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71

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T31101	CRT0273750 CRT 0273750,CRT-0273750	PDE	Metabolism
	CRT0273750 是一种 ATX 抑制剂的先导化合物，可调节血浆中 LPA 水平，用于 ATX/LPA 依赖性癌症模型。
T13554	Arimoclomol maleate BRX-220	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol maleate (BRX-220) 是一种热休克蛋白 (HSP) 的共诱导剂。它通过增强 Hsp 表达来保护运动神经元，进而通过蛋白酶体-泛素系统直接影响蛋白质聚集和错误折叠装配体的清除
T8364	Mebrofenin N-(3-溴-2,4,6-三甲基苯基甲酰甲基)乙酰乙酸,SQ 26962	Others	Others
	Mebrofenin (SQ 26962) 是一种亚氨基二乙酸 (IDA) ，可用作 Tc-99m 的放射性标记试剂盒。其中Tc-99m Mebrofenin 是一种诊断剂，用于肝胆显像，也是评价肝功能的首选放射性药物。
TQ0239	PF-06291874 Glucagon receptor antagonists-4	Glucagon Receptor	GPCR/G Protein
	PF-06291874 (Glucagon receptor antagonists-4) 是口服有活性的胰高血糖素受体非肽类拮抗剂。它正用于研究 2 型糖尿病。
T13553	Arimoclomol 阿瑞洛莫,BRX-220 free base	HSP	Cytoskeletal Signaling; Metabolism
	Arimoclomol (BRX-220 free base) 是热休克蛋白 (HSP) 的共诱导剂，可用于治疗肌萎缩侧索硬化症的研究。
T30577	BRD0418 BRD 0418,BRD-0418	Others	Others
	BRD0418作为 TRIB1表达的上调因子，导致肝脏脂蛋白代谢从脂肪生成到清除的重新编程。
T4398	LX2343	Beta Amyloid; Beta-Secretase; BACE; PI3K; Autophagy	Autophagy; Neuroscience; PI3K/Akt/mTOR signaling
	LX2343 是一种非 ATP 竞争性 PI3K 抑制剂，IC50 为 15.99±3.23 μM。它是一种 BACE1 酶抑制剂，IC50 值为 11.43±0.36 μM。它在促进 Aβ 清除中刺激自噬。
T63056	Dovramilast
	Dovramilast (CC-11050) 是一种口服具有活力的磷酸二酯酶 4 (PDE4) 抑制剂，可以降低炎症反应，改善 INH 介导的肺部细菌清除。Dovramilast (CC-11050) 能够作为辅助试剂，用于研究结核病。
T7295	Miridesap Ro63-8695,CPHPC,GSK2315698	Others	Others
	Miridesap (GSK2315698) 是一种血清淀粉样蛋白 P 组分 (SAP) 的配体，能够利用肝脏清除导致循环 SAP 的快速消耗。它也可以明显减少脑脊液和内脏淀粉样蛋白沉积物中的 SAP。
T50000	2-Iodohippuric Acid	Others	Others
	2-Iodohippuric Acid 可以用来测量肾脏的清除率用于肾功能研究，也用于某些疾病的诊断，如肝病和肾病。此外，它还用于某些药物的合成。
T9741	INE963	Others	Others
	INE963 是快速有效的血液阶段抗疟剂，EC50为 3-6 nM。INE963 有单纯性疟疾的研究潜力。
T3312	AM-2394 AM2394	Glucokinase	Metabolism
	AM-2394 是新型的 glucokinase 激活剂 (GKA)。它能够激活葡萄糖激酶 (GK)，EC50=60 nM。
T5117	Hexaflumuron	Others	Others
	Hexazinone 是一种三嗪家族的非选择性除草剂。它能够同光系统 II 电子传递链的 D-1 醌蛋白结合，抑制光合作用的发生。
T1415	Gemfibrozil 吉非罗齐,CI-719,Jezil,Decrelip,Lopid	P450; Adrenergic Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Gemfibrozil (CI-719) 是一种PPAR-α激活剂，可作为降脂药。它也是P450非选择性抑制剂，对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。
T0920	Ambroxol 氨溴索,氨溴索碱,Ambroxolum,NA-872	P450; Autophagy	Autophagy; Metabolism
	Ambroxol (NA-872) 是前药溴己辛的活性代谢产物，是一种分泌溶解剂，具有强效祛痰作用，用于治疗与粘液或过多粘液相关的呼吸道疾病。它可诱导肺组织细胞自噬，有用于帕金森氏病和神经性戈谢病的研究潜力。它是一种葡糖脑苷脂酶伴侣，可增加葡糖脑苷脂酶的活性。
T35868	BCAT-IN-2
	BCAT-IN-2 is a potent, selective and orally active inhibitor of mitochondrial branched-chain aminotransferase (BCATm), with a pIC50 of 7.3. BCAT-IN-2 shows selectivity for BCATm over BCATc (pIC50=6.6). BCAT-IN-2 can be used for the research of obesity and dislipidema[1]. BCAT-IN-2 (compound 61) inhibits BCATm in differentiated primary human adipocyte, with pIC50 of 6.5[1]. BCAT-IN-2 (compound 61) (10-100 mg/kg; p.o.) increases the level of leucine from 473 μM to 1.2 mM at the dose of 100 mg/kg i...
