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Search Results for " hsv-1 "

46

抑制剂 & 化合物

24

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T2504	Pritelivir 普瑞利韦,BAY 57-1293,AIC316	DNA/RNA Synthesis; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Pritelivir (BAY 57-1293) 是一种病毒解旋酶-引物酶复合物抑制剂，有抗病毒活性。它对 HSV-1 和 HSV-2 具有活性，IC50值为 20 nM。
T62075	HSV-1/HSV-2-IN-1
	HSV-1/HSV-2-IN-1 是一种 HSV-1 和 HSV-2 抑制剂，能够作用于 HSV-1 (KOS) (EC50: 7.6 μM)，HSV-2 (G) (EC50: 7.6 μM)，HSV-1 TK-KOS ACVr (EC50: 4 μM) 和牛痘病毒 (EC50: 12 μM)。
T12908	SIBA 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷	Nucleoside Antimetabolite/Analog; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	SIBA (5'-Deoxy-5'-isobutylthioadenosine) 是 SAH 的合成类似物，可作为 S-腺苷甲硫氨酸介导的甲基转移的抑制剂。它干扰多种酶活性，可逆地阻断单纯疱疹病毒 1 型病毒的繁殖。
T61563	HSV-1/HSV-2-IN-2
	HSV-1/HSV-2-IN-2是一种 HSV-1、HSV-2和 VV 抑制剂，EC50值为6.8、8.9和8.9 μM，并显示出抗病毒活性。
T10445	B220	HSV	Microbiology/Virology
	B220 是一种能抑制 HSV-1，HSV-2 和人巨细胞病毒 (CMV) 生长的抗病毒剂。
T50026	Aquacycline	HSV	Microbiology/Virology
	Aquacycline 是一种广谱抗生素，通过抑制细菌中的蛋白质合成起作用。它可防止氨酰-tRNA 与复杂的 m-核糖体 RNA 结合。它还具有抗 HSV-1 活性。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T60272	Isatin-β-thiosemicarbazone IBT	HSV	Microbiology/Virology
	Isatin-β-thiosemicarbazone 是一种有效的单纯疱疹病毒 (HSV) 抑制剂。Isatin-β-thiosemicarbazone 在对 HSV-1 和 HSV-2 都具有抑制作用，表现出抗病毒活性。Isatin-β-thiosemicarbazone 是一种有效的抗痘病毒剂 (anti-poxvirus）可用用于治疗猴痘病毒、正痘病毒和牛痘病毒。
T80672	1,4-Dihydroxynaphthalene Naphthalene-1,4-diol	HSV	Microbiology/Virology
	1,4-Dihydroxynaphthalene 一种有效的 HSV-1蛋白酶抑制剂，对HCMV蛋白酶有抑制作用，可用于研究疱疹病毒。
T3045	Salubrinal	Apoptosis; Phosphatase; PERK; Autophagy; HSV	Apoptosis; Autophagy; Metabolism; Microbiology/Virology
	Salubrinal 是一种磷酸酶抑制剂，对真核翻译起始因子 2 亚基 (eIF2α) 发挥作用。它作为双特异性磷酸酶 2 抑制剂，抑制抗胶原蛋白抗体诱导的关节炎。它具有抗HSV-1病毒的活性，并抑制由HSV-1蛋白 ICP34.5 介导的eIF2α的去磷酸化。
T15394	Glyceryl monocaprate 2,3-Dihydroxypropyl decanoate,一癸酸甘油酯,DECANOIN,Monocaprin	Antibacterial; HSV	Microbiology/Virology
	Glyceryl monocaprate (2,3-Dihydroxypropyl decanoate) 对单纯疱疹病毒具有抑制作用，有潜力治疗唇疱疹。它是一种癸酸的1-单甘油酯，可抗革兰氏阳性细菌感染。
T1454	Acyclovir Aciclovir,Acycloguanosine,阿昔洛韦	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Acyclovir (Aciclovir) 是鸟嘌呤类似物和具有口服活性的抗病毒剂。它对HSV-1(IC50为 0.85 μM)，HSV-2(IC50为 0.86 μM) 和水痘带状疱疹病毒有活性。
T13209L	Tromantadine hydrochloride	HSV	Microbiology/Virology
	Tromantadine hydrochloride is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).
