53
8
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T15545 |
ICA-27243
|
Potassium Channel | Membrane transporter/Ion channel |
ICA-27243 是选择性的,口服有效的 KCNQ2/Q3钾通道开放剂,EC50为 0.38 μM。对 KCNQ4 和 KCNQ3/Q5 的激活效果较差。它具有抗惊厥和抗癫痫作用。 | |||
T3563 |
Lvguidingan
|
Others | Others |
Lvguidingan 是一种抗惊厥药。 | |||
T1052 |
Proglumide
二丙谷酰胺 |
cholecystokinin | GPCR/G Protein |
Proglumide (Binoside) 是一种非肽的、口服具有活性的胆囊收缩素(CCK)-A/B 受体拮抗剂。它能够选择性阻断 CCK 在中枢神经系统中的作用。它能够抑制胃分泌,具有保护胃十二指肠粘膜的能力,并表现出抗癫痫和抗氧化活性。 | |||
T8937 |
Soticlestat
TAK-935,OV935 |
P450 | Metabolism |
Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。 | |||
T0939 |
Phenytoin
苯妥英,Diphenylhydantoin,5,5-Diphenylhydantoin |
Virus Protease; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Phenytoin (5,5-Diphenylhydantoin) 是一种有效的电压门控钠离子通道阻滞剂,可减少小鼠乳腺肿瘤的生长和转移,具有抗癫痫活性。 | |||
T0192 |
Levetiracetam
左乙拉西坦,UCB L059,SIB-S1 |
DNA Methyltransferase; Others; Calcium Channel | Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; Others |
Levetiracetam (SIB-S1) 是一种化学增敏剂,增强 Temozolomide 对胶质母细胞瘤干细胞增殖和凋亡的影响。它调节 HDAC 水平,最终使 MGMT 沉默从而提高 Temozolomide 的有效性。它是一种抗癫痫药,可结合突触小泡蛋白 SV2A。 | |||
T0008 |
Phenytoin sodium
5,5-Diphenylhydantoin sodium salt,Diphantoine,苯妥英钠,Dilantin sodium,Diphenylhydantoin Sodium |
Virus Protease; Sodium Channel | Membrane transporter/Ion channel; Microbiology/Virology |
Phenytoin sodium (Diphantoine) 是一种有效的电压门控钠离子通道阻滞剂,可减少小鼠乳腺肿瘤的生长和转移,具有抗癫痫活性。 | |||
T0128L |
Vigabatrin Hydrochloride
盐酸氨己烯酸,γ-Vinyl-GABA hydrochloride |
GABA Receptor | Membrane transporter/Ion channel; Neuroscience |
Vigabatrin Hydrochloride (γ-Vinyl-GABA hydrochloride) 是抑制性神经递质 GABA 乙烯基衍生物,不可逆地抑制 GABA 转氨酶对 GABA 的分解代谢,增加脑中 GABA 的水平。 | |||
T16427 |
Padsevonil
UCB-0942 |
Others | Others |
Padsevonil is an effective antiepileptic compound. | |||
T11278 |
FG8119
NNC13-8119 |
Others | Others |
FG8119 是一种新型苯二氮卓 (benzodiazepine) 激动剂,具有潜在的抗惊厥和抗癫痫活性,可用于研究神经系统疾病。 | |||
T14863 |
Carabersat
SB 204269 |
Others | Others |
Carabersat (SB 204269)是一种新型有效的抗惊厥和抗癫痫试剂。 | |||
T0628 |
Iminodibenzyl
|
Others | Others |
Iminodibenzyl 用作抗癫痫药carbamazepine 的中间体。 | |||
T0283 |
Trimethadione
三甲双酮,3,5,5,-Trimethyloxazolidine-2,4-dione |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Trimethadione (3,5,5,-Trimethyloxazolidine-2,4-dione) 是恶唑烷二酮类抗惊厥剂,也是一种 T 型钙通道阻滞剂,具有抗痛觉过敏作用,可用于研究失神发作。 | |||
T31354 |
Decimemide
V 285,V-285,V285 |
Others | Others |
Decimemide (V-285)是一种烷氧基苯甲酸衍生物,具有抗癫痫活性和潜在的抗惊厥活性,可用研究神经系统疾病。 | |||
T28655 |
Sabeluzole
R 58735,R58735,R-58735 |
Microtubule Associated | Cytoskeletal Signaling |
Sabeluzole (R-58735) 具有抗癫痫和增强认知的作用,抑制神经毒素诱导的tau表达和细胞死亡。Sabeluzole 对氯氮卓诱导的习惯障碍有保护作用,可用于研究阿尔茨海默症。 | |||
T0028 |
Gamibetal
3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid |
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸,对癫痫具有潜在的研究价值。 | |||
