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Search Results for " staphylococcus "

141

抑制剂 & 化合物

92

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T80707	α-Hemolysin (Staphylococcus aureus)
	α-Hemolysin (Staphylococcus aureus) 是一种由金黄色葡萄球菌分泌的毒力因子，具有破坏宿主细胞质膜的多肽特性。α-Hemolysin 绑定细胞表面后，通过其单体组装成同型七聚体预孔结构，并转变为成熟的跨膜孔，形成水通道。这一过程促使 K+ 和 Ca2+ 离子通过膜，触发靶细胞的坏死性死亡。
T5038	Cephapirin Sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Cephapirin sodium 是一种半合成头孢菌素类抗生素，对革兰氏阳性菌和革兰氏阴性菌有杀菌作用。
T19717	Cyclo-L-Trp-L-Trp	Antifungal	Microbiology/Virology
	Cyclo-L-Trp-L-Trp 是一种广谱抗真菌剂。它还诱导组蛋白的高度乙酰化。
T1440	Ethacridine lactate monohydrate 乳酸依沙吖啶一水物,利凡诺	Antibacterial; Antibiotic	Microbiology/Virology
	Ethacridine lactate monohydrate 是一种聚 (ADP-核糖) 糖基水解酶 (PARG) 抑制剂，有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。它也是抗菌剂和流产剂。
T1224	Cefuroxime sodium Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin	Antibacterial; Antibiotic	Microbiology/Virology
	Cefuroxime sodium (Cefuroxime sodium salt) 是一种具有口服活性的头孢菌素抗生素，增加了对 β-内酰胺酶的稳定性。
T5967	Ethacridine lactate 乳酸依沙吖啶,Acrinol,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE	Others; Antibacterial	Microbiology/Virology; Others
	Ethacridine lactate (Acrinol) 是一种聚 (ADP-核糖) 糖水解酶 (PARG) 抑制剂，也是一种抗菌剂和流产剂。它有抗金黄色葡萄球菌和其他革兰氏阳性球菌的活性。
T21358	Dalbavancin BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星	Antibacterial; Antibiotic	Microbiology/Virology
	Dalbavancin (BI-397) HCl 是一种半合成的脂糖肽抗生素，对革兰氏阳性细菌有杀菌活性。Dalbavancin 抑制金黄色葡萄球菌和炭疽芽孢杆菌的 MIC90分别为 0.06 μg/mL 和 0.25 μg/mL。
T4105	AFN-1252 Debio 1452,API-1252	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	AFN-1252 (Debio 1452)是一种FabI 的高效抑制剂，能抑制金黄色葡萄球菌。
T33470	Monoctanoin 辛酸2,3-二羟基酯,Glyceryl 1-caprylate,Moctanin	Antibacterial	Microbiology/Virology
	Monoctanoin (Glyceryl 1-caprylate) 对金黄色葡萄球菌和大肠杆菌具有抗菌活性。
T71699	Lanopepden mesylate GSK 1322322 mesylate,GSK-1322322J mesylate	Antibacterial	Microbiology/Virology
	Lanopepden mesylate 是一种肽去甲酰酶抑制剂，可抑制金黄色葡萄球菌。
T60093	CHEMBL1380345 N,N'-(Ethane-1,2-diyl)bis(3-methylbenzenesulfonamide)	Antibacterial	Microbiology/Virology
	CHEMBL1380345 对金黄色葡萄球菌、蜡状芽孢杆菌和大肠杆菌具有抗菌活性，pMIC 值分别为 3.64、3.56 和 3.70。
T12242	Norvancomycin hydrochloride Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素	Antibacterial	Microbiology/Virology
	Norvancomycin hydrochloride (Desmethyl-vancomycin hydrochloride) 可用于葡萄球菌所致的心内膜炎、骨髓炎、肺炎、败血症或软组织感染。
T40475	Ceftobiprole medocaril BAL5788,头孢比普酯	Antibacterial	Microbiology/Virology
	Ceftobiprole medocaril (BAL5788) 是 Ceftobiprole 的前药。Ceftobiprole 是一种广谱的头孢菌素，对耐甲氧西林金黄色葡萄球菌具有活性。
T17254	Amifloxacin Win49375,氨氟沙星	Antibacterial	Microbiology/Virology
	Amifloxacin (Win49375) 是有效的喹诺酮类抗菌剂。
TQ0077	Ceftobiprole Ro 63-9141,BAL 9141,头孢吡普	Antibacterial	Microbiology/Virology
	Ceftobiprole (Ro 63-9141) 是一种广谱头孢菌素，对甲氧西林耐受的金黄色葡萄球菌的MIC90值为 2 μg/mL。
T2331	Solithromycin 索利霉素,OP-1068,CEM-101	Antibacterial; Antibiotic	Microbiology/Virology
	Solithromycin (OP-1068) 是口服可生物利用的抗菌剂，抑制肺炎链球菌、葡萄球菌、金黄色葡萄球菌和流感嗜血杆菌的细胞活力、蛋白质合成和生长速率， IC50 值分别为 7.5 ng/mL、40 ng/mL 和 125 ng/mL。它可与核糖体的大 50S 亚基结合抑制蛋白质生物合成。
T7872	Monolaurin	Others	Others
	Monolaurin 是椰子油中的一种表面活性剂和乳化剂。它抑制葡萄球菌、链球菌、加德纳菌、念珠菌和嗜血杆菌的生长，并减少促炎细胞因子的产生。
T77686	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone	Antifungal	Microbiology/Virology
	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 具有广谱的抗真菌活性，对白色念珠菌、黑曲霉、铜绿假单胞菌、金黄色葡萄球菌等具有抑制作用。
T38137	3,5-Dimethylbenzaldehyde	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	3,5-Dimethylbenzaldehyde 具有广谱的抗菌活性，对枯草芽孢杆菌、白假丝酵母菌、大肠杆菌、铜绿假单胞菌、金黄色葡萄杆菌和肺炎链球菌具有抑制作用。
T11815	Lanopepden GSK 1322322,GSK-1322322B,GSK-1322322J	Antibiotic	Microbiology/Virology
	Lanopepden (GSK 1322322) 是一种有效的肽去甲酰酶抑制剂，抑制金黄色葡萄球菌，抑制 ATCC 29213 和 ATCC 25923 菌株，可用于研究肺炎、皮肤病和传染病。
T0391	Linezolid PNU-100766,雷奈佐利	MAO; Antibacterial; Antibiotic	Metabolism; Microbiology/Virology; Neuroscience
	Linezolid (PNU-100766) 是恶唑烷酮类合成抗生素，抑制细菌蛋白质合成的起始阶段，具有抗感染作用。
T22269	Benzyldodecyldimethylammonium Chloride Dihydrate	Antibacterial	Microbiology/Virology
	Benzyldodecyldimethylammonium chloride dihydrate 可以用作杀虫试剂，可以靶向耐药性细菌，如耐甲氧西林金黄色葡萄球菌、耐多药铜绿假单胞菌等，且具有浓度依赖性。
T1492	Gemifloxacin mesylate LB-20304a,甲磺酸吉米沙星,SB-265805S,Gemifloxacin mesylate	DNA gyrase; Topoisomerase; Antibacterial	DNA Damage/DNA Repair; Microbiology/Virology
	Gemifloxacin mesylate (Gemifloxacin mesylate) 是一种喹诺酮类口服广谱抗菌剂，可研究轻中度肺炎和慢性支气管炎的急性细菌性发作。
T50004	Phentolamine acetate 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol acetic acid	Others	Others
	Phentolamine acetate (3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol acetic acid) 是一种化合物，它在体外已被证明具有抗炎和抗癌特性，还被证明可以抑制某些细菌的生长，包括金黄色葡萄球菌。
T1031	Cloxacillin sodium monohydrate Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物	Antibacterial; Antibiotic	Microbiology/Virology
	Cloxacillin sodium monohydrate (Cloxacillin Sodium) 有抗菌作用，对Staphylococcus aureus25923 的最小抑菌浓度为256 mg/L。
T77608	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-	Antifungal	Microbiology/Virology
