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35

抑制剂 & 化合物

16

天然产物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T30767	CB-181963 CB 181963,CB181963,UNII-6784994L0W,CAB 175
	CB-181963, a new cephalosporin, is an effective antistaphylococcal drug, showing excellent activity against the resistance of MRSA strains to other cephalosporins in planktonic and biofilm cultures.
T62316	P-CAB agent 1
	P-CAB agent 1 (compound B19) 是一种高效的钾离子竞争性酸阻滞剂，能够作用于 H+/K+-ATPase (IC50: 60.50 nM)。P-CAB agent 1 在大鼠中具表现出接受的口服吸收度。P-CAB agent 1 能够用于酸相关疾病 (ARDs) 的研究。
T72897	P-CAB agent 2
	P-CAB agent 2，一种有效的口服钾竞争性酸（potassium-competitive acid) 阻滞剂及胃酸分泌抑制剂，对H+/K+-ATPase活性具有显著抑制作用，IC50值<100 nM。同时，P-CAB agent 2对hERG钾通道亦有抑制效果，IC50值为18.69 M，且表现出无急性毒性，能有效抑制组胺诱导的胃酸分泌。
T72181	P-CAB agent 2 hydrochloride
	P-CAB agent 2 hydrochloride 为具有口服活性的高效钾竞争性酸(potassium-competitive acid)阻滞剂及胃酸分泌抑制剂，能够抑制 H+/K+-ATPase 活性，其 IC50 值小于100 nM。同时，对 hERG 钾通道的抑制 IC50 值为18.69 M，表明无急性毒性并能够抑制组胺诱导的胃酸分泌。
T8388	Vonoprazan TAK-438 (free base),沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan (TAK-438 (free base)) 是一种质子泵抑制剂，是口服活性钾竞争性酸阻断剂，有抗分泌作用。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50值为 19 nM。它可用于研究胃酸相关疾病。
T21254	Vonoprazan Fumarate TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞	Proton pump	Membrane transporter/Ion channel
	Vonoprazan Fumarate (TAK438) 是质子泵的有效抑制剂，是口服有效的高效钾竞争性酸阻断剂，具有抗分泌活性。在 pH 为 6.5 时，它抑制猪胃微粒体中的 H+,K+-ATPase 酶活性，IC50为 19 nM。它被开发用于研究酸相关疾病，如消化性溃疡和胃食管反流病。
T31597	Ecabapide DQ2511,DQ 2511,DQ-2511	Others	Others
	Ecabapide (DQ-2511) 是一种新型促胃肠蠕动剂，能显著增强SHRSP的胃排空能力。Ecabapide 可激活的兔胃壁细胞中的环状 GMP 依赖性管家 Cl- 通道。
T11386L	Gemcabene PD-72953	Others	Others
	Gemcabene (PD-72953) 是一种具有抗炎活性的降脂剂。 Gemcabene 降低低密度脂蛋白胆固醇和甘油三酯，提高高密度脂蛋白胆固醇，并降低促炎急性期蛋白、C 反应蛋白。
T6098	Cabotegravir GSK744,GSK-1265744,卡博特韦,S/GSK1265744	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Cabotegravir (S/GSK1265744) 是一种HIV 整合酶抑制剂，可研究艾滋病。它抑制OAT1 和OAT3，IC50值为 0.81 和0.41 μM。
T2587	Ecabet Sodium TA-2711E,TA-2711,伊卡倍特钠	Reactive Oxygen Species; Antibacterial	Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Ecabet Sodium (TA-2711) 可通过抑制活性氧的产生，促进幽门螺杆菌的根除，可用于胃肠道疾病的相关研究。
T5164	Cabozantinib hydrochloride XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼	VEGFR; FLT; c-Met/HGFR; TAM Receptor; c-Kit; ROR	Angiogenesis; Metabolism; Tyrosine Kinase/Adaptors
	Cabozantinib hydrochloride (XL184) 是一种有效的泛酪氨酸激酶抑制剂，可抑制 VEGFR2、c-Met、Kit、Axl 和 Flt4（IC50：0.035、1.3、4.6、7 和 6 nM）。
T2586	Cabozantinib 卡博替尼,XL184,BMS-907351	Apoptosis; VEGFR; FLT; c-Met/HGFR; c-RET; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib (XL184) 是一种多靶点酪氨酸激酶受体抑制剂，可以抑制 VEGFR2、c-Met、Kit、Axl 和 Flt3 (IC50=0.035/1.3/4.6/7/11.3 nM)。Cabozantinib 具有抗肿瘤和抗血管生成活性。
T17220	Vecabrutinib SNS-062	Tyrosine Kinases; BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Vecabrutinib (SNS-062) (SNS-062) 是一种有效的，非共价的 BTK 和 ITK 抑制剂，Kd 值分别为 0.3 nM 和 2.2 nM。Vecabrutinib 对 ITK 的 IC50 值为 24 nM。
T1797	Cabozantinib S-malate 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate	Apoptosis; VEGFR; c-Met/HGFR; TAM Receptor; c-Kit	Angiogenesis; Apoptosis; Tyrosine Kinase/Adaptors
	Cabozantinib S-malate (XL184) 是一种多受体酪氨酸激酶抑制剂，抑制VEGFR2，c-Met，Kit，Axl 和Flt3的IC50分别为0.035，1.3，4.6，7 和 11.3 nM。
T20709	Levocabastine hydrochloride R50,547,R-50,547,Levocabastine HCl,R 50,547,Livostin
	Levocabastine HCl is an agent with antihistaminic activity.
T61623	Ecabet
	Ecabet sodium (TA-2711) is a chemical compound utilized for the clinical treatment of gastrointestinal disease through the suppression of reactive oxygen species (ROS) generation and enhancement of Helicobacter pylori eradication [1]. Moreover, Ecabet sodium effectively attenuates apoptosis [2].
T68551	Cabergoline diphosphate
	Cabergoline diphosphate is a dopamine D2 receptor agonist used for prolactinoma treatment. Cabergoline permits rapid and effective hormonal and tumor control by normalizing prolactin-producing pituitary adenomas levels.
