67
27
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T63429 |
SMO-IN-2
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SMO-IN-2 是一种有效的 smoothened (SMO) 抑制剂,对 hedgehog (Hh) 信号传导有抑制作用。SMO-IN-2 对人髓母细胞瘤细胞系 显示出抗增殖活性和抗癌活性。SMO-IN-2 可用于研究癌症。 | |||
T63387 |
SMO-IN-3
|
||
SMO-IN-3 是 smoothened (SMO) 对有效抑制剂,能够作用于 hedgehog (Hh) 信号通路 (IC50: 34.09 nM)。SMO-IN-3 能够抑制人髓母细胞瘤细胞系 Daoy 的增殖,表现出抗癌作用。 | |||
T61897 |
SMO-IN-1
|
||
SMO-IN-1 (Compound 15) 是口服有效的Smoothened (SMO)抑制剂, sonic Hh protein (shh) 的EC50值为 89 nM。 | |||
T3460 |
HhAntag
|
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
HhAntag 是高效的、特异性的、具有口服活性的 Hh 通路的SMO 拮抗剂。 | |||
T23027 |
MRT-10
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
MRT 10 是一种七跨膜平滑受体 (Smo) 拮抗剂,通过多种 Hedgehog (Hh) 测定,其IC50=0.65 μM。它与Smo 受体结合的位点是 Bodipycyclopamine。它可用于研究癌症。 | |||
T9531 |
MRT-14
|
Smo | Stem Cells |
MRT-14 是有效的 Smo 拮抗剂。Smo 是参与 Hedgehog 形态发生素信号转导的主要成分。MRT-14 在研究与异常 Hh 信号传导相关的多种癌症方面有价值。 | |||
T6891 |
MK-4101
|
Apoptosis; Hedgehog/Smoothened; Smo | Apoptosis; GPCR/G Protein; Stem Cells |
MK-4101 是一种 SMO 拮抗剂 ,对 293 细胞的 IC50为 1.1 µM。它也是一种 hedgehog 信号通路的有效抑制剂 ,对小鼠细胞和KYSE180 食管癌细胞的IC50分别为 1.5 µM 和 1 µM。它能抗肿瘤,抑制肿瘤细胞增殖并诱导细胞凋亡。 | |||
T12109 |
MRT-83
|
Smo | Stem Cells |
MRT-83 是一种 Smo 拮抗剂,其IC50值在纳摩尔级别。它能够抑制 Hedgehog 信号通路。 | |||
T6514 |
Glasdegib
PF-04449913 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Glasdegib (PF-04449913) 是一种口服具有活力的 smoothened 抑制剂,能够结合到人 SMO(181-787氨基酸位点),IC50=4 nM。 | |||
T24159 |
IHR-1
IHR 1 |
Smo | Stem Cells |
IHR-1 是一种Smo 拮抗剂,不能透过细胞膜。 | |||
T14188 |
ALLO-2
|
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
ALLO-2 是一种 Smo 耐药突变体的拮抗剂。在TM3-Gli-Luc 细胞中,它可抑制Smo 激动剂Hh-Ag1.5诱导的荧光素酶表达,其IC50=6 nM。 | |||
T2450 |
SANT-1
SANT 1 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
SANT-1 是Smo 拮抗剂,能够抑制Hedgehog 通路,在 Shh-LIGHT2 和 SmoA1-LIGHT2 实验中,得到的IC50值分别为 20 nM 和 30 nM。 | |||
T2666 |
Taladegib
LY2940680 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Taladegib (LY2940680) 是smoothened 受体拮抗剂。 | |||
T1810 |
Purmorphamine
Shh Signaling Antagonist VI |
Hedgehog/Smoothened; Smo; Autophagy | Autophagy; GPCR/G Protein; Stem Cells |
Purmorphamine (Shh Signaling Antagonist VI) 是平滑受体激动剂,EC50为 1 μM。它阻止 BODIPY-cyclopamine 与 Smo 结合。它也是成骨细胞分化的诱导剂。 | |||
T9532 |
MRT-81
|
Others | Others |
MRT-81 是一种人和啮齿动物 smoothened 受体的有效拮抗剂,能够抑制 hedgehog 的活性,在 Shh-light2 细胞中的IC50值为 41 nM。它可用于研究癌症。 | |||
T1779 |
SAG
Smoothened Agonist (SAG) HCl,Smoothened Agonist |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
SAG (Smoothened Agonist) 是一种 Smo 受体激动剂 (EC50=3 nM),具有细胞渗透性和选择性。SAG 可以直接结合 Smo 螺旋束调节 Smo 活性,可以活化 Hedgehog 信号通路。 | |||
T22814 |
GSA-10
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
GSA-10是新型的喹啉甲酰胺衍生物,有效激动平滑受体剂,EC50为 1.2 μM。它作用于Smo,促进多能间充质干细胞分化为成骨细胞。它介导 Hedgehog 信号传导,这可能对癌症疾病的再生医学具有研究意义。 | |||
T5465 |
