37
17
Cat. No. | Product Name | Target | Signaling Pathways |
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T20540 |
N-Valyltryptophan
二肽-2,Val-trp,L-Valyl-L-tryptophan |
Others | Others |
N-Valyltryptophan (Val-trp) 是蛋白质分解代谢或蛋白质消化的不完全分解产物。 | |||
T68182L |
3-Hydroxykynurenamine HCl
3-OH-Kynurenamine HCl,3-Hydroxykynurenamine HCl(99362-47-7 Free base) |
Others | Others |
3-Hydroxykynurenamine HCl (3-OH-Kynurenamine HCl) 是一种免疫调节生物胺,是氨基酸分解代谢的中间体,可诱导氧化损伤和促进细胞死亡。 | |||
T8104 |
Glycyl-L-valine
|
Others; Endogenous Metabolite | Metabolism; Others |
Glycyl-L-valine 是含有甘氨酸和缬氨酸的二肽。 | |||
T38173 |
Propargylcholine
Propargylcholine (bromide) |
Antibacterial | Microbiology/Virology |
Propargylcholine (Propargylcholine (bromide)) 是一种炔烃修饰的胆碱类似物,在铜绿假单胞菌中 Dgc 酶催化的二甲基甘氨酸去甲基化水平上抑制胆碱分解代谢。 | |||
T4179 |
Probucol disuccinate
|
LDL | Metabolism |
Probucol disucinate 是一种 Probucol 的衍生物。其中 Probucol 是脂质调节的化合物,它能降低 LDL-cholesterol 水平。 | |||
T0128 |
Vigabatrin
Sabril,Vigabatrine,氨己烯酸 |
GABA Receptor; ABC | Membrane transporter/Ion channel; Neuroscience |
Vigabatrin (Sabril) 是 γ-氨基丁酸的类似物,是 4-氨基丁酸转氨酶的不可逆抑制剂,负责 γ-氨基丁酸分解代谢。它可用于可卡因依赖的治疗。 | |||
T10509 |
Xanthine oxidase-IN-1
4-(3-Cyano-5,6-difluoroindol-1-yl)-2-hydroxybenzoic acid |
Xanthine Oxidase | Metabolism |
Xanthine oxidase-IN-1是一种有效的黄嘌呤氧化酶抑制剂(IC50值:6.5 nM),是一种利用核酸和核苷酸介质降解产生的生物活性核苷酸在嘌呤分解代谢中起核心作用的化合物, | |||
T50094 |
DL-Willardiine
2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid |
Others | Others |
DL-Willardiine (2-amino-3-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid) 是一种非天然氨基酸,谷氨酸的衍生物。它是mGluR5的激动剂,可以调节参与神经递质合成和分解的酶的活性,并影响离子通道和其他膜蛋白的活性。 | |||
T4374 |
Edoxudine
依度尿苷,Aedurid,EUDR,Epoxudine,乙去氧尿啶 |
Antiviral; Antibacterial | Immunology/Inflammation; Microbiology/Virology |
Edoxudine (Epoxudine) 是胸苷的类似物,是一种抗病毒药物,对单纯疱疹病毒有效。 | |||
T1602 |
Valproic acid sodium salt
丙戊酸钠,Sodium Valproate |
Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy | Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells |
Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂,可抑制HDAC1的活性,诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。 | |||
T30128 |
Arginylphenylalanine
L-Arg-L-phe |
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Arginylphenylalanine, a dipeptide composed of arginine and phenylalanine, is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T29828 |
Alanyltyrosine
|
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Alanyltyrosine is a dipeptide composed of alanine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T30129 |
Arginylproline
Arg-pro |
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Arginylproline is a dipeptide composed of arginine and proline. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T33323 |
Methionyltryptophan
Met-trp,Methionyl-tryptophan,Methionyl tryptophan |
||
Methionyl-Tryptophan is a dipeptide composed of methionine and tryptophan. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T33083 |
Lysyl threonine
L-Threonine, l-lysyl-,Dipeptide-7,Dipeptide KT |
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Lysyl threonine is a dipeptide composed of lysine and threonine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T35032 |
Valyllysine
Val-lys,Valyl-lysine |
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Valyllysine is a dipeptide composed of valine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T31161 |
Cysteinyllysine
|
