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Cat. No.	Product Name	Target	Signaling Pathways
T6351	MGCD-265 analog MGCD-265,Glesatinib	Apoptosis; VEGFR; c-Met/HGFR	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	MGCD-265 analog (Glesatinib) 是一种口服生物可利用的多靶点酪氨酸激酶抑制剂，具有抗肿瘤活性，对 c-Met 和 VEGFR2 的 IC50 分别为 29 nM 和 10 nM。
T23127	PD-161570 PD 161570	EGFR; FGFR; PDGFR; Src	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PD-161570 是一种有效的 ATP 竞争性人 FGF-1 受体抑制剂，IC50 为 39.9 nM，Ki 为 42 nM。它还是骨形态发生蛋白 (BMPs) 和TGF-β信号抑制剂。它抑制PDGF 刺激的自磷酸化和FGF-1受体磷酸化，IC50分别为 450 和 622 nM。它抑制 PDGFR、EGFR 和 c-Src 酪氨酸激酶，IC50 值分别为 310、240 和 44 nM。
T8491	Vorolanib CM082,X-82	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Vorolanib (X-82) 是一种有效的 ATP 结合盒 (ABC) 转运蛋白抑制剂，是一种有效的、具有口服活性的 VEGFR/PDGFR 抑制剂，是一种血管生成抑制剂，与 ZD1839 联用具有抗肿瘤作用。
T13238	Tyrphostin AG1433 SU1433,AG1433	VEGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Tyrphostin AG1433 (AG1433) 是选择性的PDGFRβ和VEGFR-2 (Flk-1/KDR)抑制剂，IC50分别为 5.0 μM 和 9.3 μM。Tyrphostin AG1433有防止血管形成的活性。
T2586	Cabozantinib 卡博替尼,XL184,BMS-907351	Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂，可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
T5164	Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼	VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂，可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4（IC50：0.035、1.3、4.6、7 和 6 nM）。
T3980	Su1498 Tyrphostin SU 1498,AG 1498	VEGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Su1498 (Tyrphostin SU 1498) 是一种选择性的 VEGFR2 抑制剂，能够抑制 Flk-1 (IC50:700 nM)。
T1895	SKLB 610	VEGFR; FGFR; PDGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	SKLB 610 是一种新型多靶点抑制剂，在生化激酶测定中，浓度为 10 μM 时，对血管生成相关酪氨酸激酶 VEGFR2、FGFR2 和 PDGFR 的抑制率分别为 97%、65% 和 55%。
T2288	Motesanib AMG 706,莫特塞尼,莫替沙尼	VEGFR; c-Kit	Angiogenesis; Tyrosine Kinase/Adaptors
	Motesanib (AMG 706) 是有效的、ATP 竞争性的 VEGFR1/2/3 的抑制剂，其IC50值为 2 nM/3 nM/6 nM，与对 Kit 的选择性相似，是 PDGFR 和 Ret 的 10 倍多。
T79860	TIE-2/VEGFR-2 kinase-IN-5	VEGFR; Tie-2	Angiogenesis; Tyrosine Kinase/Adaptors
	TIE-2/VEGFR-2 kinase-IN-5 是一种高效的 TIE-2 和 VEGFR-2 酪氨酸激酶受体抑制剂，具有的抗血管生成活性，常用于血管生成相关的生物医学研究领域。
T3211	Midostaurin 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Midostaurin (PKC412) 是一种多靶点蛋白激酶抑制剂，有抗肿瘤活性，对 PKCα/β/γ、Syk、Flk-1、Akt、PKA、c-Kit、c-Fgr、c-Src、FLT3、PDFRβ和VEGFR1/2的IC50值范围为 22 到500 nM 之间。
T4235	Roblitinib FGF-401	FGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Roblitinib (FGF-401) 是一种口服有效的，高选择性的FGFR4抑制剂(IC50:1.9 nM)，具有抗癌作用。
T6517	Golvatinib E-7050,戈伐替尼	VEGFR; c-Met/HGFR	Angiogenesis; Tyrosine Kinase/Adaptors
	Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。
T0097L	Pazopanib 帕唑帕尼,GW786034	VEGFR; FGFR; PDGFR; c-Kit; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Pazopanib (GW786034) 是一种小分子抑制剂，可抑制多种具有潜在抗肿瘤活性的蛋白酪氨酸激酶。它抑制VEGFR1、VEGFR2、VEGFR3、PDGFRβ、c-Kit、FGFR1和c-Fms 的IC50分别为10、30、47、84、74、140和146 nM。
T2576	Brivanib (alaninate) 丙氨酸布立尼布,BMS-582664,Brivanib Alaninate	VEGFR; FGFR; Autophagy	Angiogenesis; Autophagy; Tyrosine Kinase/Adaptors
	Brivanib Alaninate (BMS-582664) 是一种血管内皮生长因子受体 2 (VEGFR2) 抑制剂的丙氨酸盐，IC50值为 25 nM，具有潜在的抗肿瘤活性。它对 VEGFR1 和 FGFR1 适度抑制，对 VEGFR2 的选择性是对 PDGFRβ 的 240 倍。
T63505	Tivozanib hydrochloride hydrate
	Tivozanib hydrochloride hydrate 是选择性的、有效的、口服具有活力的 VEGFR 酪氨酸激酶抑制剂，能够作用于 VEGFR-1 (IC50: 0.21 nM)、VEGFR-2 (IC50: 0.16 nM)、VEGFR-3 (IC50: 0.24 nM)。Tivozanib hydrochloride hydrate 能够抑制肿瘤组织中的血管生成和血管通透性，并具有抗肿瘤作用，对转移性肾细胞癌 (RCC) 具有研究潜力。
T27417	Glutathione arsenoxide GSAO
	Glutathione arsenoxide is a hydrophilic derivative of phenylarsine oxide (PAO), a protein tyrosine phosphatase inhibitor. Glutathione arsenoxide inhibits angiogenesis and tumour growth.
T71441	Glutathione palmitamide
	Glutathione palmitamide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T69992	Glutathione sodium
	Glutathione sodium is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T70331	Glutathione sulfonate
	Glutathione sulfonate is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T68833	Glutathione sulfinanilide
