keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Vasopressin (argipressin) 是一种由下丘脑神经元合成的环状九肽,是肽原激素合成中的一种激素。Vasopressin 参与下丘脑-垂体-肾上腺轴调节过程,增加无溶质水从肾小管的滤液中重新吸收回循环中的量,收缩小动脉提高压强,增强促肾上腺皮质激素释放因子的刺激作用调节垂体促肾上腺皮质激素分泌。Vasopressin 在神经传导过程中可作为神经递质,与特定的 G 蛋白偶联受体结合发挥作用。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 182 | 现货 | ||
5 mg | ¥ 388 | 现货 | ||
10 mg | ¥ 643 | 现货 | ||
25 mg | ¥ 927 | 现货 | ||
50 mg | ¥ 1,650 | 现货 | ||
100 mg | ¥ 2,470 | 现货 | ||
1 mL * 10 mM (in DMSO) | ¥ 766 | 现货 |
产品描述 | Vasopressin (argipressin), a cyclic nine-peptide synthesized by hypothalamic neurons, is one of the hormones involved in peptide prohormone synthesis. Vasopressin is involved in the regulation process of hypothalamic-pituitary-adrenal axis, increasing the amount of solute free water reabsorbed from the renal tubule's colate back into the circulation, narrowing arteries to increase pressure, enhancing the stimulating effect of corticotropin releasing factor to regulate pituitary corticotropin secretion. Vasopressin acts as a neurotransmitter during nerve conduction by binding to specific G-protein-coupled receptors. |
体外活性 | AVP (0.01 nM-1 μM) triggers Ca2+ elevation in Chinese hamster ovary cells expressing either rat or human V1b receptors.[1] |
体内活性 |
Vasopressin (0.03-0.3 μg/kg; i.p.) enhances corticotropin release elicited by exogenous corticoliberin and amplifies corticotropin secretion following dehydration.[1] Vasopressin (0.001-0.1 mg/kg; i.p.) significantly promotes proximity, wherein rats encountering each other for the first time exhibit passive side-by-side positioning.[2] |
别名 | antidiuretic hormone (ADH), argipressin, arginine vasopressin (AVP) |
分子量 | 1084.24 |
分子式 | C46H65N15O12S2 |
CAS No. | 11000-17-2 |
keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90.0 mg/mL (83.0 mM), Sonication is recommended.
H2O: 45.0 mg/mL (41.5 mM), Sonication is recommended.
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO / H2O | 1 mM | 0.9223 mL | 4.6115 mL | 9.2231 mL | 23.0576 mL |
5 mM | 0.1845 mL | 0.9223 mL | 1.8446 mL | 4.6115 mL | |
10 mM | 0.0922 mL | 0.4612 mL | 0.9223 mL | 2.3058 mL | |
20 mM | 0.0461 mL | 0.2306 mL | 0.4612 mL | 1.1529 mL | |
DMSO | 50 mM | 0.0184 mL | 0.0922 mL | 0.1845 mL | 0.4612 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Vasopressin 11000-17-2 Metabolism Endogenous Metabolite AVP ADH antidiuretic hormone (ADH) argipressin arginine vasopressin (AVP) arginine vasopressin antidiuretic hormone Inhibitor inhibitor inhibit