T24385	L-Acosamine nucleoside
	L-Acosamine nucleoside has antiviral activity against HIV and HSV-1.
T80374	HBA(111–142)	HSV	Microbiology/Virology
	HBA(111-142) 是一种源于 α-血红蛋白 C 端的32-聚体抗菌肽片段，对 ESKAPE 病原体展示出了抗菌效果。它能形成淀粉样原纤维结构，并表现出针对多种病毒，包括麻疹病毒和疱疹病毒（HSV-1、HSV-2、HCMV）的抗病毒活性。
T73983	Cidofovir diphosphate tri(triethylamine)
	Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂，对 HCMV，HSV-1和 HSV-2的 Ki 值分别为 6.6，0.86 和 1.4 μM。
TP1536	Histone H4 (2-21)
	Histone H4 (2-21) is a pivotal core histone involved in the process of chromatinization specific to the genomes of herpes simplex virus 1 (HSV-1).
T76336	Astodrimer
	Astodrimer (SPL7013 free base) 是一种体积较大（3-4 nm, ~ 16.5 kDa）、带负电荷、高度分支化的树状高分子，有效抑制并杀灭多种病毒，包括 SARS-CoV-2、HIV-1、HSV-1、HSV-2、HPV 等，具有广谱的抗病毒和杀病毒活性，同时展现出抗菌特性。
T75518	Galactofucan
	Galactofucan (Fucogalactan) 是一种硫酸多糖。Galactofucan 可以从棕色海藻 Saccharina longicruris 中提取，具有抗凝血、抗肿瘤、抗血栓形成、抗炎、抗病毒等特性。Galactofucan 对 HSV-1和 HSV-2具有抗病毒活性，IC50值分别为 0.76 和 1.34 µg/mL 。Galactofucan 可用于癌症和炎症的研究。
T80295	GLR-19	HSV	Microbiology/Virology
	GLR-19 为一种具有抗HIV功能的肽类化合物，亦展现出对HSV-2的抗病毒活性。
T68619	FR-48217
	FR-48217 is an immunoactive peptide that inhibits multiplication of HSV-1 and HSV-2.
T76581	HHV-2 Envelope Glycoprotein G (552-574)
	HHV-2 包膜糖蛋白 G (552-574) 是 gG-2 的免疫显性区域，能够与所有单纯疱疹 (HSV-2) 血清产生反应。
T13209	Tromantadine	HSV	Microbiology/Virology
	Tromantadine is an amantadine derivative with antiherpetic activity (inhibits HSV-1 and HSV-2 replication).
T80761	XQ2B
	XQ2B为cGAS抑制剂，针对蛋白质-DNA相互作用及其相分离。该化合物可阻止单纯疱疹病毒1（HSV-1）触发的抗病毒免疫响应，在体外与体内都能增强HSV-1的感染效果。
T72864	Perillic acid 紫苏酸
	Perillic acid 是 Perillyl alcohol 的代谢物。Perillic acid 诱导肺癌细胞周期阻滞和凋亡 (apoptosis)。Perillic acid 具有抗HSV-1和免疫调节活性。
T11549	Helioxanthin 8-1 Helioxanthin analogue 8-1	Others	Others
	Helioxanthin 8-1, an analogue of helioxanthin, exhibits significant in vitro anti-HBV/HCV/HSV-1/HIV activity with EC50 of >5/10/1.4/15 μM.
T10615	BRL44385	HSV	Microbiology/Virology
	BRL44385 is an effective and selective inhibitor of the replication of HSV-1 and HSV2, Epstein-Barr virus (EBV), and varicella-zoster virus (VZV).
T81293	Retrocyclin-2
	Retrocyclin-2是一种具有针对HIV、Influenza A和HSV的抗微生物活性的肽类化合物。
T38130	Z-LVG-CHN2 Z-Leu-Val-Gly-diazomethylketone
