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54

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T35817	Photoswitchable PAD Inhibitor (technical grade)
	Photoswitchable PAD inhibitor is a photoactivated protein arginine deiminase (PAD) inhibitor and a derivative of BB-Cl-amidine that contains an azobenzene photoswitch allowing optical control of PAD activity.1 Without photoactivation, it is a weak inhibitor of PAD2 (IC50 = >100 μM) and is less potent than BB-Cl-amidine in inhibiting citrulline production in vitro (kinact/KIs = 2,300, 600, 1,000, and 10,510 M-1min-1 for PAD1-4, respectively) and does not inhibit histone H3 citrullination in HEK29...
T63284	PAD-IN-2
	PAD-IN-2 是 pad4 的有效抑制剂，IC50 值 <1 μM，能够用于研究自身免疫性疾病和癌症，如类风湿性关节炎、血管炎、系统性红斑狼疮、皮肤红斑狼疮、囊性纤维化、溃疡性结肠炎、哮喘、多发性硬化和牛皮癣。
T39515	PAD2-IN-1 PAD2-IN-1
	PAD2-IN-1, a benzimidazole-based derivative, is an efficacious and specific inhibitor of protein arginine deiminase 2 (PAD2). Demonstrating remarkable selectivity, PAD2-IN-1 exhibits a 95-fold higher affinity for PAD2 in comparison to PAD4 and a 79-fold higher affinity than PAD3.
T63601	PAD2-IN-1 hydrochloride
	PAD2-IN-1 hydrochloride 是有效的、选择性的蛋白精氨酸脱亚氨酶 2 (PAD2) 抑制剂，且对 PAD2 的选择性优于 PAD4 (95 倍) 和 PAD3 (79 倍)，是一种基于苯并咪唑的衍生物。
T79276	PAD4-IN-2
	PAD4-IN-2（化合物5i）是一种具有IC50为1.94 μM的PAD4抑制剂。该化合物能够通过特异性抑制中性粒细胞内PAD4-H3cit-NETs途径，从而有效抑制小鼠体内肿瘤生长。
T22178L	Spadin Acetate Spadin Acetate(1270083-24-3 Free base)	Others	Others
	Spadin Acetate 是一种天然肽，来源于血液中释放的前肽。 Spadin Acetate 能够阻断 TREK-1 通道活动。 Spadin Acetate 与 TREK-1 特异性结合，亲和力为 10 nM。
T26641L	Apadenoson TFA BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Apadenoson TFA 是一种有效的腺苷 A2A 受体（A2AR）激动剂,可用于提高SARS感染患者的存活率。
T0113	Mebhydrolin napadisylate Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline	5-HT Receptor; AChR; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mebhydrolin napadisylate (Incidal) 是一种抗组胺药，用于缓解组胺释放引起的过敏症状，如鼻过敏和过敏性皮肤病。
T16411	Otenzepad AF-DX 116	AChR	Neuroscience
	Otenzepad (AF-DX 116) 是 M2 mAChR 的特异性拮抗剂，对大鼠心脏和兔外周肺的 IC50 分别为 386 nM 和 640 nM。
T2373	Vipadenant CEB-4520,BIIB-014	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Vipadenant (CEB-4520) 是一种腺苷受体拮抗剂，抑制 A2A 和 A1 活性的 Ki 值分别为 1.3 和 68 nM。
T16564	PPADS tetrasodium	P2X Receptor; Na+/Ca2+ Exchanger	Membrane transporter/Ion channel; Neuroscience
	PPADS tetrasodiuma 是一种有效的 P2X 受体拮抗剂，也是是豚鼠气道平滑肌 Na/Ca²⁺ 交换逆模式的抑制剂，对谷氨酸/NMDA毒性有神经保护作用。PPADS tetrasodiuma 抑制 P2X1、P2X-2、P2X-3 和 P2X-5。
TQ0125	Capadenoson BAY 68-4986,卡帕诺生	Adenosine Receptor	GPCR/G Protein; Neuroscience
	Capadenoson (BAY 68-4986) 是 A1 腺苷受体的选择性激动剂。
T16999	Tavapadon PF-6649751,CVL-751	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Tavapadon (CVL-751) 是一种具有口服活性，高选择性的多巴胺 D1/D5受体部分激动剂，它可有效促进运动并减少残疾，对帕金森氏病具有潜在的应用价值。
T76735	Mupadolimab CPI-006	CD73	Immunology/Inflammation
	Mupadolimab (CPI-006) 是一种人源化 FcγR 结合缺陷型 IgG1 抗 CD73抗体，具有潜在的抗癌活性，可激活 CD73POS B 细胞。
T16427	Padsevonil UCB-0942	Others	Others
	Padsevonil is an effective antiepileptic compound.
T5167	Cebranopadol 西博帕多,GRT6005	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	Cebranopadol (GRT6005) 是镇痛 NOP 和阿片受体激动剂，对人 NOP、μ-阿片 (MOP)、κ-阿片 (KOP) 和 δ-阿片 (DOP) 受体的 Ki 值分别为 0.9、0.7、2.6 和 18 nM。
