首页工具

登录

搜索结果

Search Results for " t-lymphocyte "

35

抑制剂 & 化合物

2

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T9919	Alemtuzumab	Others	Others
	Alemtuzumab 是人源化抗 CD52单克隆抗体， CD52是一种表达于大多数淋巴细胞以及少数的髓细胞类型的糖蛋白。Alemtuzumab 与能够特异性作用于 CD52 抗原，诱导淋巴细胞深度耗竭，恢复具有调节表型的 T 细胞和 B 细胞。。
T9616	PD-1/PD-L1-IN-10	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-10 是一种口服有效的PD-1/PD-L1抑制剂 (IC50of 2.7 nM)，显示出抗肿瘤活性。
T10389L	Aspartyl-alanyl-diketopiperazine acetate DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)	Others	Others
	Aspartyl-alanyl-diketopiperazine acetate (DA-DKP) 可以通过与 T 淋巴细胞无反应有关的分子途径调节炎症免疫反应。
TQ0007	Cintirorgon LYC-55716	ROR	Metabolism
	Cintirorgon (LYC-55716) 是一种首创的、口服有活力的的RORγ选择性激动剂。它通过调节 RORγ 表达的 T 淋巴免疫细胞的基因表达，提高效应子功能，降低免疫抑制，抑制肿瘤生长，提高生存率。
T77466	Tremelimumab Ticilimumab,CP-675206	Others	Others
	Tremelimumab 是一种细胞毒性T淋巴细胞相关抗原-4（CTLA-4）阻断抗体.Tremelimumab 常与 Durvalumab 联合使用来治疗肝癌、肺癌等实体癌。
T3977	Lifitegrast SHP-606,SAR 1118,立他司特,利非司特	Integrin	Cytoskeletal Signaling
	Lifitegrast (SAR 1118) 是一种整合素淋巴细胞功能相关抗原 1 拮抗剂，抑制 Jurkat T 细胞附着于ICAM-1的IC50为 2.98 nM。
T0944	Levamisole hydrochloride (-)-Tetramisole hydrochloride,盐酸左旋咪唑	Phospholipase; AChR; Parasite; HSV	Metabolism; Microbiology/Virology; Neuroscience
	Levamisole hydrochloride ((-)-Tetramisole hydrochloride) 是驱虫剂和免疫调节剂。它对HSV 病毒有明显抗病毒作用。
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T3614	Inosine pranobex Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun	IL Receptor; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Inosine pranobex (Delimmun) 是一种免疫增强剂，它是一种广谱抗病毒剂，用于 HIV 感染。
T26752	BC12 BC 12,BC-12
	BC12 exhibits unusually potent immunomodulatory actions on T lymphocyte function, including inhibition of T cell proliferation and IL-2 cytokine production.
TP1612	OVA sequence (323-336) OVA sequence 323-336
	This peptide is a cognate helper T-lymphocyte peptide that is employed to enhance CTL epitope immunogencity
T80573	Firastotug
	Firastotug为针对CTLA4的IgG1κ抗体。CTLA4作为细胞毒性T淋巴细胞相关抗原，它在自身免疫和癌症研究中扮演着重要的免疫检查点角色。
T3977L	Lifitegrast sodium SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra
	Lifitegrast sodium (SAR-1118) is an LFA-1 antagonist for the therapy of vascular complications of the eye. It inhibits T cell-mediated inflammation by blocking the binding of two cell surface proteins (lymphocyte function-associated antigen 1 and intercel
T77103	Nurulimab
	Nurulimab (BCD-145) 是一种抗细胞毒性 T 淋巴细胞抗原 4 (抗 CTLA-4) 人源化单克隆抗体。Nurulimab 可用于黑色素瘤的研究。
TP1515	HPV16-E711-20 epitope
	HPV16-E711-20 epitope is a well-known HLA-A*0201-restricted human cytotoxic T lymphocyte (CTL) epitope of the HPV16 E7 protein that shows high-affinity binding to HLA-A2 in vitro.
T39292	NS2 (114-121), Influenza NS2 (114-121), Influenza
	NS2 (114-121), Influenza, is a fragment derived from the nonstructural protein 2 (NS2) of the influenza virus. This compound serves as an epitope for influenza research and can be utilized to study the CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses.
T27192	DMI-9523 DA-DKP,Ampion,DMI 9523,DM-9523
	DMI-9523 is nuclear factor NF-κB activation inhibitor. Antigen-stimulated human T lymphocytes produce significantly lower quantities of interferon-gamma and tumor necrosis factor-alpha after stimulation in vitro in the presence of DA-DKP. DA-DKP can modul
T82743	CFP10 (71–85)
	CFP10 (71–85) 是具生物活性的肽类，能激活表达不同MHC II类与I类分子的人类CD4+和CD8+ T细胞，诱导IFN-γ产生及CTL活性。(CFP10 71–85).
T77106	Odulimomab