	Glutathione sulfinanilide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T70602	Glutathione glycylethyl ester
	Glutathione glycylethyl ester is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T23660	AG1433 Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433
	AG1433 is a tyrosine kinases inhibitor that acts as a direct and selective inhibitor of photosynthetic PEP carboxylase and an inhibitor of PDGFR-β, Flk-1, and angiogenesis.
T68202	Glutathione diethyl ester
	Glutathione diethyl ester is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T70831	Glutathione maleimide
	Glutathione maleimide is a hydrophilic derivative of the protein tyrosine phosphatase inhibitor phenylarsine oxide (PAO). It inhibits angiogenesis and tumour growth.
T2500L	Cediranib maleate AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171
	Cediranib is a potent and selective inhibitor of VEGF with antineoplastic activities. It inhibits all three vascular endothelial growth factor receptor (VEGF-1,-2,-3) tyrosine kinases, thereby blocking VEGF-signaling, angiogenesis, and tumor cell growth.
T80870	VE-PTP-IN-1
	VE-PTP-IN-1 (compound 2) 为一种选择性VE-PTP抑制剂，呈弱酸性，涉及调控血管稳态及血管生成。
T71576	SIM010603
	SIM010603 is a structurally novel, oral, multi-targeted receptor tyrosine kinase inhibitor. SIM010603 inhibited stem cell factor receptor (Kit), vascular endothelial growth factor receptor-2 (VEGFR-2), platelet-derived growth factor receptor-β (PDGFR-β), glial cell line-derived neurotrophic factor receptor (Rearranged during Transfection; RET), and Fms-like tyrosine kinase-3 (FLT3) with IC(50) values between 5.0 and 68.1 nmol/l. SIM010603 inhibited the phosphorylation of PDGFR-β and VEGFR-2. Mor...
T68546	PF-00337210
	PF-00337210 is an orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may even...
T37079	VEGFR2 Kinase Inhibitor II
	Vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR and FLK1) is a receptor tyrosine kinase that regulates angiogenesis, vascular development, and embryonic hematopoiesis in response to VEGF isoforms A, C, and D. VEGFR2 kinase inhibitor II is a reversible, cell-permeable inhibitor of VEGFR2's kinase activity (IC50 = 70 nM). It less potently inhibits the platelet-derived growth factor receptor β (PDGFRβ; IC50 = 920 nM) and related receptor and non-receptor tyrosine kinases. V...
T79859	TIE-2/VEGFR-2 kinase-IN-4
	TIE-2/VEGFR-2 kinase-IN-4，一种苯并咪唑衍生物，作为有效的TIE-2和VEGFR-2酪氨酸激酶受体抑制剂，其IC50值分别为5.2 nM和5.1 nM，适用于血管生成相关研究。
T79858	TIE-2/VEGFR-2 kinase-IN-3
	TIE-2/VEGFR-2 kinase-IN-3，为苯并咪唑衍生物，具备高效的抑制作用于TIE-2与VEGFR-2受体酪氨酸激酶，其IC50值分别达到6.9 nM和3.5 nM。本化合物主要用于血管生成相关研究。
T36367	RK-682 (calcium salt)
	Protein tyrosine phosphatases (PTPs) remove phosphate from tyrosine residues of cellular proteins. Reversible phosphorylation catalyzed by the coordinated actions of protein tyrosine kinases and phosphatases is key to the regulation of the signaling events that control cell growth and proliferation, differentiation, and survival or apoptosis, as well as adhesion and motility. RK-682, a bioactive compound originally isolated from the fermentation of Streptomyces sp. 88-682, is an inhibitor of the...
T36643	PKI-166 hydrochloride
	Potent EGFR-kinase inhibitor (IC50 = 0.7 nM). Displays >3000-fold selectivity against a panel of serine/threonine kinases. Reduces metastasis and angiogenesis in a mouse model of pancreatic cancer. Antihypertensive and orally bioavailable. Bruns et al (2000) Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res. 60 2926 PMID:10850439 \|Ulu et al (2013) Epidermal ...
T71082	DW532
	DW532 is one of simplified analogues of hematoxylin that has shown broad-spectrum inhibition on tyrosine kinases and in vitro anti-cancer activities. DW532 inhibited EGFR and VEGFR2 in vitro kinase activity (the IC50 values were 4.9 and 5.5 μmol/L, respectively), and suppressed their downstream signaling. DW532 dose-dependently inhibited tubulin polymerization via direct binding to tubulin, thus disrupting the mitotic spindle assembly and leading to abnormal cell division. In a panel of human ca...

