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Search Results for " congestive heart failure "

44

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T5329	Trandolapril	Angiotensin-converting Enzyme (ACE)	Metabolism
	Trandolapril 是 Trandolaprilat 的前体药物。Trandolapril 是一种口服血管紧张素转换酶抑制剂，在高血压和充血性心力衰竭及心肌梗死领域有研究价值。
T0154	Nebivolol hydrochloride R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824	Apoptosis; Adrenergic Receptor	Apoptosis; GPCR/G Protein; Neuroscience
	Nebivolol hydrochloride (R 065824 hydrochloride) 是一种β1-肾上腺素受体选择性抑制剂，IC50为0.8 nM。
T1462	Captopril SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333	RAAS	Endocrinology/Hormones
	Captopril (SA333) 是一种含巯基的，具有口服活性的血管紧张素转换酶(ACE)抑制剂，IC50=0.025 μM，广泛应用于高血压和充血性心力衰竭的研究。Captopril 也是NDM-1抑制剂，IC50=7.9 μM。
T0342	Carvedilol phosphate hemihydrate Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐	VEGFR; Others; Potassium Channel; LDL; Integrin; Gap Junction Protein; NADPH; Adrenergic Receptor; Autophagy	Angiogenesis; Autophagy; Cytoskeletal Signaling; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience; Others; Tyrosine Kinase/Adaptors
	Carvedilol phosphate hemihydrate (BM 14190 phosphate hemihydrate) 是一种外消旋混合物，是一种非选择性β/α-1受体阻断剂，具有抗高血压活性且缺乏内在拟交感神经活性。
T33600L	(Rac)-Naxifylline (Rac)-Naxifylline（(Rac)-166374-49-8）	Others	Others
	(Rac)-Naxifylline 可用于研究充血性心力衰竭。
T27596	Imazodan hydrochloride CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl	PDE	Metabolism
	Imazodan hydrochloride (CI-914 HCl) 是一种强效的选择性 III 型磷酸二酯酶抑制剂，用于治疗慢性充血性心力衰竭。
T1182	Levocarnitine propionate hydrochloride Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Levocarnitine propionate hydrochloride (ST-261) 可用于肾功能恶化，充血性心脏衰竭，间歇性跛行等疾病的研究。
T6595	Moexipril hydrochloride 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。
T16782	Rolofylline KW-3902,MK-7418,KF-15372	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Rolofylline (KW-3902) 是一种具有选择性腺苷 A1 受体拮抗剂，可用于研究急性充血性心力衰竭和肾功能障碍，可用与研究神经退行性疾病。
T0805	Quinapril hydrochloride CI-906,PD-109452-2,盐酸喹那普利,Quinapril HCl	RAAS	Endocrinology/Hormones
	Quinapril hydrochloride (PD-109452-2) 是一种血管紧张素转化酶(ACE) 抑制剂的原药。
T27119L	(Rac)-Daglutril SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid	Others	Others
	(Rac)-Daglutril (SLV 306 acetic acid) 是 Daglutril 的消旋体。Daglutril 是一种口服活性的混合中性内肽酶/内皮素转化酶抑制剂，正在开发用于治疗原发性高血压和充血性心力衰竭。
T8462	Enoximone 依诺昔酮,烯氟酮	PDE	Metabolism
	Enoximone 是一种选择性的，具有口服活性的磷酸二酯酶 III 抑制剂，也是正性肌力血管舒张剂。它通过抑制 cGMP 抑制的 PDE 来诱导血管舒张并增加细胞内 cAMP 水平。它还表现出 PDE4抑制作用，对心肌 PDE4A 的 IC50为 21.1 μM。它用于充血性心力衰竭的研究，并具有支气管扩张，抗哮喘和抗炎作用。
T2530	Levosimendan OR1259,OR1855,左西孟旦	Potassium Channel; PDE; Carbonic Anhydrase; Autophagy	Autophagy; Membrane transporter/Ion channel; Metabolism
	Levosimendan (OR1259) 是一种钙增敏剂，通过以钙依赖性方式与心肌肌钙蛋白 C 结合，增加肌细胞对钙的敏感性来发挥其作用，可治疗急性失代偿性充血性心力衰竭。
T16444	PD-118057	Potassium Channel; HER	Angiogenesis; JAK/STAT signaling; Membrane transporter/Ion channel; Tyrosine Kinase/Adaptors
	PD-118057 是一种有效的乙醚相关(hERG)钾通道激活剂，对 hERG 不显示活性。PD-118057 通过激活 hERG 通道来抑制膜的兴奋性变化。PD-118057预防和逆转 QT 间期延长，是治疗遗传性或获得性长 QT 综合征和充血性心力衰竭的延迟复极的潜在化合物。
T35336	Furosemide sodium Frusemide Sodium,Lasix	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Furosemide sodium (Frusemide Sodium) 是 Na+/K+/2Cl- (NKCC)，NKCC1 和 NKCC2 共转运蛋白的有效的和具有口服活性抑制剂。Furosemide sodium 也是 GABAA 受体拮抗剂，对含 α6 受体的选择性是含 α1 受体的 100 倍。Furosemide sodium 用作利尿试剂，用于充血性心力衰竭，高血压和水肿的研究。
T29995	Amisometradine Aminoisometradin,Aminoisometradine,Rolicton