	Odulimomab (anti-LFA1) 是一种抗 LFA-1单克隆抗体。Odulimomab 抑制 T 淋巴细胞增殖，对缺血再灌注损伤有保护作用。Odulimomab 可用于移植排斥反应和免疫疾病的研究。
T76241	Trichomide A
	Trichomide A 是一种有效的 SHP2激活剂。Trichomide A 是一种天然的环缩肽。Trichomide A 在 Con A 激活的 T 细胞中对激活的 T 淋巴细胞介导的免疫反应具有免疫抑制活性。Trichomide A 具有研究免疫相关皮肤病的潜力。
T82485	ELAAWCRWGFLLALLPPGIAG
	ELAAWCRWGFLLALLPPGIAG (P5) 是源自大鼠HER2/neu蛋白的21个氨基酸长肽（氨基酸5-25）。此肽可诱导携带HER2阳性肿瘤小鼠中的细胞毒性T淋巴细胞（CTL）反应。
T77104	Obrindatamab
	Obrindatamab 是一种人源化抗 B7-H3/CD3双特异性抗体。Obrindatamab 结合 B7-H3和 CD3，从而介导针对表达 B7-H3的癌细胞的重定向细胞毒性 T 淋巴细胞 (CTL) 活性。Obrindatamab 可用于癌症研究。
T16578	PRN694	Others	Others
	PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible T-cell kinase (ITK) and resting ly
T82484	ELAAWCRWGFLLALLPPGIAG TFA
	ELAAWCRWGFLLALLPPGIAG TFA (P5) 是由大鼠HER2/neu蛋白衍生的21个氨基酸长的肽段（氨基酸序号5至25）。该化合物在携带HER2阳性肿瘤的小鼠模型中，能够诱发细胞毒性T淋巴细胞(CTL)的反应。
T76933	Botensilimab
	Botensilimab (AGEN 1181)，一种针对细胞毒性T淋巴细胞抗原4 (CTLA-4) 的人源化单克隆抗体，既能激活先天性免疫也能激活适应性免疫，主要应用于癌症研究领域。
T37577	Glycogen Phosphorylase Inhibitor
	Glycogen phosphorylase in the liver, muscle, and brain initiate glycogenolysis by releasing glucose-1-phosphate from glycogen. Glycogen phosphorylase inhibitor is a cell-permeable acyl urea first identified as an inhibitor of human liver glycogen phosphorylase (IC50 = 53 nM). It blocks glucagon-induced hepatic glycogenolysis in vivo. Glycogen phosphorylase inhibitor has been used to study glycogen utilization in human liver HepG2 cells, retinal explants, and human T lymphocyte Kit 225 cells.
T77188	Tifcemalimab
	Tifcemalimab (JS004) 是一种人源化抗 BTLA(B 和 T 淋巴细胞衰减因子) 单克隆抗体。Tifcemalimab 通过与 BTLA 结合，阻断 HVEM-BTLA 的相互作用，从而阻断BTLA 介导的抑制信号通路。Tifcemalimab 可用于癌症的研究。
T78293	TSR-033
	TSR-033为针对LAG-3（淋巴细胞活化基因-3）的人源化IgG4高亲和力抗体，能增强T细胞功能及PD-1阻断效果，适用于体外及体内。作为与T细胞功能障碍相关的共抑制受体，LAG-3常与PD-1共同表达，TSR-033因此表现出抗肿瘤活性。
T64017	RORγt agonist 3
	RORγt agonist 3 是 RORγt 的有效激动剂。RORγt agonist 3 能够促使 Th17 细胞分化，增加促炎细胞因子水平，进而提高淋巴细胞的细胞毒性。RORγt agonist 3 能够阻碍调节性 T 细胞的产生，并免疫反应产生抑制作用。
T64140	RORγt agonist 2
	RORγt agonist 2 是 RORγt 的有效的激动剂。RORγt agonist 2 能够诱导 Th17 细胞分化，增加促炎细胞因子水平，进而增强淋巴细胞的细胞毒性。RORγt agonist 2 对调节性 T 细胞的产生表现出抑制作用，能够抑制免疫反应。
T83930	SJ 11646
	SJ11646是一种高效的LCK（淋巴细胞特异性蛋白酪氨酸激酶）降解剂（PROTAC；DC50= 0.00838 pM）。该化合物由Dasatinib作为LCK配体，以及基于苯基谷氨酰亚胺的cereblon结合体组成。它在体外对LCK激活的T细胞急性淋巴细胞白血病（T-ALL）细胞株和初级白血病样本展现出细胞毒性。在体内，SJ11646在源自患者的T-ALL异种移植模型中显示出抗白血病效果。
T83910	S1PL-IN-31 Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31
	S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM)，同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内，S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中，由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平，并且在雌性大鼠中降低了心率。
T37548	azido-FTY720 azido-FTY720
	FTY720 is a derivative of ISP-1 (myriocin), a fungal metabolite of the Chinese herb Iscaria sinclarii as well as a structural analog of sphingosine. It is a novel immune modulator that prolongs allograft transplant survival in numerous models by inhibiting lymphocyte emigration from lymphoid organs. FTY720 is phosphorylated by sphingosine kinase, which then acts as a potent agonist at four of the sphingosine-1-phosphate (S1P) receptors (S1P1, S1P3, S1P4, and S1P5). Down-regulation of S1P1 recept...
T80066	ShK toxin	Potassium Channel	Membrane transporter/Ion channel
	ShK toxin 是从加勒比海葵（Stichodactylu helianthus）的全身提取物中分离出的一种蛋白，能够阻断电压依赖性钾通道(Kv1.3 通道)。在竞争实验中，ShK toxin 与树突毒素 I 及α-树突毒素相互竞争，以与大鼠脑突触体膜结合，从而促进乙酰胆碱的释放。此外，ShK toxin 抑制培养的大鼠背根神经节神经元中的K+ 电流，并且能够抑制T淋巴细胞的增殖。
T37052	Tetranactin
	Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen...

