Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Maytansinol (Ansamitocin P-0) 在体外抑制微管组装并导致微管分解。它与辐射联用,用于果蝇和人类癌细胞。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 327 | 现货 | ||
2 mg | ¥ 478 | 现货 | ||
5 mg | ¥ 815 | 现货 | ||
10 mg | ¥ 1,230 | 现货 | ||
25 mg | ¥ 2,250 | 现货 | ||
50 mg | ¥ 3,730 | 现货 | ||
100 mg | ¥ 5,330 | 现货 | ||
200 mg | ¥ 7,280 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 987 | 现货 |
产品描述 | Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro. |
体外活性 | Maytansinol inhibits the growth of HCT116 human colon cancer cells. Maytansinol causes apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae. Maytansinol induces apoptosis in imaginal discs of wild-type larvae but not p53 mutant larvae at 24 hours after exposure to the drug. Maytansinol decreases the growth and/or survival of HCT116 cells in a dose-dependent manner and that the effect was more severe for p53+/+ than for p53-/- cells at both low and high doses. Maytansinol disrupts the mitotic spindle and prevents mitotic exit in Drosophila. This parallels the finding in human HCT116 cells, in which Maytansinol was more effective when p53 was present, at least at some doses. |
别名 | 美登醇, Ansamitocin P-0 |
分子量 | 565.05 |
分子式 | C28H37ClN2O8 |
CAS No. | 57103-68-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 35 mg/mL (61.94 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.7698 mL | 8.8488 mL | 17.6975 mL | 44.2439 mL |
5 mM | 0.354 mL | 1.7698 mL | 3.5395 mL | 8.8488 mL | |
10 mM | 0.177 mL | 0.8849 mL | 1.7698 mL | 4.4244 mL | |
20 mM | 0.0885 mL | 0.4424 mL | 0.8849 mL | 2.2122 mL | |
50 mM | 0.0354 mL | 0.177 mL | 0.354 mL | 0.8849 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Maytansinol 57103-68-1 Apoptosis Cytoskeletal Signaling Microtubule Associated 美登醇 Inhibitor Ansamitocin P 0 ADC Cytotoxin Ansamitocin P0 inhibit Microtubule/Tubulin Ansamitocin P-0 ADC Payload inhibitor