PF-5274857
PF-5274857 freebase |
Smo | Stem Cells |
PF-5274857 (PF-5274857 free base) freebase 是有效的、具有口服活性的、选择性的、可透过血脑屏障的 Smo 拮抗剂,其 IC50=5.8 nM,Ki=4.6 nM。它有用于包括激活的 Hh 途径驱动的脑肿瘤和脑转移在内的多种肿瘤的研究潜力。 | |||
T2299 |
BMS-833923
XL-139 |
Apoptosis; Hedgehog/Smoothened; Smo | Apoptosis; GPCR/G Protein; Stem Cells |
BMS-833923 (XL-139) 是一种口服生物可利用的 Smoothened 拮抗剂,以剂量依赖性方式抑制 BODIPY cyclopamine 与 SMO 的结合,IC50为21 nM。 | |||
T11838 |
LEQ506
NVP-LEQ506 |
Smo | Stem Cells |
LEQ506 是一种 Smo 抑制剂,对 hSmo 和 mSmo 的 IC50 分别为 2 nM 和 4 nM。 | |||
T1926 |
Sonidegib
Erismodegib,NVP-LDE225,LDE225 |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Sonidegib (Erismodegib) 是一种Smo 的选择性拮抗剂,能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。 | |||
T0107 |
Halcinonide
Halcimat,Halciderm,哈西奈德,Halcinonida,氯氟舒松,SQ-18566 |
Glucocorticoid Receptor; Smo | Endocrinology/Hormones; Stem Cells |
Halcinonide (Halciderm) 是一种糖皮质激素,可用于局部皮肤感染的研究。 | |||
T2250 |
DY131
DY 131,GSK 9089,DY-131 |
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Smo | Endocrinology/Hormones; Stem Cells |
DY131 (DY-131) 是选择性的 ERRγ 和 ERRβ 激动剂,对 ERRα,ERα 和 ERβ 无效。它对Smo 的信号传导具有抑制作用。 | |||
T15727 |
Sonidegib diphosphate
NVP-LDE 225 diphosphate,Erismodegib diphosphate,LDE225 diphosphate |
Smo | Stem Cells |
Sonidegib diphosphate (LDE225 diphosphate) 是 Smo 的选择性拮抗剂,能够抑制鼠 Smo (IC50:1.3 nM)和人 Smo (IC50:2.5 nM)。 | |||
T5144 |
Desmopressin acetate (16679-58-6 free base)
Desmopressin acetate,醋酸去氨加压素,DDAVP |
Vasopressin Receptor | GPCR/G Protein |
Desmopressin acetate (16679-58-6 free base) (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。 | |||
T5019 |
Desmopressin
去氨加压素,DDAVP,Desmopressin Acetate |
Vasopressin Receptor | GPCR/G Protein |
Desmopressin (DDAVP) 是抗利尿激素精氨酸加压素的合成类似物。 | |||
T124384 |
Jasmonic acid
(-)-Jasmonic acid |
||
Jasmonic acid (JA) 是一种植物激素,也是植物生长调节剂,参与植物迫防御和生长发育。Jasmonic acid 在信号传导过程中起着很重要的作用,诱导 MAP 激酶级联通路和钙通道发挥作用。 | |||
T2590 |
Vismodegib
Erivedge,GDC-0449,RG 3616,维莫德吉 |
Hedgehog/Smoothened; ABC; Autophagy | Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Stem Cells |
Vismodegib (GDC-0449) 是一种刺猬抑制剂,IC50值为 3 nM。它还可抑制 P-gp 和ABCG2的活性,IC50值分别为 3.0 μM 和 1.4 μM。 | |||
T39910 |
Desmorpholinyl Navitoclax-NH-Me
Desmorpholinyl ABT-263-NH-Me,Desmorpholinyl Navitoclax-NH-Me |
BCL | Apoptosis |
Desmorpholinyl Navitoclax-NH-Me (Desmorpholinyl ABT-263-NH-Me) is a Bcl-xL inhibitor, which can be employed alongside a CRBN ligand to synthesize XZ739, a PROTAC BCL-XL degrader [1] [2]. | |||
T39818 |
Desmorpholinyl Quizartinib-PEG2-COOH
Desmorpholinyl Quizartinib-PEG2-COOH |
||
Desmorpholinyl Quizartinib-PEG2-COOH is a compound featuring an FLT-3 ligand and a PEG-based PROTAC linker. It is employed in the synthesis of PROTAC FLT-3 degrader 1, which serves as a degrader for the FLT-3 internal tandem duplication (ITD) through PROTAC technology. The degrader exhibits an IC50 of 0.6 nM. | |||
