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Search Results for " cytomegalovirus "

46

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T0718	Brivudine Bromovinyldeoxyuridine,BVDU,溴夫定	Others; HSV	Microbiology/Virology; Others
	Brivudine (BVDU) 是胸苷类似物，有抗病毒活性，用于早期急性带状疱疹的研究。
T38514	PMEDAP	Others; HIV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	PMEDAP 是有效的人类免疫缺陷病毒 (HIV) 复制抑制剂。它具有抗小鼠巨细胞病毒活性。它有效抑制莫罗尼鼠肉瘤病毒诱导的肿瘤形成和相关死亡率。
T9648	SIRT1-IN-1	Antiviral; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation
	SIRT1-IN-1 是一种选择性的 SIRT1 抑制剂，IC50 为 205 nM。 SIRT1-IN-1 是一种具有抗病毒活性的巨细胞病毒 (CMV) 抑制剂。
T14324	Artemisone BAY 44-9585,Artemifone,青蒿酮	Others; Parasite	Microbiology/Virology; Others
	Artemisone (BAY 44-9585) 是一种半合成的有效抗疟疾剂，还是一种人CMV 的有效抑制剂，可抑制多种P. falciparum，平均IC50值为 0.83 nM。
T2162	Maribavir BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Maribavir (GW257406X) 是一种可口服的苯并咪唑核苷化合物，具有抗巨细胞病毒的活性。
T15235	Enocitabine	Nucleoside Antimetabolite/Analog; HCV Protease; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Proteases/Proteasome
	Enocitabine 是一种核苷类似物，抑制 DNA 复制剂。Enocitabine 抑制人巨细胞病毒的复制，显示出抗白血病和抗病毒活性。
T7659	Bisindolylmaleimide IV	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	Bisindolylmaleimide IV 是一种蛋白激酶 C 细胞渗透抑制剂，其 IC50范围为 0.1-0.55 μM。它也抑制 PKA，IC50范围为3.1-11.8 μM。在细胞培养中，它有效抑制人巨细胞病毒(HCMV)复制，IC50为 0.2 μM。
T5396	Letermovir AIC246,MK-8828,莱莫维韦	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	Letermovir (AIC246) 是一种新型抗 CMV 抑制剂，靶向病毒末端酶，抑制其活性。
T1533	Valganciclovir hydrochloride Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte	Others; Antiviral	Immunology/Inflammation; Others
	Valganciclovir hydrochloride (Valganciclovir HCl) 是 ganciclovir 的原药，具有抗巨细胞病毒活性，可抑制病毒 DNA 聚合酶和病毒复制。
T0220	Foscarnet sodium Phosphonoformate,膦甲酸钠	Virus Protease; Reverse Transcriptase; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Foscarnet sodium (Phosphonoformate) 是一种病毒 DNA 聚合酶活性抑制剂，可逆地抑制病毒复制。它是一种用于治疗巨细胞病毒性视网膜炎的抗病毒剂。
T6593	ML324	Histone Demethylase; Others; HSV	Chromatin/Epigenetic; Microbiology/Virology; Others
	ML324 是 jumonji 组蛋白去甲基化酶的特异性抑制剂，IC50值为920 nM。
TQ0095	Brincidofovir CMX001,HDP-CDV	Others; Antiviral; HSV	Immunology/Inflammation; Microbiology/Virology; Others
	Brincidofovir (HDP-CDV) 是 Cidofovir 的一种具有口服活性的亲脂性形式的前体药物，是一种口服长效的抗病毒药物，有广泛的抗 DNA 病毒活性。
T39477	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate Ca-DTPA trisodium salt hydrate	Others	Others
	Calcium trinatrium diethylenetriaminepentaacetic acid hydrate (Ca-DTPA trisodium salt hydrate) 是螯合剂和有用的解毒剂，如急性镉中毒。它是一种无毒的 CMV 复制抑制剂。
T6244	Cidofovir HPMPC,GS 0504,西多福韦,(S)-HPMPC	Others; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Cidofovir ((S)-HPMPC) 通过特异性抑制病毒 DNA 合成来抑制病毒复制。
T8972	FIT-039	Others; DNA/RNA Synthesis; CDK; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	FIT-039 是一种选择性和 ATP 竞争性的口服活性 CDK9 抑制剂，对CKD9/cyclin T1的IC50为 5.8 μM。它抑制HSV-1(IC50为 0.69 μM)，HSV-2，人腺病毒和人CMV 的复制。它可抑制耐药性HSV 和其他 DNA 病毒，是有前途的抗病毒药物。
T8736	Cidofovir dihydrate HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物	Others	Others
	Cidofovir dihydrate (HPMPC) 是注射型巨细胞病毒 DNA 聚合酶抑制剂，通过选择性抑制病毒 DNA 聚合酶来抑制 CMV 复制，从而阻止病毒复制和转录。