	The diazomethyl ketone Z-LVG-CHN2 mimics part of the human cysteine proteinase-binding center, has been shown to be an irreversible inhibitor of this proteinase. The compound was also tested for antiviral activity against herpes simplex virus type 1 (HSV) and found to block the HSV replication. Irreversible inhibitor of streptopain.
T80655	BVDU 5′-Triphosphate BVdUTP,(E)-5-(2-Bromovinyl)-dUTP	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	BVDU 5′-Triphosphate 是带有 5′-Triphosphate 标记、针对 DNA 聚合酶的抗病毒药物。它对水痘-带状疱疹病毒（VZV）和单纯疱疹病毒 1 型（HSV-1）具有高度选择性，这种选择性归因于病毒编码的胸苷激酶对其进行特异性磷酸化的能力。
T75444	Peniterphenyl A
	Peniterphenyl A，一种源于深海青霉属植物的天然产物，能够抑制HSV-1/2病毒的细胞内入侵。它可能通过与HSV-1/2病毒的糖蛋白D直接相互作用，干扰病毒的吸附和膜融合过程，进而有效阻断病毒感染。因此，Peniterphenyl A是抗HSV-1/2研究领域中一个极具潜力的先导化合物。
T81292	Retrocyclin-3
	Retrocyclin-3是一种具有抗HIV（人类免疫缺陷病毒）、H1N1（甲型流感）以及HSV（单纯疱疹病毒）活性的抗菌肽。
T36073	S-Acetyl-L-glutathione
	S-Acetyl-L-glutathione is a derivative of glutathione .1 It increases intracellular GSH levels in primary fibroblasts derived from patients with glutathione synthetase deficiency when used at a concentration of 50 μM. S-Acetyl-L-glutathione (5 mM) induces apoptosis in Daudi, Raji, and Jurkat lymphoma cells.2 It inhibits the replication of herpes simplex virus 1 (HSV-1) in human foreskin fibroblasts when used at concentrations of 5 and 10 mM.3 S-Acetyl-L-glutathione (6.25 μg/g per day) increases ...
T16576	Pritelivir mesylate BAY 57-1293 mesylate,AIC316 mesylate	Others	Others
	Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate shows antiviral activity in vitro and in animal models
T35701	FSL-1 TFA
	FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2]. FSL-1 significantly reduces HSV-2 replication in human vaginal epithelial cells (EC)[1].FSL-1 induces significant resistance to experimental genital HSV-2 infection through elaboration of a specific cytokine response profile[1].FSL-1 (50 ng/mL, 24 hours) induce...
T1087L	Valaciclovir
	Valacyclovir (Valaciclovir) 是一种具有口服活性的抗病毒药物，用于抑制单纯疱疹，带状疱疹和疱疹 B。Valacyclovir 抑制 HSV-1W (50=2.9 μg/ml)。Valacyclovir 是 Aciclovir 的前药。
T35696	Olomoucine II
	Olomoucine II is an inhibitor of cyclin-dependent kinases (CDKs; IC50s = 7.6, 0.1, 19.8, 0.45, and 0.06 μM for Cdk1, -2, -4, -7, and -9, respectively).1It is selective for CDKs over 10 additional kinases (IC50s = >100 μM for all) but does inhibit ERK2 (IC50= 32 μM) and the ATP-binding cassette transporter B1 (ABCB1; IC50= 6.4 μM).1,2Olomoucine II inhibits proliferation of a variety of cancer cells, including those expressing wild-type p53 or mutant p53 (mean IC50s = 7.4 and 10.1 μM, respectively...