	1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 可作为一种广谱抗菌剂，对黑曲霉枯草芽孢杆菌、白假丝酵母、大肠杆菌和金黄色葡萄球菌有抑制作用。1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl- 在体外实验中显示出抗炎活性，可用于治疗细菌感染。
T64316	VP-4604 1-((4-Nitrophenyl)sulfonyl)piperidine
	VP-4604是一种有效的抗耐甲氧西林金黄色葡萄球菌（MRSA）化合物。VP-4604对金黄色葡萄球菌展现出显著的抑制微生物生长的作用，MIC 为4-8μg/mL。VP-4604抑制耐甲氧西林金黄色葡萄球菌的生长，其生长抑制率达到95%以上。
T4165	Delpazolid LCB01-0371	Antibacterial; Antibiotic	Microbiology/Virology
	Delpazolid (LCB01-0371) 是一种恶唑烷酮类新型抗生素，能抑制MSSA 和MRSA 的生长，对它们的MIC90值都为 2 μg/mL。
T22297	Clindamycin hydrochloride monohydrate Clindamycin alcoholate	Antibiotic	Microbiology/Virology
	Clindamycin hydrochloride monohydrate（Clindamycin alcoholate）是一种口服蛋白质合成抑制剂，具有在金黄色葡萄球菌中以亚抑制浓度(sub-MICs)抑制毒力因子表达的能力。其抗性来源于50S核糖体亚基（23S rRNA）的抗生素结合位点通过酶促甲基化。此外，Clindamycin hydrochloride monohydrate能显著减少杀白细胞毒素（PVL）、毒性休克-葡萄球菌毒素（TSST-1）或α-溶血素（Hla）的产生。
T13063	T6167923	MyD88	Immunology/Inflammation
	T6167923是一种有效的、选择性的MyD88依赖性信号通路抑制剂。T6167923 与 MyD88 的 Toll/IL1 受体 (TIR) 结构域结合良好，破坏 MyD88 的同二聚体形成。T6167923 抑制 NF-κB 驱动的葡萄球菌肠毒素AP (SEAP) 活性，并且改善抗炎活性，对 IFN-γ，IL-1β，IL-6 和 TNF-α 的 IC50分别为 2.7 μM，2.9 μM，2.66 μM 和 2.66 μM。
T23871	Cefuzonam sodium CZON,L-105,Cosmosin,CL 251931 sodium salt,L 105
	Cefuzonam sodium is a second-generation cephalosporin antibiotic. It may be effective against Staphylococcus aureus against which third-generation cephalosporins are largely ineffective.
T27995	MDK-3046 HK-inhibitor-2,MDK3046,HK inhibitor 2
	MDK-3046 is a YycG histidine kinase (HK) inhibitor with potent antibiofim activity against Staphylococcus epidermidis.
T32990	LY 164846 LY164846,LY-164846,7-Bgmcc
	LY 164846 is a novel oral cephalosporin that is effective against Staphylococcus, Streptococcus, Haemophilus influenzae, Catabella and Neisseria.
T82949	Atidortoxumab
	Atidortoxumab是针对Staphylococcus aureus alpha毒素的人类IgG1κ单克隆抗体。
T60525	VP-4556
	VP-4556 是一种有效的抗耐甲氧西林金黄色葡萄球菌 (MRSA) 剂，对金黄色葡萄球菌 (ATCC 43300) 具有显著的生长抑制作用，MIC 为 8 μg/mL。VP-4556 对于耐甲氧西林金黄色葡萄球菌(MRSA)的生长抑制率达 95% 以上。
T69823	MC4
	MC4 is a first-in-class inhibitor of ribosomal RNA synthesis with antimicrobial activity against Staphylococcus aureus.
T11062	dmDNA31	Others	Others
	dmDNA31 is a rifamycin antibiotic that can inhibit the DNA-dependent RNA polymerase of bacteria and has strong bactericidal activity against Staphylococcus aureus.
T30509	BMS-247243 BMS247243,UNII-KG8365V22L
	BMS-247243 is a novel cephalosporin inhibitor that is mainly active against Gram-positive bacteria and also against methicillin-resistant Staphylococcus.
T80398	Brevinin-1PMa
	Brevinin-1PMa为宿主防御肽，对金黄色葡萄球菌（Staphylococcus aureus）和大肠杆菌（Escherichia coli）展现出抗菌活性，并具溶血活性。
T33094	Lysylphosphatidylglycerol
	Lysylphosphatidylglycerol is glycerol with two fatty acids plus a lysine-glycerol-phosphate, a major membrane phospholipid of Staphylococcus and the lysine positive charge repels DEFENSINS.
T73859	Methicillin sodium hydrate
	Methcillin sodium hydrate 是一种窄谱 β-内酰胺类抗生素，通过抑制青霉素结合蛋白 (penicillin-binding proteins,PBP) 发挥作用。Methcillin sodium hydrate 对青霉素耐药性的金黄色葡萄球菌Staphylococcus aureu 和表皮葡萄球菌Staphylococcus epidermidis 有活性。Methcillin sodium hydrate 可用于研究皮肤感染、骨髓炎和心内膜炎等疾病。
T15142	Vebufloxacin OPC7241,Flumenique,DM8966	Antibacterial	Microbiology/Virology
	Vebufloxacin (OPC-7251) shows potent antibacterial activity against gram-positive and -negative bacteria, including Staphylococcus aureus and Pseudomonas aeruginosa. It has potent activity characteristically against Propionibacterium acnes.
T61799	Antibacterial agent 75
	Antibacterial agent 75 (compound 24) possesses antibacterial properties. Its notable attribute is the ability to re-sensitize VRSA (Vancomycin-Resistant Staphylococcus aureus) strains to vancomycin, as reported in reference [1].
T26256	Teicoplanin aglycone TD-A3
	Teicoplanin aglycone is an antibacterial glycopeptide antibiotic used in the prophylaxis and treatment of serious infections caused by Gram-positive bacteria, including Enterococcus faecalis and methicillin-resistant Staphylococcus aureus.
T82930	Autoinducing Peptide I
	Autoinducing Peptide I为金黄色葡萄球菌分泌的环状八肽，主要用于疫苗研究领域。
T70436	BMS 188745 Potassium Salt
	BMS 188745 Potassium Salt inhibits the biosynthesis of the Staphylococcus aureus virulence factor staphyloxanthin via inhibition of dehydrosqualene synthase (CrtM).
T80323	Bovine neutrophil beta-defensin 12 BNBD-12
	Bovine neutrophil beta-defensin 12，一种牛中性粒细胞来源的抗菌肽，展现针对大肠杆菌(Escherichia coli)和金黄色葡萄球菌(Staphylococcus aureus)的抗菌活性。
T68203	Tuberine, (+)-
	Tuberine, (+)- is an alkaloid isolated from Haplophyllum tuberculatum that has high antimicrobial activity against Staphylococcus aureus, Bacillus subtilis and Saccharomyces cerevisiae. Tuberine, (+)- is also slightly inhibitory to Escherichia coli .
T76658	SYNV-cyclo(CGGYF)
	SYNV-cyclo(CGGYF)，一种源自人葡萄球菌(S. hominis)C5的自诱导肽，能抑制金黄色葡萄球菌(S. aureus)的活性，展现出研究金黄色葡萄球菌引发的上皮损伤及炎症的潜力。
T81024	Tefibazumab INH-H 2002
	Tefibazumab是一种人源化IgG1κ单克隆抗体，它能特异性结合至金黄色葡萄球菌表面表达的粘附蛋白凝集因子A。该抗体主要用于针对严重金黄色葡萄球菌感染的研究。