T16960 |
Sultiame
|
Others; Carbonic Anhydrase | Metabolism; Others |
Sultiame 是一种碳酸酐酶抑制剂。 Sultiame 可用于抗癫痫研究。 | |||
T73586 |
Anticonvulsant agent 2
|
Others | Others |
Anticonvulsant agent 2 是一种有效的口服活性抗惊厥剂,在耐药性癫痫模型中显示出抗癫痫活性。 | |||
TNU0187 |
2',5-Difluoro-2'-deoxy-1-arabinosyluracil
2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine |
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2',5-Difluoro-2'-deoxy-1-arabinosyluracil (2'-Deoxy-2'-fluoro-5-fluoro-arabinouridine) 是一种尿嘧啶核苷类似物,具有潜在的抗癫痫活性和降压活性,可用于研究抗惊厥和焦虑症。 | |||
T3562 |
Valrocemide
TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺 |
Others | Others |
Valrocemide (TV1901) 是有前景的抗癫痫候选药物,具有广泛的抗惊厥特性。 | |||
T22171 |
WWL123
|
MAGL | Metabolism |
WWL123 是一种有效的选择性 ABHD6 抑制剂,IC50 为 430 nM。WWL123 可穿过血脑屏障并抑制脑实质中的 ABHD6。WWL123 阻断 ABHD6 在 Pentylenetetrazole (PTZ)诱导的 R6/2 小鼠癫痫样发作和自发性癫痫发作中发挥抗癫痫作用。 | |||
T6474 |
Divalproex Sodium
Valproate semisodium,Epival,双丙戊酸钠 |
HDAC | Chromatin/Epigenetic; DNA Damage/DNA Repair |
Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶,其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成,具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。 | |||
T23651 |
AF-CX 921XX
AF-CX 921,AF-CX-921-XX |
||
AF-CX 921XX is an antiepileptic agent. | |||
T30848 |
CGP-47292
CGP 47,292,UNII-266244C47B,CGP 47292 |
||
CGP-47292 is a metabolite of the novel antiepileptic compound CGP 33,101. | |||
T23567 | Zonisamide sodium | Others | Others |
Zonisamide sodium is a 1,2 benzisoxazole derivative. It is the first agent of this chemical class to be developed as an antiepileptic drug. | |||
T30748 |
Carisbamate
JNJ10234094,JNJ-10234094,RWJ 333369,RWJ-333369,RWJ333369 |
||
CarisbAMate (JNJ-10234094, RWJ 333369, YKP-509) is an antiepileptic drug candidate. | |||
T24958 |
(R)-Licarbazepine Acetate
BIA2-059,Licarbazepine acetate, (R)-,BIA 2-059,BIA-2-059 |
||
(R)-Licarbazepine Acetate is a hopeful antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. | |||
T12544 | Proglumide hemicalcium | Others | Others |
Proglumide hemicalcium is a antagonist of nonpeptide and orally active cholecystokinin (CCK)-A/B receptors, has antiepileptic and antioxidant activities. | |||
T26017 |
R 57720
R57720,R-57720 |
||
R 57720 is an antiepileptic agent. | |||
T13185 |
Topiramate D12
RWJ 17021 D12,McN 4853 D12 |
Others | Others |
Topiramate D12 is a deuterium labeled Topiramate. Topiramate is an agent of broad-spectrum antiepileptic. Topiramate is an antagonist of GluR5 receptor. | |||
T14281 |
Becampanel
AMP 397 |
Others | Others |
Becampanel (AMP397) is the first competitive AMPA antagonist. Becampanel (AMP397) also is an antiepileptic agent. | |||
T23986 |
Dezinamide
ADD94057,ADD-94057,ADD 94057 |
||
Dezinamide is a potential antiepileptic drug. It shows preliminary evidence of efficacy and safety in an open-label study. | |||