T60709	Acyclovir monophosphate
	Acyclovir monophosphate 是抗单纯疱疹病毒 (HSV)剂，并且具有抗肿瘤活性。Acyclovir monophosphate 通过抑制病毒 DNA 聚合酶从而阻断 DNA 合成，同时能终止病毒 DNA 的链延伸。
T75282	Oxytetracycline calcium
	Oxytetracycline calcium 是一种属于四环素类的抗生素。Oxytetracycline calcium 强力抑制革兰氏阴性和革兰氏阳性细菌。Oxytetracycline calcium 是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合。Oxytetracycline calcium 还具有抗HSV-1的活性。
T80120	FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578)	HSV	Microbiology/Virology
	FITC-εAhx-HHV-2 EnvelopeGlycoproteinG (561-578) 是带有FITC标记的糖蛋白G (gG-2)的免疫原性片段，涵盖了其氨基酸序列的561至578位点。此段具有广泛的与单纯疱疹病毒2型(HSV-2)血清呈现交叉反应的特性。
T36040	16,16-dimethyl Prostaglandin A1 16,16-dimethyl Prostaglandin A1
	16,16-dimethyl Prostaglandin A1 是一种前列腺素类似物，可以抑制 Lewis 肺癌和 B 16无黑色素瘤细胞中的 DNA 合成 (DNA synthesis)，以及抑制 HSV 和 HIV-1的病毒复制。
T16575	Pritelivir mesylate hydrate BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate	Others	Others
	Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (IC50: 0.02 μM against HSV1-2). Pritelivir mesylate hydrate is an inhibitor of the viral helicase-primase complex. Pritelivir mesylate hydrate shows antiviral activity in vit
T60488	Ganciclovir hydrate
	Ganciclovir (BW 759) hydrate 是一种核苷类似物，是具有口服活性的抗病毒剂，显示出抗巨细胞病毒活性。Ganciclovir hydrate 对疱疹病毒和其他一些 DNA 病毒也具有体外抗病毒活性。Ganciclovir hydrate 在体外抑制人类疱疹病毒 (HSV 1 型和 2 型，CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的复制。Ganciclovir hydrate 对猫疱疹病毒 1 型 (FHV-1) 的 IC50为 5.2 μM，可扩散到大脑。
T83706	BMAP 28 (bovine) TFA Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28
	BMAP 28是一种合成抗菌肽，对应牛防御素-5的132-158氨基酸。对大肠杆菌(E. coli)、金黄色葡萄球菌(S. aureus)、耐甲氧西林金黄色葡萄球菌(MRSA)、表皮葡萄球菌(S. epidermidis)及白色念珠菌(C. albicans)具有活性(MICs分别为2、2、4、1和8 µM)。在200 nM浓度下，BMAP 28能够使大肠杆菌的内膜渗透。在5 µM浓度下，减少Vero 76细胞中单纯疱疹病毒1型(HSV-1)的复制。在30 µM浓度下，对分离的人类红细胞引起溶血，并对分离的人类嗜中性粒细胞具有细胞毒性。BMAP 28 (0.8 mg/kg)可提高大肠杆菌或MRSA感染的小鼠的生存率，但对铜绿假单胞菌(P. aeruginosa)感染的小鼠无效。
T11449	Golotimod hydrochloride (229305-39-9 free base) Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride	STAT	JAK/STAT signaling; Stem Cells
	Golotimod (SCV 07) hydrochloride 是一种免疫调节肽，具抗菌活性，能显著提升抗结核疾病研究效果。该化合物通过刺激胸腺和脾细胞增殖、改善巨噬细胞功能，展现其生物调节能力。此外，Golotimod hydrochloride 通过抑制STAT3信号传导，有效调节接受放疗或与顺铂联用治疗动物模型中的口腔粘膜炎持续时间和严重程度。还显示出对研究复发性生殖器单纯疱疹病毒 2 型 (HSV-2) 具有潜在应用价值。

