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11

抑制剂 & 化合物

5

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21826	TC-E 5003 NSC 30176	Histone Methyltransferase	Chromatin/Epigenetic
	TC-E 5003 (NSC-30176) 是选择性 PRMT1抑制剂，其 IC50值为1.5 µM。它在 TLR4 信号传导中具有抗炎特性。
T11598	IAXO-102	TLR	Immunology/Inflammation
	IAXO-102 是一种 TLR4 拮抗剂，可负向调节 TLR4 信号传导，还可以防止实验性腹主动脉瘤的发展。它抑制 MAPK 和 p65 NF-κB 磷酸化和 TLR4 依赖性促炎蛋白的表达。
TQ0181	Resatorvid CLI-095,TAK-242,瑞沙托维	TNF; TLR; Autophagy; Interleukin	Apoptosis; Autophagy; Immunology/Inflammation
	Resatorvid (TAK-242) 是一种 Toll 样受体 4 (TLR4) 的抑制剂，具有选择性。Resatorvid 直接与 Cys747 结合，阻止 TLR4 与 TIRAP 结合，从而阻止下游信号转导。Resatorvid 具有抗肿瘤活性、抗炎活性和神经保护作用。
T40423	L48H37
	L48H37是Curcumin的一个化学稳定类似物。它对髓系分化蛋白2 (MD2) 表现出强效的抑制性质，作为一个特异性抑制剂。其机制包括抑制LPS-TLR4/MD2的相互作用和信号传导。L48H37主要用于脓血症和肺损伤研究[1]。
T35593	Semapimod tetrahydrochloride CPSI-2364 tetrahydrochloride	TLR; MAPK	Immunology/Inflammation; MAPK
	Semapimod tetrahydrochloride (CPSI-2364 tetrahydrochloride) 是一种合成鸟腙丝裂原活化蛋白激酶阻滞剂,也是促炎细胞因子生成抑制剂，干扰巨噬细胞和小胶质细胞功能。Semapimod tetrahydrochloride 可抑制 TLR4 信号传导，抑制 TNF-α、IL-1β 和 IL-6，可用于研究克罗恩病和其他炎症。
T12781	RV01	Others	Others
	RV01 是一种新型的白藜芦醇喹啉取代类似物，可抑制 DNA 损伤，降低乙醇诱导的乙醛脱氢酶 (ALDH2) 的 mRNA 表达，具有清除羟自由基的活性。RV01 降低 iNOS 的表达，具有抗神经炎症作用。RV01降低肿瘤坏死因子-a (TNF-a)和白细胞介素-6 (IL-6) mRNA 水平和分泌，抑制lps 诱导的ROS 生成和烟酰胺腺嘌呤二核苷酸磷酸(NADPH)氧化酶活化，降低toll 样受体4 (TLR4)的蛋白表达，抑制lps 诱导的丝裂原活化蛋白激酶(MAPK)和核转录因子-кB (NF-кB)信号通路的激活。
T69626	L6H21
	L6H21 is an inhibitor of the interaction and signaling transduction of LPS-TLR4/MD-2 (myeloid differentiation 2).
T38261	Sparstolonin B
	Sparstolonin B is a chemical compound that functions as a selective antagonist for TLR2 and TLR4, specifically targeting TLR2- and TLR4-mediated inflammatory signaling. This compound demonstrates additional pharmacological properties, including anti-HIV and anticancer activities[1][2].
T70145	LYRM03
	LYRM03 is an aminopeptidase inhibitor. LYRM03 is also an ubenimex derivative. LYRM03 attenuates LPS-induced acute lung injury in mice by suppressing the TLR4 signaling pathway. LYRM03 effectively attenuates LPS-induced ALI by inhibiting the expression of pro-inflammatory mediators and Myd88-dependent TLR4 signaling pathways in alveolar macrophages. LYRM03 may serve as a potential treatment for sepsis-mediated lung injuries.
T70595	Artemisinin B
	Artemisinin B is a drug which may improve spatial memory in dementia patients and alter the levels of inflammatory cytokines in the hippocampus and the cortex. Artemisinin B may inhibit neuroinflammation and exert neuroprotective effects on cognitive functions by modulating the TLR4-MyD88-NF-κB signaling pathway. Artemisinin B has shown potential in the treatment of neuroinflammatory diseases.
T79304	Semapimod CPSI-2364,CNI-1493 free base
	Semapimod是一种抑制促炎细胞因子产生的化合物，具有抑制TNF-α、IL-1β和IL-6功能。它通过抑制巨噬细胞的p38 MAPK以及一氧化氮的生成发挥作用，并且能够抑制TLR4信号传导（IC50约为0.3 μM）。Semapimod对于治疗各类炎症和自身免疫性疾病显示出潜在效用。