	Amisometradine is a diuretic which may be used in the treatment of congestive heart failure.
T13599	Benzofurodil CB4091,Benfurodil,Eudilat	Others	Others
	Benzofurodil is cardiotonic used for the chronic treatment of congestive heart failure.
T28191	NP-252 NP252
	NP-252 is a calcium channel antagonist potentially for the treatment of angina pectoris and congestive heart failure.
T30501	BMS-193884 BMS193884,BMS 193884
	BMS-193884 is an oral endothelin antagonist for the treatment of congestive heart failure (CHF) and pulmonary arterial hypertension.
T33711	Nolomirole CHF1025,CHF-1025,CHF 1025
	Nolomirole is a dopamine receptor agonist that reduces symptoms of congestive heart failure caused by monoclinine.
T26423	A 58365 B A-58365 B,A58365 B
	A 58365 B, an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus, is used for the treatment of congestive heart failure and hypertension.
T28309	PD 113413 PD-113413,PD113413
	PD 113413 is a metabolite of quinapril, an angiotensin-converting enzyme inhibitor for the treatment of hypertension and congestive heart failure.
T30955	CK 2289 CK-2289,CK2289
	CK 2289 is an inhibitor of type III cyclic 3'5' -adenosine monophosphate phosphodiesterase with potential use in the treatment of congestive heart failure.
T33805	OPC 18692 OPC-18692,OPC18692
	OPC 18692 is a metabolite of Vesnarinone, a positive inotropic drug developed for congestive heart failure.
T30956	CK 3197 CK3197,CK-3197
	CK 3197 is a selective positive inotropic agent for the treatment of congestive heart failure. It has hemodynamic and myocardial energetic effects.
T26422	A 58365 A A 58365A,A58365A,A-58365A
	A 58365 A, an angiotensin converting enzyme (ACE) inhibitor isolated from Streptomyces chromofuscus, is used for the treatment of congestive heart failure and hypertension.
T33600	Naxifylline CVT 124,CVT-124,CVT124,BG9719
	Naxifylline is an A1 adenosine receptor antagonist that promotes urine volume to prevent the decline in renal function observed during diuretic therapy for the treatment of edema associated with congestive heart failure.
T28485	Quinaprilat hydrate Quinaprilat,CI-928,CI 928,BRN 5653070
	Quinaprilat is the active metabolite of quinapril, an angiotensin-converting enzyme inhibitor used in the treatment of congestive heart failure and hypertension.
T34107	Polythiazide P2525,NSC-108161,NSC 108161,P-2525,NSC108161
	Polythiazide (NSC-108161, P-2525) is used to treat fluid retention (edema) caused by a variety of causes, including congestive heart failure, severe liver disease (cirrhosis), kidney disease, or steroid or hormonal medication.
T6444	Cilazapril Monohydrate Ro 31-2848 monohydrate,Justor,西拉普利,西拉普利水合物	RAAS	Endocrinology/Hormones
	Cilazapril Monohydrate (Justor) 是一种血管紧张素转化酶抑制剂，能够作用于高血压和充血性心力衰竭的研究。
T13195	Trandolapril D5 RU44570 D5	Others	Others
	Trandolapril D5 is a deuterium labeled Trandolapril. Trandolapril is an orally active inhibitor of angiotensin converting enzyme (ACE) for hypertension and congestive heart failure (CHF).
T71205	Fosinopril-d7 sodium salt
	Fosinopril-d7 is intended for use as an internal standard for the quantification of fosinopril by GC- or LC-MS. Fosinopril is a prodrug form of the angiotensin-converting enzyme inhibitor fosinoprilat. Oral administration of fosinopril inhibits angiotensin I-induced pressor responses in normotensive rats, dogs, and monkeys when administered at doses of 15, 15, and 10 µmol/kg, respectively. Fosinopril reduces fractional shortening and decreases left ventricular size in a porcine model of congesti...
