63
10
Cat. No. | Product Name | Target | Signaling Pathways |
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T36205 |
Methylcarbamyl PAF C-16
|
||
Methylcarbamyl PAF C-16 is a stable analog of PAF C-16 with a half-life greater than 100 minutes in platelet poor plasma due to its resistance to degradation by PAF-AH. It is nearly equipotent with PAF C-16 in its ability to induce platelet aggregation both in isolated platelets and in platelet-rich plasma. In NRK-49 cells overexpressing the PAF receptor, both PAF C-16 and methylcarbamyl PAF C-16 cause the induction of c-myc and c-fos and the activation of mitogen-activated protein kinase. Methy... | |||
T37268 |
PAF C-16 Carboxylic Acid
|
||
PAF C-16 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is a potent mediator of neutrophil migration and the production of reactive oxygen species and IL-6. Pathological processes involving PAF include necrotizing enterocolitis | |||
T35805 |
C16 Sphingomyelin (d18:1/16:0)
Sphingomyelin 16:0,N-Palmitoyl-D-sphingomyelin |
Endogenous Metabolite | Metabolism |
C16 Sphingomyelin (d18:1/16:0) (N-Palmitoyl-D-sphingomyelin) 是磷脂双层膜的磷脂类化合物,可用于研究生物膜的活性。 | |||
T37562 |
C16 Ceramide
N-acylsphingosine,C16 Ceramide (d18:1/16:0),Palmitoyl Ceramide,N-Palmitoylsphingosine |
p53 | Apoptosis |
C16 Ceramide (Palmitoyl Ceramide) 是一种天然小分子,通过直接选择性结合激活 p53。 | |||
T9783 |
Boc-C16-COOH
|
PROTAC Linker | PROTAC |
Boc-C16-COOH 可以作为 ADC linker 或 PROTAC linker,用于合成抗体偶联药物或合成 PROTAC。 | |||
T16550 |
PKR-IN-C16
|
Others | Others |
PKR-IN-C16 是一种特异性蛋白激酶抑制剂。它能够抑制 PKR 的自磷酸化,解除 PKR 在原代神经元细胞培养中诱导的翻译阻断。 | |||
T2676 |
PF-04217903
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
PF04217903 是一种高效的、 ATP 竞争性的c-Met 激酶抑制剂(Ki=4.8 nM),相对于 208 个激酶,PF04217903 显示出 1000 倍以上的选择性。它抗血管生成作用。 | |||
T40997 |
GLP-1R modulator C16
GLP-1R modulator C16 |
Glucagon Receptor | GPCR/G Protein |
GLP-1R modulator C16 是一种变构调节剂,显著增加了 GLP-4 的结合亲和力。 | |||
T7760 |
Thalidomide-O-amido-C3-NH2 TFA
Cereblon Ligand-Linker Conjugates 16 TFA,E3 Ligase Ligand-Linker Conjugates 52 TFA |
E3 Ligase Ligand-Linker Conjugate; Ligand for E3 Ligase | PROTAC |
Thalidomide-O-amido-C3-NH2 TFA (Cereblon Ligand-Linker Conjugates 16 TFA) 包含基于 Thalidomide 的 cereblon 配体和 1 个 linker,是一种合成的 E3 连接酶配体-linker 偶联物,。 | |||
T24150 |
HR22C16
HR-22-C-16,HR 22 C 16 |
||
HR22C16 is an effective, selective, and cell-permeable mitotic kinesin Eg5 inhibitor. | |||
TQ0219 |
MK-8033
|
c-Met/HGFR | Tyrosine Kinase/Adaptors |
MK-8033 是一种新型ATP 竞争性c-Met/Ron 双重抑制剂,对野生型c-Met 的IC50=1 nM,对c-Met N1100Y 的IC50=2.0 nM。 | |||
T21547 |
PAF (C16)
C16-PAF |
ERK; MEK; MAPK; Endogenous Metabolite | MAPK; Metabolism |
PAF (C16) 是有效的 MAPK 和 MEK/ERK 激活剂,可诱导血管通透性增加。PAF (C16) (PAF (C16)) 是血小板活化因子,是一种磷脂衍生介质,也是 PAF G 蛋白偶联受体 (PAFR) 的配体。PAF (C16) 在体外实验中显示出抗凋亡和抗炎活性,通过与其受体 (PAF-R) 相互作用以执行细胞信号传导来抑制 caspase 依赖性凋亡。 | |||
T29308 |
Lyso-PAF C-16
|
||
Lyso-PAF C-16 is a biologically inactive precursor of platelet activating factor. | |||
T35804 | C16 Lactosylceramide (d18:1/16:0) | ||
C16 Lactosylceramide is an endogenous bioactive sphingolipid. It forms membrane microdomains with Lyn kinase and the αi subunits of inhibitory G protein-coupled receptors (GPCRs), suggesting a role in cell signaling. Plasma levels of C16 lactosylceramide are elevated in insulin-resistant cattle. C16 Lactosylceramide is also upregulated in a mouse model of Niemann-Pick type C1 disease, a neurodegenerative cholesterol-sphingolipid lysosomal storage disorder. | |||
T38180 |
C16 Phytoceramide (t18:0/16:0)
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||