化合物

MGCD-265 analog

Cat.No: T6351

Synonym: MGCD-265,Glesatinib

Target: Apoptosis, VEGFR, c-Met/HGFR

Cat.No: T23127

Synonym: PD 161570

Target: EGFR, FGFR, PDGFR, Src

Cat.No: T8491

Synonym: CM082,X-82

Target: VEGFR, PDGFR

Tyrphostin AG1433

Cat.No: T13238

Synonym: SU1433,AG1433

Target: VEGFR, PDGFR

Cat.No: T2586

Synonym: 卡博替尼,XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cabozantinib hydrochloride

Cat.No: T5164

Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼

Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR

Cat.No: T3980

Synonym: Tyrphostin SU 1498,AG 1498

Target: VEGFR

Cat.No: T1895

Target: VEGFR, FGFR, PDGFR

Cat.No: T2288

Synonym: AMG 706,莫特塞尼,莫替沙尼

Target: VEGFR, c-Kit

TIE-2/VEGFR-2 kinase-IN-5

Cat.No: T79860

Target: VEGFR, Tie-2

Cat.No: T3211

Synonym: 米哚妥林,N-Benzoylstaurosporine,PKC412,CGP41231,CGP 41251,苯甲酰基十字孢碱

Target: Others, PKC

Cat.No: T4235

Synonym: FGF-401

Target: FGFR

Cat.No: T6517

Synonym: E-7050,戈伐替尼

Target: VEGFR, c-Met/HGFR

Cat.No: T0097L

Synonym: 帕唑帕尼,GW786034

Target: VEGFR, FGFR, PDGFR, c-Kit, Autophagy

Brivanib (alaninate)

Cat.No: T2576

Synonym: 丙氨酸布立尼布,BMS-582664,Brivanib Alaninate

Target: VEGFR, FGFR, Autophagy

Tivozanib hydrochloride hydrate

Cat.No: T63505

Glutathione arsenoxide

Cat.No: T27417

Synonym: GSAO

Glutathione palmitamide

Cat.No: T71441

Glutathione sodium

Cat.No: T69992

Glutathione sulfonate

Cat.No: T70331

Glutathione sulfinanilide

Cat.No: T68833

Glutathione glycylethyl ester

Cat.No: T70602

Cat.No: T23660

Synonym: Tyrphostin AG-1433,Tyrphostin AG1433,AG-1433,Tyrphostin AG 1433,AG 1433

Glutathione diethyl ester

Cat.No: T68202

Glutathione maleimide

Cat.No: T70831

Cediranib maleate

Cat.No: T2500L

Synonym: AZD-2171,Recentin,西地尼布马来酸盐,AZD2171,AZD2171 maleate,AZD 2171

Cat.No: T80870

Cat.No: T71576

Cat.No: T68546

VEGFR2 Kinase Inhibitor II

Cat.No: T37079

TIE-2/VEGFR-2 kinase-IN-4

Cat.No: T79859

TIE-2/VEGFR-2 kinase-IN-3

Cat.No: T79858

RK-682 (calcium salt)

Cat.No: T36367

PKI-166 hydrochloride

Cat.No: T36643

Cat.No: T71082

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