T15434	GSK2798745	TRP/TRPV Channel	Membrane transporter/Ion channel
	GSK2798745 is an orally active transient receptor potential vanilloid 4 (TRPV4) ion channel blocker (IC50s: 1.8 and 1.6 nM for hTRPV4 and rTRPV4). It is used in research for the treatment of pulmonary edema associated with congestive heart failure.
T68600	Enoximone sulfoxide
	Enoximone sulfoxide is a selective phosphodiesterase III (PDE3) inhibitor with vasodilating and positive inotropic activity that does not cause changes in myocardial oxygen consumption. Enoximone prevents the degradation of cAMP by PDE, which prolongs signal transduction and its subsequent effects. It is used in patients with congestive heart failure.
T80891	Urodilatin
	Urodilatin为ANF-(99-126)的同类物，属于利尿钠调节肽。该化合物主要应用于急性肾功能衰竭、充血性心力衰竭、支气管哮喘等疾病的研究领域。
T33851	Ozolinone W 3282,W3282,W-3282
	Ozolinone is an active metabolite of etozoline which acts as a loop diuretic --- a diuretic that acts at the ascending limb of the loop of Henle in the kidney. Loop diuretics are primarily used in medicine to treat hypertension and edema often due to cong
T62992	Trandolapril hydrochloride
	Trandolapril (RU44570) hydrochloride 是一种非巯基前体化合物，水解为活性双乙酰 (Trandolapril hydrochlorideat)。Trandolapril hydrochloride 是一种口服具有活力的血管紧张素转换酶 (ACE) 抑制剂。Trandolapril hydrochloride 能够高血压和充血性心力衰竭及心肌梗死的研究。
T79913	GRK2 Inhibitor 2
	GRK2 Inhibitor 2 (Compound 8h) 作为一种高效的抑制剂，对GRK2有显著的抑制活性（IC50: 19 nM），同样对Aurora-A也表现出抑制作用（IC50: 137 nM）。该化合物能增强GRK2过表达的HEK293细胞中β-AR介导的cAMP积累。此外，GRK2 Inhibitor 2适用于充血性心力衰竭（HF）的相关研究。
T63425	Spirapril hydrochloride
	Spirapril (SCH 33844) hydrochloride 是血管紧张素转换酶 (ACE) 的有效抑制剂，是一种口服具有活力的螺普利拉前药。Spirapril hydrochloride 能够竞争性地与 ACE 结合，阻断血管紧张素I 向血管紧张素 II 的转化，表现出降压活性。Spirapril hydrochloride 能够用于研究高血压、充血性心力衰竭。
T76357	Neuropeptide Y (18-36) (porcine)
	Neuropeptide Y (18-36) (porcine) 是一种与Neuropeptide Y(NPY)心脏受体进行竞争性拮抗的化合物。该化合物通过浓度依赖的方式，抑制I-NPY与心室膜的结合，具有IC50值158 nM和Ki值140 nM。Neuropeptide Y (18-36) (porcine) 主要用于充血性心力衰竭的研究。
T60383	Captopril hydrochloride
	Captopril (SQ 14225) hydrochloride 是一种含巯基的口服活性血管紧张素转换酶(ACE)抑制剂，IC50值为0.025 μM，已广泛应用于高血压和充血性心力衰竭的研究。Captopril hydrochloride 也是 NDM-1抑制剂，IC50值为 7.9 μM。
T70990	ADMA-d6
	NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Da...
T69600	Spermidine-d6
	Spermidine-d6 is intended for use as an internal standard for the quantification of spermidine by GC- or LC-MS. Spermidine is an endogenous polyamine. It is formed from putrescine by spermidine synthase. Spermidine (25 µM) inhibits the activity of the human inward-rectifying potassium channel Kir2.3 in a patch-clamp assay. It induces autophagy in HeLa cells when used at a concentration of 100 µM and increases the lifespan of D. melanogaster, yeast, and C. elegans. Spermidine (30 mM in the drinki...
T68616	Pentoprilat
	Pentoprilat is a member of a series of l-glutarylindoline-2(S)-carboxylic acid derivatives. Pentopril was evaluated as an inhibitor of a cell-free preparation of angiotensin-converting enzyme (ACE) isolated from rabbit lung. Intravenous administration of incremental doses of pentopril to anesthetized normotensive rats produced a dose-related inhibition of angiotensin I (AI) pressor responses. The onset of inhibition of the A1 pressor response was rapid, and substantial inhibition occurred at 5 m...

