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Search Results for " lix "

Targets Recommended: Others

56

抑制剂 & 化合物

5

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T39057	Rozanolixizumab UCB7665	Others	Others
	Rozanolixizumab（RYSTIGGO）是一种针对人类新生儿 Fc 受体（FcRn）的高亲和力人源化免疫球蛋白 G4 单克隆抗体，用于研究自身免疫和同种免疫疾病中致病性 IgG 。
T25742	Linzagolix choline	GNRH Receptor	GPCR/G Protein
	Linzagolix choline 是一种可口服的非肽类的促性腺激素释放激素（GnRH）拮抗剂。可用于研究子宫肌瘤和子宫内膜异位症相关疼痛。
T5520L	Cetrorelix diacetate NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate	GNRH Receptor	GPCR/G Protein
	Cetrorelix diacetate (NS-75A) 是GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T77456	Lumiliximab IDEC-152,ST-152
	Lumiliximab (IDEC-152) 是一种灵长类化的靶向 CD23 猕猴/人嵌合抗体，对 IgE 抗体的产生有抑制作用，用于研究过敏性疾病。
T76856	Andecaliximab GS-5745	MMP; Virus Protease	Microbiology/Virology; Proteases/Proteasome
	Andecaliximab 是一种靶向基质金属蛋白酶 9 (MMP9) 的重组 IgG4 单克隆抗体。Andecaliximab 在特发性肺纤维化小鼠模型中显示出抗纤维化作用。Andecaliximab 可用于研究胃腺癌和特发性肺纤维化 (IPF) 以及登革热病毒。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
T7005	Ulixertinib BVD-523,VRT752271,优立替尼	ERK	MAPK
	Ulixertinib (VRT752271) 是一种有效且可逆的 ERK1/ERK2 抑制剂，可抑制 ERK2 和下游蛋白 RSK 的磷酸化，对 ERK2 的IC50值小于 0.3 nM。
T11174	(R)-Elagolix 恶拉戈利,NBI-56418	GNRH Receptor	GPCR/G Protein
	(R)-Elagolix (NBI-56418) 是口服具有活性的、选择性高的非肽类促性腺激素释放激素受体短期有效拮抗剂 (KD = 54 pM)。
T9921	Infliximab	TNF	Apoptosis
	Infliximab 是一种与 TNF-α特异性结合的嵌合单克隆 IgG1 抗体，可阻止 TNF-α与 TNFR1和 TNFR2 的相互作用，用于治疗克罗恩病和类风湿性关节炎。
T17301	Opigolix ASP-1707	GNRH Receptor	GPCR/G Protein
	Opigolix (ASP-1707)是一种可口服促性腺激素释放激素 (GnRH) 受体拮抗剂，可用于研究子宫内膜异位症相关疼痛、风湿性关节炎和子宫肌瘤。
T3630	Relugolix RVT-601,瑞卢戈利,TAK-385	GNRH Receptor	GPCR/G Protein
	Relugolix (RVT-601) 是口服有活性的非肽性促性腺激素释放激素的拮抗剂。同 TAK-013 相比，它对人和猴子的受体具有高亲和力和强拮抗活性，它们的 IC50值分别为0.33 nM 和0.32 nM。它可用于研究性激素依赖性疾病，如子宫肌瘤、子宫内膜异位症、前列腺癌等。
T5520	Cetrorelix Acetate 醋酸西曲瑞克,Cetrorelix	GNRH Receptor	GPCR/G Protein
	Cetrorelix Acetate 是一种GnRH 受体的强效拮抗剂(IC50:1.21 nM)。
T5031	Elagolix sodium NBI-56418 sodium,恶拉戈利钠	GNRH Receptor	GPCR/G Protein
	Elagolix sodium (NBI-56418 sodium) 是人GnRH 受体拮抗剂，其IC50=0.25 nM，Ki=3.7 nM。
T60625	Tigulixostat LC350189	Xanthine Oxidase	Metabolism
	Tigulixostat (LC350189) 是一种新型黄嘌呤氧化酶抑制剂（XOI），可降低尿酸生成，可用于研究痛风相关的疾病。
T3538	Sufugolix TAK-013	LHRH	Endocrinology/Hormones
	Sufugolix (TAK-013) 是一种高效的、有口服活性的黄体激素释放激素(LHRH) 受体拮抗剂(IC50:0.1 nM)。
T7303	LIXIVAPTAN VPA-985,利伐普坦,WAY-VPA 985	Vasopressin Receptor	GPCR/G Protein
	Lixivaptan (VPA-985) 是一种具有口服活性的选择性加压素受体 V2 拮抗剂，对人和大鼠的IC50值分别为 1.2 和 2.3 nM。
T32873	Maralixibat Chloride SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625	Potassium Channel	Membrane transporter/Ion channel
	Maralixibat Chloride (LUM001 chloride) 是一种钠依赖性的胆汁酸转运抑制剂，可阻止胆汁酸在肠肝内的再循环
TP2337	Ganirelix Acetate	GNRH Receptor	GPCR/G Protein
	Ganirelix Acetate 是一种促性腺激素释放激素 (GnRH) 受体拮抗剂。
T10988L	Degarelix acetate(214766-78-6 free base)	GNRH Receptor	GPCR/G Protein
	Degarelix acetate(214766-78-6 free base) 是促性腺激素释放激素受体 (GnRHR) 的竞争性可逆拮抗剂。
T76830	Teneliximab Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819	TNF	Apoptosis