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Cysteinyllysine is a dipeptide composed of cysteine and lysine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T40932 |
Benzylacyclouridine
5-Benzylacyclouridine,BAU |
||
Benzylacyclouridine (BAU) is a powerful and selective inhibitor of uridine phosphorylase, the initial enzyme involved in uridine catabolism. Additionally, it can regulate the cytotoxic adverse effects of 5-fluorouracil (5-FU) and its derivatives. | |||
T31162 |
Cysteinyltyrosine
N-L-Cysteinyl-L-tyrosine,Cys-tyr |
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Cysteinyltyrosine is a dipeptide composed of cysteine and tyrosine. It is an incomplete breakdown product of protein digestion or protein catabolism. | |||
T36724 |
6,15-diketo-13,14-dihydro Prostaglandin F1α
6,15-diketo-13,14-dihydro Prostaglandin F1α |
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6,15-diketo-13,14-dihydro PGF1α is a metabolite of PGI2. It was shown to enhance intracellular cAMP and cholesterol catabolism in bovine arterial smooth muscle cells. | |||
T37809 |
Alphitonin
|
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Alphitonin is a flavonoid that has been found in L. leptolepis wood.1 It is also a metabolic intermediate that is formed during the catabolism of quercetin by the human gut bacteria E. ramulus.2,3 |1. Chen, K., Ohmura, W., Doi, S., et al. Termite feeding deterrent from Japanese larch wood. Bioresour. Technol. 95(2), 129-134 (2004).|2. Braune, A., Gütschow, M., Engst, W., et al. Degradation of quercetin and luteolin by Eubacterium ramulus. Appl. Environ. Microbiol. 67(12), 5558-55567 (2001).|3. J... | |||
T36842 |
Isobutyryl Coenzyme A (sodium salt)
|
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Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency. | |||
T0128L |
Vigabatrin Hydrochloride
盐酸氨己烯酸,γ-Vinyl-GABA hydrochloride |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) 是抑制性神经递质 GABA 乙烯基衍生物,不可逆地抑制 GABA 转氨酶对 GABA 的分解代谢,增加脑中 GABA 的水平。 | |||
T35886 |
L-hydroxy Arginine (acetate)
|
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L-hydroxy Arginine is a substrate for nitric oxide synthase in the catabolism of L-arginine to form nitric oxide. It has been used as a biomarker for reduced nitric oxide formation in patients with cardiovascular disease and metabolic syndrome. | |||
T74651 |
L-Inosine
|
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L-Inosine 是 L-构型形式的 Inosine。Inosine 是一种由腺苷分解代谢产生的内源性嘌呤核苷。Inosine 具有抗炎免疫调节,抗伤害和神经保护作用。 | |||
T33088 |
Lysylcysteine
LYS CYS,LYS-CYS,L-Cysteine, L-lysyl-,LYSCYS |
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Lysylcysteine is a dipeptide composed of lysine and cysteine. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived | |||
T34019 |
Phenylalanylglutamate
Phe-glu |
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Phenylalanylglutamate is a dipeptide composed of phenylalanine and glutamate. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are sim | |||
T33091 |
Lysyllysine
Lys-lys,L-Lys-L-lys |
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Lysyllysine is a dipeptide composed of two lysine residues. It is an incomplete breakdown product of protein digestion or protein catabolism. Some dipeptides are known to have physiological or cell-signaling effects although most are simply short-lived in | |||
T81233 | S-(p-Nitrobenzyl)glutathione | ||
S-(p-Nitrobenzyl)glutathione 是一种竞争性谷胱甘肽酶(GGT)抑制剂,能被大鼠肾微粒体转化成相应的半胱氨酸衍生物。该化合物用于研究谷胱甘肽酶系统中GSH的代谢及其降解过程。 | |||