化合物

α-Hemolysin (Staphylococcus aureus)

Cat.No: T80707

Cephapirin Sodium

Cat.No: T5038

Target: Antibacterial, Antibiotic

Cyclo-L-Trp-L-Trp

Cat.No: T19717

Target: Antifungal

Ethacridine lactate monohydrate

Cat.No: T1440

Synonym: 乳酸依沙吖啶一水物,利凡诺

Target: Antibacterial, Antibiotic

Cefuroxime sodium

Cat.No: T1224

Synonym: Anaptivan,头孢呋辛钠,Cefuroxime sodium salt,Biociclin

Target: Antibacterial, Antibiotic

Ethacridine lactate

Cat.No: T5967

Synonym: 乳酸依沙吖啶,Acrinol,6,9-DIAMINO-2-ETHOXYACRIDINE LACTATE

Target: Others, Antibacterial

Cat.No: T21358

Synonym: BI 397,BI-397,VER 001,A-A 1,BI397,VER-001,Dalbavancin HCl,达巴万星

Target: Antibacterial, Antibiotic

Cat.No: T4105

Synonym: Debio 1452,API-1252

Target: Others, Antibacterial, Antibiotic

Cat.No: T33470

Synonym: 辛酸2,3-二羟基酯,Glyceryl 1-caprylate,Moctanin

Target: Antibacterial

Lanopepden mesylate

Cat.No: T71699

Synonym: GSK 1322322 mesylate,GSK-1322322J mesylate

Target: Antibacterial

Cat.No: T60093

Synonym: N,N'-(Ethane-1,2-diyl)bis(3-methylbenzenesulfonamide)