	Teneliximab (Chi220) 是一种嵌合的单克隆抗体，也是一种肿瘤坏死因子受体超家族成员5(CD40)抑制剂，可阻断CD40-CD40L 的相互作用。Teneliximab 通过CD40 和外周B细胞损耗发挥部分激动剂活性，可用于研究器官移植排斥和类风湿关节炎。
T73698	Basiliximab CHI 621	Interleukin	Immunology/Inflammation
	Basiliximab (CHI 621) 是一种嵌合鼠/人 IgG1 单克隆抗白细胞介素 2 受体 (interleukin-2 receptor) 重组抗体。Basiliximab 具有良好的免疫抑制活性，可用于研究肾移植。
T10217L	Abarelix R3827,阿巴瑞克,PPI 149	GNRH Receptor	GPCR/G Protein
	Abarelix (PPI 149) 是一种促性腺激素释放激素 (GnRH) 拮抗剂，用于前列腺癌研究。
T27837	Linzagolix	GNRH Receptor	GPCR/G Protein
	Linzagolix 是一种口服有活性的非多肽GnRH 拮抗剂。可用于研究子宫肌瘤、子宫腺肌症、子宫内膜异位症。
T26040	Ramorelix HOE 013,HOE013,HOE-013
	Ramorelix is an antagonist of luteinizing hormone-releasing hormone (LHRH).
T76962	Vapaliximab
	Vapaliximab (2D10) 是一种抗人VAP-1的单克隆抗体。
T76754	Otelixizumab
	Otelixizumab (ChAglyCD3) 是一种抗人 CD3单克隆抗体，可用于 1 型糖尿病的研究。
T75999	Balixafortide TFA
	Balixafortide TFA (POL6326 TFA) 是一种有效的，选择性的，耐受性好的肽类CXCR4拮抗剂，其IC50小于 10 nM。Balixafortide TFA 对CXCR4的选择性比包括CXCR7在内的许多受体高出 1000 倍。Balixafortide TFA 以 IC50< 10 nM 阻断β-arrestin 募集和钙通量。Balixafortide TFA 还是一种有效的造血干细胞和祖细胞 (HSPC) 动员剂，并具有抗癌作用。
T73466	Pulixin
	Pulixin 阻碍了 FREP1 与恶性疟原虫感染细胞的裂解物的结合，防止传播至蚊子，其中EC50值为11 µM。同时，Pulixin 抑制无性期恶性疟原虫的增殖，EC50值达47 nM。
T81925	Lixudebart
	Lixudebart为人源化IgG1-kappa亚型抗CLDN1单克隆抗体。
T81357	PTBP1 α3-helix derived peptide P1 TFA
	PTBP1 α3-螺旋衍生的多肽P1是一种多肽，具有抑制RNA结合的能力。
TP2141	Balixafortide TFA (1051366-32-5 free base) Balixafortide TFA,POL6326 TFA	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Balixafortide TFA (POL6326 TFA) is a selective, well-tolerated peptidic CXCR4 antagonist (IC50 < 10 nM). It shows 1000-fold selective for CXCR4 than a large panel of receptors including CXCR7. Balixafortide TFA blocks β-arrestin recruitment and calcium fl
T77049	Keliximab
	Keliximab (SB-210396) 是一种嵌合的人/猕猴IgG1抗CD4单克隆抗体，对可溶性CD4的Kd 值为 1.0 nM。Keliximab 阻断 T 细胞增殖并抑制IL-2的产生。Keliximab 可用于癌症研究。
T69492	Ozarelix
	Ozarelix is a fourth generation GnRH antagonist, induces apoptosis in hormone refractory androgen receptor negative prostate cancer cells modulating expression and activity of death receptors. Mechanistically, LHRH antagonists exert rapid inhibition of luteinizing hormone and follicle stimulating hormone with an accompanying rapid decrease in sex hormones and would therefore be expected to be effective in a variety of hormonally dependent disease states including ovarian cancer, prostate cancer,...
T82708	Clenoliximab IDEC-151
	Clenoliximab (IDEC-151)为一种猕猴-人嵌合型单克隆抗体（immunoglobulin G4），特异性结合于T淋巴细胞表面CD4分子。该化合物主要用于类风湿性关节炎的科研领域。
T71126	Allixin
	Allixin is a phytoallexin found in garlic (Allium sativum) bulbs. Allixin has weak antimicrobial activity and exerts an anti-promoting activity against skin tumors induced by the chemical 12-O-tetradecanoylphorbol-13-acetate (TPA). Allixin also demonstrates an inhibitory effect on aflatoxin B1-induced mutagenesis.
TP2141L	Balixafortide POL6326	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Balixafortide (POL6326) is a potent, selective, well-tolerated peptidic CXCR4 antagonist with an IC50 < 10 nM and it is also a potent hematopoietic stem and progenitor cell (HSPC) mobilizing agent. Anti-cancer effects[1][2]. Balixafortide blocks β-arresti