T37755 |
Phenylacetyl-Coenzyme A (sodium salt)
|
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Phenylacetyl-coenzyme A (CoA) is a key intermediate in aerobic catabolism of phenylacetate in bacteria such asPseudomonas, when cultured in minimal media using phenylacetate as the sole carbon source.1It is a precursor in the synthesis of the antibiotic penicillin G found in industrial strains ofP. chrysogenum. Phenylacetyl-CoA also acts as an effector molecule of the TetR family transcriptional repressor PaaR inT. thermophilusand the GntR family transcriptional regulator PaaX inE. coliandPseudo... | |||
T17059 |
Tetrahydrouridine
NSC 112907,NSC112907,四氢尿苷,NSC-112907 |
DNA Methyltransferase | Chromatin/Epigenetic |
Tetrahydrouridine (NSC-112907; THU) 是一种多药耐药调节剂。它可用于癌症治疗,使肿瘤细胞对放射治疗更加敏感。 它是一种竞争性胞苷脱氨酶 (CDA) 抑制剂,可抑制 ara-C 和吉西他滨等细胞毒性脱氧胞苷类似物分解代谢中的脱氨作用。 | |||
T60348 |
N1,N11-Diethylnorspermine
|
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N1,N11-Diethylnorspermine (DENSPM) 是一种有效的抗癌剂。N1,N11-Diethylnorspermine 是一种精胺类似物,可激活多胺分解代谢。N1,N11-Diethylnorspermine 诱导细胞色素 c 从线粒体中释放,导致 caspase 3的激活。N1,N11-Diethylnorspermine 通过诱导亚精胺/精胺 N1- 乙酰转移酶 (SSAT) 结合产生过氧化氢杀灭多形胶质母细胞瘤 (GBM) 细胞。 | |||
T36921 |
16α-Hydroxyetiocholanolone
|
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16α-Hydroxyetiocholanolone is a metabolite of 16α-hydroxydehydroisoandrosterone (16α-DHEA) and androstenedione.1,2 1.Lai, E.Y., and Solomon, S.The in vivo metabolism of 16ɑ-hydroxydehydroisoandrosterone in manBiochemistry6(7)2040-2052(1967) 2.Christakoudi, S., Cowan, D.A., Christakudis, G., et al.21-hydroxylase deficiency in the neonate - trends in steroid anabolism and catabolism during the first weeks of lifeJ. Steroid Biochem. Mol. Biol.138334-347(2013) | |||
T37354 |
CAY10680
CAY10680 |
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CAY10680 is a dopamine-sparing, benzothiazinone compound that selectively inhibits both MAO-B activity (IC50 = 34.9 nM in human) and adenosine A2A receptors (Ki = 39.5 nM in human). It demonstrates significantly less potent inhibitory values for other adenosine receptor subtypes (Kis > 1 μM) and MAO-A (IC50 ≥ 10 μM). At 1-20 μM, CAY10680 has been shown to abolish cAMP accumulation in CHO cells transfected with adenosine A2A receptors. In the central nervous system adenosine A2A receptor expressi... | |||
T79358 |
PF-07247685
|
Endogenous Metabolite | Metabolism |
PF-07247685是一种BCKDC激酶(BDK)抑制剂,具有较强的活性(EC50=2.2 nM)。该化合物能有效稳定BDK与BCKDH E2核心亚基之间的相互作用,并阻断E1亚基的磷酸化过程。BCKDH的活性受到BDK介导的磷酸化调控,从而控制支链氨基酸(BCAA)降解的关键步骤。BCAA的代谢失调与心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖等多种疾病相关联,尤其在心脏代谢疾病中表现明显。PF-07247685在小鼠模型中对心脏代谢终点产生改善效果,并提升了葡萄糖耐量。 | |||
T79357 |
PF-07238025
|
Endogenous Metabolite | Metabolism |
PF-07238025是一种BCKDC激酶(BDK)抑制剂,具有EC50值为19 nM。它通过稳定BDK和BCKDH复合体中的E2亚基相互作用,阻碍E1亚基的磷酸化过程,从而抑制了BCKDH的活性。由于BDK的磷酸化作用是控制支链氨基酸(BCAA)降解过程中的限速步骤,PF-07238025的作用与包括心力衰竭(HF)、2型糖尿病(T2DM)、非酒精性脂肪肝病(NAFLD)及肥胖在内的多种代谢性疾病的发病机制相关。研究显示PF-07238025能在小鼠体内改善心脏代谢指标并提升葡萄糖耐量。 | |||
T35890 |
Pentosidine
|
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Advanced glycation end products (AGEs) are compounds formed by non-enzymatic chemical reactions following the bonding of sugars to proteins or lipids during diabetes, uremia, aging, rheumatic arthritis, and other conditions. A receptor for the AGEs (RAGE) binds certain members of this class to initiate cell signaling.[1][2] Pentosidine is a well-characterized natural AGE that is often used as a biomarker for the production of all AGEs. While pentosidine can be measured in urine, the majority of ... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T2934 |