化合物

Cat.No: T5329

Target: Angiotensin-converting Enzyme (ACE)

Nebivolol hydrochloride

Cat.No: T0154

Synonym: R 065824 hydrochloride,盐酸奈必洛尔,Nebivolol HCl,R-65824

Target: Apoptosis, Adrenergic Receptor

Cat.No: T1462

Synonym: SQ 14225,甲巯丙脯酸,卡托普利,SQ-14534,SA333

Target: RAAS

Carvedilol phosphate hemihydrate

Cat.No: T0342

Synonym: Carvedilol phosphate,BM 14190 (phosphate hemihydrate),卡维地洛磷酸盐

Target: VEGFR, Others, Potassium Channel, LDL, Integrin, Gap Junction Protein, NADPH, Adrenergic Receptor, Autophagy

(Rac)-Naxifylline

Cat.No: T33600L

Synonym: (Rac)-Naxifylline（(Rac)-166374-49-8）

Target: Others

Imazodan hydrochloride

Cat.No: T27596

Synonym: CI914 HCl,CI-914 HCl,CI 914 HCl,Imazodan HCl

Target: PDE

Levocarnitine propionate hydrochloride

Cat.No: T1182

Synonym: Propionyl-L-carnitine hydrochloride,L-Propionylcarnitine chloride,丙酰左旋肉碱盐酸盐,ST-261,丙酰肉碱盐酸盐

Target: Histamine Receptor

Moexipril hydrochloride

Cat.No: T6595

Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Cat.No: T16782

Synonym: KW-3902,MK-7418,KF-15372

Target: Adenosine Receptor

Quinapril hydrochloride

Cat.No: T0805

Synonym: CI-906,PD-109452-2,盐酸喹那普利,Quinapril HCl

Target: RAAS

(Rac)-Daglutril

Cat.No: T27119L

Synonym: SLV 306 acetic acid,2-((3S)-3-(1-(2-(ethoxycarbonyl)-4-phenylbutyl)cyclopentane-1-carboxamido)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-1-yl)acetic acid

