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106

抑制剂 & 化合物

29

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T2164	Wiskostatin	Others	Others
	Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂，能够不可逆的使细胞 ATP 水平快速下降。
T8473	MLS000532223	Rho; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	MLS000532223 是一种具有高亲和力的 Rho 家族 GTPases 选择性抑制剂，其EC50=16~120 μM。它能阻止几种 GTPases 同 GTP 的结合。
T23372	SMIFH2	Others	Others
	SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合，影响肌动蛋白细胞骨架。
T22260	Aminopurvalanol A	CDK	Cell Cycle/Checkpoint
	Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂，优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。
T9107	NP-G2-044	Others	Others
	NP-G2-044 是fascin 蛋白抑制剂，具有口服活性，IC50值约为 2 μM。它可阻断肿瘤转移并增强抗肿瘤免疫应答。
T5007	Benproperine phosphate 磷酸苯丙哌林,Blascorid,Pirexyl phosphate	Others; Microtubule Associated	Cytoskeletal Signaling; Others
	Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的，肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移，有用于治疗止咳的潜力。
T5860	CK-869	Microtubule Associated	Cytoskeletal Signaling
	CK-869 是一种肌动蛋白相关蛋白 2/3 复合体抑制剂，其 IC50值为 7 μM。
T1855	ZCL278 ZCL 278	CDK; Ras	Cell Cycle/Checkpoint; GPCR/G Protein; MAPK
	ZCL278 是一种选择性 Cdc42 GTPase 抑制剂，与Cdc42结合，Kd 为 11.4 μM。
T7764	CCG-222740	ROCK; Rho; Ras	Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells
	CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂，可减少皮肤纤维化并阻止黑色素瘤转移。
T10826	CK-666	HIV Protease; Microtubule Associated	Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	CK-666 是一种肌动蛋白相关蛋白 Arp2/3 复合物的细胞渗透性抑制剂。它与 Arp2/3 复合物结合，稳定复合物的非活性状态，阻止 Arp2 和 Arp3 亚基进入活化的丝状短节距构象。
T1820	CK-636 CK-0944636,CK 636	Microtubule Associated	Cytoskeletal Signaling
	CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂，能抑制肌动蛋白的聚合，对人，裂殖酵母和牛的IC50值分别为4、24 和 32 μM。
T7144	BTS N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide	ATPase; Myosin	Cytoskeletal Signaling; Membrane transporter/Ion channel
	BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂，可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。
T13041	Surfactin	HSV	Microbiology/Virology
	Surfactin 是一种有效的环状脂肽生物表面活性剂，可介导单价和二价阳离子（如钙）穿过脂质双层膜的通量，具有抗菌、抗真菌、抗支原体和溶血作用。
T9501	Enterobactin Enterochelin	Others	Others
	Enterobactin (Enterochelin) 是一种高亲和力铁载体，可为微生物系统获取铁。
T1996	Defactinib PF-04554878,VS-6063	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Defactinib (VS-6063) 是新型的 FAK 抑制剂，能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。
T24695	Quinabactin LC-66C6,ABA mimics 1,AM1,LC66C6,LC 66C6	Others	Others
	Quinabactin (LC-66C6) 是一种有效的磺酰胺脱落酸 ABA 激动剂。Quinabactin 促进成年拟南芥和大豆植物的保卫细胞关闭、抑制水分流失，抑制种子萌发，提高耐旱性。
TQ0033	Zegocractin CM-4620,N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide,CM4620	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Zegocractin (CM-4620) 是一种钙离子释放激活通道的抑制剂，对Orai1/STIM1和Orai2/STIM1的IC50值分别为 119 和 895 nM。
T124888	Actinine
	Actinine 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T124888。
T82705	Clovibactin	Antibiotic	Microbiology/Virology
	Clovibactin为一种新型抗生素，能有效消灭耐药细菌病原体，且未观察到耐药性。该化合物能从未培养的土壤细菌中提取。
T81391	Prolactin-Releasing Peptide (12-31), rat
	Prolactin-Releasing Peptide (12-31), rat 为催乳素释放肽的一个段落，对 GPR10 受体具有高度亲和性，并能在转染了 PrRP 受体的 CHOK1 细胞中激发钙离子动员。
T30912	Chrysobactin
	Chrysobactin has siderophore activity that is isolated from Erwinia chrysanthemi.
T123940	Infractin
	Infractin 是一种有用的有机化合物，可用于生命科学领域的相关研究，其产品编号为 T123940。
T31386	Desferriferribactin Desferri-ferribactin
	Desferriferribactin is a biogenetic precursor of pyoverdin.
T68795	Actinomycin D1
	Actinomycin D1 is a DNA inhibitor.
T81390	Prolactin-Releasing Peptide (1-31) (rat)
	Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入，有效提升血浆LH、FSH及睾酮水平。
T25767	Lysobactin Katanosin A, 7-L-isoleucine-,Katanosin B