T61145 | Topiramate lithium | ||
Topiramate lithium (McN 4853) is a wide-ranging antiepileptic compound with GluR5 receptor antagonistic properties. Its mechanism of action involves enhancing GABAergic activity, inhibiting kainate/AMPA receptors, voltage-sensitive sodium and calcium channels, and increasing potassium conductance. Additionally, this compound inhibits carbonic anhydrase. [1][2][3] | |||
T16869 |
Seletracetam
Ucb 44212 |
Others | Others |
Seletracetam is an analog of the antiepileptic agent Levetiracetam. Seletracetam is a small molecule SV2A modulator for the research of epilepsy. | |||
T39708 |
Loreclezole hydrochloride
R 72063 hydrochloride,Loreclezole hydrochloride |
||
Loreclezole hydrochloride, an antiepileptic compound, functions as a selective modulator of GABA A receptors. Specifically, it acts as a positive allosteric modulator on receptors containing β2 or β3-subunits. | |||
T39428 |
Seletracetam lithium bromide
Ucb 44212 lithium bromide |
||
Seletracetam (Ucb 44212) lithium bromide is a SV2A modulator, intended for epilepsy research. It is an analog of Levetiracetam, an antiepileptic agent. | |||
TP1810 |
Somatostatin-25
|
||
Somatostatin is an endogenous neuropeptide hormone found in the brain and pancreas. Somatostatin binds several isoforms of the somatostatin receptor, exhibiting anxiolytic, antiepileptic/anticonvulsant, and anorexigenic activities. | |||
T75079 | 5’(R)-C-Methyl-5-fluorouridine | ||
5’(R)-C-Methyl-5-fluorouridine 是尿嘧啶核苷类似物,具有潜在抗癫痫能力。该类似物用于研究抗惊厥和抗焦虑活性,进而开发新型降压药物。 | |||
T75237 | N3-[(Pyrid-4-yl)methyl]uridine | ||
N3-[(Pyrid-4-yl)methyl]uridine 是尿嘧啶核苷类似物,潜在拥有抗癫痫作用。此类似物适用于探究抗惊厥和抗焦虑活性,进而用于开发新型降压药物。 | |||
T75080 | 2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine | ||
2’-Deoxy-2’-fluoro-N3-[(pyrid-2-yl)methyl]uridine 为一种尿嘧啶核苷类似体,具备潜在抗癫痫效用。此类似物适用于探究抗惊厥与抗焦虑活性,并用于开发新型降压药物。 | |||
T15818 |
LY367385
|
FXR | Metabolism |
LY367385 is a highly effective and selective mGluR1a antagonist. LY367385 has neuroprotective, anticonvulsant, and antiepileptic effects. Compared with > 100 μM for mGlu5a, LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis. | |||
T60355 | LY367385 hydrochloride | ||
LY367385 hydrochloride 是一种高效且选择性的mGluR1a 拮抗剂,抑制喹喹啉诱导的磷酸肌醇水解的IC50值为 8.8 μM,而对 mGlu5a 的IC50值大于 100 μM。LY367385 hydrochloride 具有神经保护,抗惊厥和抗癫痫作用。 | |||
T75233 | N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine | ||
N3-(2S)-[2-(tert-Butoxycarbonyl)amino-3-(tert-butoxy carbonyl)]propyluridine是一种尿嘧啶核苷类似物,具有潜在的抗癫痫作用。这种类似物可用于抗惊厥和抗焦虑活性的研究,以及新型降压剂的开发。 | |||
T37149 |
Carbamazepine 10,11-epoxide
|
Others | Others |
Carbamazepine 10,11-epoxide 是抗惊厥药卡马西平 (carbamazepine) 的活性代谢物。它由卡马西平通过微粒体中的细胞色素 P450 (CYP) 同种型 CYP3A4 和 CYP2C8 形成,微粒体分别由表达 CYP3A4 或 CYP2C8 的 HepG2 细胞制备。它对小鼠电击诱发的癫痫发作具有抗惊厥活性。 | |||