T31279	Decaborane, diammonium salt Diammonium decaborane
	Decaborane, diammonium salt is a biochemical.
T11386	Gemcabene calcium PD-72953 calcium	Others	Others
	Gemcabene calcium , a first-in-class lipid-lowering agent, lowers low-density lipoprotein cholesterol (LDL-C), decreases triglycerides, and raises high-density lipoprotein cholesterol (HDL-C) andexerting anti-inflammatory activity, lowers pro-inflammatory acute-phase protein, C-reactive protein (CRP).
T32700	Levocabastine Livostin,Bilina
	Levocarbastine is a second-generation H1 receptor antagonist for allergic conjunctivitis. It also acts as a potent selective antagonist for the neurotensin receptor NTS2 and is the first drug to be used to characterize different neurotensin subtypes.
T30681	CABP 2-CABP,2CABP,2 CABP
	CABP is a transition analog of ribulos-1, 5-diphosphate carboxylase/oxygenase (Rubisco).
T38101	Bisucaberin
	Bisucaberin is a siderophore and bacterial metabolite that has been found inA. haloplanktisand has anticancer activity.1,2It inhibits the growth of L1210 and 1MC carcinoma cells (IC50s = 9.7 and 12.7 μM, respectively) and sensitizes fibrosarcoma 1023 cells to macrophage-mediated cytolysis. 1.Hou, Z., Raymond, K.N., O’Sullivan, B., et al.A preorganized siderophore: Thermodynamic and structural characterization of alcaligin and bisucaberin, microbial macrocyclic dihydroxamate chelating agentsInorg...
T20068	Decabromodiphenyl ether NSC 82553,NSC-82553,NSC82553
	Decabromodiphenyl ether is a compound of flame retardant.
T62328	Cabotegravir sodium
	Cabotegravir sodium 是一种 HIV 整合酶的高效抑制剂，能够作用于 HIVADA (IC50: 2.5 nM)。Cabotegravir sodium 主要由尿苷二磷酸葡萄糖醛酸转移酶 (UGT) 1A1 代谢，与其他抗逆转录病毒药物 (ARVs) 相互作用的可能性较小。
T30680	Cabiotraxetan
	Cabiotraxetan is a therapeutic carrier.
T70808	Cabazitaxel-d6
	Cabazitaxel-d6 is a deuterium labeled cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity. Cabazitaxel binds to and stabilizes tubulin, resulting in the inhibition of microtubule depolymerization and cell division, cell cycle arrest in the G2/M phase, and the inhibition of tumor cell proliferation. Unlike other taxane compounds, this agent is a poor substrate for the membrane-associated, multidrug resistance...
T76786	Cabiralizumab
	Cabiralizumab (FPA 008) 是一种抗 CSF1R 单克隆抗体 (MAb)。Cabiralizumab 可增强 T 细胞浸润和抗肿瘤 T 细胞免疫反应。Cabiralizumab 抑制破骨细胞的活化并阻止骨质破坏，可用于类风湿性关节炎 (RA) 的研究。Cabiralizumab 可与 Nivolumab 结合用于肺癌研究。
T31280	Decaborane, ethyl-, Ethyldecaborane,Decaborane, ethyl-,Ethyldekaboran
	Decaborane, ethyl-, Nonaborane and decaborane cluster anions can enhance the ignition delay in hypergolic ionic liquids and induce hypergolicity in molecular solvents.
TP2454	Decabassianolide
	Decabassianolide is a biochemical.
T2404	Vonoprazan fumarate 富马酸沃诺拉赞,TAK-438	ATPase	Membrane transporter/Ion channel
	Vonoprazan fumarate (TAK-438) 是一种新型 P-CAB（钾竞争性酸阻滞剂），可可逆地抑制 H+/K+、ATP 酶。
T2093	PF 03716556 PF-3716556	ATPase	Membrane transporter/Ion channel
	PF 03716556 (PF-3716556) 是一种有效且特异性的 P-CAB（钾竞争性酸阻滞剂），用于治疗胃食管反流病。
T2405	Revaprazan hydrochloride 盐酸瑞伐拉赞,YH1885	ATPase; COX; Antibacterial	Immunology/Inflammation; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Revaprazan hydrochloride (YH1885) 是一种新型酸泵拮抗剂，可降低COX-2的表达，在幽门螺杆菌感染中，显著抑制炎症。
T69613	Ar-H047108 free base
	Ar-H047108 free base is an imidazopyridine potassium competitive acid blocker (P-CAB). This drug may be used to treat early stellate cell activation and veno-occlusive-disease (VOD)-like hepatotoxicity.
T80609	Mecbotamab
	Mecbotamab是一款针对AXL受体酪氨酸激酶的人源化IgG1-κ抗体。作为条件活性生物制剂(CAB)，Mecbotamab通过一个可降解连接子与MMAE结合，组成ADC（抗体-药物偶联物）产品Mecbotamab vedotin (BA3011)。
T61643	Vonoprazan hydrochloride
	Vonoprazan hydrochloride 是一种高效且具口服活性的质子泵抑制剂 (PPI) 和钾竞争性酸阻断剂 (potassium-competitive acid blocker, P-CAB)，展示出优秀的抗分泌活性。在 pH 为 6.5 的条件下，该化合物可抑制猪胃微粒体内 H+,K+-ATPase 的酶活性，呈现出 19 nM 的 IC50 值。Vonoprazan hydrochloride 主要应用于胃酸相关疾病的研究，包括胃食管反流病和消化性溃疡，并可用于根除幽门螺杆菌。

