73
16
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TP1211 |
BAM-22P
Bovine adrenal medulla-22P |
||
Bovine adrenal medulla docosapeptide (BAM-22P) is a potent opioid agonist, derived from the proenkephalin A gene, which is present in the adrenal medulla. | |||
TP1031 |
Tetracosactide
Tetracosactrin,替可克肽 |
Others | Others |
Tetracosactide (Tetracosactrin) 是一种肾上腺皮质激素 (ACTH) 的类似物,能够刺激肾上腺皮质激素分泌。 | |||
T35664 |
Tetracosactide acetate
|
Others | Others |
Tetracosactide acetate 是一种合成的多肽,可刺激肾上腺释放皮质类固醇 ,如皮质醇。Tetracosactide acetate 在溃疡性结肠炎和克罗恩病、青少年和成人类风湿性关节炎和骨关节病方面有研究的价值。 | |||
T9047 |
Fluprednisolone
NSC-47439,NSC 47439,氟泼尼龙,NSC47439 |
Others | Others |
Fluprednisolone (NSC-47439) 是一种合成糖皮质激素,具有抗炎特性。 | |||
T0948 |
Adrenalone hydrochloride
Adrenalone HCl,肾上腺酮盐酸盐,盐酸肾上腺酮 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Adrenalone hydrochloride (Adrenalone HCl) 是一种多巴胺β氧化酶 (dopamine β oxidase) 抑制剂,结构与去甲肾上腺素转运蛋白 (NET) 配体相似,IC50=36.9 μM。它是一种肾上腺素能 (adrenergic) 激动剂,用作局部血管收缩剂和止血剂。 | |||
T0871 |
Noradrenaline bitartrate
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Noradrenaline bitartrate 直接作用于 α 和 β 肾上腺素能受体。它是去甲肾上腺素的酒石酸氢盐,去甲肾上腺素是一种合成苯乙胺,可模拟内源性去甲肾上腺素的拟交感神经作用。临床上,去甲肾上腺素用作外周血管收缩剂,通过其α-肾上腺素能作用导致动脉和静脉床收缩。它还被用作通过其 β-1 肾上腺素能作用介导的强效正性肌力和变时性心脏刺激剂。 | |||
T69151 |
Adrenaline sulfate
|
||
Adrenaline sulfate 是一种由肾上腺髓质分泌的口服活性激素。Adrenaline sulfate 是一种 α-adrenergic 和 β-adrenergic 受体激动剂。Adrenaline sulfate 可用于治疗过敏反应。Adrenaline sulfate 具有心脏骤停研究潜力[4]。 | |||
T32536 |
l-Adrenalin ascorbinate
Tonhormon |
||
l-Adrenalin ascorbinate is a bioactive chemical. | |||
T20332L |
Bam 12P acetate
Bam 12P acetate(75513-71-2 Free base) |
Endogenous Metabolite | Metabolism |
Bam 12P acetate 是牛肾上腺、垂体和下丘脑中推定的脑啡肽前体。 | |||
T26278 |
Tildacerfont
|
CRFR | GPCR/G Protein |
Tildacerfont 是 CRF1 的拮抗剂,可降低促肾上腺皮质激素和肾上腺雄激素的水平。 Tildacerfont 可用于先天性肾上腺增生的研究。 | |||
T0947 |
Dexamethasone acetate
Dexamethasone 21-acetate,醋酸地塞米松,Dexamethason acetate,NSC 39471 |
Glucocorticoid Receptor; Mitophagy; IL Receptor; Annexin A; NOS; Antibacterial; Autophagy | Autophagy; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology |
Dexamethasone acetate (NSC 39471) 是一种糖皮质素类甾体,有抗炎和免疫抑制活性。它可研究眼部感染。 | |||
T31095 |
Crinecerfont
SSR125543,SSR 125543,SSR-125543,SSR125543A,SSR 125543A,SSR-125543A |
CRFR | GPCR/G Protein |
Crinecerfont (SSR-125543) 是促肾上腺皮质激素释放因子 1 受体 (CRF1) 的特异性拮抗剂,可用于经典先天性肾上腺增生的研究。 | |||
T32160 |
Indolidan
LY 195115 |
||
Indolidan (LY 195115) 诱导费舍尔344大鼠的心血管和肾上腺增生性病变。 Indolidan 可增加心血管疾病的风险。 | |||
T1473 |
Trilostane
曲洛斯坦,Win 24540,曲洛司坦 |
Dehydrogenase | Metabolism |
Trilostane (Win 24540) 是一种3 β-羟化类固醇脱氢酶抑制剂,能够作用于库兴氏综合征。 | |||
T66580 |
Azilsartan Methyl Ester
|
RAAS | Endocrinology/Hormones |