化合物

Cat.No: T9919

Target: Others

PD-1/PD-L1-IN-10

Cat.No: T9616

Target: PD-1/PD-L1

Aspartyl-alanyl-diketopiperazine acetate

Cat.No: T10389L

Synonym: DA-DKP,Aspartyl-alanyl-diketopiperazine acetate(110954-19-3 Free base)

Target: Others

Cat.No: TQ0007

Synonym: LYC-55716

Target: ROR

Cat.No: T77466

Synonym: Ticilimumab,CP-675206

Target: Others

Cat.No: T3977

Synonym: SHP-606,SAR 1118,立他司特,利非司特

Target: Integrin

Levamisole hydrochloride

Cat.No: T0944

Synonym: (-)-Tetramisole hydrochloride,盐酸左旋咪唑

Target: Phospholipase, AChR, Parasite, HSV

Cat.No: T63790

Target: E1/E2/E3 Enzyme

Inosine pranobex

Cat.No: T3614

Synonym: Groprinosin,Isoprinosine,异丙肌苷,Immunovir,Delimmun

Target: IL Receptor, HIV Protease

Cat.No: T26752

Synonym: BC 12,BC-12

OVA sequence (323-336)

Cat.No: TP1612

Synonym: OVA sequence 323-336

Cat.No: T80573

Lifitegrast sodium

Cat.No: T3977L

Synonym: SAR-1118-023,SAR1118-023,SAR 1118-023,Xiidra

Cat.No: T77103

HPV16-E711-20 epitope

Cat.No: TP1515

NS2 (114-121), Influenza

Cat.No: T39292

Synonym: NS2 (114-121), Influenza

Cat.No: T27192

Synonym: DA-DKP,Ampion,DMI 9523,DM-9523

CFP10 (71–85)

Cat.No: T82743

Cat.No: T77106

Cat.No: T76241

ELAAWCRWGFLLALLPPGIAG

Cat.No: T82485

Cat.No: T77104

Cat.No: T16578

Target: Others

ELAAWCRWGFLLALLPPGIAG TFA

Cat.No: T82484

Cat.No: T76933

Glycogen Phosphorylase Inhibitor

Cat.No: T37577

Cat.No: T77188

Cat.No: T78293

RORγt agonist 3

Cat.No: T64017

RORγt agonist 2

Cat.No: T64140

Cat.No: T83930

Cat.No: T83910

Synonym: Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31

Cat.No: T37548

Synonym: azido-FTY720

Cat.No: T80066

Target: Potassium Channel

Cat.No: T37052

Cat. No.	Product Name	Target	Signaling Pathways
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T1257	Bestatin Ubenimex,乌苯美司	Others; Aminopeptidase; Antibacterial; Antibiotic; LTR	Immunology/Inflammation; Metabolism; Microbiology/Virology; Others
	Bestatin (Ubenimex) 是 CD13 (Aminopeptidase N)/APN 和 leukotriene A4 hydrolase 抑制剂，可用于癌症研究。

天然产物

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T1257

Synonym: Ubenimex,乌苯美司

Target: Others, Aminopeptidase, Antibacterial, Antibiotic, LTR

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