化合物

Cat.No: T30767

Synonym: CB 181963,CB181963,UNII-6784994L0W,CAB 175

P-CAB agent 1

Cat.No: T62316

P-CAB agent 2

Cat.No: T72897

P-CAB agent 2 hydrochloride

Cat.No: T72181

Cat.No: T8388

Synonym: TAK-438 (free base),沃诺拉赞

Target: Proton pump

Vonoprazan Fumarate

Cat.No: T21254

Synonym: TAK-438,TAK 438,Vonoprazan Fumurate,TAK438,富马酸沃诺拉赞

Target: Proton pump

Cat.No: T31597

Synonym: DQ2511,DQ 2511,DQ-2511

Target: Others

Cat.No: T11386L

Synonym: PD-72953

Target: Others

Cat.No: T6098

Synonym: GSK744,GSK-1265744,卡博特韦,S/GSK1265744

Target: HIV Protease

Cat.No: T2587

Synonym: TA-2711E,TA-2711,伊卡倍特钠

Target: Reactive Oxygen Species, Antibacterial

Cabozantinib hydrochloride

Cat.No: T5164

Synonym: XL184,Cabozantinib hydrochloride (849217-68-1(free base)),BMS-907351,盐酸卡博替尼

Target: VEGFR, FLT, c-Met/HGFR, TAM Receptor, c-Kit, ROR

Cat.No: T2586

Synonym: 卡博替尼,XL184,BMS-907351

Target: Apoptosis, VEGFR, FLT, c-Met/HGFR, c-RET, TAM Receptor, c-Kit

Cat.No: T17220

Synonym: SNS-062

Target: Tyrosine Kinases, BTK

Cabozantinib S-malate

Cat.No: T1797

Synonym: 苹果酸卡博替尼,Cabozantinib,卡博替尼苹果酸盐,XL184,Cabozantinib Malate

Target: Apoptosis, VEGFR, c-Met/HGFR, TAM Receptor, c-Kit

Levocabastine hydrochloride

Cat.No: T20709

Synonym: R50,547,R-50,547,Levocabastine HCl,R 50,547,Livostin

Cat.No: T61623

Cabergoline diphosphate

Cat.No: T68551

Decaborane, diammonium salt

Cat.No: T31279

Synonym: Diammonium decaborane

Gemcabene calcium

Cat.No: T11386

Synonym: PD-72953 calcium

Target: Others

Cat.No: T32700

Synonym: Livostin,Bilina

Cat.No: T30681

Synonym: 2-CABP,2CABP,2 CABP

Cat.No: T38101

Decabromodiphenyl ether

Cat.No: T20068

Synonym: NSC 82553,NSC-82553,NSC82553

Cabotegravir sodium

Cat.No: T62328

Cabiotraxetan

Cat.No: T30680

Cabazitaxel-d6

Cat.No: T70808

Cabiralizumab

Cat.No: T76786

Decaborane, ethyl-,

Cat.No: T31280

Synonym: Ethyldecaborane,Decaborane, ethyl-,Ethyldekaboran

Decabassianolide

Cat.No: TP2454

Vonoprazan fumarate

Cat.No: T2404

Synonym: 富马酸沃诺拉赞,TAK-438

Target: ATPase

Cat.No: T2093

Synonym: PF-3716556

Target: ATPase

Revaprazan hydrochloride

Cat.No: T2405

Synonym: 盐酸瑞伐拉赞,YH1885

Target: ATPase, COX, Antibacterial

Ar-H047108 free base

Cat.No: T69613

Cat.No: T80609

Vonoprazan hydrochloride

Cat.No: T61643

Cat. No.	Product Name	Target	Signaling Pathways
TQ0096	Scabertopin	Others	Others
	Scabertopin 是一种从地胆草中分离得到倍半萜内酯，具有抗癌和抑菌活性。
T14853	Cabergoline FCE-21336,卡麦角林	Dopamine Receptor; 5-HT Receptor; Autophagy	Autophagy; GPCR/G Protein; Neuroscience
