Powder: -20°C for 3 years | In solvent: -80°C for 1 year
10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) 是一种紫杉醇衍生物,具有改进的药理特性和更高的水溶性,用于治疗癌症。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
5 mg | ¥ 160 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | 10-Deacetyl-7-xylosyl paclitaxel (7-Xylosyl-10-deacetyltaxol) is a Paclitaxel derivative with improved pharmacological features and higher water solubility,used in Chinese clinics to treat cancer. |
体外活性 | 7-Xylosyl-10-deacetyltaxol induced mitotic cell cycle arrest and apoptosis as measured by flow cytometry, DNA laddering, and transmission electron microscopy. Pro-apoptotic Bax and Bad protein expression was up-regulated and anti-apoptotic Bcl-2 and Bcl-XL expression down-regulated, which lead to a disturbance of the mitochondrial membrane permeability and to the activation of caspase-9[1]. |
体内活性 | 7-Xylosyl-10-deacetyltaxol is an active compound used in traditional Chinese medicine to treat cancer.7-Xylosyl-10-deacetyltaxol through the intestinal epithelium is partially counteracted by the action of an outwardly directed efflux pump, presumably P-glycoprotein. The relatively high apparent permeability coefficient ( P(app)) for the apical to basolateral 7-Xylosyl-10-deacetyltaxol transport (16.3?±?6.3?×?10 (-6)?cm/s; n?=?3) suggests that the drug may still be effectively absorbed in the intestinal tract[2]. |
别名 | 10-Deacetyl-7-xylosyltaxol, 10-Deacetyltaxol 7-Xyloside, 7-Xylosyl-10-deacetyltaxol, 7-木糖甙-10-脱乙酰基紫杉醇, 10-Deacetylpaclitaxel 7-Xyloside |
分子量 | 943.98 |
分子式 | C50H57NO17 |
CAS No. | 90332-63-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (26.48 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.0593 mL | 5.2967 mL | 10.5934 mL | 26.4836 mL |
5 mM | 0.2119 mL | 1.0593 mL | 2.1187 mL | 5.2967 mL | |
10 mM | 0.1059 mL | 0.5297 mL | 1.0593 mL | 2.6484 mL | |
20 mM | 0.053 mL | 0.2648 mL | 0.5297 mL | 1.3242 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
10-Deacetyl-7-xylosyl paclitaxel 90332-63-1 Cytoskeletal Signaling Others Microtubule Associated 10-Deacetyl-7-xylosyltaxol 10-Deacetyltaxol 7-Xyloside inhibit 7-Xylosyl-10-deacetyltaxol 10Deacetyl7xylosyl paclitaxel Microtubule/Tubulin ADC Payload 10 Deacetyl 7 xylosyl paclitaxel 7-木糖甙-10-脱乙酰基紫杉醇 ADC Cytotoxin Inhibitor 10-Deacetylpaclitaxel 7-Xyloside inhibitor