T0964	Floxuridine 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640	Apoptosis; Nucleoside Antimetabolite/Analog; Others; DNA/RNA Synthesis; Antibacterial; HSV	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Floxuridine (FUDR) 是一种嘧啶类似物，也是一种抗肿瘤代谢物。它抑制胸苷酸合成酶，导致 DNA 合成中断和细胞毒性。它是一种可诱导细胞凋亡的金黄色葡萄球菌感染抑制剂，具有抗HSV 和CMV 病毒的作用。
T0688	Ganciclovir BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine	Nucleoside Antimetabolite/Analog; Others; Antibiotic; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir (2'-Nor-2'-deoxyguanosine) 是核苷类似物和口服抗病毒药物，对CMV 具有抗病毒活性。它用于治疗与艾滋病相关的巨细胞病毒感染的并发症。
T22337	Ganciclovir sodium RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠	Nucleoside Antimetabolite/Analog; Others; Antifection; HSV	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; Others
	Ganciclovir sodium (Cytovene IV sodium) 是核苷类似物和口服抗病毒药物，具有抗病毒活性，尤其是针对巨细胞病毒和单纯疱疹病毒 1 型。
T10445	B220	HSV	Microbiology/Virology
	B220 是一种能抑制 HSV-1，HSV-2 和人巨细胞病毒 (CMV) 生长的抗病毒剂。
TP1687L	CEF20 acetate(153045-21-7 free base)	Others	Others
	CEF20 acetate(153045-21-7 free base) 是 CEF 对照肽库，是来自巨细胞病毒 pp65 (495-503) 的 HLA-A*0201 限制性表位。
T67788	BAY-43-9695	HCV Protease	Microbiology/Virology; Proteases/Proteasome
	BAY-43-9695是具有抗人巨细胞病毒(HCMV)活性的非核苷类化合物，是BAY-38-4766的主要代谢产物。
TP1822L	CEF6 acetate(913545-15-0 free base)	Influenza Virus	Microbiology/Virology
	CEF6 acetate(913545-15-0 free base) 是 HLA-B7限制性流感病毒核蛋白表位，属于 CEF 对照肽。 CEF 对照肽长度为 8-12 个氨基酸，其序列来自人类巨细胞病毒、爱泼斯坦-巴尔病毒和流感病毒。
T69390	T-0902611 benzenesulfonate
	T-0902611 benzenesulfonate is a cytomegalovirus replication inhibitor that may be useful in the treatment of cytomegalovirus infections.
T69396	MLS000108969
	MLS000108969 is a novel inhibitor of human cytomegalovirus.
T61840	pUL89 Endonuclease-IN-2
	pUL89 Endonuclease-IN-2 (Compound 15k) is a highly effective inhibitor of the pUL89 endonuclease of human cytomegalovirus (HCMV). With an IC50 of 3.0 μM, it exhibits potent antiviral activities [1].
T28905	T-611 free base T-0902611,T-2611,T0902611,T-902611,T2611,T-611
	T-611, a cytomegalovirus replication inhibitor, is used potentially for the treatment of cytomegalovirus infections.
T28767	SGM8
	SGM8 is a covalent allosteric inhibitor of human cytomegalovirus DNA polymerase subunit Interactions.
TP1687	CEF20
	CEF20, a CEF control peptide pool, is an HLA-A0201-restricted epitope from cytomegalovirus* pp65 (495-503).
T71066	Cidofovir sodium
	Cidofovir sodium is the salt form of Cidofovir, a Cytomegalovirus Nucleoside Analog DNA Polymerase Inhibitor that is an injectable antiviral medication primarily used as a treatment for cytomegalovirus (CMV) retinitis in people with AIDS. The mechanism of action of cidofovir is as a DNA Polymerase Inhibitor. The chemical classification of cidofovir anhydrous is Nucleoside Analog.
T15028	Cyclopropavir MBX-400,Filociclovir,ZSM-I-62	Others	Others
	Cyclopropavir (Filociclovir; MBX-400) is a compound of broad-spectrum anti-herpesvirus. It has good antiviral activity against cytomegalovirus (CMV), herpes simplex virus (HHV)-6 and HHV-8 (EC50s: 0.7 μM to 8 μM).
T68495	Ganciclovir triphosphate