T19849L	2-PADQZ hydrochloride 2-PADQZ hydrochloride (60547-97-9 Free base)	Antiviral; Influenza Virus	Immunology/Inflammation; Microbiology/Virology
	2-PADQZ hydrochloride 显示出抗病毒活性并靶向甲型流感病毒 RNA 启动子。
T7503	Upadacitinib 乌帕替尼,ABT-494	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	Upadacitinib (ABT-494) 是高效选择性的，具有口服活性的 JAK1抑制剂，IC50为43 nM，可用于多种自身免疫性疾病的研究。它对 JAK1 的选择性约为 JAK2 的 74 倍。
T126544	3-O-Acetylpadmatin
	3-O-Acetylpadmatin 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T126544，CAS号为 100595-93-5。
T71693	Nepadutant
	Nepadutant 是一种有用的有机化合物，可用于生命科学领域的相关研究。其产品编号为 T71693，CAS号为 183747-35-5。
T70857	Scopadulciol
	Scopadulciol is and enzyme and proton pump inhibitor.
T26553	Aclatonium Napadisilate Acaltonium napadisilate
	Aclatonium Napadisilate, a cholinergic agonist, has been shown to stimulates endocrine and exocrine pancreatic secretion.
T37014	Inupadenant
	Inupadenant is an orally active, highly selective A2A receptor antagonist. Inupadenant is not brain-penetrant. Inupadenant has potent anti-tumor activity[1]. [1]. Laurence Buisseret, et al. Phase 1 trial of the adenosine A2Areceptor antagonist inupadenant (EOS-850): Update on tolerability, and antitumor activity potentially associated with the expression of the A2A receptor within the tumor. Journal of Clinical Oncology. Volume 39, Issue 15_suppl.
T75944	Spadin TFA
	Spadin TFA 是一种从血液中释放的前肽衍生的天然肽，是一种有效的 TREK-1 通道阻滞剂，其 IC50值为 10 nM。Spadin TFA 增强小鼠中缝背核 5-HT 神经传递，诱导海马 CREB 激活和神经发生。Spadin TFA 可用于抗抑郁研究。
T19849	2-PADQZ 2PADQZ,2-PADQZ
	DPQ is an antiviral compound. DPQ has also been shown to bind to a widened RNA major groove at the internal loop. DPQ acts against the H1N1 and H3N2 strains of influenza A as well as influenza B.
T33793	Olpadronic acid Me2 APD,Me2-APD,Me2APD
	Olpadronic acid is a biochemical.
T32076	Hippadine
	Hippadine is isolated from Crinum bulbs and has reproductive effect.
T20599	Padimate O Escalol 507,Eusolex 6007,Arlatone UVB
	Padimate O, a UVB absorber, is a major ingredient in sunscreens.
T33863	Padimate A
	Padimate A is a sunscreen ingredient.
T32722	Lexanopadol GRT-13106G,GRT6006,GRT 13106G,GRT-6006,GRT 6006,GRT13106G
	Lexanopadol (GRT6006) is a potent ORL-1 agonist (opioid receptor-like-1), suitable for the treatment of moderate to severe chronic pain, including neuropathic pain.
T24995	Abediterol napadisylate LAS100977 napadisylate
	Abediterol napadisylate is a novel long-acting β2-agonist in persistent asthma that is efficacy, safe, and tolerable.
T79638	Lepadin E	Glutathione Peroxidase	Metabolism
	Lepadin E 是一种铁死亡（ferroptosis）诱导剂，它通过激活 p53-SLC7A11-GPX4 途径显著诱发细胞毒性。该化合物增强 p53 的表达，减少 SLC7A11 及 GPX4 的水平，进而导致活性氧 (ROS) 和脂质过氧化物的增加，并通过上调 ACSL4 来促进细胞死亡。Lepadin E 还具有显著的抗肿瘤效果。
T79639	Lepadin H	Ferroptosis	Apoptosis
	Lepadin H 是一种具有显著细胞毒性的海洋生物碱，能够诱导铁死亡。它通过增加 p53 表达、提升 ROS 生成和脂质过氧化来展开作用，同时抑制 SLC7A11 和 GPX4，上调 ACSL4。Lepadin H 主要通过 p53-SLC7A11-GPX4 路径实现其诱导铁死亡的功能。
T7503L	Upadacitinib tartrate ABT 494,ABT-494,ABT494
	Upadacitinib is a potent and selective JAK inhibitor. Upadacitinib is approximately 74 fold selective for Jak1 over Jak2 in cellular assays dependent on specific, relevant cytokines. Upadacitinib demonstrates efficacy in rat arthritis models.
T34058	Phyllospadine
	Phyllospadine is a natural flavonoidal alkaloid from the sea-grass Phyllosphadix iwatensis.