化合物

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cat.No: T2504

Synonym: 普瑞利韦,BAY 57-1293,AIC316

Target: DNA/RNA Synthesis, HSV

HSV-1/HSV-2-IN-1

Cat.No: T62075

Cat.No: T12908

Synonym: 5'-Deoxy-5'-isobutylthioadenosine,5'-Isobutylthioadenosine,5ˊ-异丁硫基-5ˊ-脱氧腺苷

Target: Nucleoside Antimetabolite/Analog, HSV

HSV-1/HSV-2-IN-2

Cat.No: T61563

Cat.No: T10445

Target: HSV

Cat.No: T50026

Target: HSV

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Isatin-β-thiosemicarbazone

Cat.No: T60272

Synonym: IBT

Target: HSV

1,4-Dihydroxynaphthalene

Cat.No: T80672

Synonym: Naphthalene-1,4-diol

Target: HSV

Cat.No: T3045

Target: Apoptosis, Phosphatase, PERK, Autophagy, HSV

Glyceryl monocaprate

Cat.No: T15394

Synonym: 2,3-Dihydroxypropyl decanoate,一癸酸甘油酯,DECANOIN,Monocaprin

Target: Antibacterial, HSV

Cat.No: T1454

Synonym: Aciclovir,Acycloguanosine,阿昔洛韦

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic, HSV

Tromantadine hydrochloride

Cat.No: T13209L

Target: HSV

L-Acosamine nucleoside

Cat.No: T24385

Cat.No: T80374

Target: HSV

Cidofovir diphosphate tri(triethylamine)

Cat.No: T73983

Histone H4 (2-21)

Cat.No: TP1536

Cat.No: T76336

Cat.No: T75518

Cat.No: T80295

Target: HSV

Cat.No: T68619

HHV-2 Envelope Glycoprotein G (552-574)

Cat.No: T76581

Cat.No: T13209

Target: HSV

Cat.No: T80761

Cat.No: T72864

Synonym: 紫苏酸

Helioxanthin 8-1

Cat.No: T11549

Synonym: Helioxanthin analogue 8-1

Target: Others

Cat.No: T10615

Target: HSV

Cat.No: T81293

Cat.No: T38130

Synonym: Z-Leu-Val-Gly-diazomethylketone

BVDU 5′-Triphosphate

Cat.No: T80655

Synonym: BVdUTP,(E)-5-(2-Bromovinyl)-dUTP

Target: DNA/RNA Synthesis

Peniterphenyl A

Cat.No: T75444

Cat.No: T81292

S-Acetyl-L-glutathione

Cat.No: T36073

Pritelivir mesylate

Cat.No: T16576

Synonym: BAY 57-1293 mesylate,AIC316 mesylate

Target: Others

Cat.No: T35701

Cat.No: T1087L

Cat.No: T35696

Acyclovir monophosphate

Cat.No: T60709

Oxytetracycline calcium

Cat.No: T75282

FITC-εAhx-HHV-2 Envelope Glycoprotein G (561-578)

Cat.No: T80120

Target: HSV

16,16-dimethyl Prostaglandin A1

Cat.No: T36040

Synonym: 16,16-dimethyl Prostaglandin A1

Pritelivir mesylate hydrate

Cat.No: T16575

Synonym: BAY 57-1293 mesylate hydrate,AIC316 mesylate hydrate

Target: Others

Ganciclovir hydrate

Cat.No: T60488

BMAP 28 (bovine) TFA

Cat.No: T83706

Synonym: Cathelicidin-5 (132-158),Bovine Myeloid Antimicrobial Peptide 28

Golotimod hydrochloride (229305-39-9 free base)

Cat.No: T11449

Synonym: Golotimod hydrochloride,Gamma-D-glutamyl-L-tryptophan hydrochloride,SCV 07 hydrochloride