Azilsartan Methyl Ester 是血管紧张素 II 受体拮抗剂,抑制[125I]AII(0.2nM)与牛肾上腺皮质的特异性结合,IC50值为0.44uM。 | |||
T1199 |
Mitotane
Mitotan,o,p'-DDD,NCI-C04933,2,4′-DDD,米托坦 |
Apoptosis; AChR | Apoptosis; Neuroscience |
Mitotane (NCI-C04933) 是 DDD 的同分异构体和 DDT 的衍生物,可作用于肾上腺皮质癌,有抗癌活性。 | |||
T62893 |
SM-2470
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
SM-2470 是一种α1-adrenoceptor拮抗剂,具有降压活性,可减低前神经节肾上腺神经活性和主动脉降压神经活性。SM-2470 具有降胆固醇活性,可抑制胆固醇吸收。 | |||
TP1295 |
Angiotensin I (human, mouse, rat)
Angiotensin 1 Human,血管紧张素 1 (人) |
Others | Others |
Angiotensin I (human, mouse, rat) 是血管紧张素Ⅱ的前体物质,在血管紧张素转化酶 (ACE) 的参与下裂解成血管紧张素Ⅱ。 | |||
TP1248L |
ACTH 11-24 acetate(4237-93-8 free base)
Adrenocorticotropic Hormone (11-24) acetate |
Melanocortin Receptor | GPCR/G Protein; Neuroscience |
ACTH 11-24 acetate(4237-93-8 free base) (Adrenocorticotropic Hormone (11-24) acetate) 是促肾上腺皮质激素的片段,可诱导皮质醇释放。 ACTH (11-24) 已被确定为分离的肾上腺细胞中 ACTH (1-39) 和 ACTH (1-10) 的竞争性拮抗剂。 | |||
T1484L |
Perindopril erbumine
培哚普利叔丁胺,培哚普利叔丁胺盐,S9490-3,Perindopril tert-butylamine salt |
Apoptosis; RAAS; MRP | Apoptosis; Endocrinology/Hormones; Immunology/Inflammation |
Perindopril erbumine (S9490-3) 是一种长效血管紧张素转换酶抑制剂。 | |||
T0272 |
Nilutamide
尼鲁米特,RU23908 |
Androgen Receptor | Endocrinology/Hormones |
Nilutamide (RU23908) 是一种非甾体抗雄激素药物,有用于转移性前列腺癌的潜力。 | |||
TP1238L |
ACTH 1-14 acetate(25696-21-3 free base)
Adrenocorticotropic Hormone Fragment 1-14 acetate |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段,可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH),也称为促肾上腺皮质激素,由垂体前叶产生和分泌。作为对生物应激的反应,ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。 | |||
T9857 |
Vasopressin
antidiuretic hormone (ADH),argipressin,arginine vasopressin (AVP) |
Endogenous Metabolite | Metabolism |
Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽,是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程,增加无溶质水从肾小管的滤液中重新吸收回循环中的量,收缩小动脉提高压强,增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质,与特定的 G 蛋白偶联受体结合发挥作用。 | |||
T28540 |
Ripisartan
UP 269-6,UP-2696,UP 2696,UP-269-6,UP269-6 |
RAAS | Endocrinology/Hormones |
Ripisartan (UP-269-6) 是一种强效的特异性血管紧张素 II 受体拮抗剂,对血管紧张素 II 介导的交感神经性心动过速反应有抑制作用。 | |||
T31826 |
Fluperolone acetate
P 1742,P-1742,P1742 |
||
Fluperolone acetate is a Glucocorticoid/Adrenal Cortex Hormone. | |||
T28873 |
Su 9055
Su-9055,Su9055 |
||
Su 9055 is an antagonist of adrenal cortex hormone. | |||
T32051 |
HE-2000
HE2000,16-Bromoepiandrosterone,PPB2 |
||
HE-2000(epistrosterone, 16-bromide, PPB2) is a potential adrenal hormone for the treatment of HIV infection. | |||
T31635 |
Enkephalin-met, lys(6)-
Met-enk-L,6-Lys-met-enkephalin |
||
Enkephalin-met, lys(6)- is an opioid hexapeptide found in adrenal medulla. | |||
TP1256 |