T16424	p38 MAPK-IN-1	p38 MAPK	MAPK
	p38 MAPK-IN-1 displays sustained levels, low clearance, and good bioavailability. p38 MAPK-IN-1 is a novel effective and selective inhibitor of p38 MAPK (IC50: 68 nM).
T34662	SMER10 SMER-10,SMER 10
	SMER10 is an enhancer of the clearance of mutant aggregate-prone proteins by autophagy in mammalian cell models of Huntington's and Parkinson's disease, independent of rapamycin.
T25826	MMV024101 MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101
	MMV024101 is a PI4K inhibitor. MMV024101 exhibits submicromolar potency against P. falciparum NF54 (IC50 =543 nM), low aqueous solubility (<5 μM), and rapid clearance by mouse liver microsomes with only 2% of parent compound remaining after 30 min of incu
T62850	IRAK4-IN-13
	IRAK4-IN-13 (compound 21) 是一种选择性的、有效的 IRAK4 抑制剂 (IC50: 0.6 nM)。IRAK4-IN-13 具有高代谢清除率，人肝微粒体 (HLM) 固有清除率为 96 μL/min/mg。
T13667L	Dusquetide SGX942	Others	Others
	Dusquetide is a first-in-class innate defense regulator. Dusquetide displays activity in both reducing inflammation and increasing the clearance of bacterial infection.
T40280	JH-XVI-178
	JH-XVI-178 is a highly potent and selective CDK8/19 inhibitor with favorable pharmacokinetic attributes, including low clearance and moderate oral bioavailability.
T33785	o-Iodohippurate sodium Hippodin,NSC-63351,Sodium iodohippurate NSC 63351,NSC63351
	o-Iodohippurate sodium is an analogue of p-aminohippuric acid used to determine effective renal plasma flow. Labelled OIH has a higher clearance than other radiopharmaceutical yet developed and is extremely suitable for renography. It is eliminated mainly
T13667	Dusquetide TFA (931395-42-5 free base) SGX942 TFA,Dusquetide TFA	Others	Others
	Dusquetide TFA is a kind of innate defense regulator (IDR).Dusquetide TFA has been shown to be active in reducing inflammation and increasing clearance of bacterial infections.Dusquetide TFA regulates innate immune responses to PAMPs and DAMPs in combinat
T78744	IRAK4-IN-24	IRAK	Immunology/Inflammation; NF-κB
	IRAK4-IN-24（compound 16）是IRAK4高效抑制剂，显示高Cl及较低口服生物可用性，适用于炎症与自身免疫性疾病研究。
T35865	Telmisartan Acyl-β-D-Glucuronide
	Telmisartan acyl-β-D-glucuronide is a major metabolite of the angiotensin II receptor antagonist telmisartan . It does not bind human serum albumin and is cleared from rat plasma with a clearance rate of 180 ml/min/kg following intravenous administration.