	Cabergoline (FCE-21336) 是一种麦角衍生的多巴胺 D2亚类受体激动剂，高亲和力作用于D2、D3和5-HT2B 受体，Ki 分别为 0.7、1.5 和 1.2。
T2543	Cabazitaxel XRP6258,卡巴他塞,RPR-116258A,TXD 258,taxoid XRP6258	Microtubule Associated; Autophagy	Autophagy; Cytoskeletal Signaling
	Cabazitaxel (taxoid XRP6258) 是一种紫杉烷类的抗肿瘤剂，可用于治疗多西他赛失败后的去势抵抗性转移性前列腺癌。
TN3561	Cabraleone	Others	Others
	The mixture of cabraleone and ocotillone shows cytotoxicity against HL-60 leukaemia cell line.
TN3558	Cabraleahydroxylactone acetate	Others	Others
	Cabraleahydroxylactone acetate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3558，CAS号为 35833-70-6。
TN3554	Cabazitaxel intermediate	Others	Others
	Cabazitaxel intermediate 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN3554，CAS号为 1354900-65-4。
TN2183	Scabioside C	Others	Others
	Scabioside C is a natural product
TN1135	Isoscabertopin	Others	Others
	Isoscabertopin 是一种倍半萜内酯，分离自Elephantopus scaber L 中，具有抗肿瘤作用。
TN3555	Caboxine A	Others	Others
	Caboxine A是一种天然产物，属于夹竹桃科长春花属，其产品编号为 TN3555，CAS号为 53851-13-1。Caboxine A可用作对照参考。
TN2926	3-Epicabraleahydroxylactone	Others	Others
	3-Epicabraleahydroxylactone has anti-tumor promoting effect, it has anti-carcinogenic activity by the inhibitory effect on the induction of Epstein-Barr virus early antigen(EBV-EA) by the tumor promoter.
TN2925	3-Epicabraleadiol	Others	Others
	3-Epicabraleadiol是一种天然产物，属于山茶科山茶属，其产品编号为 TN2925，CAS号为 19942-04-2。3-Epicabraleadiol可用作对照参考。
T75567	Cabenoside D
	Cabenoside D（化合物 8）是从苔藓根的甲醇提取物中分离的一种三萜苷，显示出对12-O-十四烷酰基激素-13-乙酸酯（TPA）诱导的小鼠炎症的抗炎活性，并能抑制TPA促使的Epstein-Barr病毒（EBV）早期抗原（EBV-EA）激活。
TN3560	Cabralealactone	Antifection	Microbiology/Virology
	Cabralealactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line, it is moderately active against a small-cell lung cancer (NCI-H187) cell line.
TN3559	Cabraleahydroxylactone	HSV	Microbiology/Virology
	Cabraleahydroxylactone displays antimycobacterial activity against Mycobacterium tuberculosis, it is weakly cytotoxic to a breast cancer (BC) cell line.It shows antiviral activity against herpes simplex virus type-1 with an IC50 value of 3.20 ug/mL, in comparison with the standard acyclovir (IC50=1.90ug/mL).
TN3557	Cabraleadiol	ATPase; Antifection	Membrane transporter/Ion channel; Microbiology/Virology
	Cabraleadiol displays antimycobacterial activity against Mycobacterium tuberculosis, it also is weakly cytotoxic to a breast cancer (BC) cell line. Cabraleadiol inhibits photosystem II (PS II) and induces the appearance of small G band which is related wi
TN3556	Cabraleadiol 3-acetate	Others	Others
	Cabraleadiol 3-acetate是一种天然产物，属于楝科米仔兰属，其产品编号为 TN3556，CAS号为 35833-62-6。Cabraleadiol 3-acetate可用作对照参考。