T131458 |
Acetyl-alpha-desmotroposantonin
|
||
Acetyl-alpha-desmotroposantonin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131458。 | |||
T40880 |
(±)-Jasmonic acid
|
||
(±)-Jasmonic acid, a plant growth regulator and derivative of α-linolenic acid, exhibits chlorophyll-lowering effects in green and etiolated barley leaf segments, while also inhibiting the elongation of rice seedlings. | |||
T31472 |
Dihydrojasmone lactone
gamma-Methyldecalactone,gamma-Methyl decalactone,4-Methyldecanolide |
||
Dihydrojasmone lactone is a biochemical. | |||
T131459 |
alpha-Desmotroposantonin methylether
|
||
alpha-Desmotroposantonin methylether 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T131459。 | |||
T32269 |
Jasmone, (E)-
EINECS 228-410-7 |
||
Jasmone, (E)- is a type of perfuming agent. | |||
T36941 |
Sporidesmolide III
|
||
Sporidesmolide III is a cyclodepsipeptide originally isolated from P. chartarum. | |||
T65308 |
Methyl jasmonate
|
||
Methyl jasmonate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65308,CAS号为 1211-29-6。 | |||
T13523 |
Bronchospasmolytic agent 1
|
Others | Others |
Bronchospasmolytic agent 1 is a flutropium bromide compound and acts as a bronchospasmolytic agent. | |||
T74190 |
(-)-Jasmonoyl-L-isoleucine
|
||
(-)-Jasmonoyl-L-isoleucine ((-)-JA-L-Ile),为(+)-JA-L-Ile的对映体,是一种无活性的内源性激素。 | |||
T23769 |
AZSMO-23
AZSMO 23 |
||
AZSMO-23 is the human ether-a-go-go-related gene (hERG)-encoded potassium channel activator that acts by blocking hKv4.3-hKChIP2.2, hCav3.2, and hKv1.5 and activating hCav1.2/β2/α2δ. | |||
T40465 |
SAG dihydrochloride
|
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG dihydrochloride 是一种强效的 Smoothened(Smo)受体激动剂(EC 50 =3 nM;K d =59 nM)。SAG dihydrochloride 可激活刺猬信号通路并抵消环丙胺对 Smo 的抑制。 | |||
T4211 |
SAG hydrochloride (912545-86-9(free base))
Smoothened Agonist HCl |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
SAG hydrochloride (912545-86-9(free base)) (Smoothened Agonist HCl) 可作为 SMO 激动剂。 | |||
T24754 |
Hh-Ag1.5
SAG-1.5,SAG1.5,SAG 1.5 |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50: 1 nM)和Smoothened (Smo)受体激动剂,对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态,从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。 | |||
T64351 |
GI-560192
RL-0070933 |
Smo | Stem Cells |
GI-560192 (RL-0070933) 是一种有效的纤毛调节剂。GI-560192 通过 hedgehog 信号通路调节 smoothed (Smo) 向初级纤毛的易位和/或积累。 | |||
T15019L |
CUR61414 hydrochloride
CUR61414 hydrochloride (334998-36-6 Free base) |
Hedgehog/Smoothened | GPCR/G Protein; Stem Cells |
CUR61414 hydrochloride 是属于氨基脯氨酸类化合物的小分子。CUR61414 hydrochloride 是一种细胞渗透性的 Hedgehog 信号通路抑制剂(IC50= 100-200 nM),可选择性结合 Smoothened (Smo, Ki= 44 nM)。CUR61414 hydrochloride 可以诱导癌细胞凋亡 (apoptosis) 而不影响非癌症细胞。 | |||