T61086 | HN37 | ||
HN37 是有效且稳定的抗癫痫活性的化合物,其对KCNQ2的EC50值为 37 nM。 | |||
T75232 | 2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine | ||
2’-O-Acetyl-5’-O-benzoyl-3’-O-(2-methoxyethyl) uridine 是一种具有抗癫痫潜能的尿嘧啶核苷类似物。其不仅用于研究抗惊厥和抗焦虑活性,也用于开发新型降压药物。 | |||
T16948 |
Suclofenide
PB385,Neosulfalepsine,琥氯非尼 |
Others | Others |
Suclofenide 是一种苯磺酰胺衍生物,可作为抗惊厥和抗癫痫剂。在临床前模型中,它对小鼠电击和戊四唑诱导的惊厥表现出强大的抗惊厥活性。亚致死毒性表现为嗜睡、肌阵挛抽搐和腹泻。 | |||
T25455L |
Glutaurine aceate
|
Thyroid hormone receptor(THR) | Endocrinology/Hormones |
含有谷氨酰胺和牛磺酸残基的 Glutaurine aceate 是甲状旁腺的一种口服活性激素。Glutaurine 作为一种激素,从甲状旁腺嗜氧细胞中分离出来。Glutaurine 可用于抗癫痫和抗遗忘的研究。 | |||
T77991 |
Glutaurine TFA
Litoralon TFA |
||
Glutaurine (Litoralon) TFA,含谷氨酰胺与牛磺酸残基,为甲状旁腺源嗜氧细胞分离的口服活性激素。该化合物在抗癫痫与抗健忘症研究中有应用。 | |||
T60492 |
Lamotrigine hydrate
|
||
Lamotrigine hydrate 是口服有效的抗惊厥剂或抗癫痫剂 ,通过选择性地阻断电压门控Na+通道,稳定突触前神经元膜并抑制谷氨酸释放。Lamotrigine hydrate 可用于研究癫痫、局灶性癫痫等神经性疾病。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10147 |
4-Hydroxymephenytoin
(+/-)-4'-Hydroxymephenytoin |
Others; Drug Metabolite | Metabolism; Others |
4-Hydroxymephenytoin ((+/-)-4'-Hydroxymephenytoin) 是抗癫痫药 mephenytoin 的代谢产物。Mephenytoin 是 CYP2C19的配体。 | |||
T7024 |
Qingyangshengenin
青阳参甙元,Qingyangshengenin A,Cynanchagenin |
Others | Others |
Qingyangshengenin (Cynanchagenin) 是一种孕烷糖苷,是一种分离自Cychuchumot ophyllum(Asclepiadaceae) 的根中的 C21 类固醇糖苷配基。它具有抗癌作用。 | |||
T3003 |
5-hydroxytryptophan
5-羟基色氨酸,NSC-92523 |
Others; Endogenous Metabolite | Metabolism; Others |
5-hydroxytryptophan (NSC-92523) 是色氨酸的代谢物,是5-羟色胺直接的前体,是芳香氨基酸脱羧酶底物。 | |||
T1379 |
L-5-Hydroxytryptophan
5-羟基色氨酸,L-oxitriptan,Oxitriptan,L-5-HTP |
Amino Acids and Derivatives; Endogenous Metabolite | Metabolism |
L-5-Hydroxytryptophan (L-5-HTP) 是一种天然氨基酸和膳食补充剂,可以用作抗抑郁剂、食欲抑制剂和睡眠辅助剂,是神经递质血清素的前体,是利血平(reserpine) 的拮抗剂。它能够用于肌阵挛、纤维肌痛症、偏头痛和小脑共济失调的研究。 | |||
T2S1814 |
p-Hydroxybenzaldehyde
4-Formylphenol,4-羟基苯甲醛;对羟基苯甲醛,4-hydroxybenzaldehyde,对羟基苯甲醛,p-Oxybenzaldehyde |
Transaminase; GABA Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
p-Hydroxybenzaldehyde (p-Oxybenzaldehyde) 是从天麻中提取的一种天然产物,对 GABA 转氨酶有抑制作用,有助于抗癫痫和抗惊厥活性。 | |||
TMS1461 |
Qingyangshengenin B
青阳参甙元B,青阳参苷元B,Otophylloside B |
Beta Amyloid | Neuroscience |
Qingyangshengenin B (Otophylloside B) 是一种分离自 Qingyangshen 的 C-21 甾体苷。它能够在 mRNA 水平上抑制 Aβ 的表达来减少 Aβ 的沉积,对 Aβ 的毒性有保护作用。它具有抗癫痫作用。 | |||
T2768 |
Saikosaponin A
柴胡皂苷A,柴胡皂苷 A |
NF-κB; Antibacterial; Liver X Receptor | Metabolism; Microbiology/Virology; NF-κB |
Saikosaponin A 是银柴胡中的主要活性成分,有抗炎活性,可上调 LXRα的表达。 | |||
T3S1416 |
Decursin
Decursinol angelate,前胡素,(+)-Decursin,紫花前胡素 |
Apoptosis; PKC | Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling |
Decursin (Decursinol angelate) 是一种细胞毒性剂,是一种来自朝鲜当归根的有效蛋白激酶 C 激活剂。它通过 Hippo/YAP 信号通路抑制 HepG2 细胞的生长。它通过下调 CXCR7 表达来抑制胃癌中的肿瘤生长,迁移和侵袭。 |