	Ganciclovir triphosphate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.
T77146	Regavirumab
	Regavirumab (MCA C23)为针对巨细胞病毒(CMV)、人血清白蛋白(HSA)及氨基乙酸的人源单克隆抗体。
T70514	Ganciclovir monophosphonate
	Ganciclovir monophosphonate is a synthetic analog of 2'-deoxy-guanosine which is used to treat or prevent cytomegalovirus (CMV) infections. It inhibits the replication of human CMV with an IC50 value of 0.01 μM and is effective against strains of CMV from human, monkey, mouse, and guinea pig.
T60379	pUL89 Endonuclease-IN-1
	pUL89 Endonuclease-IN-1 (Compound 13d) 是人巨细胞病毒 (HCMV) pUL89 核酸内切酶的有效抑制剂，IC50值为 0.88 μM，具有抗病毒活性。
TP1822	CEF6
	CEF6, a HLA-B7 restricted influenza virus nucleoprotein epitope, belongs to the CEF control peptides. The CEF control peptides are 8-12 amino acids in length, with sequences derived from the human cytomegalovirus, Epstein-Barr virus and influenza virus.
T77168	Sevirumab
	Sevirumab (MSL-109) 是一种人抗巨细胞病毒 (CMV)IgG1中和单克隆抗体。Sevirumab 识别CMVgH 复合物，抑制CMV 复制，EC50为 0.3 μg/mL。
T39068	Fomivirsen sodium
	Fomivirsen sodium is an antisense 21 mer phosphorothioate oligonucleotide. Fomivirsen is an antiviral agent that is used cytomegalovirus retinitis (CMV) research, incluiding in AIDs. Fomivirsen sodium binds to and degrades the mRNAs encoding CMV immediate-early 2 protein (required for viral replication), thus providing bioactive effects for CMV retinitis by inhibition of virus proliferation.
T72385	LDC4297 hydrochloride
	LDC4297 hydrochloride为CDK7选择性抑制剂，IC50为0.13 nM。针对人巨细胞病毒(HCMV)复制展现抑制作用，EC50为24.5 nM，并对疱疹病毒、腺病毒、痘病毒、逆转录病毒及正粘病毒显示广谱抗病毒活性，EC50范围0.02-1.21 μM。适用于感染研究。
T82701	CMV pp65(13-27)
	CMVpp65(13-27)是一种源自人巨细胞病毒65k下层基质磷蛋白的氨基酸残基13至27的生物活性肽。它含有的九个氨基酸序列(LGPISGHVL)与主要组织相容性复合物H2-Dd T细胞表位的共有结合基序匹配。
T77010	Fiztasovimab
	Fiztasovimab (NPC-21; EV2038) 是一种全人 IgG1λ 单克隆抗体，具有抗人巨细胞病毒 (hCMV) 活性。Fiztasovimab 通过结合 hCMV 包膜上糖蛋白 B 的抗原结构域 1 发挥中和活性。Fiztasovimab 还抑制 hCMV 的细胞间传播。
T60419	Cyclic HPMPC
	Cyclic HPMPC 是有效的抗病毒剂，可以增加感染致死性牛痘苗病毒 (IHD 株) 小鼠的动脉氧饱和度水平。用 Cyclic HPMPC 治疗可改善先天性豚鼠巨细胞病毒 (GPCMV) 感染的结果并减少豚鼠模型中的病毒复制。
T73983	Cidofovir diphosphate tri(triethylamine)
	Cidofovir diphosphate tri triethylamine 是西多福韦的细胞内活性代谢物。diphosphate tri triethylamine 是病毒 DNA 聚合酶的选择性抑制剂，对 HCMV，HSV-1和 HSV-2的 Ki 值分别为 6.6，0.86 和 1.4 μM。
T60488	Ganciclovir hydrate
	Ganciclovir (BW 759) hydrate 是一种核苷类似物，是具有口服活性的抗病毒剂，显示出抗巨细胞病毒活性。Ganciclovir hydrate 对疱疹病毒和其他一些 DNA 病毒也具有体外抗病毒活性。Ganciclovir hydrate 在体外抑制人类疱疹病毒 (HSV 1 型和 2 型，CMV) 和腺病毒血清型1、2、4、6、8、10、19、22 和 28 的复制。Ganciclovir hydrate 对猫疱疹病毒 1 型 (FHV-1) 的 IC50为 5.2 μM，可扩散到大脑。
T61259	Valganciclovir
	Valganciclovir 是ganciclovir 的原药，具有抗巨细胞病毒CMV 感染的活性。
T36673	CC 401 dihydrochloride
	High affinity JNK inhibitor (Ki values are 25-50 nM). Inhibits JNK via competitive binding of the ATP-binding site of active, phosphorylated JNK. Exhibits > 40-fold selectivity for JNK over p38, ERK, IKK2, protein kinase C, Lck and ZAP70. Hepatoprotective. Also inhibits HCMV replication. Uehara et al (2004) c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantation. Transplantation. 78 324 PMID:15316358 \|Uehara et al (2005) JNK mediates hepatic ischemia reperfusion injury. J...