T22958 | M 25 | Others | Others |
Smoothened (Smo) receptor antagonist | |||
T38767 |
MRT-83 hydrochloride
|
||
MRT-83 (hydrochloride) is a potent antagonist of the Smoothened (Smo) receptor, effectively inhibiting the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. With its potential applications in the study of cancer disease, MRT-83 (hydrochloride) demonstrates promising prospects for research purposes. | |||
T35539 |
IHR-Cy3
IHR-Cy3 |
||
Potent fluorescent Smo antagonist (IC50 = 100 nM). Non-fluorescent analog also available. Fan et al (2014) The Hedgehog pathway effector smoothened exhibits signaling competency in the absence of ciliary accumulation. Chem.Biol. 21 1680 PMID:25484239 | |||
T70178 |
Sonidegib metabolite M25
|
||
Sonidegib metabolite M25 is a smoothened (SMO) antagonist. | |||
T26723 |
AZD8542
AZD-8542,AZD 8542 |
||
AZD8542 is an antagonist of Smoothened (SMO) with potential as an oncology therapeutic. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2825 |
Cyclopamine
环巴胺,11-Deoxojervine |
Hedgehog/Smoothened; Endogenous Metabolite; Smo | GPCR/G Protein; Metabolism; Stem Cells |
Cyclopamine (11-Deoxojervine) 是Hedgehog 通路的拮抗剂,细胞实验中IC50=46 nM。它还是选择性Smo 抑制剂。 | |||
T3363 |
Jervine
蒜黎芦碱,Iervin,11-Ketocyclopamine,Jerwiny |
Hedgehog/Smoothened; Smo | GPCR/G Protein; Stem Cells |
Jervine (Jerwiny) 是一种有效的刺猬 (Hh) 抑制剂(IC50:500-700 nM)。它是一种天然致畸性甾体生物碱,来自于 Veratrumalbum 的根茎,具有抗炎和抗氧化作用。 | |||
T3912 |
Saikosaponin B1
柴胡皂苷B1,柴胡皂苷 B1 |
Others | Others |
Saikosaponin B1 是柴胡的生物活性成分,具有抗癌作用。它能够靶向SMO 抑制 Hedgehog 通路,显著抑制髓母细胞瘤模型中的肿瘤生长。 | |||
T7220 |
Prohydrojasmon racemate
Propyl dihydrojasmonate,茉莉酮,Prohydrojasmon |
Others | Others |
Prohydrojasmon racemate (Propyl dihydrojasmonate) 是 Prohydrojasmon 的外消旋体。其中Prohydrojasmon 是合成的植物生长调节剂。 | |||
TJS0161 |
Eudesmol
β-Eudesmol,桉叶醇,Β-桉叶醇 |
Others | Others |
β-Eudesmol (β-Eudesmol) 是一种倍半萜类化合物,由Streptomyces tendae 产生。 | |||
T8077 |
Dihydrojasmone
|
Others | Others |
Dihydrojasmone 是一种重要的香料成分,是佛手柑油的成分。 | |||
T4900 |
(±)-Methyl Jasmonate
(±)-茉莉酸甲酯,甲基茉莉酮酸酯,(±)-Jasmonic Acid methyl ester,Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate |
Others; Endogenous Metabolite | Metabolism; Others |
Methyl 2-(3-oxo-2-(pent-2-en-1-yl)cyclopentyl)acetate ((±)-Jasmonic Acid methyl ester) 是内源性代谢产物的一种。 | |||
T2783 |
Methyl dihydrojasmonate
Methyl Dihydrojasmonate,Kharismal,Hedione,二氢茉莉酮酸甲酯 |
Others | Others |
Methyl dihydrojasmonate (Kharismal) 是一种香料成分,具有茉莉花香气,常用于许多香料混合物中。 | |||
T8076 |
cis-Jasmone
茉莉酮,Jasmone,顺式茉莉酮 |
Others | Others |
cis-Jasmone 是一种来源于植物中的天然产物。它由许多花组成型释放,有时通过叶子作为传粉者的引诱剂或作为昆虫花食草动物宿主定位的化学提示。它处理作物可以诱导对食草动物的直接防御,并能够释放吸收天敌的挥发性化合物来诱导间接防御。 | |||
T6S2247 |
Alismoxide
(+)-Alismoxide,环氧泽泻烯 |
Others | Others |
Alismoxide ((+)-Alismoxide) 一种具有抗炎作用的天然化合物。 | |||
T3865 |
beta-Eudesmol
β-桉叶醇,Beta-Selinenol,beta-桉叶醇 |