Target: Antibacterial

Norvancomycin hydrochloride

Cat.No: T12242

Synonym: Desmethyl-vancomycin hydrochloride,盐酸去甲万古霉素

Target: Antibacterial

Ceftobiprole medocaril

Cat.No: T40475

Synonym: BAL5788,头孢比普酯

Target: Antibacterial

Cat.No: T17254

Synonym: Win49375,氨氟沙星

Target: Antibacterial

Cat.No: TQ0077

Synonym: Ro 63-9141,BAL 9141,头孢吡普

Target: Antibacterial

Cat.No: T2331

Synonym: 索利霉素,OP-1068,CEM-101

Target: Antibacterial, Antibiotic

Cat.No: T7872

Target: Others

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Cat.No: T77686

Target: Antifungal

3,5-Dimethylbenzaldehyde

Cat.No: T38137

Target: Endogenous Metabolite, Antifungal

Cat.No: T11815

Synonym: GSK 1322322,GSK-1322322B,GSK-1322322J

Target: Antibiotic

Cat.No: T0391

Synonym: PNU-100766,雷奈佐利

Target: MAO, Antibacterial, Antibiotic

Benzyldodecyldimethylammonium Chloride Dihydrate

Cat.No: T22269

Target: Antibacterial

Gemifloxacin mesylate

Cat.No: T1492

Synonym: LB-20304a,甲磺酸吉米沙星,SB-265805S,Gemifloxacin mesylate

Target: DNA gyrase, Topoisomerase, Antibacterial

Phentolamine acetate

Cat.No: T50004

Synonym: 3-[(4,5-dihydro-1H-imidazol-2-ylmethyl)(4-methylphenyl)amino]phenol acetic acid

Target: Others

Cloxacillin sodium monohydrate

Cat.No: T1031

Synonym: Cloxacillin Sodium,Bactopen,氯唑西林钠一水合物

Target: Antibacterial, Antibiotic

1H-Indole, 3,3'-(2-thienylmethylene)bis[2-methyl-

Cat.No: T77608

Target: Antifungal

Cat.No: T64316

Synonym: 1-((4-Nitrophenyl)sulfonyl)piperidine

Cat.No: T4165

Synonym: LCB01-0371

Target: Antibacterial, Antibiotic

Clindamycin hydrochloride monohydrate

Cat.No: T22297

Synonym: Clindamycin alcoholate

Target: Antibiotic

Cat.No: T13063

Target: MyD88

Cefuzonam sodium

Cat.No: T23871

Synonym: CZON,L-105,Cosmosin,CL 251931 sodium salt,L 105

Cat.No: T27995

Synonym: HK-inhibitor-2,MDK3046,HK inhibitor 2

Cat.No: T32990

Synonym: LY164846,LY-164846,7-Bgmcc

Cat.No: T82949

Cat.No: T60525

Cat.No: T69823

Cat.No: T11062

Target: Others

Cat.No: T30509

Synonym: BMS247243,UNII-KG8365V22L

Cat.No: T80398

Lysylphosphatidylglycerol

Cat.No: T33094

Methicillin sodium hydrate

Cat.No: T73859

Cat.No: T15142

Synonym: OPC7241,Flumenique,DM8966

Target: Antibacterial

Antibacterial agent 75

Cat.No: T61799

Teicoplanin aglycone

Cat.No: T26256

Synonym: TD-A3

Autoinducing Peptide I

Cat.No: T82930

BMS 188745 Potassium Salt

Cat.No: T70436

Bovine neutrophil beta-defensin 12

Cat.No: T80323

Synonym: BNBD-12

Cat.No: T68203

SYNV-cyclo(CGGYF)