化合物

Cat.No: T0718

Synonym: Bromovinyldeoxyuridine,BVDU,溴夫定

Target: Others, HSV

Cat.No: T38514

Target: Others, HIV Protease

Cat.No: T9648

Target: Antiviral, Sirtuin

Cat.No: T14324

Synonym: BAY 44-9585,Artemifone,青蒿酮

Target: Others, Parasite

Cat.No: T2162

Synonym: BW1263W94,GW257406X,Benzimidavir,马立巴韦,1263W94

Target: Others, HCV Protease

Cat.No: T15235

Target: Nucleoside Antimetabolite/Analog, HCV Protease, DNA/RNA Synthesis

Bisindolylmaleimide IV

Cat.No: T7659

Target: Others, PKC

Cat.No: T5396

Synonym: AIC246,MK-8828,莱莫维韦

Target: Others, HCV Protease

Valganciclovir hydrochloride

Cat.No: T1533

Synonym: Valganciclovir HCl,Valcyt,缬更昔洛韦盐酸盐,Valcyte

Target: Others, Antiviral

Foscarnet sodium

Cat.No: T0220

Synonym: Phosphonoformate,膦甲酸钠

Target: Virus Protease, Reverse Transcriptase, DNA/RNA Synthesis

Cat.No: T6593

Target: Histone Demethylase, Others, HSV

Cat.No: TQ0095

Synonym: CMX001,HDP-CDV

Target: Others, Antiviral, HSV

Calcium trinatrium diethylenetriaminepentaacetic acid hydrate

Cat.No: T39477

Synonym: Ca-DTPA trisodium salt hydrate

Target: Others

Cat.No: T6244

Synonym: HPMPC,GS 0504,西多福韦,(S)-HPMPC

Target: Others, DNA/RNA Synthesis

Cat.No: T8972

Target: Others, DNA/RNA Synthesis, CDK, HSV

Cidofovir dihydrate

Cat.No: T8736

Synonym: HPMPC,(S)-HPMPC,GS 0504,西多福韦二水合物

Target: Others

Cat.No: T0964

Synonym: 氟尿苷,5-Fluorouracil 2'-deoxyriboside,FUDR,Deoxyfluorouridine,NSC 27640

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Others, DNA/RNA Synthesis, Antibacterial, HSV