Target: STAT

Cat. No.	Product Name	Target	Signaling Pathways
T3S1068	Oxyresveratrol trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene	Tyrosinase; Autophagy; HSV	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Oxyresveratrol (trans-Oxyresveratrol) 是非竞争性酪氨酸酶抑制剂，对蘑菇酪氨酸酶的 IC50值为 1.2 µM。它抑制HSV-1，HSV-2和水痘带状疱疹病毒，具有神经保护作用。它是天然抗氧化剂和自由基清除剂。
T0895	Oxytetracycline 土霉素,Terramycin	ribosome; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology
	Oxytetracycline (Terramycin) 是一种四环素类抗生素。它强力抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，具有抗 HSV-1的活性。
T6624	Oxytetracycline Dihydrate 土霉素二水合物,地霉素,Terramycin Dihydrate	Others; Endogenous Metabolite; Antibacterial; Antibiotic; HSV	Metabolism; Microbiology/Virology; Others
	Oxytetracycline Dihydrate (Terramycin Dihydrate) 是一种四环素类抗生素，可抑制革兰氏阴性和革兰氏阳性细菌。它是一种蛋白质合成抑制剂，可阻止 aminoacil-tRNA 与复杂的核糖体 RNA 结合，还具有抗 HSV-1的活性。
T5S0018	Betulonic acid 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid	Parasite; HSV	Microbiology/Virology
	Betulonic acid (Liquidambaric acid) 是一种在许多植物中存在的三萜类天然产物，具有抗肿瘤，抗炎，抗寄生虫和抗病毒的活性。
T0884	1-Docosanol Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol	Antifection; HSV	Microbiology/Virology
	1-Docosanol (Behenic alcohol) 是一种具有抗病毒活性的饱和 22 碳脂肪醇，局部用于治疗复发性单纯性唇疱疹发作并缓解相关疼痛并可能有助于更快地治愈疮。
T21430	Oxytetracycline Hydrochloride Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin	Antiviral; Endogenous Metabolite; Antibacterial; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology
	Oxytetracycline Hydrochloride (Dalimycin) 是由 Streptomyces rimosus 生产的，一种具有抗菌活性的四环素衍生物。它干扰氨酰-tRNA 与 mRNA-核糖体复合物的结合，从而阻止肽延伸并抑制蛋白质合成。
T2822	Ginsenoside Rb1 Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III	ATPase; Mitophagy; IRAK; NF-κB; Autophagy; HSV	Autophagy; Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; NF-κB
	Ginsenoside Rb1 (Gypenoside Ⅲ) 是中药人参的成分，可能具有抑制或阻止肿瘤生长的特性。
T7972	Gallic aldehyde 3,4,5-三羟基苯甲醛,五倍子醛	HSV	Microbiology/Virology
	Gallic aldehyde 对 HSV-1 显示出有效的抗病毒活性。
T2927	Trigonelline chloride Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride	Others; Antibacterial; Antifungal; HSV	Microbiology/Virology; Others
	Trigonelline chloride (Coffearine Hydrochloride) 是一种大量存在于咖啡中的生物碱，具有潜在抗糖尿病活性。它还具有抗HSV-1，抗菌和抗真菌活性。
T6S1885	Benzoylmesaconine Mesaconine 14-benzoate,苯甲酰新乌头原碱	Others	Others
	Benzoylmesaconine (Mesaconine 14-benzoate) 是乌头汤最丰富的组分。其中乌头汤可用于研究类风湿性关节炎。
T1506	Vidarabine Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A	Nucleoside Antimetabolite/Analog; Tyrosine Kinases; DNA/RNA Synthesis; Antibiotic; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Tyrosine Kinase/Adaptors
	Vidarabine (Adenine Arabinoside) 是从链霉菌分离的核苷类抗生素，能抗单纯性疱疹和水痘-带状疱疹病毒。它对 HSV-1 和 HSV-2 的 IC50值分别为 9.3 μg/ml 和 11.3 μg/ml。
T2S1865	Octyl gallate Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯	Antioxidant; Influenza Virus; Reactive Oxygen Species; Antibacterial; Antifungal; HSV	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; oxidation-reduction
	Octyl gallate (Octyl 3,4,5-trihydroxybenzoate) 具有抗菌、抗氧化作用，有选择性和敏感性的荧光特性，广泛用作食品添加剂。它对 HSV-1，水泡性口炎病毒和脊髓灰质炎病毒有显著的抗病毒作用。
T0853L	Adenosine 5'-monophosphate monohydrate 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid	AMPK; Adenosine Receptor; HSV	Chromatin/Epigenetic; GPCR/G Protein; Microbiology/Virology; Neuroscience; PI3K/Akt/mTOR signaling