	Lysobactin, also known as katanosin B, is an effective antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis.
T80397	Darobactin	Antibiotic	Microbiology/Virology
	Darobactin为一种有效的抗生素，其针对多种重要革兰氏阴性病原体展现出显著的抑制作用，无论是在体外实验还是动物感染模型中均有证实。
T78006	Prolactin Releasing Peptide (1-31), human acetate
	ProlactinReleasing Peptide (1-31), human (acetate) 是一款针对 GPR10 的高亲和力配体，并具备诱导催乳素释放的功能。该肽段与人类和大鼠的 GPR10 结合力极强，Ki 值分别为 1.03 nM 和 0.33 nM，适用于针对下丘脑-垂体轴进行的生物医学研究。
T34952	Trinactin Akd1D,Akd 1D,Akd-1D
	Trinactin is a nonactin homolog that has Immunosuppressive effects.
T35857	Actinopyrone A
	Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities. It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis. Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL. Intravenous administration of actinopyrone A (30 μg/kg) increases coron...
T126026	Purpactin A
	Purpactin A 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126026，CAS号为 133806-59-4。
T25996	Protactin
	Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins.
T34174	Pseudobactin Ferric pseudobactin
	Pseudobactin is a linear hexapeptide fluorescent iron transport agent (siderophore) from plant growth promoter Pseudomonas B10.
T26257	Teixobactin
	Teixobactin is a recently described antibiotic . It is a new class produced by a hitherto undescribed soil microorganism (provisionally named Eleftheria terrae).
T60486	Mycobactin-IN-1
	Mycobactin-IN-1 (compound 44) 是一种吡唑啉类似物。Mycobactin-IN-1 与分支菌素生物合成途径中的关键酶，水杨酸-AMP 连接酶 (MbtA) 结合。Mycobactin-IN-1 是分支菌素生物合成的抑制剂，具有抗分枝杆菌的作用。
T18906	7-Aminoactinomycin D 7-AAD	Others	Others
	7-Aminoactinomycin D is a fluorescent DNA stain.
T125603	Surfactin C2
	Surfactin C2 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T125603，CAS号为 171039-18-2。
T68797	Actinomycin D2
	Actinomycin D2 is a DNA inhibitor.
T29677	Aerobactin
	Aerobactin, as a bacterial iron chelating agent (siderophore), can be found in E. coli. It is a virulence factor that can enable E. coli to sequester iron in iron-poor environments.
T124910	Arthrobactin
	Arthrobactin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T124910，CAS号为 39007-57-3。
T15092	Defactinib hydrochloride VS-6063 hydrochloride,PF 04554878 hydrochloride	FAK	Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
	Defactinib hydrochloride (PF 04554878 hydrochloride) (VS-6063 hydrochloride; PF 04554878 hydrochloride) 是一种新型 FAK 抑制剂，抑制 FAK 在 Tyr397 位点磷酸化，这种作用具有时间和剂量依赖性。
T60833	Mycobactin-IN-2
	Mycobactin-IN-2 (化合物 49) 是与水杨酰-AMP 连接酶 (MbtA) 结合的分枝杆菌素生物合成抑制剂，MbtA 是分枝杆菌素生物合成途径的关键酶。
TP1769	Prolactin Releasing Peptide (1-31), human
	Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with Kis of 1.03 and 0.33 nM, respectively.Prolactin-releasing peptide is a
T39319	Actinomycin X2 放线菌素X2；放线菌素V,Actinomycin V
	Actinomycin X2 (Actinomycin V) is a compound synthesized by various species of Streptomyces. It displays potent inhibition against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. Actinomycin X2 possesses potential applications in the treatment of both cancer and bacterial infections.
TP2451	Arthrofactin
	Arthrofactin is a lipopeptide biosurfactant.
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...
T33538	Mycobactin S
	Mycobactin S is made from metabolic products of the acid-resistant form of Mycobacterium phlei, a tuberculosis bacillus derived originally from the cold-blooded sea turtle. Importantly, it is not based on cell wall fragments or killed bacteria.
T33537	Mycobactin P
	Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors.
T72817	Colibactin 742
	Colibactin 742 是一种稳定的大肠杆菌素衍生物，可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。
T69869	Cyanabactin
	Cyanabactin is a novel ABA receptor agonist. It preferentially activates Pyrabactin Resistance 1 (PYR1) with low nanomolar potency.