T69648	Inupadenant HCl
	Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors.
T81604	Opadotina
	Opadotina为anvatabart opadotin的小分子衍生物，具备抗肿瘤(antineoplastic)活性。
T10749	Cebranopadol ((1α,4α)stereoisomer) GRT6005 (1α,4α)stereoisomer	Others	Others
	Cebranopadol ((1α,4α)stereoisomer) is a stereoisomer of cebranopadol which is a potent ORL-1 agonist.
T40572	Lesogaberan napadisylate AZD-3355 napadisylate
	Lesogaberan (AZD-3355) napadisylate is a potent and selective agonist of GABA B receptors, with an EC 50 of 8.6 nM for human recombinant GABA B receptors. It demonstrates an affinity (Ki) of 5.1 nM for rat GABA B receptors and 1.4 μM for GABA A receptors, as determined by its displacement of [3H]GABA binding in brain membranes. Notably, Lesogaberan napadisylate exerts a peripheral mode of action, inhibiting transient lower esophageal sphincter relaxation.
T26641	Apadenoson ATL 146e,BMS 068645,ATL146e,BMS-068645,ATL-146e,BMS068645
	Apadenoson 是一种有效的腺苷A2受体激动剂，对Adenosine A3 receptors 有抑制作用，IC 为45 nM。Apadenoson 具有抗炎活性，可用来研究神经系统疾病。
T35906	Padanamide A
	Padanamide A is a bacterial metabolite originally isolated from a marine Streptomyces species. It is active against five strains of P. falciparum (EC50s = 160-340 nM), is not cytotoxic to HEK293 or HepG2 human cell lines, but is cytotoxic to Jurkat T lymphocytes with an IC50 value of approximately 60 μg/ml.
T19356	HTBA	Others	Others
	HTBA 是一种用于测定尿肌酐的低成本酶促纸基分析试剂 (enz-PAD)。
T9828	N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide	PAD	Chromatin/Epigenetic
	N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide 是Cl-amidine (S 构型)的消旋形式。Cl-amidine 口服有效的 PAD 抑制剂。
T20982	Sodium 3-nitrobenzenesulfonate	Others	Others
	Sodium 3-nitrobenzenesulfonate 是一种温和的氧化剂。 Sodium 3-nitrobenzenesulfonate 在轧染印花或蒸汽印花时可以保护色光，并抵消还原物质的作用。
T10831L	Cl-amidine hydrochloride	Apoptosis; PAD	Apoptosis; Chromatin/Epigenetic
	Cl-amidine hydrochloride 是一种口服有效的PAD 抑制剂，可阻断组蛋白 3 瓜氨酸化和中性粒细胞胞外陷阱的形成，并提高败血症小鼠的存活率。它可诱导癌细胞凋亡，还可诱导 miR-16 引起细胞周期阻滞。
T4978	Sarpogrelate hydrochloride 盐酸沙格雷酯,MCI-9042	5-HT Receptor	GPCR/G Protein; Neuroscience
	Sarpogrelate hydrochloride (MCI-9042) 是一种选择性5-HT2R 拮抗剂，可用于研究与血栓形成有关的血管疾病，对 5-HT2A、5-HT2B 和 5-HT2C 受体的pKi 值分别为 8.52、6.57 和 7.43。
T10831L2	Cl-amidine TFA	Others	Others
	Cl-amidine TFA is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells.
T10482L	BB-Cl-Amidine hydrochloride BB-Cl-Amidine hydrochloride (1802637-39-3 free base)	Others	Others
	BB-Cl-Amidine hydrochloride 是一种肽基精氨酸脱胺酶(PAD)的抑制剂。
T10831	Cl-amidine	Others	Others
	Cl-amidine is an orally active inhibitor of peptidyl arginine deminase (PAD) (IC50s: 0.8 μM, 6.2 μM, and 5.9 μM for PAD1, PAD3, and PAD4). Cl-amidine induces apoptosis in cancer cells.
T36107	YW3-56 YW3-56
	YW3-56 is a potent peptidylarginine deiminase (PAD) inhibitor, with an IC50 of 1-5 μM for PAD4. Compared with Cl-amidine, YW3-56 shows >60-fold increase in cell growth inhibition efficacy (IC50 about 2.5 μM) but only 5-fold increase in PAD4 inhibition (IC sub>50 about 1-5 μM). At 2-4 μM concentrations, YW3-56 displays mainly cytostatic effects by slowing cell division, whereas at higher concentrations, it exerts cytotoxic effects by altering cell morphology and killing cells[1]. [1]. Wang Y, et ...