T16113	ML753286	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions. ML753286 is an orally active and selective inhibitor of BCRP (IC50: 0.6 μM). It is also stable in plasma across species.
T61136	Enpp-1-IN-11
	Enpp-1-IN-11 (compound 23) is a highly potent inhibitor of Ecto-nucleotide pyrophosphatase/phosphodiesterases 1 (ENPP1), with a Ki value of 45 nM. It demonstrates excellent stability in human and mouse plasma and exhibits low clearance in both human and mouse liver microsomes. Enpp-1-IN-11 holds promise for anticancer research [1].
T38641	AP 811
	AP 811, a selective antagonist of the atrial natriuretic peptide clearance receptor (APN-CR, NPR3) with a K i value of 0.48 nM, exhibits remarkable selectivity for NPR3 over NPR1 by more than 20,000-fold. Moreover, AP 811 effectively eliminates ANP-induced pump stimulation.
T70170	Milvexian TFA
	Milvexian, also known as BMS-986177 and JNJ-70033093, is a blood coagulation factor XIa inhibitor. Milvexian demonstrated good selectivity over plasma kallikreinKi = 44 nM (400-fold selective), and chymotrypsinKi = 35 nM (318-fold selective). At a dose of 1.5 mg/kg, Milvexian exhibited an overall exposure of 1215 nM/h, low clearance of 10.3 mL/min/kg, and oral bioavailability of 32%.
T60335	BTA-1
	BTA-1 是一种不带电的硫代黄素-T 衍生物。BTA-1 对 Aβ 原纤维具有高亲和力，并具有良好的脑进入和清除能力。
T36968	ARN-21934	Topoisomerase	DNA Damage/DNA Repair
	ARN-21934 是高选择性的人拓扑异构酶 II α 抑制剂，具有血脑屏障通透性。依托泊苷抑制 DNA 松弛的IC50为120 μM，ARN-21934 抑制 DNA 松弛的IC50为 2 μM。ARN-21934具有良好的体内药代动力学特性。
T37912	Furanone C-30
	Synthetic furanone bacterial quorum sensing inhibitor. Inhibits virulence factor expression in Pseudomonas aeruginosa and increases bacterial susceptibility to antibiotics in vitro. Also inhibits bacterial quorum sensing in vivo and promotes bacterial clearance in a mouse pulmonary infection model. Hentzer et al (2003) Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J. 22 3803 PMID:12881415
T40468	Arimoclomol citrate Arimoclomol citrate,BRX-220 citrate
	Arimoclomol citrate (BRX-220 citrate) is a heat shock protein (HSP) co-inducer that acts by enhancing Hsp expression and directly impacting protein aggregation, clearance of misfolded assemblies, and the proteasome-ubiquitin system. This compound is known for its ability to protect motor neurons.
T83451	14,15-Epoxyeicosatrienoic acid 14,15-EET
	14,15-Epoxyeicosatrienoic acid（14,15-EET）是花生四烯酸的代谢物，具有显著的体内抑制血小板聚集的作用。此外，它能促进星形胶质细胞清除Aβ，因而在老年痴呆症的研究中具有潜在应用价值。
T79017	GSK737	Epigenetic Reader Domain	Chromatin/Epigenetic
	GSK737作为BRD4BD1和BD2的抑制剂，其pIC50值分别为5.3和7.3。该化合物在大鼠体内展现出低清除率并且具有良好的溶解度与渗透性。
T61259	Valganciclovir
	Valganciclovir 是ganciclovir 的原药，具有抗巨细胞病毒CMV 感染的活性。
T10589L	BPN-15606	Others	Others
	BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. BPN-15606 has acceptable PK/PD properties, including bioavai
T63165	LX-039
	LX-039 是一种高效的、选择性的、口服具有活力的雌激素受体降解剂 (EC50: 2.99 nM)，具有抗肿瘤作用。LX-039 有吲哚 C-3 氯原子。LX-039 具有良好的小鼠药代动力学性质、低清除、高血药浓度和口服暴露率。
T83187	AChE-IN-41
	AChE-IN-41（Compound 2）是一种加兰他敏-美金刚杂交体化合物，能够抑制胆碱酯酶。在体外，该化合物展现出较高的血浆稳定性和良好的微粒体稳定性；而在体内，则具有较短的半衰期和较快的清除速率。
T36564	(S)-Acenocoumarol
	Acenocoumarol is a short-lived oral anti-coagulant, which, like warfarin, functions by inhibiting vitamin K epoxide reductase. It has higher intrinsic anticoagulant potency than warfarin and phenprocoumon, when evaluated in vitro. Acenocoumarol has a single chiral center that gives rise to two different enantiomeric forms. (S)-Acenocoumarol has a shorter plasma elimination half-life (1.8 hours) and faster plasma clearance (28.5 L/hour), compared to the (R)-enantiomer (6.6 hours, 1.9 L/hour). The...
T61983	Trichlormethiazide sodium
	Trichlormethiazide sodium 是口服有效的噻嗪类利尿剂，显示降压活性。在急性肾功能衰竭大鼠中，Trichlormethiazide sodium 可增加尿量、Na 和 K 排泄，并有改善肌酐清除率 (CCRE)。
T79438	c-Myc inhibitor 11	c-Myc	Cell Cycle/Checkpoint
	c-Myc inhibitor11（Compound 67e），一种c-MYC抑制剂（pEC50: 6.4），在大鼠药代动力学评估中表现出高清除率、中等体积分布和短半衰期，适用于癌症研究领域。
T78599	CK2-IN-9
	CK2-IN-9是一种有效的CK2 kinase选择性抑制剂，IC50值为3 nM。它能降低Wnt报告因子的活性，达到IC50为75 nM。在大鼠体内显示出低暴露量（AUC=0.36 μM/h）及高清除率（CL=65 mL/min/kg）。
T33766	OAB-14 OAB 14,OAB14
	OAB-14 是一种 Bexarotene 衍生物，通过清除 APP/PS1 转基因小鼠的 β-淀粉样蛋白，改善其阿尔茨海默病相关的病理学和认知障碍。OAB-14 可有效改善 APP/PS1 转基因小鼠内体自噬溶酶体（EAL）途径的功能障碍。
T79441	DprE1-IN-6
	DprE1-IN-6（Compound 56）是DprE1的一种抑制剂，对Mtb H37Rv菌株表现出抗结核活性（MIC: 4 μM），同时也对耐药分枝杆菌株有抗菌效果。该化合物具有较强的微粒体稳定性以及中等的清除速率。
T28449	Pradefovir ICN-2001-3,MB-6866,帕拉德福韦,ICN-20013,MB-06866,Remofovir	HBV	Microbiology/Virology
	Pradefovir (Remofovir) 是一种逆转录酶抑制剂，可能用于治疗慢性 HBV 感染。它也是阿德福韦的肝脏靶向前药。代谢激活后，它在人肝微粒体中转化为 PMEA(9-(2-膦酰基甲氧基乙基)腺嘌呤)，Km 为 60 microM，最大代谢速率为 228 pmol/min/mg 蛋白质，以及内在的清除率约为 359 ml/min。
T82993	AP 811 acetate
	AP 811 acetate是一款选择性的ANP-CR（即NPR3）拮抗剂，其Ki值为0.48 nM。该化合物对NPR3的选择性是对NPR1的两万倍。此外，AP 811 acetate能够消除ANP诱导的泵激活现象。
T65387	Paromomycin, sulfate (1:1)
	Paromomycin (Sulfate Salt) is an aminoglycoside that is active against Gram-negative and many Gram-positive bacteria as well as some protozoa and cestodes. Paromomycin in combination with sodium stibogluconate has proven to be effective in African and Indian VL (visceral leishmaniasis) and improves survival in African VL[3]. PS (Paromomycin Sulfate) is effective for elimination of B. coli without hematological side effects[4]. The activity of phosphoglucose isomerase was slightly inhibited by 10...
T81286	RG33 Peptide
	"RG33 Peptide 是抗 2 型糖尿病 (T2D) 的化合物，它显著增强了胰岛素抵抗小鼠的葡萄糖清除效率。此外，该肽还能高效溶解脂质囊泡，并在培养的巨噬细胞中促进胆固醇排泄。RG33 Peptide 主要用于 2 型糖尿病的研究领域。"