Target: Others

Cat.No: T8462

Synonym: 依诺昔酮,烯氟酮

Target: PDE

Cat.No: T2530

Synonym: OR1259,OR1855,左西孟旦

Target: Potassium Channel, PDE, Carbonic Anhydrase, Autophagy

Cat.No: T16444

Target: Potassium Channel, HER

Furosemide sodium

Cat.No: T35336

Synonym: Frusemide Sodium,Lasix

Target: Na-K-Cl cotransporter

Cat.No: T29995

Synonym: Aminoisometradin,Aminoisometradine,Rolicton

Cat.No: T13599

Synonym: CB4091,Benfurodil,Eudilat

Target: Others

Cat.No: T28191

Synonym: NP252

Cat.No: T30501

Synonym: BMS193884,BMS 193884

Cat.No: T33711

Synonym: CHF1025,CHF-1025,CHF 1025

Cat.No: T26423

Synonym: A-58365 B,A58365 B

Cat.No: T28309

Synonym: PD-113413,PD113413

Cat.No: T30955

Synonym: CK-2289,CK2289

Cat.No: T33805

Synonym: OPC-18692,OPC18692

Cat.No: T30956

Synonym: CK3197,CK-3197

Cat.No: T26422

Synonym: A 58365A,A58365A,A-58365A

Cat.No: T33600

Synonym: CVT 124,CVT-124,CVT124,BG9719

Quinaprilat hydrate

Cat.No: T28485

Synonym: Quinaprilat,CI-928,CI 928,BRN 5653070

Cat.No: T34107

Synonym: P2525,NSC-108161,NSC 108161,P-2525,NSC108161

Cilazapril Monohydrate

Cat.No: T6444

Synonym: Ro 31-2848 monohydrate,Justor,西拉普利,西拉普利水合物

Target: RAAS

Trandolapril D5

Cat.No: T13195

Synonym: RU44570 D5

Target: Others

Fosinopril-d7 sodium salt

Cat.No: T71205

Cat.No: T15434

Target: TRP/TRPV Channel

Enoximone sulfoxide

Cat.No: T68600

Cat.No: T80891

Cat.No: T33851

Synonym: W 3282,W3282,W-3282

Trandolapril hydrochloride

Cat.No: T62992

GRK2 Inhibitor 2

Cat.No: T79913

Spirapril hydrochloride

Cat.No: T63425

Neuropeptide Y (18-36) (porcine)

Cat.No: T76357

Captopril hydrochloride

Cat.No: T60383

Cat.No: T70990

Cat.No: T69600

Cat.No: T68616

Cat. No.	Product Name	Target	Signaling Pathways
T3212	Digoxigenin 地谷新配基,异羟基洋地黄毒苷元	Others	Others
	Digoxigenin, a therapeutic drug belonging to the group of cardiac glycosides, is widely used in the management of congestive heart failure and other cardiac diseases
T1694	Oxypurinol Oxipurinol,羟基嘌呤	ROS; Xanthine Oxidase; Endogenous Metabolite	Immunology/Inflammation; Metabolism
	Oxypurinol 是一种黄嘌呤氧化酶 (xanthine oxidase) 抑制剂，是 Allopurinol 的主要特性代谢产物。它能够用于调节血尿酸水平，有潜力用于痛风的研究。
T1670	Lanatoside C Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C	ATPase; Virus Protease; Autophagy	Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Lanatoside C (Ceglunate) 是一种可用于治疗充血性心力衰竭和心律失常的强心苷类药物。它作用于 HuH-7细胞，可抗登革病毒感染， IC50为0.19 μM。
T8183	Deslanoside 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C	ATPase; Drug Metabolite	Membrane transporter/Ion channel; Metabolism
	Deslanoside (Desacetyllanatoside C) 是一种快速作用的强心苷，可抑制Na-K-ATPase 膜泵，导致细胞内钠和钙浓度增加。它用于研究充血性心力衰竭和因折返机制引起的室上性心律失常，并在研究慢性心房颤动时控制心室率。
T29599	Acetyldigitoxin Acylanide
	Acetyldigitoxin is a derivative of lanatoside A or of DIGITOXIN and can be used for fast digitalization in congestive heart failure.

天然产物

Cat.No: T3212

Synonym: 地谷新配基,异羟基洋地黄毒苷元

Target: Others

Cat.No: T1694

Synonym: Oxipurinol,羟基嘌呤

Target: ROS, Xanthine Oxidase, Endogenous Metabolite

Cat.No: T1670

Synonym: Cedilanid,Ceglunate,Isolanid,毛花甙丙,毛花苷C

Target: ATPase, Virus Protease, Autophagy

Cat.No: T8183

Synonym: 洋地黄,去乙酰西地兰,Desacetyllanatoside C,Deacetyllanatoside C

Target: ATPase, Drug Metabolite

Acetyldigitoxin

Cat.No: T29599

Synonym: Acylanide

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