	Adenosine 5'-monophosphate monohydrate (5'-AMP) 是一种核苷酸，用作 RNA 中的单体。它是一个腺苷 A1受体激动剂，对HSV-1和HSV-2具有显著的抗病毒活性。
T7983	Isoborneol DL-Isoborneol,异冰片,异龙脑	HSV	Microbiology/Virology
	Isoborneol (DL-Isoborneol) 是存在于许多药用植物精油中的一种单萜醇，具有抗氧化和抗病毒特性，是 1 型单纯疱疹病毒(HSV-1)的有效抑制剂。
T3795	Corilagin	Apoptosis; TLR; Reverse Transcriptase; Antibacterial; Autophagy	Apoptosis; Autophagy; Immunology/Inflammation; Microbiology/Virology
	Corilagin 是一种鞣酸，有抑制 RNA 肿瘤病毒逆转录酶的活性。它抑制金黄色葡萄球菌的生长，MIC 为 25 μg/mL。它有抗肿瘤活性，可用于肝癌和卵巢癌。
T5429	Theaflavin 3,3'-digallate 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG	Virus Protease; Antioxidant; HIV Protease; HSV	Microbiology/Virology; oxidation-reduction; Proteases/Proteasome
	Theaflavin 3,3'-digallate (8-Gingerol) 是一种寨卡病毒蛋白酶抑制剂，IC50为 2.3 μM。它直接与 ZIKVpro 结合并抑制 ZIKV 复制，可抑制 gp41 和 NS2B-3 蛋白酶的活性，并具有抗 HSV 和 HIV-1病毒活性。它是红茶中的主要多酚，有抗肿瘤作用。
T79987	Cangorinine E-1	HSV	Microbiology/Virology
	Cangorinine E-1 (compound 11) 为一种倍半萜类的二氢沉香呋喃衍生物，对 II 型单纯疱疹病毒(HSV)展现出轻度抑制效果。
TN4587	Mulberrofuran C	HSV	Microbiology/Virology
	Mulberrofuran C shows protective effects on t-BHP-induced oxidative stress with the EC50 value of 0.41 ± 0.48 uM ; it also shows protective effects on glutamate-induced cell death with the EC50 value of 16.50 ± 7.82 uM. Mulberrofuran C has antiviral effects against herpes simplex virus type 1 and 2 (HSV-1 and HSV-2).
T38441	Manzamine A hydrochloride
	Manzamine A hydrochloride is an orally active beta-carboline alkaloid that exhibits specific inhibitory effects on GSK-3β (IC50 = 10.2 μM) and CDK-5 (IC50 = 1.5 μM). Additionally, it targets vacuolar ATPases, leading to the inhibition of autophagy in pancreatic cancer cells. Manzamine A hydrochloride possesses antimalarial and anticancer properties, and also demonstrates potent activity against HSV-1[4].
TN4585	Moronic acid	HIV Protease; Antifection; HSV	Microbiology/Virology; Proteases/Proteasome
	Moronic acid shows oral therapeutic efficacy in HSV-infected mice and possessed novel anti-HSV activity. It also shows significant anti-HIV activity (EC(50) 186) and was modified to develop more potent anti-AIDS agents. Moronic acid is a new structural lead for anti-EBV drug development, can substantially reduce the numbers of EBV particles produced by the cells after lytic induction. Morolic and moronic acids have shown sustained antidiabetic and antihyperglycemic action possibly mediated by an...
T83693	Magainin 2 TFA MG2
	Magainin 2是一种从非洲爪蟾（X. laevis）皮肤中分离出的阳离子肽，具有宿主防御和抗菌活性。该化合物对细菌E. coli、K. pneumoniae、S. epidermidis、S. aureus及真菌C. albicans表现出活性（MICs分别为5、10、10、50和80 µg/ml）。Magainin 2（20 µM）能降低猕猴桃花粉的萌发率和平均管长。在被单纯疱疹病毒1型（HSV-1）或2型（HSV-2）感染的Vero细胞中，它可减少病毒复制（EC50s分别为22.16和19.8 µM），同时不影响细胞活性，其50%细胞毒性浓度值（CC50）大于100 µM。
TN6014	Norcepharadione B 鱼腥草
	Norcepharadione B shows good inhibitory activity against the replication of HSV-1, it also shows antimalarial activity with EC50 values of 7.5mug/ml. Norcepharadione B exhibits significant cytotoxicity against five human tumor cell lines (A-549, SK-OV-3,
TN4456	Lucidadiol	AChR; HSV	Microbiology/Virology; Neuroscience
	Lucidadiol exhibits butyrylcholinesterase-inhibitory activity at concentrations up to 200 uM, it also possesses inhibitory activity against acetylcholinesterase (AChE) with the percentage inhibition at 100 uM. Lucidadiol shows antiviral activity against i
T35779	Oosporein
	Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ...