化合物

Cat.No: T31101

Synonym: CRT 0273750,CRT-0273750

Target: PDE

Arimoclomol maleate

Cat.No: T13554

Synonym: BRX-220

Target: HSP

Cat.No: T8364

Synonym: N-(3-溴-2,4,6-三甲基苯基甲酰甲基)乙酰乙酸,SQ 26962

Target: Others

Cat.No: TQ0239

Synonym: Glucagon receptor antagonists-4

Target: Glucagon Receptor

Cat.No: T13553

Synonym: 阿瑞洛莫,BRX-220 free base

Target: HSP

Cat.No: T30577

Synonym: BRD 0418,BRD-0418

Target: Others

Cat.No: T4398

Target: Beta Amyloid, Beta-Secretase, BACE, PI3K, Autophagy

Cat.No: T63056

Cat.No: T7295

Synonym: Ro63-8695,CPHPC,GSK2315698

Target: Others

2-Iodohippuric Acid

Cat.No: T50000

Target: Others

Cat.No: T9741

Target: Others

Cat.No: T3312

Synonym: AM2394

Target: Glucokinase

Cat.No: T5117

Target: Others

Cat.No: T1415

Synonym: 吉非罗齐,CI-719,Jezil,Decrelip,Lopid

Target: P450, Adrenergic Receptor, PPAR

Cat.No: T0920

Synonym: 氨溴索,氨溴索碱,Ambroxolum,NA-872

Target: P450, Autophagy

Cat.No: T35868

Cat.No: T16424

Target: p38 MAPK

Cat.No: T34662

Synonym: SMER-10,SMER 10

Cat.No: T25826

Synonym: MMV-024101,TCMDC 134293,TCMDC134293,TCMDC-134293,MMV 024101

Cat.No: T62850

Cat.No: T13667L

Synonym: SGX942

Target: Others

Cat.No: T40280

o-Iodohippurate sodium

Cat.No: T33785

Synonym: Hippodin,NSC-63351,Sodium iodohippurate NSC 63351,NSC63351

Dusquetide TFA (931395-42-5 free base)

Cat.No: T13667

Synonym: SGX942 TFA,Dusquetide TFA

Target: Others

Cat.No: T78744

Target: IRAK

Telmisartan Acyl-β-D-Glucuronide

Cat.No: T35865

Cat.No: T16113

Target: AMPK

Cat.No: T61136

Cat.No: T38641

Cat.No: T70170

Cat.No: T60335

Cat.No: T36968

Target: Topoisomerase

Cat.No: T37912

Arimoclomol citrate

Cat.No: T40468

Synonym: Arimoclomol citrate,BRX-220 citrate

14,15-Epoxyeicosatrienoic acid

Cat.No: T83451

Synonym: 14,15-EET

Cat.No: T79017

Target: Epigenetic Reader Domain

Cat.No: T61259

Cat.No: T10589L

Target: Others

Cat.No: T63165

Cat.No: T83187

(S)-Acenocoumarol

Cat.No: T36564

Trichlormethiazide sodium

Cat.No: T61983

c-Myc inhibitor 11

Cat.No: T79438

Target: c-Myc

Cat.No: T78599

Cat.No: T33766

Synonym: OAB 14,OAB14

Cat.No: T79441

Cat.No: T28449

Synonym: ICN-2001-3,MB-6866,帕拉德福韦,ICN-20013,MB-06866,Remofovir

Target: HBV

Cat.No: T82993

Paromomycin, sulfate (1:1)

Cat.No: T65387

Cat.No: T81286

Cat. No.	Product Name	Target	Signaling Pathways
TN1420	Bacopaside I	Others	Others
	Bacopaside I 是一种皂苷，分离自 Bacopa monniera 中，具有抗氧化活性和清除自由基的功能，有抗抑郁作用。
TL0007	Bisdemethoxycurcumin 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin	Epigenetic Reader Domain; Wnt/beta-catenin	Chromatin/Epigenetic; Cytoskeletal Signaling; Stem Cells
	Bisdemethoxycurcumin (Curcumin III) 是一种具有抗炎及抗氧化作用的姜黄素。
TN5880	Mesuol
	Mesuol has antioxidant activity, it shows very high scavenging activity against DPPH radical; it also has immunomodulatory activity, can potentiate percentage neutrophil adhesion in neutrophil adhesion test in rats and phagocytosis in carbon clearance assay. Mesuol can suppress HIV-1 replication in Jurkat T cells, it inhibits TNFα-induced HIV-1-LTR transcriptional activity by targeting the nuclear factor-κB (NF-κB) pathway.

天然产物

Cat.No: TN1420

Target: Others

Bisdemethoxycurcumin

Cat.No: TL0007

Synonym: 双去甲氧基姜黄素,Curcumin III,Didemethoxycurcumin

Target: Epigenetic Reader Domain, Wnt/beta-catenin

Cat.No: TN5880

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