化合物

Cat.No: T2164

Target: Others

Cat.No: T8473

Target: Rho, Ras

Cat.No: T23372

Target: Others

Aminopurvalanol A

Cat.No: T22260

Target: CDK

Cat.No: T9107

Target: Others

Benproperine phosphate

Cat.No: T5007

Synonym: 磷酸苯丙哌林,Blascorid,Pirexyl phosphate

Target: Others, Microtubule Associated

Cat.No: T5860

Target: Microtubule Associated

Cat.No: T1855

Synonym: ZCL 278

Target: CDK, Ras

Cat.No: T7764

Target: ROCK, Rho, Ras

Cat.No: T10826

Target: HIV Protease, Microtubule Associated

Cat.No: T1820

Synonym: CK-0944636,CK 636

Target: Microtubule Associated

Cat.No: T7144

Synonym: N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide

Target: ATPase, Myosin

Cat.No: T13041

Target: HSV

Cat.No: T9501

Synonym: Enterochelin

Target: Others

Cat.No: T1996

Synonym: PF-04554878,VS-6063

Target: FAK

Cat.No: T24695

Synonym: LC-66C6,ABA mimics 1,AM1,LC66C6,LC 66C6

Target: Others

Cat.No: TQ0033

Synonym: CM-4620,N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide,CM4620

Target: Calcium Channel

Cat.No: T124888

Cat.No: T82705

Target: Antibiotic

Prolactin-Releasing Peptide (12-31), rat

Cat.No: T81391

Cat.No: T30912

Cat.No: T123940

Desferriferribactin

Cat.No: T31386

Synonym: Desferri-ferribactin

Actinomycin D1

Cat.No: T68795

Prolactin-Releasing Peptide (1-31) (rat)