Cat.No: T76658

Cat.No: T81024

Synonym: INH-H 2002

Cat. No.	Product Name	Target	Signaling Pathways
T5780	HYPOCRELLIN B	Apoptosis; Parasite; Antifungal	Apoptosis; Microbiology/Virology
	Hypocrellin B 是从真菌Hypocrella bambusae 和Shiraia bambusicola 中分离得到的一种感光颜料，可用于癌症光动力研究。它是一个凋亡诱导剂，还拥有抗菌和抗利什曼活性。
T2904	Sclareolide 香紫苏内酯,Norambreinolide	Others; Antibacterial	Microbiology/Virology; Others
	Sclareolide (Norambreinolide) 是一种从Salvia sclarea 的花中分离得到的天然产物，具有抗菌和细胞毒性作用。
T4S1114	Dryocrassin ABBA 东北贯众素,Dryocrassin	Influenza Virus; Antibacterial	Microbiology/Virology
	Dryocrassin ABBA (Dryocrassin) 是一种从苦参中提取的黄酮类天然产物，具有抗病毒和抗菌活性。它抑制树突状细胞的免疫刺激功能，延长同种异体皮肤移植成活率。
T1465	Mupirocin Pseudomonic acid,莫匹罗星,BRL-4910A	DNA/RNA Synthesis; Antibacterial; Antibiotic	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Mupirocin (BRL-4910A) 是从Pseudomonas fluorescens 中分离得到的一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA，并抑制细菌蛋白和RNA 的合成起抗菌作用。
T8148	Mupirocin calcium hydrate 莫匹罗星钙,Mupirocin calcium	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Mupirocin calcium hydrate 是从Pseudomonas fluorescens 中分离得到的，一种有口服活性的抗生素。它可逆地抑制异亮氨酸转移RNA，并抑制细菌蛋白和RNA 的合成起到抗菌作用。
TN1527	(-)-Corynoxidine Corynoxidine	Antibacterial; AChE; Antifection	Microbiology/Virology; Neuroscience
	(-)-Corynoxidine 是一种源自 Stephania succifera 块茎的 AChE 抑制剂。 Corynoxidine 对金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌具有不同程度的抗菌活性。
TN4943	Sanguisorbigenin 地榆皂苷元,Tomentosolic acid,3β-Hydroxyurs-12,19-dien-28-oic acid,19-Dehydroursolic acid,Ursa-12,19-dien-28-oic acid	Antibacterial	Microbiology/Virology
	Sanguisorbigenin (Tomentosolic acid) 抑制耐甲氧西林金黄色葡萄球菌，是一种天然抗菌剂。
TN1524	Continentalic acid	NOS; COX; Antibacterial; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Continentalic acid 是来自 Aralia continentalis 的，对金黄色葡萄球菌的 MIC 约为 8-16 µg/mL，包括对甲氧西林敏感的金黄色葡萄球菌和耐甲氧西林金黄色葡萄球菌标准菌株。
T40646	Lipoteichoic acid	Complement System	Immunology/Inflammation
	Lipoteichoic acid 是 Staphylococcus aureus 细胞壁的聚合物，通过诱导 C3 和抑制 CD55 来激活补体系统，通过 IGF-1 途径减少脂肪沉积。
TN6746	(-)-TERPINEN-4-OL	Antibacterial	Microbiology/Virology
	(-)-TERPINEN-4-OL 可用作抗金黄色葡萄球菌的抗菌剂和抗生物膜剂。
TJS0368	4-Phenyl-7,8-dihydroxycoumarin 7,8-二羟基-4-苯基香豆素,7,8-Dihydroxy-4-Phenyl-2H-Chromen-2-One,7,8-Dihydroxy-4-phenylcoumarin	Others	Others
	4-Phenyl-7,8-dihydroxycoumarin (7,8-Dihydroxy-4-phenylcoumarin) 是香豆素衍生物，可用于研究支气管扩张。
TN7224	2,2'-Dihydroxy chalcone	Antibacterial; Autophagy	Autophagy; Microbiology/Virology
	2,2'-Dihydroxy chalcone 是一种用 fMLP/CB 刺激的大鼠中性粒细胞释放β-葡糖醛酸酶（IC50=1.6±0.2μM）和溶菌酶（IC50=1.4±0.2μM）的有效抑制剂。2,2'-Dihydroxy chalcone 对大肠杆菌、福氏志贺氏菌、白葡萄球菌和金黄色葡萄球菌有抑菌活性。
TN1041	Quercimeritrin 槲皮素-7-O-葡萄糖苷,槲皮素-7-0-葡萄苷,Quercetin-7-O-beta-D-glucopyranoside	Anti-infection; COX; NO Synthase	Immunology/Inflammation; Microbiology/Virology; Neuroscience
	Quercimeritrin (Quercetin-7-O-beta-D-glucopyranoside) 是分离自齿状苦艾叶中，具淀粉酶作用。
T7335	2,3-Diaminopropionic acid L-2,3-二氨基丙酸,L-2,3-Diaminopropionic acid	Endogenous Metabolite	Metabolism
	2,3-Diaminopropionic acid (L-2,3-Diaminopropionic acid) 是一种神经毒性氨基酸 b-oxalyl-L-a, b-diaminopropionic acid 的代谢产物。
TN1204	2,3-Dehydrokievitone 2,3-脱氢维酮	Antifungal	Microbiology/Virology
	2,3-Dehydrokievitone 是一种从刺桐属植物 Erythrina sacleuxii 中提取的一种异黄酮，具有抗菌活性，可通过降低α-溶血素表达来对抗耐甲氧西林金黄色葡萄球菌感染。
TN7242	5-Hydroxyvanillin 3,4-Dihydroxy-5-methoxybenzaldehyde	Antifungal	Microbiology/Virology
	5-Hydroxyvanillin (3,4-Dihydroxy-5-methoxybenzaldehyde) 可从籼稻中就分离得到对金黄色葡萄球菌具有抑制作用，可用于治疗和预防骨质疏松症。
T8070	Nonadecanoic acid	Others	Others
	Nonadecanoic acid 是19 C 长的饱和脂肪酸，是白蚁防御时分泌的主要物质。
T21552	5-deoxy Thymidine 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione	Others	Others
	5-deoxy Thymidine (5'-Deoxythymidine) 是5'位被氢取代的胸苷形式。它对枯草芽孢杆菌和金黄色葡萄球菌的活性有效。