Adrenomedullin (AM) (22-52), human TFA
22-52-Adrenomedullin (human) (TFA) |
||
Adrenomedullin (AM) (22-52), human (22-52-Adrenomedullin human) TFAis a kind of NH2 TFA truncated at the end of the quality of adrenal medullary analogue, is a kind of quality of adrenal medullary receptor antagonist. | |||
T28094 | MR2034 | ||
MR2034 is an agonist of kappa-Opioid receptor. MR2034 stimulates hypothalamic-pituitary-adrenal axis. | |||
T19185 |
Aldosterone-d8
醛固酮 D8,Aldosterone D8 |
Others | Others |
Aldosterone D8, a deuterium-labeled variant of Aldosterone produced in the adrenal zona glomerulosa, regulates blood pressure. | |||
T71015 | Azastene | ||
Azastene is a progesterone antagonist that has been shown to inhibit ovarian & adrenal steroidogenesis in rats. | |||
T23984 |
Dexamethasone phosphate
Neodecadron,EGP437,Hexadrol phosphate,EGP 437,EGP-437 |
||
Dexamethasone phosphate is a synthetic adrenal corticosteroid. It also has potent anti-inflammatory properties. | |||
T27229 |
E-4177
E4177 |
||
E-4177 is an angiotensin type 1 receptor antagonist. In rat adrenal cortex and liver, E4177 competitively inhibited the specific binding of 125I-[Sar1,Ile8]Ang II, with IC50 being (5.2 +/- 1.0) x 10(-8) M for the adrenal cortex and (1.2 +/- 0.3) x 10(-7) | |||
T20332 |
Bam 12P
Bam12P,Bam-12P |
||
Bam 12P is a Pro-Met-enkephalin precursor that is isolated from the bovine adrenal medulla. | |||
TC0008 |
Desoxycorticosterone pivalate
DOCP |
Others | Others |
Deoxycorticosterone (DOCP) is a mineralocorticoid and is an analog of deoxycorticosterone. Deoxycorticosterone pivalate is used in the treatment of canine low adrenal cortex hormones. | |||
T40398 |
Crinecerfont hydrochloride
SSR-125543A,SSR-125543 hydrochloride |
||
Crinecerfont hydrochloride (SSR-125543) is a highly potent, orally active, non-peptide antagonist of the CRF1 receptor. It has demonstrated efficacy in the context of Classic congenital adrenal hyperplasia (CAH) research. | |||
T2195L |
Epiandrosterone Sulfate
Epiandrosterone 16-bromo,Epiandrosterone |
||
Epiandrosterone sulfate is a steroid hormone with weak androgenic activity. Epiandrosterone is naturally produced by the enzyme 5α-reductase of the adrenal hormone DHEA. | |||
T61333 | PDE11-IN-1 | ||
PDE11-IN-1 是一种PDE11抑制剂,可用于肾上腺机能不全的研究。 | |||
T29207 |
ZD 7155
ZD 7155,ZD-7155 |
||
ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. It displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes with an IC50 value of 3.8 nM. | |||
T31845 |
Forasartan
SC52458,SC 52458,SC-52458 |
||
Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, lead | |||
T38046 |
Cholesteryl Homo-γ-Linolenate
|
||