T7005L	Ulixertinib hydrochloride Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271
	Ulixertinib is an inhibitor of ERK protein kinase. Downmodulation of ERK protein kinase activity inhibits VEGF secretion by human myeloma cells and myeloma-induced angiogenesis. Upon oral administration, BVD-523 inhibits both ERK 1 and 2, thereby preventi
T20857	Polixetonium chloride
	Polixetonium chloride is a cooling tower biocide.
T70309	Dicetrorelix pamoate
	Dicetrorelix pamoate is a synthetic decapeptide with gonadotropin-releasing hormone (GnRH) antagonistic activity. GnRH induces the production and release of luteinizing hormone (LH) and follicle stimulating hormone (FSH) from the gonadotrophic cells of the anterior pituitary. Due to a positive estradiol (E2) feedback at midcycle, GnRH liberation is enhanced resulting in an LH-surge. This LH-surge induces the ovulation of the dominant follicle, resumption of oocyte meiosis and subsequently lutein...
T73327	Merigolix
	Merigolix 是一种有效的促性腺激素释放激素GnRH 拮抗剂。
T76809	Galiximab
	Galiximab (IDEC 114)，一种IgG1类免疫球蛋白单克隆抗体，针对CD80抗原。其可变区来源于灵长类动物，而恒定区则来自人类。Galiximab主要用于研究B细胞淋巴瘤。
T17236	Volixibat SHP626,LUM002	Others	Others
	Volixibat is a highly selective and competitive apical sodium-dependent bile acid transporter inhibitor. Volixibat has the potential for treatment for non-alcoholic steatohepatitis.
T71592	Detirelix acetate
	Detirelix acetate is an LHRH Antagonist
T68701	Abarelix acetate
	Abarelix acetate is a synthetic third generation gonadotropin-releasing hormone receptor (GnRHR) antagonist. It increases histamine release from rat peritoneal mast cells in vitro and from a human skin model ex vivo. In vivo, abarelix decreases plasma luteinizing hormone (LH) levels six hours post-treatment in castrated rats, with levels returning to baseline within 24 hours.3 Abarelix (2 mg/kg) also transiently decreases plasma testosterone levels in intact rats, with levels returning to baseli...
TP1057	Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa Phe-Met-Arg-Phe Like Peptide
	Phe-Met-Arg-Phe-like peptide, derived from the visceral and somatic muscles of the snail Helix aspersa, is a neuropeptide known as FMRF (Phe-Met-Arg-Phe). This peptide comprises four amino acid residues[1].
T75991	Ganirelix
	Ganirelix为一种竞争性且选择性的促性腺激素释放激素(GnRH)拮抗剂，其主要作用机制为抑制内源性GnRH，从而抑制黄体生成素(LH)及促卵泡激素的释放。
T28954	Teverelix
	Teverelix is a water-soluble antagonist of luteinizing hormone-releasing hormone (LHRH).
T68420	Detirelix
	Detirelix is an LHRH antagonist.
T80547	Thioether-cyclized helix B peptide, CHBP TFA	mTOR	PI3K/Akt/mTOR signaling
	Thioether-cyclized helix B peptide, CHBP(TFA)为Thioether-cyclized helix B peptide, CHBP的三氟乙酸盐形式，通过抑制mTORC1及激活mTORC2来诱导自噬(autophagy)，进而增强代谢稳定性及肾脏保护效果。
T78294	Tavolixizumab MEDI 0562,Tavolimab
	Tavolixizumab (MEDI 0562; Tavolimab)为一种针对TNFRSF4（TNF受体超家族成员4）的人源化单克隆抗体，主要应用于癌症免疫学领域的研究。