T13305	Viridicatol	Anti-infection; Antifungal	Microbiology/Virology
	Viridicatol 是从夹竹桃的内生真菌青霉菌属的发酵中分离出的一种喹诺酮类生物碱，对金黄色葡萄球菌有抗菌活性，MIC 值为 15.6 μg/mL。
T3S2381	Perillene 3-Isohexenylfuran,紫苏烯,Perillen	Others; Antibacterial	Microbiology/Virology; Others
	Perillene (3-Isohexenylfuran) 是促进肠蠕动的药物中的活性成分，它对金黄色葡萄球菌和大肠杆菌具有很强的抗药性。
T37753	Aureusimine B	Cysteine Protease; Antibacterial	Microbiology/Virology; Proteases/Proteasome
	Aureusimine B 是一种钙蛋白酶抑制剂，由金黄色葡萄球菌生物膜产生，可能是金黄色葡萄球菌生物膜感染的潜在生物标志物。
TN1905	Magnolioside 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷	Antifection	Microbiology/Virology
	Magnolioside 是分离自Angelica gigas Nakai(Umbelliferae) 中，对谷氨酸诱导的毒性有显著的神经保护作用。它显示出对金黄色葡萄球菌 CIP 53.154 的中等抗菌活性。它具有抗疟原虫活性，对氯喹敏感的恶性疟原虫菌株具有强烈的生长抑制作用。
TN1084	1,3,5,8-Tetrahydroxyxanthone Desmethylbellidifolin,去甲基雏叶龙胆酮	Anti-infection	Microbiology/Virology
	1,3,5,8-Tetrahydroxyxanthone (Desmethylbellidifolin) 是一种天然黄酮，从 Gentianella acuta 中提取得到。它具有镇痉作用和抗炎作用。
T8724	6-Methoxydihydrosanguinarine	Others	Others
	6-Methoxydihydrosanguinarine 是一种从M. cordata 果实中分离出的生物碱，它对 MCF-7 细胞系(IC50:0.61 μM)和 SF-268 细胞系(IC50:0.54 μM)具有强的细胞毒性。
T70955	Vinaxanthone SM-345431	Phospholipase; Antibacterial	Metabolism; Microbiology/Virology
	Vinaxanthone (SM-345431) 是一种从青霉菌中提取的小分子化合物，是一种具有选择性和有效性的 semaphorin3A、phospholipase C (PLC) 和 FabI 抑制剂，抑制semaphorin3A 和 FabI。Vinaxanthone 具有抗菌活性，阻止细胞内脂肪酸合成，抑制金黄色葡萄球菌的生长。
T0926	Azelaic acid Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid	Others; DNA/RNA Synthesis; Endogenous Metabolite	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others
	Azelaic acid (Anchoic acid) 是头发和皮肤调理剂的组分，可由油酸臭氧分解产生。Azelaic acid 通过抑制微生物细胞原蛋白合成对痤疮丙酸杆菌和表皮葡萄球菌具有抑菌活性。Azelaic acid 还具有抑制色素沉着的功能，这是由于其清除自由基作用。
TN1722	Hamamelitannin	Antifection	Microbiology/Virology
	Hamamelitannin 是分离自 Hamamelis virginiana 树皮的一种多酚，是群体感应抑制剂。它通过影响肽聚糖生物合成和 eDNA 释放增加金黄色葡萄球菌生物膜的抗生素敏感性。
TN3861	Dihydropinosylvin 山药	Anti-infection	Microbiology/Virology
	Dihydropinosylvin 是一种植物抗毒素，对枝孢枝孢菌、Botryodiplodia theobromae、黑曲霉和石化青霉具有抗真菌活性，对蜡状芽孢杆菌、金黄色葡萄球菌、铜绿假单胞菌和大肠杆菌也有很强的抗菌活性。双色高粱幼苗的种子和根伸长。
T6S2384	Poliumoside	Reductase	Endocrinology/Hormones; Metabolism
	Poliumoside 是从 Brandisia hancei 的茎和叶中分离出来的咖啡酰化的苯丙烷糖苷。Poliumoside 能够抑制晚期糖基化终产物的形成和大鼠晶状体醛糖还原酶，IC50分别为 19.69 和 8.47 μM。Poliumoside 具有抗炎和抗氧化特性。
TN3013	4,5-Dimethoxycanthin-6-one Methylnigakinone	P450; Antibacterial; PDE	Metabolism; Microbiology/Virology
	4,5-Dimethoxycanthin-6-one 从 Picrasma quassioides BENNET (Simaroubaceae)是一种从 Picrasma quassioides BENNET (Simaroubaceae) 中分离得到生物碱。4,5-Dimethoxycanthin-6-one 是一种有效的、非竞争性的 CYP1A2 介导的 phenacetin O-deethylation 抑制剂（IC50 ： 1.7 μM, Ki ： 2.6 μM），对环磷酸腺苷（cAMP）磷酸二酯酶有很强的抑制作用。4,5-Dimethoxycanthin-6-one 具有抗菌活性，对金黄色葡萄球菌及其耐药菌株有抑制作用。4,5-Dimethoxycanthin-6-one 对肿瘤细胞株 U937 和 HepG2 具有细胞毒性。
TN2032	Pachypodol 霍香黃酮醇	Antifection	Microbiology/Virology
	Pachypodol has antibacterial and antifungal activities against Bacillus subtilis, Staphylococcus aureus, Staphylococcus faecalis, Echerichia coli, Pseudomonas aeruginosa, Candida albicans, Candida krusei and Candida galabrata.
TN1203	2,3,8-Tri-O-methylellagic acid 2,3,8-三邻甲基鞣花酸	Antifection	Microbiology/Virology
	2,3,8-tri-O-Methyl ellagic acid has antimicrobial activity agaist Vibro cholera, Staphylococcus aureus, Klebsiella pneumoniae, Pseudomonas aeruginosa, Bacillus cereus, Escherichia coli.
T74206	Kalimantacin A
	Kalimantacin A是具有针对葡萄球菌（包括耐甲氧西林金黄色葡萄球菌）抗菌活性的有效抗生素。
TN2820	24-Methylenecycloartan-3-ol	Antifection	Microbiology/Virology
	24-Methylenecycloartan-3-ol and methyl caffeate show weak activity against Staphylococcus aureus and Escherichia coli.
TN4167	Grifolic acid	Antifection	Microbiology/Virology