Cholesteryl homo-γ-linolenate is a cholesterol ester. It accumulates in the adrenal gland of rabbits fed a diet high in linolenic acid. Levels of cholesteryl homo-γ-linolenate are decreased and positively correlate with cognitive decline in HIV-infected humans. | |||
TP1824 |
Cerebellin
|
||
Cerebellin is a 16-amino acid peptide, originally isolated from rat cerebellum, whose presence has been recently demonstrated in the human adrenal glands and especially in medullary chromaffin cells. | |||
T81511 |
Peptide F, bovine
|
||
Peptide F, bovine,是源自牛大脑和肾上腺髓质的前脑啡肽F,与脑啡能系统的疼痛传导过程相关。 | |||
T80687 |
γ3-MSH
|
||
γ3-MSH 源于 pro-opiomelanocortin (POMC) 的 N 端,能够激活人肾上腺肿瘤细胞分泌醛固酮。 | |||
T82149 |
Hydrin 1′
|
||
Hydrin 1′,在(Xenopus)神经垂体中首次发现,此化合物在爪蟾肾上腺中显示出显著的类固醇释放活性。 | |||
T31383 |
D-Epinephrine
L-(+)-Adrenaline,Racepinefrine, (S)-,BRN-2938799,d-Adrenaline,BRN 2938799 |
||
D-Epinephrine can be used as a hormone, neurotransmitter, and medication. Epinephrine can be normally obtained from the adrenal glands and certain neurons. It involves in the fight-or-flight response by increasing blood flow to muscles, output of the hear | |||
TP1914 |
BAM(8-22)
BAM (8-22) |
||
Endogenous peptide fragment that is a potent agonist for MRGPRX1 (EC50 values are 8 - 150 nM); first isolated from bovine adrenal medulla. Unlike BAM 22P , does not contain the met-enkephalin motif therefore displays no affinity for opioid receptors. | |||
T79793 |
CRF1 receptor antagonist-1
|
CFTR | Membrane transporter/Ion channel |
CRF1 receptor antagonist-1 (Compound 2)为CRF1受体拮抗剂,适用于先天性肾上腺增生症(CAH)的研究领域。 | |||
TP1144 |
Corticotropin-releasing factor (human)
Human corticotropin-releasing factor,Human CRF,Corticotropin-releasing factor human |
||
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions b |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8270 |
Deserpidine
地舍平,Harmonyl |
RAAS | Endocrinology/Hormones |
Deserpidine (Harmonyl) 是从 Rauwolfia canescens 的根中分离的生物碱。Deserpidine 与 Reserpine 相关。Deserpidine 是竞争性血管紧张素转化酶抑制剂,可以被用作抗高血压药以及镇定剂。Deserpidine 还减少了肾上腺皮质血管紧张素 II 诱导的醛固酮分泌。 | |||
T14001 |
11-Beta-hydroxyandrostenedione
4-雄烯-11β-醇-3,17-二酮,NSC-17102,4-Androsten-11β-ol-3,17-dione |
Endogenous Metabolite | Metabolism |
11-Beta-hydroxyandrostenedione (NSC-17102) 是主要存在于肾上腺的类固醇,也是 11β-羟基类固醇脱氢酶同工酶抑制剂。随着 4-androstenedione 的提高,通过测量血浆中的11-Beta-hydroxyandrostenedione,能够区分高雄激素血症的肾上腺或卵巢起源。 | |||
T1071L |
DL-Adrenaline Hydrochloride
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
DL-Adrenaline Hydrochloride 是天然存在的拟交感神经胺的盐酸盐,具有收缩血管、降低眼内压的活性。 | |||
T20173 |
Noradrenaline tartrate
NSC 169106,NSC-169106,l-Noradrenaline d-bitartrate,NSC169106,Norepinephrine bitartrate |
||
Norepinephrine bitartrate is a precursor of epinephrine. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. | |||