化合物

Rozanolixizumab

Cat.No: T39057

Synonym: UCB7665

Target: Others

Linzagolix choline

Cat.No: T25742

Target: GNRH Receptor

Cetrorelix diacetate

Cat.No: T5520L

Synonym: NS-75A,醋酸西曲瑞克,SB-075 acetate,SB-075 diacetate,Cetrorelix acetate,NS-75A diacetate

Target: GNRH Receptor

Cat.No: T77456

Synonym: IDEC-152,ST-152

Cat.No: T76856

Synonym: GS-5745

Target: MMP, Virus Protease

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Cat.No: T7005

Synonym: BVD-523,VRT752271,优立替尼

Target: ERK

Cat.No: T11174

Synonym: 恶拉戈利,NBI-56418

Target: GNRH Receptor

Cat.No: T9921

Target: TNF

Cat.No: T17301

Synonym: ASP-1707

Target: GNRH Receptor

Cat.No: T3630

Synonym: RVT-601,瑞卢戈利,TAK-385

Target: GNRH Receptor

Cetrorelix Acetate

Cat.No: T5520

Synonym: 醋酸西曲瑞克,Cetrorelix

Target: GNRH Receptor

Elagolix sodium

Cat.No: T5031

Synonym: NBI-56418 sodium,恶拉戈利钠

Target: GNRH Receptor

Cat.No: T60625

Synonym: LC350189

Target: Xanthine Oxidase

Cat.No: T3538

Synonym: TAK-013

Target: LHRH

Cat.No: T7303

Synonym: VPA-985,利伐普坦,WAY-VPA 985

Target: Vasopressin Receptor

Maralixibat Chloride

Cat.No: T32873

Synonym: SHP-625,SHP625,Livmarli,LUM001 chloride,Lopixibat chloride,Lopixibat,SHP625 chloride,SHP 625

Target: Potassium Channel

Ganirelix Acetate

Cat.No: TP2337

Target: GNRH Receptor

Degarelix acetate(214766-78-6 free base)