Bilirubin
胆红素,Bilibubin,Principal bile pigment,Hematoidin,Hemetoidin |
Endogenous Metabolite | Metabolism |
Bilirubin (Principal bile pigment) 是血红素分解代谢产生的黄色产物,是肝功能的重要指标。Bilirubin 具有抗诱变和抗氧化作用。 | |||
T7357 |
(S)-b-aminoisobutyric acid
|
Endogenous Metabolite | Metabolism |
(S)-b-aminoisobutyric acid 是由胸腺嘧啶和缬氨酸分解代谢得到的非蛋白质氨基酸。 | |||
T0738 |
Urea
尿素,Ureophil,Carbamide,E-Cardamoni,Carbonyldiamide |
Others; DHFR; Wnt/beta-catenin; Arginase; Endogenous Metabolite; Carbonic Anhydrase | Cell Cycle/Checkpoint; Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Others; Stem Cells |
Urea (Carbonyldiamide) 在肝脏中由氨基酸脱氨产生的氨形成。它是蛋白质分解代谢的主要终代谢产物。 | |||
T4813 |
L-Citrulline
|
Endogenous Metabolite | Metabolism |
L-Citrulline 是一种氨基酸,源自于精氨酸-瓜氨酸途径获得的 l-精氨酸,或脯氨酸、谷氨酰胺和谷氨酸盐的分解代谢过程中产生的鸟氨酸。 | |||
T40490 |
Phenylalanylalanine
H-Phe-Ala-OH,苯并氨酰丙氨酸 |
Others | Others |
Phenylalanylalanine(H-Phe-Ala-OH)是由苯丙氨酸和丙氨酸融合形成的二肽。它在蛋白质的不完全消化或分解过程中形成[1]。 | |||
T5253 |
3-Methyladipic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
3-Methyladipic acid 是 ω 氧化途径的终产物。它是植烷酸分解代谢的代谢物。 | |||
T0626 |
Uric Acid
尿酸,2,6,8-Trioxopurine,2,6,8-Trioxypurine,2,6,8-Trihydroxypurine,Lithic acid,Urate |
Reactive Oxygen Species; Endogenous Metabolite; Phosphorylase | Immunology/Inflammation; Metabolism; NF-κB |
Uric Acid (Lithic acid) 是一种重要的抗氧化剂。Uric acid 能清除活性氧(ROS) ,如单线态氧和过氧亚硝酸盐,抑制脂质过氧化。Uric acid 有助于维持血压的稳定和抗氧化应激。 | |||
T19384 |
Isovalerylcarnitine
|
Apoptosis; Cysteine Protease | Apoptosis; Proteases/Proteasome |
Isovalerylcarnitine (3-methylbutyrylcarnitine) 是 L-亮氨酸分解代谢和异戊酸的积累产生的小分子化合物,也是一种具有选择性和有效性的钙蛋白酶 (calpain) 激活剂,可促使细胞凋亡,与异戊酸血症有关,可作为异戊酸血症的标志。 | |||
T4904 |
1-Methylguanidine hydrochloride
|
Others; Endogenous Metabolite | Metabolism; Others |
1-Methylguanidine hydrochloride 是内源性代谢产物的一种。 | |||
TWA2417 |
Sodium taurocholate
牛黄胆酸钠(牛胆酸钠,牛胆酸钠盐,牛磺膽酸鈉,牛磺胆酸钠,牛磺胆酸钠盐,牛胆酸钠水合物,水合牛磺胆酸钠,牛胆酸钠(混合物),牛黄胆酸钠(水合),牛磺胆酸钠(标准品)),Taurocholate Sodium |
Others | Others |
Sodium taurocholate (Taurocholate Sodium) hydrate 具有显著的生物学效应,例如通过上调 VEGF-A 的表达抑制肝动脉结扎所致的胆道损伤。对免疫系统具有一定的调节作用。 | |||
T5245 |
N-Isovaleroylglycine
N-异戊酰氨基乙酸,Isovaleroylglycine,N-Isovalerylglycine |
Others; Endogenous Metabolite | Metabolism; Others |
N-Isovaleroylglycine (Isovaleroylglycine) 是酰基甘氨酸,能够作为体重提高和肥胖的生物标记物。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T4909 |
N-Acetyl-DL-methionine
N-乙酰-DL-蛋氨酸,N-乙酰-DL-甲硫氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-DL-methionine 是内源性代谢产物的一种。 | |||
T5089 |
5-Aminovaleric acid
|
Others; Endogenous Metabolite | Metabolism; Others |
5-Aminovaleric acid 被认为是 GABA 的亚甲基同系物,是GABA 的弱激动剂。它是赖氨酸降解产物。 它既能够内源性产生,也能够通过赖氨酸的细菌分解代谢产生。 | |||
T4858 |
4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid |
Endogenous Metabolite | Metabolism |
4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物,是一种酶抑制剂。 | |||
T20555 |
Glycyltyrosine
NSC 118362,Gly Tyr,NSC-118362,Gly-Tyr,NSC118362,N-Glycyl-L-tyrosine |
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Glycyltyrosine, a dipeptide composed of tyrosine and glycine, is an incomplete breakdown product of protein catabolism or protein digestion. | |||
T36563 |
(E)-Guggulsterone
|
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Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... |