Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Taladegib (LY2940680) 是smoothened 受体拮抗剂。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
1 mg | ¥ 376 | 现货 | ||
2 mg | ¥ 539 | 现货 | ||
5 mg | ¥ 913 | 现货 | ||
10 mg | ¥ 1,450 | 现货 | ||
25 mg | ¥ 2,460 | 现货 | ||
50 mg | ¥ 3,670 | 现货 | ||
100 mg | ¥ 5,290 | 现货 | ||
500 mg | ¥ 10,800 | 现货 |
产品描述 | Taladegib (LY2940680) is an orally bioavailable small molecule antagonist of the Hedgehog (Hh)-ligand cell surface receptor smoothened (Smo) with potential antineoplastic activity. |
体外活性 | LY2940680 inhibits cancer growth in cell lines containing a mutation in the gene encoding Smoothened that researchers had previously observed in patient with cancer who developed resistance to vismodegib. [1] |
体内活性 | LY2940680 has excellent pharmacokinetic properties in rodent and non-rodent species. LY2940680 administrated orally treats Ptch+/- p53-/- transgenic mice which spontaneously develop medulloblastoma, produces remarkable efficacy and significantly improves their survival. LY2940680 reveals rapid kinetics of anti-tumor activity through magnetic resonance imaging of these mice, and LY2940680 induces Caspase-3 activity and reduces proliferation by immunohistochemistry analysis of medulloblastoma tumors. LY2940680 inhibits Hh regulated gene expression in the subcutaneous xenograft tumor stroma and produces significant anti-tumor activity. [2] |
别名 | LY2940680 |
分子量 | 512.5 |
分子式 | C26H24F4N6O |
CAS No. | 1258861-20-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5.64 mg/mL (11 mM)
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
DMSO | 1 mM | 1.9512 mL | 9.7561 mL | 19.5122 mL | 48.7805 mL |
5 mM | 0.3902 mL | 1.9512 mL | 3.9024 mL | 9.7561 mL | |
10 mM | 0.1951 mL | 0.9756 mL | 1.9512 mL | 4.878 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Taladegib 1258861-20-9 GPCR/G Protein Stem Cells Hedgehog/Smoothened Smo inhibit LY 2940680 LY-2940680 LY2940680 Inhibitor Smoothened inhibitor