天然产物

Cat.No: T3S1068

Synonym: trans-Oxyresveratrol,2,3',4,5'-tetrahydroxystilbene,氧化白藜芦醇,Tetrahydroxystilbene

Target: Tyrosinase, Autophagy, HSV

Oxytetracycline

Cat.No: T0895

Synonym: 土霉素,Terramycin

Target: ribosome, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Oxytetracycline Dihydrate

Cat.No: T6624

Synonym: 土霉素二水合物,地霉素,Terramycin Dihydrate

Target: Others, Endogenous Metabolite, Antibacterial, Antibiotic, HSV

Cat.No: T5S0018

Synonym: 路路通酸,(+)-Betulonic acid,Betunolic acid,Liquidambaric acid

Target: Parasite, HSV

Cat.No: T0884

Synonym: Behenic alcohol,Behenyl alcohol,n-Docosanol,二十二醇,Docosanol

Target: Antifection, HSV

Oxytetracycline Hydrochloride

Cat.No: T21430

Synonym: Biosolvomycin,盐酸土霉素,Oxytetracycline HCl,Oxytetracycline.HCl,Dalimycin,Oxytetracycline, Sodium Salt,Dalinmycin

Target: Antiviral, Endogenous Metabolite, Antibacterial, HSV

Ginsenoside Rb1

Cat.No: T2822

Synonym: Gypenoside Ⅲ,人参皂苷Rb1,人参皂苷 Rb1,Gypenoside III

Target: ATPase, Mitophagy, IRAK, NF-κB, Autophagy, HSV

Gallic aldehyde

Cat.No: T7972

Synonym: 3,4,5-三羟基苯甲醛,五倍子醛

Target: HSV

Trigonelline chloride

Cat.No: T2927

Synonym: Gynesine Hydrochloride,盐酸葫芦巴碱,Coffearine Hydrochloride,Nicotinic acid N-methylbetaine Hydrochloride,Trigonelline hydrochloride

Target: Others, Antibacterial, Antifungal, HSV

Benzoylmesaconine

Cat.No: T6S1885

Synonym: Mesaconine 14-benzoate,苯甲酰新乌头原碱

Target: Others

Cat.No: T1506

Synonym: Adenine Arabinoside,阿糖腺苷,9-β-D-Arabinofuranosyladenine,Vira-A,Arabinosyladenine,Ara-A

Target: Nucleoside Antimetabolite/Analog, Tyrosine Kinases, DNA/RNA Synthesis, Antibiotic, HSV

Cat.No: T2S1865

Synonym: Gallic acid octyl ester,n-Octylgallate,Octyl 3,4,5-trihydroxybenzoate,Progallin O,Stabilizer GA-8,没食子酸辛酯

Target: Antioxidant, Influenza Virus, Reactive Oxygen Species, Antibacterial, Antifungal, HSV

Adenosine 5'-monophosphate monohydrate

Cat.No: T0853L

Synonym: 5'-AMP,腺苷-5'-单磷酸一水合物,5'-AMP monohydrate,5'-Adenylic acid

Target: AMPK, Adenosine Receptor, HSV

Cat.No: T7983

Synonym: DL-Isoborneol,异冰片,异龙脑

Target: HSV

Cat.No: T3795

Target: Apoptosis, TLR, Reverse Transcriptase, Antibacterial, Autophagy

Theaflavin 3,3'-digallate

Cat.No: T5429

Synonym: 茶黄素-3,3'-双没食子酸,8-Gingerol,TFDG

Target: Virus Protease, Antioxidant, HIV Protease, HSV

Cangorinine E-1

Cat.No: T79987

Target: HSV

Mulberrofuran C

Cat.No: TN4587

Target: HSV

Manzamine A hydrochloride

Cat.No: T38441

Cat.No: TN4585

Target: HIV Protease, Antifection, HSV

Cat.No: T83693

Synonym: MG2

Norcepharadione B

Cat.No: TN6014

Synonym: 鱼腥草

Cat.No: TN4456

Target: AChR, HSV

Cat.No: T35779

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