化合物

Cat.No: T21826

Synonym: NSC 30176

Target: Histone Methyltransferase

Cat.No: T11598

Target: TLR

Cat.No: TQ0181

Synonym: CLI-095,TAK-242,瑞沙托维

Target: TNF, TLR, Autophagy, Interleukin

Cat.No: T40423

Semapimod tetrahydrochloride

Cat.No: T35593

Synonym: CPSI-2364 tetrahydrochloride

Target: TLR, MAPK

Cat.No: T12781

Target: Others

Cat.No: T69626

Cat.No: T38261

Cat.No: T70145

Cat.No: T70595

Cat.No: T79304

Synonym: CPSI-2364,CNI-1493 free base

Cat. No.	Product Name	Target	Signaling Pathways
T5S0167	Atractylenolide I 白术内酯 I,白术内酯I；苍术内酯I	IL Receptor; TNF; TLR; JAK; STAT	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Immunology/Inflammation; JAK/STAT signaling; Stem Cells
	Atractylenolide I 是从白术根中得到的一种倍半萜烯，具有神经保护、抗过敏、抗炎和抗癌等多种生物活性。它是一种TLR4拮抗剂，在 A375 细胞中，能够降低JAK2和STAT3的磷酸化水平。
T6S1917	Schisandrol B Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B	P450; Reactive Oxygen Species; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; NF-κB
	Schisandrol B (Besigomsin) 是华中五味子的主要活性成分，具有保肝、抗炎、抗糖尿病和抗氧化的作用。它抑制活性氧的产生，也抑制 P-糖蛋白和CYP3A 的活性。
T3826	Polygalasaponin F 异牡荆苷,瓜子金皂苷己	NF-κB; TLR; Akt; PI3K	Cytoskeletal Signaling; Immunology/Inflammation; NF-κB; PI3K/Akt/mTOR signaling
	Polygalasaponin F 是从瓜子金中提取的齐墩果烷型三萜皂苷，可通过调节TLR4-PI3K/AKT-NF-kB 信号通路减少神经炎症细胞因子的分泌，能降低炎性细胞因子肿瘤坏死因子 α 的释放。
T27191	D-Mannuronic Acid
	D-Mannuronic Acid is a blocker of the TLR2 and TLR4 downstream signaling pathway. D-Mannuronic Acid effectively inhibits mRNA expression of MyD88 and p65, major subunit of nuclear factor-kappaB.
TN3587	Capillarisin	MMP; ERK; IL Receptor; BCL; VEGFR; TNF; NOS; NF-κB; TLR; MAPK; COX; DNA/RNA Synthesis; Prostaglandin Receptor; JNK; STAT	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with

天然产物

Atractylenolide I

Cat.No: T5S0167

Synonym: 白术内酯 I,白术内酯I；苍术内酯I

Target: IL Receptor, TNF, TLR, JAK, STAT

Cat.No: T6S1917

Synonym: Gomisin A,TJN-101,Besigomsin,五味子醇乙,Gamma-Schisandrin,戈米辛A,Schizandrol B,Wuweizi alcohol-B

Target: P450, Reactive Oxygen Species, Autophagy

Polygalasaponin F

Cat.No: T3826

Synonym: 异牡荆苷,瓜子金皂苷己

Target: NF-κB, TLR, Akt, PI3K

D-Mannuronic Acid

Cat.No: T27191

Cat.No: TN3587

Target: MMP, ERK, IL Receptor, BCL, VEGFR, TNF, NOS, NF-κB, TLR, MAPK, COX, DNA/RNA Synthesis, Prostaglandin Receptor, JNK, STAT

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