinholide A 是可从海绵中提取的聚酮化合物，可于肌动蛋白结合，使肌动蛋白二聚化，Kd 约为 50 nM。Swinholide A 是一种细胞毒素，可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性，可破坏细胞的肌动蛋白细胞骨架。

天然产物

Cat.No: T16016

Synonym: 美登醇,Ansamitocin P-0

Target: Apoptosis, Microtubule Associated

Cat.No: T0968

Synonym: Taxol,紫杉醇,NSC 125973

Target: Apoptosis, Microtubule Associated, Autophagy

Methyl indole-3-carboxylate

Cat.No: T5868

Synonym: 吲哚-3-甲酸甲酯,Methyl 3-indolecarboxylate,3-吲哚甲酸甲酯

Target: Others, Antibacterial

Daunorubicin hydrochloride

Cat.No: T1511

Synonym: Daunomycin HCl,盐酸佐柔比星,盐酸柔红霉素,RP-13057 Hydrochloride,Rubidomycin hydrochloride,Daunorubicin HCl,Daunomycin

Target: Apoptosis, DNA/RNA Synthesis, Topoisomerase, Antibacterial, Antibiotic, Autophagy

Cat.No: T1123

Synonym: NSC-100880,Campathecin,喜树碱,(S)-(+)-Camptothecin,CPT

Target: Apoptosis, Influenza Virus, Topoisomerase, Antibiotic, Antifungal

Cat.No: TP1180

Synonym: 尾海兔素10,NSC 376128,DLS 10

Target: Microtubule Associated

Cat.No: T1703

Synonym: 7-乙基-10-羟基喜树碱,NK012,伊立替康杂质B,SN 38

Target: DNA/RNA Synthesis, Topoisomerase, Autophagy

Doxorubicin hydrochloride

Cat.No: T1020

Synonym: Adriamycin,Doxorubicin (Adriamycin) HCl,Hydroxydaunorubicin hydrochloride,盐酸多柔比星,盐酸阿霉素,NSC 123127

Target: Apoptosis, Mitophagy, HBV, HIV Protease, Topoisomerase, Antibacterial, Antibiotic, AMPK, Autophagy

10-Deacetyl-7-xylosyl paclitaxel

Cat.No: T5749

Synonym: 10-Deacetyl-7-xylosyltaxol,10-Deacetyltaxol 7-Xyloside,7-Xylosyl-10-deacetyltaxol,7-木糖甙-10-脱乙酰基紫杉醇,10-Deacetylpaclitaxel 7-Xyloside

Target: Others, Microtubule Associated

Cat.No: T1456

Synonym: Hydroxydaunorubicin,阿霉素,Adriamycin

Target: Topoisomerase, AMPK

DL-Glyceraldehyde

Cat.No: T4918

Synonym: Glyceric aldehyde,DL-甘油醛晶体

Target: Reductase

7Beta-Hydroxycholesterol

Cat.No: TN1338

Target: LDL, Calcium Channel, MAPK

Cat.No: T73915

Cat.No: T39562

Cat.No: T35782

Synonym: MK-7684

Target: Antifungal

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