化合物

Photoswitchable PAD Inhibitor (technical grade)

Cat.No: T35817

Cat.No: T63284

Cat.No: T39515

Synonym: PAD2-IN-1

PAD2-IN-1 hydrochloride

Cat.No: T63601

Cat.No: T79276

Cat.No: T22178L

Synonym: Spadin Acetate(1270083-24-3 Free base)

Target: Others

Cat.No: T26641L

Synonym: BAY 68-4986 TFA,Apadenoson TFA(250386-15-3 Free base),Discontinued TFA

Target: Adenosine Receptor

Mebhydrolin napadisylate

Cat.No: T0113

Synonym: Incidal,Diazolin,Mebhydroline 1,5-naphthalenedisulfonate salt,美海屈林萘二磺酸盐,Omeril,Diazoline

Target: 5-HT Receptor, AChR, Histamine Receptor

Cat.No: T16411

Synonym: AF-DX 116

Target: AChR

Cat.No: T2373

Synonym: CEB-4520,BIIB-014

Target: Adenosine Receptor

PPADS tetrasodium

Cat.No: T16564

Target: P2X Receptor, Na+/Ca2+ Exchanger

Cat.No: TQ0125

Synonym: BAY 68-4986,卡帕诺生

Target: Adenosine Receptor

Cat.No: T16999

Synonym: PF-6649751,CVL-751

Target: Dopamine Receptor

Cat.No: T76735

Synonym: CPI-006

Target: CD73

Cat.No: T16427

Synonym: UCB-0942

Target: Others

Cat.No: T5167

Synonym: 西博帕多,GRT6005

Target: Opioid Receptor

2-PADQZ hydrochloride

Cat.No: T19849L

Synonym: 2-PADQZ hydrochloride (60547-97-9 Free base)

Target: Antiviral, Influenza Virus

Cat.No: T7503

Synonym: 乌帕替尼,ABT-494

Target: JAK

3-O-Acetylpadmatin

Cat.No: T126544

Cat.No: T71693

Cat.No: T70857

Aclatonium Napadisilate

Cat.No: T26553

Synonym: Acaltonium napadisilate

Cat.No: T37014

Cat.No: T75944

Cat.No: T19849

Synonym: 2PADQZ,2-PADQZ

Olpadronic acid

Cat.No: T33793

Synonym: Me2 APD,Me2-APD,Me2APD

Cat.No: T32076

Cat.No: T20599

Synonym: Escalol 507,Eusolex 6007,Arlatone UVB

Cat.No: T33863

Cat.No: T32722

Synonym: GRT-13106G,GRT6006,GRT 13106G,GRT-6006,GRT 6006,GRT13106G

Abediterol napadisylate

Cat.No: T24995

Synonym: LAS100977 napadisylate

Cat.No: T79638

Target: Glutathione Peroxidase

Cat.No: T79639

Target: Ferroptosis

Upadacitinib tartrate

Cat.No: T7503L

Synonym: ABT 494,ABT-494,ABT494

Cat.No: T34058

Inupadenant HCl

Cat.No: T69648

Cat.No: T81604

Cebranopadol ((1α,4α)stereoisomer)