Cat.No: T81390

Cat.No: T25767

Synonym: Katanosin A, 7-L-isoleucine-,Katanosin B

Cat.No: T80397

Target: Antibiotic

Prolactin Releasing Peptide (1-31), human acetate

Cat.No: T78006

Cat.No: T34952

Synonym: Akd1D,Akd 1D,Akd-1D

Actinopyrone A

Cat.No: T35857

Cat.No: T126026

Cat.No: T25996

Cat.No: T34174

Synonym: Ferric pseudobactin

Cat.No: T26257

Mycobactin-IN-1

Cat.No: T60486

7-Aminoactinomycin D

Cat.No: T18906

Synonym: 7-AAD

Target: Others

Cat.No: T125603

Actinomycin D2

Cat.No: T68797

Cat.No: T29677

Cat.No: T124910

Defactinib hydrochloride

Cat.No: T15092

Synonym: VS-6063 hydrochloride,PF 04554878 hydrochloride

Target: FAK

Mycobactin-IN-2

Cat.No: T60833

Prolactin Releasing Peptide (1-31), human

Cat.No: TP1769

Actinomycin X2

Cat.No: T39319

Synonym: 放线菌素X2；放线菌素V,Actinomycin V

Cat.No: TP2451

Cat.No: T37052

Cat.No: T33538

Cat.No: T33537

Cat.No: T72817

Cat.No: T69869

Cat. No.	Product Name	Target	Signaling Pathways
T3234	Dihydroactinidiolide R-(-)Dihydro actinidiolide,二氢猕猴桃内酯	Others	Others
	Dihydroactinidiolide (R-(-)Dihydro actinidiolide) 是一种植物生长抑制剂，也是基因表达的调节剂，存在于植物叶片和果实中，能够负责拟南芥中的光适应。它具有抗氧化活性，抗菌活性，抗癌活性和神经保护作用。
T8177	Galactinol	Others	Others
	Galactinol Hydrate 清除羟基自由基并保护植物细胞免受氧化损伤。
TN3346	Actinidic acid	Others	Others
	Actinidic acid is a triterpene phytoalexin from unripe kiwi fruit.
TN6246	Actinodaphnine
	Actinodaphnine 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6246，CAS号为 517-69-1。
T64891	(±)-Dihydroactinidiolide
	(±)-Dihydroactinidiolide 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 T64891，CAS号为 15356-74-8。
T14121	Actinonin (-)-Actinonin	Aminopeptidase	Metabolism
	Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5].
T25827	Monactin
	Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species.
T7097	Cytochalasin B Phomin,细胞松弛素 B,细胞松弛素B	Arp2/3 Complex	Cytoskeletal Signaling
	Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin).
T3229	Cytochalasin D	ATPase; p38 MAPK; Calcium Channel; Akt; PI3K	Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit
T21513	Cytochalasin H (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H	MMP	Proteases/Proteasome
	Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。
T13864	Resolvin D1 RvD1	Apoptosis	Apoptosis
	Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质，可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移，减少 TNF-α 介导的炎症在巨噬细胞中的作用，并增强巨噬细胞对凋亡细胞的吞噬作用。
TN1711	Gossypetin	Antioxidant; p38 MAPK; MAPK; Antibacterial	MAPK; Microbiology/Virology; oxidation-reduction
	Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮，是一种有效的 MKK3 和 MKK6 抑制剂，可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用，它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。
TN2143	3,7,4'-Trihydroxyflavone Resokaempferol,5-Deoxykampferol	DNA	DNA Damage/DNA Repair
	3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物，可抑制 NF-κB 配体（RANKL）受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。
T20945	2,4-D Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素，用作植物生长调节剂，也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分，用于破坏肌动蛋白细胞骨架，以控制根系伸长和细胞生成。
T3S1471	Cucurbitacin IIA 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA	Apoptosis; Survivin	Apoptosis
	Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯，可诱导细胞凋亡和增强自噬，有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达，降低磷酸化组蛋白 H3 的水平，增加裂解的 PARP 的水平。
T5S1981	alpha-Cyperone (+)-α-Cyperone,α-香附酮,α-Cyperone	Others; Endogenous Metabolite	Metabolism; Others
	alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。
T4839	Ac-Ala-OH N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸	Others; Endogenous Metabolite	Metabolism; Others
	Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T15721	Latrunculin A LAT-A	Others	Others
	Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re
T15039	Cytochalasin E	Others	Others
	Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong
T11712	Jasplakinolide Jaspamide,NSC-613009	Microtubule Associated; Antifungal	Cytoskeletal Signaling; Microbiology/Virology
	Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽，是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性，可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白，对 F-肌动蛋白的 Kd 值为 15 nM。
T35782	Swinholide A MK-7684	Antifungal	Microbiology/Virology
	Swinholide A 是可从海绵中提取的聚酮化合物，可于肌动蛋白结合，使肌动蛋白二聚化，Kd 约为 50 nM。Swinholide A 是一种细胞毒素，可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性，可破坏细胞的肌动蛋白细胞骨架。
TN1533	Cucurbitacin A	ROCK	Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells
	Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase.
T40298	Phallacidin
	Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins.
T35609	19-O-Acetylchaetoglobosin A
	19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ...
T38799	2,3-Bis(3-indolylmethyl)indole
	2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption.
T10928	Cytochalasin A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy
T75520	Aplyronine A
	Aplyronine A是具有特异性肌动蛋白解聚活性、抗肿瘤及促凋亡功能的化合物，适用于癌症、肌肉收缩、细胞运动和细胞分裂等研究领域。
T20636	Latrunculin B LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644	Antifungal	Microbiology/Virology
	Latrunculin B 是一种来自红海海绵的生物碱，是一种肌动蛋白聚合 (actin polymerization) 抑制剂，具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生，可用于研究青少年青光眼。

天然产物

Dihydroactinidiolide

Cat.No: T3234

Synonym: R-(-)Dihydro actinidiolide,二氢猕猴桃内酯

Target: Others

Cat.No: T8177

Target: Others

Actinidic acid

Cat.No: TN3346

Target: Others

Actinodaphnine

Cat.No: TN6246

(±)-Dihydroactinidiolide

Cat.No: T64891

Cat.No: T14121

Synonym: (-)-Actinonin

Target: Aminopeptidase

Cat.No: T25827

Cat.No: T7097

Synonym: Phomin,细胞松弛素 B,细胞松弛素B

Target: Arp2/3 Complex

Cat.No: T3229

Target: ATPase, p38 MAPK, Calcium Channel, Akt, PI3K

Cat.No: T21513

Synonym: (16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H

Target: MMP

Cat.No: T13864

Synonym: RvD1

Target: Apoptosis

Cat.No: TN1711

Target: Antioxidant, p38 MAPK, MAPK, Antibacterial

3,7,4'-Trihydroxyflavone

Cat.No: TN2143

Synonym: Resokaempferol,5-Deoxykampferol

Target: DNA

Cat.No: T20945

Synonym: Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸

Target: DNA/RNA Synthesis

Cucurbitacin IIA

Cat.No: T3S1471

Synonym: 葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA

Target: Apoptosis, Survivin

Cat.No: T5S1981

Synonym: (+)-α-Cyperone,α-香附酮,α-Cyperone

Target: Others, Endogenous Metabolite

Cat.No: T4839

Synonym: N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸

Target: Others, Endogenous Metabolite

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

Cat.No: T15721

Synonym: LAT-A

Target: Others

Cat.No: T15039

Target: Others

Cat.No: T11712

Synonym: Jaspamide,NSC-613009

Target: Microtubule Associated, Antifungal

Cat.No: T35782

Synonym: MK-7684

Target: Antifungal

Cat.No: TN1533

Target: ROCK

Cat.No: T40298

19-O-Acetylchaetoglobosin A

Cat.No: T35609

2,3-Bis(3-indolylmethyl)indole

Cat.No: T38799

Cat.No: T10928

Target: HIV Protease

Cat.No: T75520

Cat.No: T20636

Synonym: LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644

Target: Antifungal

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