	Grifolic acid is a natural carbonic anhydrase Ⅱ inhibitor(CAⅡ), it shows in-hibitory activities against CAⅡ with IC50 of 6.37 umol/L. Grifolic acid has antibacterial activity, it can inhibit the growth of Staphylococcus aureus and Staphylococcus epidermid
TN6010	Picrasidine S
	Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus
TN1561	Dehydroglaucine	Antifection	Microbiology/Virology
	Dehydroglaucine is an acetylcholinesterase inhibitor, it shows antimicrobial activity against Staphylococcus aureus, Mycobacterium smegmatis, Candida albicans, and Aspergillus niger.
TN2760	2-Hydroxy-1,8-cineole	Antifection	Microbiology/Virology
	1. 2-endo-Hydroxy-1,8-cineole shows antimicrobial and bactericidal activities against against test bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas fluorescens) .<BR/>
TN4579	Monomethylsulochrin	Antifection	Microbiology/Virology
	Monomethylsulochrin shows antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus. It shows moderately inhibitory effects on the human bacterial pathogen Helicobacter pylori with the MIC value of 28.9+/-0.1 microM.
TN2625	14-Deoxycoleon U	Antifection	Microbiology/Virology
	14-Deoxycoleon U has anti-termitic activity, it is highly active against both wood-decay fungi. 14-Deoxycoleon U shows antibacterial activity against the Gram-positive bacteria Staphylococcus aureus, Staphylococcus epidermidis, Enterococcus faecalis, and
T2S0058	6-Ethoxychelerythrine 乙氧基白屈菜红碱,Ethoxychelerythrin	Antibacterial	Microbiology/Virology
	6-Ethoxychelerythrine (Ethoxychelerythrin) 具有抗菌活性，对烟曲霉和耐甲氧西林金黄色葡萄球菌 (MRSA) 表现出很强的活性。
TN4852	Pterodontic acid	Antifection	Microbiology/Virology
	Pterodontic acid and pterodondiol showed moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis.
TN5117	Taxiphyllin	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Taxiphyllin can inhibit tyrosinase activity in vitro significantly and is a potent tyrosinase inhibitor. Taxiphyllin displays mild antibacterial activity against Staphylococcus aureus.
TN1444	Bis(dihydrochelerythrinyl)amine bis[6-(5,6-dihydrochelerythrinyl)]amine	Antifection	Microbiology/Virology
	BIS-[6-(5,6-dihydro-chelerythrinyl)] ether shows strong activity against Aspergillus fumigatus and methicillin-resistant Staphylococcus aureus (MRSA).
TN4851	Pterodondiol	Antifection	Microbiology/Virology
	Pterodondiol has moderate activity against bacteria including Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, Mycobacteium phlei and Bacillus circulans.
TMA0017	Sideroxylin	Antifection	Microbiology/Virology
	Sideroxylin can synergistically enhance the antimicrobial activity of the alkaloid berberine (also a constituent of H. canadensis) against Staphylococcus aureus by inhibition of the NorA multidrug resistance pump.
T72250	4aα,7α,7aα-Nepetalactone
	4aα,7α,7aα-Nepetalactone 具有抗菌 (antibacterial) 活性，抑制Escherichia coli，Pseudomonas aeruginosa，Staphylococcus aureus，Salmonella typhi 和Enterococcus faecalis。
T40924	Tellimagrandin II Eugeniin
	Tellimagrandin II (Eugeniin) is the initial intermediate in the 4 C 1 -glucose derived series of ellagitannins. Additionally, it possesses the ability to inhibit antibiotic resistance exhibited by drug-resistant Staphylococcus aureus.
TN4670	Norlichexanthone	Antibacterial; Parasite	Microbiology/Virology
	Norlichexanthone 具有治疗和/或预防生活方式相关疾病的潜力，例如 2 型糖尿病、代谢综合征、动脉粥样硬化和心血管疾病。它具有抗菌和抗疟活性，对枯草芽孢杆菌有很强的活性，IC50范围为1-5uM，对耐甲氧西林金黄色葡萄球菌的生长也有很强的抑制作用，IC50为20.95±1.56uM。
TN3216	(3R)-7,4’-Dihydrohomoisoflavanone 7,4'-Dihydroxyhomoisoflavanone	Antibacterial	Microbiology/Virology
	(3R)-7,4’-Dihydrohomoisoflavanone 是一种天然化合物，对金黄色葡萄球菌和耐甲氧西林金黄色葡萄菌（MRSA）都具有强大的抗菌性能。
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天然产物