Cat.No: T10749

Synonym: GRT6005 (1α,4α)stereoisomer

Target: Others

Lesogaberan napadisylate

Cat.No: T40572

Synonym: AZD-3355 napadisylate

Cat.No: T26641

Synonym: ATL 146e,BMS 068645,ATL146e,BMS-068645,ATL-146e,BMS068645

Cat.No: T35906

Cat.No: T19356

Target: Others

N-[1-(Aminocarbonyl)-4-[(2-chloro-1-iminoethyl)amino]butyl]benzamide

Cat.No: T9828

Target: PAD

Sodium 3-nitrobenzenesulfonate

Cat.No: T20982

Target: Others

Cl-amidine hydrochloride

Cat.No: T10831L

Target: Apoptosis, PAD

Sarpogrelate hydrochloride

Cat.No: T4978

Synonym: 盐酸沙格雷酯,MCI-9042

Target: 5-HT Receptor

Cat.No: T10831L2

Target: Others

BB-Cl-Amidine hydrochloride

Cat.No: T10482L

Synonym: BB-Cl-Amidine hydrochloride (1802637-39-3 free base)

Target: Others

Cat.No: T10831

Target: Others

Cat.No: T36107

Synonym: YW3-56

Cat. No.	Product Name	Target	Signaling Pathways
TN2033	Padmatin 李属素,Blumeatin C	Others	Others
	Padmatin (Blumeatin C) 是一种从 Prunus puddum 中分离出来的二氢黄酮醇。
TN4850	Pterocarpadiol D	Others	Others
	Pterocarpadiols A-D are a kind of very rare 6a,11b-dihydroxypterocarpans, and their presence as markers may be helpful in chemotaxonomical classification.
TN4847	Pterocarpadiol A	Others	Others
	Pterocarpadiols A-D are a kind of very rare 6a,11b-dihydroxypterocarpans, and their presence as markers may be helpful in chemotaxonomical classification.
TN4849	Pterocarpadiol C	Others	Others
	Pterocarpadiols A-D are a kind of very rare 6a,11b-dihydroxypterocarpans, and their presence as markers may be helpful in chemotaxonomical classification.
T83360	3-epi-Padmatin
	3-epi-Padmatin是从Inula graveolens中提取的一种天然产物。
TN4848	Pterocarpadiol B	Others	Others
	Pterocarpadiols A-D are a kind of very rare 6a,11b-dihydroxypterocarpans, and their presence as markers may be helpful in chemotaxonomical classification.
T2205	Acefylline Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid	TNF; PAD; PKA; HDAC; PDE; Adenosine Receptor	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience; Tyrosine Kinase/Adaptors
	Acefylline (Theophylline-7-acetic acid) 是黄嘌呤衍生物，是一种腺苷受体拮抗剂。它是蛋白质精氨酸脱亚氨酶 (PAD) 激活剂，也是一种支气管扩张剂，可抑制大鼠肺 cAMP 磷酸二酯酶同工酶。
T16946	Streptonigrin Bruneomycin	Others	Others
	Streptonigrin is a natural product produced by Streptomyces flocculus, has both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor (IC50s: 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD

天然产物

Cat.No: TN2033

Synonym: 李属素,Blumeatin C

Target: Others

Pterocarpadiol D

Cat.No: TN4850

Target: Others

Pterocarpadiol A

Cat.No: TN4847

Target: Others

Pterocarpadiol C

Cat.No: TN4849

Target: Others

3-epi-Padmatin

Cat.No: T83360

Pterocarpadiol B

Cat.No: TN4848

Target: Others

Cat.No: T2205

Synonym: Theophylline-7-acetic acid,茶碱乙酸,Carboxymethyltheophylline,acetyloxytheophylline,Theophyllineacetic acid

Target: TNF, PAD, PKA, HDAC, PDE, Adenosine Receptor

Cat.No: T16946

Synonym: Bruneomycin

Target: Others

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