TRP/TRPV Channel; AChR | Membrane transporter/Ion channel; Neuroscience |
beta-Eudesmol (Beta-Selinenol) 是天然的含氧倍半萜烯,可激活hTRPA1,EC50值为 32.5 μM。Beta-Eudesmol 有增加食欲的功效。 | |||
T19711 |
Desmosterol
Desmesterol,24-Dehydrocholesterol |
Endogenous Metabolite | Metabolism |
Desmosterol(24-Dehydrocholesterol) 是一种胆固醇生物合成中间体,抑制巨噬细胞炎症小体活化,防止血管炎症和动脉粥样硬化。 | |||
TN5801 | 12-Hydroxyjasmonic acid | ||
12-Hydroxyjasmonic acid glucoside is a COI1-JAZ-independent activator of leaf-closing movement in samanea saman. | |||
T40450 |
Dihydrojasmonic acid
|
||
Dihydrojasmonic acid is a plant growth regulator. | |||
TN3962 |
epi-Eudesmol
|
Others | Others |
epi-Eudesmol is a natural product from Laggera alata var. montana C. D. Adams. | |||
TN5377 |
Nardoeudesmol A
|
||
Nardoeudesmol A 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN5377,CAS号为 1445952-30-6。 | |||
T19782 |
Antidesmone
|
||
Antidesmone is one compound mainly isolated from Ajugade cumbers Thunb (Labiatae). Antidesmone prevents acute lung injury via regulating MAPK and NF-κB activities. | |||
TN2668 |
1beta-Hydroxy-beta-eudesmol
|
Others | Others |
1beta-Hydroxy-beta-eudesmol is a natural product from Cymbopogon proximus STAPF. | |||
TN1367 |
Alismol
泽泻醇 |
Potassium Channel; Calcium Channel; PI3K | Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Alismol has antihypertensive action, it decreases cardiac output, heart rate and left ventricular pressure, but it increases coronary flow, it has been used for the prevention of anginal attacks. | |||
TSP-41868968 |
alpha-Desmotroposantonin
|
||
alpha-Desmotroposantonin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TSP-41868968。 | |||
T83460 |
11-O-β-D-glucopyranosyl thamnosmonin
|
||
11-O-β-D-glucopyranosyl thamnosmonin是一种香豆素苷,能够从Angelica apaensis根部提取。该化合物对PAF、AA和ADP诱发的兔血小板聚集表现出轻度的抑制效果。 | |||
TN4351 |
Jasmoside
|
Others | Others |
Jasmoside is a natural product from Jasminum mesnyi. | |||
T81113 |
Sporidesmolide V
|
||
Sporidesmolide V为从Pithornyces chartarum培养物中分离得到的环缩肽类化合物。 | |||
TN5886 | Thamnosmonin | ||
Thamnosmonin is a natural product from Citrus sinensis. | |||
T21296 |
Desmopressin acetate trihydrate
Desmogalen,Adiuretin,Deamino Arginine Vasopressin,Vasopressin 1-Desamino-8-arginine |
||
Desmopressin acetate is a synthetic replacement for vasopressin, which reduces urine production. Medical use of Desmopressin acetate includes: (a) bed wetting; (b) diabetes insipidus; (c) nighttime urination; (d) clotting disorders. | |||
TN2585 |
11-Hydroxyjasmonic acid
|
Others | Others |
11-Hydroxyjasmonic acid是一种天然产物,属于防己科千金藤属,其产品编号为 TN2585,CAS号为 140447-14-9。11-Hydroxyjasmonic acid可用作对照参考。 | |||
T10085 |
20(S)-Hydroxycholesterol
20α-Hydroxycholesterol |
Smo | Stem Cells |
20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) 是平滑 (smo) 癌蛋白的变构激活剂。 |