Cat.No: T10988L

Target: GNRH Receptor

Cat.No: T76830

Synonym: Chi220,Anti-Human CD40 Recombinant Antibody,BMS 224819

Target: TNF

Cat.No: T73698

Synonym: CHI 621

Target: Interleukin

Cat.No: T10217L

Synonym: R3827,阿巴瑞克,PPI 149

Target: GNRH Receptor

Cat.No: T27837

Target: GNRH Receptor

Cat.No: T26040

Synonym: HOE 013,HOE013,HOE-013

Cat.No: T76962

Cat.No: T76754

Balixafortide TFA

Cat.No: T75999

Cat.No: T73466

Cat.No: T81925

PTBP1 α3-helix derived peptide P1 TFA

Cat.No: T81357

Balixafortide TFA (1051366-32-5 free base)

Cat.No: TP2141

Synonym: Balixafortide TFA,POL6326 TFA

Target: CXCR

Cat.No: T77049

Cat.No: T69492

Cat.No: T82708

Synonym: IDEC-151

Cat.No: T71126

Cat.No: TP2141L

Synonym: POL6326

Target: CXCR

Ulixertinib hydrochloride

Cat.No: T7005L

Synonym: Ulixertinib HCl,BVD-523,VRT752271,BVD 523,BVD523,VRT 752271

Polixetonium chloride

Cat.No: T20857

Dicetrorelix pamoate

Cat.No: T70309

Cat.No: T73327

Cat.No: T76809

Cat.No: T17236

Synonym: SHP626,LUM002

Target: Others

Detirelix acetate

Cat.No: T71592

Abarelix acetate

Cat.No: T68701

Phe-Met-Arg-Phe Like Peptide, Snail Helix aspersa

Cat.No: TP1057

Synonym: Phe-Met-Arg-Phe Like Peptide

Cat.No: T75991

Cat.No: T28954

Cat.No: T68420

Thioether-cyclized helix B peptide, CHBP TFA

Cat.No: T80547

Target: mTOR

Cat.No: T78294

Synonym: MEDI 0562,Tavolimab

Cat. No.	Product Name	Target	Signaling Pathways
T2985	Gypenoside XLIX 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX	PPAR	DNA Damage/DNA Repair; Metabolism
	Gypenoside XLIX 是一种达玛烷型糖苷，是绞股蓝的主要成分。它是选择性过氧化物酶体增殖物激活受体 (PPAR)-α激活剂，可抑制细胞因子诱导的血管细胞粘附分子-1 (VCAM-1) 在人体内皮细胞中过度活跃和表达。
TN4740	Parvifolixanthone B	Others	Others
	Parvifolixanthone B is a natural product from Garcinia parvifolia.
TN4739	Parvifolixanthone A	Others	Others
	Parvifolixanthone A is a natural product from Garcinia parvifolia.
TN1066	Filixic acid ABA	Influenza Virus	Microbiology/Virology
	Filixic acid ABA exhibits inhibitory effects on neuraminidase of influenza virus H5N1 with IC50 as 29.57 ± 2.48 μM, it may have anti-influenza virus activity.
TN6532	Polygalasaponin XLIX
	Polygalasaponin XLIX 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN6532，CAS号为 1033593-12-2。

天然产物

Gypenoside XLIX

Cat.No: T2985

Synonym: 绞股蓝皂苷 XLIX,绞股蓝皂苷XLIX

Target: PPAR

Parvifolixanthone B

Cat.No: TN4740

Target: Others

Parvifolixanthone A

Cat.No: TN4739

Target: Others

Filixic acid ABA

Cat.No: TN1066

Target: Influenza Virus

Polygalasaponin XLIX

Cat.No: TN6532

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04790	CXCL5 Protein, Mouse, Recombinant (His) AMCF-II,GCP-2,Scyb6,LIX,chemokine (C-X-C motif) lig...	Mouse	P. pastoris (Yeast)
	CXCL5 Protein, Mouse, Recombinant (His) is expressed in yeast with His tag. The predicted molecular weight is 9.4 kDa and the accession number is P50228.

重组蛋白

CXCL5 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04790

Species: Mouse

Expression System: P. pastoris (Yeast)

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