T2S1778 |
DL-Goitrin
DL-甲状腺肿素,板蓝根,Goitrin,(R,S)-告依春 |
Others | Others |
DL-Goitrin 也称为 (R,S)-Goitrin,由 epigoitrin (R-Goitrin) 和告依春 (S-Goitrin) 两种异构体组成,是板蓝根的成分。 | |||
T20302 |
Deoxycorticosterone
Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone |
Endogenous Metabolite | Metabolism |
Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体,具有盐皮质激素活性。 | |||
T0856 |
Dehydroisoandrosterone 3-acetate
Dehydroepiandrosterone 3-acetate,Dehydroepiandrosterone acetate,Prasterone acetate,DHEA acetate,醋酸去氢表雄酮,androstenolone acetate |
Androgen Receptor | Endocrinology/Hormones |
Dehydroisoandrosterone 3-acetate (Prasterone acetate) 是一种雄性激素/雌性激素的前体物质,是一种由肾上腺皮质产生的主要 C19 类固醇,能够调节脊椎动物的攻击性行为。 | |||
T2748 |
Cortodoxone
可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Cortodoxone (11-Desoxycortisol) 是糖皮质类固醇激素,能够氧化为皮质醇。 | |||
T2207 |
Adrenosterone
肾上腺甾酮,11-ketoandrostenedione,11-oxoandrostenedione,Reichstein's substance G |
Androgen Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Adrenosterone (11-ketoandrostenedione) 是一种人内源性代谢物,由肾上腺皮质产生。Adrenosterone 是一种竞争性羟基类固醇脱氢酶 1 抑制剂。它是一种的类固醇激素,具有较弱的雄激素特性。它是一种膳食补充剂,能够减少脂肪并提高肌肉质量。它能够抑制人类癌细胞的转移进展。 | |||
T3S0488 |
Syringaresinol diglucoside
Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷 |
Others | Others |
Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。 | |||
T0034 |
Cortisone acetate
醋酸可的松,Cortisone 21-acetate,NSC 49420 |
Glucocorticoid Receptor; Endogenous Metabolite | Endocrinology/Hormones; Metabolism |
Cortisone acetate (NSC-49420) 是 Cortisol(一种糖皮质激素)的氧化代谢产物。它在高浓度下能够部分干预 Glucocorticoid 与Glucocorticoid-receptor 的结合。它具有免疫抑制和消炎的作用。 | |||
T5S2343 |
Acetylshikonin
乙酰紫草素,Acetyl shikonin |
Others; P450; AChE | Metabolism; Neuroscience; Others |
Acetylshikonin 来源于紫草根,具有抗癌、抗炎作用。它是一种 AChE 抑制剂,具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂,对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
T19186 |
Aldosterone
|
Others | Others |
Aldosterone is the primary mineralocorticoid. Aldosterone is synthesized and secreted in response to renin-angiotensin system activation or high dietary potassium by the zona glomerulosa of the adrenal cortex. | |||
T36915 |
21-Deoxycortisol
|
||
21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal glandvia11-hydroxylation by 11β-hydroxylase.1,2Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations inCYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies. 1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive... | |||
T39991 |
18-Oxocortisol
|
||
18-Oxocortisol is a cortisol derivative generated by aldosterone synthase (CYP11B2). It acts as a naturally occurring mineralocorticoid agonist and serves as a biomarker in adrenal vein sampling. |