Powder: -20°C for 3 years | In solvent: -80°C for 1 year
11-Beta-hydroxyandrostenedione (NSC-17102) 是主要存在于肾上腺的类固醇,也是 11β-羟基类固醇脱氢酶同工酶抑制剂。随着 4-androstenedione 的提高,通过测量血浆中的11-Beta-hydroxyandrostenedione,能够区分高雄激素血症的肾上腺或卵巢起源。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 185 | 现货 | ||
5 mg | ¥ 413 | 现货 | ||
10 mg | ¥ 663 | 现货 | ||
25 mg | ¥ 1,330 | 现货 | ||
50 mg | ¥ 2,120 | 现货 | ||
100 mg | ¥ 3,170 | 现货 | ||
500 mg | ¥ 6,890 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 455 | 现货 |
产品描述 | 11-Beta-hydroxyandrostenedione (NSC-17102) is a steroid mainly found in the adrenal origin (11β-hydroxylase is present in adrenal tissue, but absent in ovarian tissue), which is a 11β-hydroxysteroid dehydrogenase isozymes inhibitor. Measuring plasma 11-Beta-hydroxyandrostenedione can distinguish the adrenal or ovarian origin of hyperandrogenism with 4-androstenedione increases. |
体外活性 | 21-deoxycortisol (21dF) and 21-deoxycortisone (21dE) are assayed within the LNCaP cell line to establish that this conversion is catalyzed by the lyase activity of CYP17A1. After the transfection of CYP17A1, 11-Beta-hydroxyandrostenedione (11OHA4)-pathway metabolites increase, 21dF, and 21dE are in fact metabolized to 11-Beta-hydroxyandrostenedione and 11-ketoprogesterone (11KP4) by CYP17A1, respectively [2]. |
体内活性 | In 21-hydroxylase deficiency, Cushing's syndrome, and hyperandrogenism of adrenal origin, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very high. In congenital 11-hydroxylase deficiency and adrenal insufficiency, the plasma concentration of 11-Beta-hydroxyandrostenedione (11beta-hydroxy-4-androstene-3,17-dione) is very low. Thus, when plasma 4-androstenedione is elevated, it is useful to measure the plasma 11-Beta-hydroxyandrostenedione level in order to determine the adrenal or ovarian origin of the hyperandrogenism [1]. |
别名 | 4-雄烯-11β-醇-3,17-二酮, NSC-17102, 4-Androsten-11β-ol-3,17-dione |
分子量 | 302.41 |
分子式 | C19H26O3 |
CAS No. | 382-44-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 45 mg/mL (148.8 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 3.3068 mL | 16.5338 mL | 33.0677 mL | 82.6692 mL |
5 mM | 0.6614 mL | 3.3068 mL | 6.6135 mL | 16.5338 mL | |
10 mM | 0.3307 mL | 1.6534 mL | 3.3068 mL | 8.2669 mL | |
20 mM | 0.1653 mL | 0.8267 mL | 1.6534 mL | 4.1335 mL | |
50 mM | 0.0661 mL | 0.3307 mL | 0.6614 mL | 1.6534 mL | |
100 mM | 0.0331 mL | 0.1653 mL | 0.3307 mL | 0.8267 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
11-Beta-hydroxyandrostenedione 382-44-5 Metabolism Endogenous Metabolite 11Betahydroxyandrostenedione inhibit 4-androstenedione Cushing's hyperandrogenism adrenal 4-雄烯-11β-醇-3,17-二酮 syndrome NSC-17102 Inhibitor NSC17102 4-Androsten-11b-ol-3,17-dione 4-Androsten-11β-ol-3,17-dione 4-Androsten-11beta-ol-3,17-dione NSC 17102 steroid 11-β-hydroxyandrostenedione 11 Beta hydroxyandrostenedione 11-b-hydroxyandrostenedione 11β-hydroxylase ovarian inhibitor