Cat.No: T5780

Target: Apoptosis, Parasite, Antifungal

Cat.No: T2904

Synonym: 香紫苏内酯,Norambreinolide

Target: Others, Antibacterial

Dryocrassin ABBA

Cat.No: T4S1114

Synonym: 东北贯众素,Dryocrassin

Target: Influenza Virus, Antibacterial

Cat.No: T1465

Synonym: Pseudomonic acid,莫匹罗星,BRL-4910A

Target: DNA/RNA Synthesis, Antibacterial, Antibiotic

Mupirocin calcium hydrate

Cat.No: T8148

Synonym: 莫匹罗星钙,Mupirocin calcium

Target: Others, Antibacterial, Antibiotic

(-)-Corynoxidine

Cat.No: TN1527

Synonym: Corynoxidine

Target: Antibacterial, AChE, Antifection

Sanguisorbigenin

Cat.No: TN4943

Synonym: 地榆皂苷元,Tomentosolic acid,3β-Hydroxyurs-12,19-dien-28-oic acid,19-Dehydroursolic acid,Ursa-12,19-dien-28-oic acid

Target: Antibacterial

Continentalic acid

Cat.No: TN1524

Target: NOS, COX, Antibacterial, Prostaglandin Receptor

Lipoteichoic acid

Cat.No: T40646

Target: Complement System

(-)-TERPINEN-4-OL

Cat.No: TN6746

Target: Antibacterial

4-Phenyl-7,8-dihydroxycoumarin

Cat.No: TJS0368

Synonym: 7,8-二羟基-4-苯基香豆素,7,8-Dihydroxy-4-Phenyl-2H-Chromen-2-One,7,8-Dihydroxy-4-phenylcoumarin

Target: Others

2,2'-Dihydroxy chalcone

Cat.No: TN7224

Target: Antibacterial, Autophagy

Cat.No: TN1041

Synonym: 槲皮素-7-O-葡萄糖苷,槲皮素-7-0-葡萄苷,Quercetin-7-O-beta-D-glucopyranoside

Target: Anti-infection, COX, NO Synthase

2,3-Diaminopropionic acid

Cat.No: T7335

Synonym: L-2,3-二氨基丙酸,L-2,3-Diaminopropionic acid

Target: Endogenous Metabolite

2,3-Dehydrokievitone

Cat.No: TN1204

Synonym: 2,3-脱氢维酮

Target: Antifungal

5-Hydroxyvanillin

Cat.No: TN7242

Synonym: 3,4-Dihydroxy-5-methoxybenzaldehyde

Target: Antifungal

Nonadecanoic acid

Cat.No: T8070

Target: Others

5-deoxy Thymidine

Cat.No: T21552

Synonym: 5'-脱氧胸苷,5'-Deoxythymidine,Thymidine, 5'-deoxy-1-[(2R,4S,5R)-4-hydroxy-5-methyloxolan-2-yl]-5-methylpyrimidine-2,4-dione

Target: Others

Cat.No: T13305

Target: Anti-infection, Antifungal

Cat.No: T3S2381

Synonym: 3-Isohexenylfuran,紫苏烯,Perillen

Target: Others, Antibacterial

Cat.No: T37753

Target: Cysteine Protease, Antibacterial

Cat.No: TN1905

Synonym: 七叶苷甲基醚,6-甲氧基香豆素-7-0-BETA-D-吡喃葡萄糖苷

Target: Antifection

1,3,5,8-Tetrahydroxyxanthone

Cat.No: TN1084

Synonym: Desmethylbellidifolin,去甲基雏叶龙胆酮

Target: Anti-infection

6-Methoxydihydrosanguinarine

Cat.No: T8724

Target: Others

Cat.No: T70955

Synonym: SM-345431

Target: Phospholipase, Antibacterial

Cat.No: T0926

Synonym: Finacea,Azelex,壬二酸,Nonanedioic acid,Anchoic acid

Target: Others, DNA/RNA Synthesis, Endogenous Metabolite

Cat.No: TN1722

Target: Antifection

Dihydropinosylvin

Cat.No: TN3861

Synonym: 山药

Target: Anti-infection

Cat.No: T6S2384

Target: Reductase

4,5-Dimethoxycanthin-6-one

Cat.No: TN3013

Synonym: Methylnigakinone

Target: P450, Antibacterial, PDE

Cat.No: TN2032

Synonym: 霍香黃酮醇

Target: Antifection

2,3,8-Tri-O-methylellagic acid

Cat.No: TN1203

Synonym: 2,3,8-三邻甲基鞣花酸

Target: Antifection

Cat.No: T74206

24-Methylenecycloartan-3-ol

Cat.No: TN2820

Target: Antifection

Cat.No: TN4167

Target: Antifection

Cat.No: TN6010

Dehydroglaucine

Cat.No: TN1561

Target: Antifection

2-Hydroxy-1,8-cineole

Cat.No: TN2760

Target: Antifection

Monomethylsulochrin

Cat.No: TN4579

Target: Antifection

14-Deoxycoleon U

Cat.No: TN2625

Target: Antifection

6-Ethoxychelerythrine

Cat.No: T2S0058

Synonym: 乙氧基白屈菜红碱,Ethoxychelerythrin

Target: Antibacterial

Pterodontic acid

Cat.No: TN4852

Target: Antifection

Cat.No: TN5117

Target: Tyrosinase, Antifection

Bis(dihydrochelerythrinyl)amine

Cat.No: TN1444

Synonym: bis[6-(5,6-dihydrochelerythrinyl)]amine

Target: Antifection

Cat.No: TN4851

Target: Antifection

Cat.No: TMA0017

Target: Antifection

4aα,7α,7aα-Nepetalactone

Cat.No: T72250

Tellimagrandin II

Cat.No: T40924

Synonym: Eugeniin

Norlichexanthone

Cat.No: TN4670

Target: Antibacterial, Parasite

(3R)-7,4’-Dihydrohomoisoflavanone

Cat.No: TN3216

Synonym: 7,4'-Dihydroxyhomoisoflavanone

Target: Antibacterial

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