天然产物

Cat.No: TQ0096

Target: Others

Cat.No: T14853

Synonym: FCE-21336,卡麦角林

Target: Dopamine Receptor, 5-HT Receptor, Autophagy

Cat.No: T2543

Synonym: XRP6258,卡巴他塞,RPR-116258A,TXD 258,taxoid XRP6258

Target: Microtubule Associated, Autophagy

Cat.No: TN3561

Target: Others

Cabraleahydroxylactone acetate

Cat.No: TN3558

Target: Others

Cabazitaxel intermediate

Cat.No: TN3554

Target: Others

Cat.No: TN2183

Target: Others

Cat.No: TN1135

Target: Others

Cat.No: TN3555

Target: Others

3-Epicabraleahydroxylactone

Cat.No: TN2926

Target: Others

3-Epicabraleadiol

Cat.No: TN2925

Target: Others

Cat.No: T75567

Cabralealactone

Cat.No: TN3560

Target: Antifection

Cabraleahydroxylactone

Cat.No: TN3559

Target: HSV

Cat.No: TN3557

Target: ATPase, Antifection

Cabraleadiol 3-acetate

Cat.No: TN3556

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04021	NPDC1 Protein, Human, Recombinant (His) CAB1,CAB,NPDC-1,CAB-1,CAB	Human	HEK293 Cells
	NPDC1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.9 kDa and the accession number is Q9NQX5.
TMPJ-00731	Carbonic Anhydrase 1 Protein, Human, Recombinant (His) Carbonic Anhydrase B,Carbonate Dehydratase I,CA-I,Carbonic A...	Human	E. coli
	Carbonic Anhydrase 1 (CA1) is a cytosolic enzyme, belonging to the alpha-carbonic anhydrase family. It is highly expressed in erythrocytes and acts as an early marker for erythroid differentiation. Carbonic anhydrase 1 plays a improtant role in many biological processes such as calcification, cellular respiration, bone resorption, acid-base balance. It is activated by imidazole, histamine, L-adrenaline, L- and D-histidine, and L- and D-phenylalanine. At the same time, It is inhibited by sulfonam...
TMPY-02955	CABP5 Protein, Human, Recombinant (His) calcium binding protein 5,CABP3	Human	E. coli
	CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of CABP3 gene is retina-specific. The mouse homolog of CABP3 has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of CABP3 gene is unknown. Study of the transcripts and genomic structure r...
TMPH-00551	IL-13 Protein, Equus caballus, Recombinant (His)	Horse	P. pastoris (Yeast)
	IL-13 Protein, Equus caballus, Recombinant (His) is expressed in Yeast.
TMPH-03569	IcaB Protein, S. aureus, Recombinant (His & Myc)	Staphylococcus aureus	E. coli
	Catalyzes the N-deacetylation of poly-beta-1,6-N-acetyl-D-glucosamine (PNAG, also referred to as PIA), a biofilm adhesin polysaccharide. N-deacetylation is crucial for attachment of the polysaccharide to the bacterial cell surface; it leads to the introduction of positive charges in the otherwise neutral PIA polymer, allowing electrostatic interactions. IcaB Protein, S. aureus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular ...

重组蛋白

NPDC1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04021

Species: Human

Expression System: HEK293 Cells

Carbonic Anhydrase 1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00731

Species: Human

Expression System: E. coli

CABP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02955

Species: Human

Expression System: E. coli

IL-13 Protein, Equus caballus, Recombinant (His)

Cat.No: TMPH-00551

Species: Horse

Expression System: P. pastoris (Yeast)

IcaB Protein, S. aureus, Recombinant (His & Myc)

Cat.No: TMPH-03569

Species: Staphylococcus aureus

Expression System: E. coli

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