Cat.No: T0688

Synonym: BW 759,更昔洛韦,RS-21592,2'-Nor-2'-deoxyguanosine

Target: Nucleoside Antimetabolite/Analog, Others, Antibiotic, Antifection, HSV

Ganciclovir sodium

Cat.No: T22337

Synonym: RS-21592 sodium,Cytovene IV sodium,2'-Nor-2'-deoxyguanosine sodium,BW 759 sodium,更昔洛韦钠

Target: Nucleoside Antimetabolite/Analog, Others, Antifection, HSV

Cat.No: T10445

Target: HSV

CEF20 acetate(153045-21-7 free base)

Cat.No: TP1687L

Target: Others

Cat.No: T67788

Target: HCV Protease

CEF6 acetate(913545-15-0 free base)

Cat.No: TP1822L

Target: Influenza Virus

T-0902611 benzenesulfonate

Cat.No: T69390

Cat.No: T69396

pUL89 Endonuclease-IN-2

Cat.No: T61840

T-611 free base

Cat.No: T28905

Synonym: T-0902611,T-2611,T0902611,T-902611,T2611,T-611

Cat.No: T28767

Cat.No: TP1687

Cidofovir sodium

Cat.No: T71066

Cat.No: T15028

Synonym: MBX-400,Filociclovir,ZSM-I-62

Target: Others

Ganciclovir triphosphate

Cat.No: T68495

Cat.No: T77146

Ganciclovir monophosphonate

Cat.No: T70514

pUL89 Endonuclease-IN-1

Cat.No: T60379

Cat.No: TP1822

Cat.No: T77168

Fomivirsen sodium

Cat.No: T39068

LDC4297 hydrochloride

Cat.No: T72385

CMV pp65(13-27)

Cat.No: T82701

Cat.No: T77010

Cat.No: T60419

Cidofovir diphosphate tri(triethylamine)

Cat.No: T73983

Ganciclovir hydrate

Cat.No: T60488

Cat.No: T61259

CC 401 dihydrochloride

Cat.No: T36673

Cat. No.	Product Name	Target	Signaling Pathways
TN1068	Tricin	Others; CDK	Cell Cycle/Checkpoint; Others
	Tricin 是米糠中大量存在的一种天然类黄酮。它通过抑制 CDK9 来抑制HCMV 的复制。它通过上调 FAK 靶向 microRNA-7 的表达来抑制 C6 胶质瘤细胞的增殖和侵袭。
T3342	Xanthohumol	Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others
	Xanthohumol 是从啤酒花中分离到的黄酮类化合物，可抑制 COX-1 和 COX-2 活性，具有抗肿瘤，抗血管生成的作用，还具有抗多种病毒的活性。
T1591	Ancitabine hydrochloride NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C	Others; DNA/RNA Synthesis; Autophagy	Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Others
	Ancitabine hydrochloride (NSC 145668 HCl) 是一种天然的抗白血病药物。
TN2231	Soyasaponin II	Influenza Virus; HIV Protease; HSV	Microbiology/Virology; Proteases/Proteasome
	Soyasaponin II has antiviral effects, it can inhibit the replication of human cytomegalovirus, influenza virus, and human immunodeficiency virus type 1.

天然产物

Cat.No: TN1068

Target: Others, CDK

Cat.No: T3342

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Ancitabine hydrochloride

Cat.No: T1591

Synonym: NSC 145668 HCl,盐酸环胞苷,Cyclocytidine hydrochloride,Cyclo-CMP hydrochloride,Cyclocytidine HCl,Cyclo-C

Target: Others, DNA/RNA Synthesis, Autophagy

Cat.No: TN2231

Target: Influenza Virus, HIV Protease, HSV

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