C16 Phytoceramide (t18:0/16:0) is a phytoceramide, which is a family of sphingolipids found in the intestine, kidney, and extracellular spaces of the stratum corneum of the mammalian epidermis. C16 Phytoceramide (t18:0/16:0) is composed of a phytosphingosine backbone amine-linked to a C16 fatty acid chain. The levels of C16 phytoceramide (t18:0/16:0) increase following heat stress in S. cerevisiae. It has been used with other ceramides to create stratum corneum substitutes to study percutaneous ... | |||
T36149 | 13C C16 Sphingomyelin (d18:1/16:0) | ||
13C C16 Sphingomyelin is an isotopically enriched form of C16 sphingomyelin with carbon-13 occurring on the fatty acid portion. It is intended for use as an internal standard for the quantification of C16 sphingomyelin by GC- or LC-MS. C16 Sphingomyelin is a form of sphingomyelin containing palmitate (16:0) at the variable acylation position. It is the most common form of sphingomyelin found in eggs and is less abundant in the brain and in milk. C16 Sphingomyelin interacts with cholesterol in or... | |||
T37872 |
C16 Galactosylceramide (d18:1/16:0)
C16 Galactosylceramide (d18:1/16:0) |
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C16 Galactosylceramide is a glycosphingolipid that contains a galactose moiety attached to a ceramide acylated with palmitic acid . | |||
T36859 |
C16 Globotriaosylceramide (d18:1/16:0)
C16 Globotriaosylceramide (d18:1/16:0) |
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C16 globotriaosylceramide is an endogenous sphingolipid found in mammalian cell membranes that is synthesized from C16 lactosylceramide . C16 globotriaosylceramide acts as a receptor for Shiga toxin in B cell-derived Raji cells and THP-1 monocytes. It accumulates in endothelial cells, pericytes, vascular smooth muscle cells, renal epithelial cells, dorsal ganglia neuronal cells, and myocardial cells in patients with Fabry disease. C16 globotriaosylceramide is also upregulated in plasma of patien... | |||
T72978 | c-Met-IN-16 | ||
c-Met-IN-16 是一种 c-Met 抑制剂,可用于癌症的研究。 | |||
T17648 | Boc-C16-NHS ester | Others | Others |
Boc-C16-NHS ester, an alkyl/ether-based PROTAC linker, enables the synthesis of PROTACs[1]. | |||
T37454 |
C16 dihydro Ceramide (d18:0/16:0)
Ceramide (d18:0/16:0),Cer(d18:0/16:0),N-hexadecanoyl-D-erythro-Dihydrosphingosine,N-Palmitoyl Sphinganine |
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C16 dihydro Ceramide is a bioactive sphingolipid and precursor in the de novo synthesis of C16 ceramide (d18:0/16:0) that lacks the 4,5-trans double bond.[1] C16 dihydro Ceramide (0-46 nM) inhibits C16 ceramide-induced membrane permeabilization, measured as cytochrome C oxidation, in rat liver mitochondria in a concentration-dependent manner. It also inhibits C16 ceramide-induced channel formation in liposomes. C16 dihydro ceramide is biologically inactive as a single agent, lacking the ability ... | |||
T39426 |
Thalidomide-O-amido-C3-NH2
Thalidomide-O-amido-C3-NH2,Cereblon Ligand-Linker Conjugates 16,E3LigaseLigand-LinkerConjugates52 |
||
Thalidomide-O-amido-C3-NH2 is a synthesized E3 ligase ligand-linker conjugate, which combines the cereblon ligand derived from Thalidomide with a linker utilized in PROTAC technology. | |||
T13314 |
VTX-27
|
PKC | Chromatin/Epigenetic; Cytoskeletal Signaling |
VTX-27 是蛋白激酶 C θ (PKC θ) 的一种选择性抑制剂,对 PKC θ 和 PKC δ 的 Ki 值分别为 0.08 nM 和 16 nM。 | |||
T1272L |
Cytarabine hydrochloride
Ara-C hydrochloride,Cytosine Arabinoside hydrochloride |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Cytarabine hydrochloride (Ara-C hydrochloride) 是一种核苷类似物,可导致 S 期细胞周期停滞并抑制DNA 聚合酶。Cytarabine 抑制DNA 合成,IC50为 16 nM。Cytarabine hydrochloride 对HSV 具有抗病毒作用。 | |||
T6517 |
Golvatinib
E-7050,戈伐替尼 |
VEGFR; c-Met/HGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
Golvatinib (E-7050) 是一种 c-Met (IC50:14 nM) 和 VEGFR2 (IC50:16 nM) 的双重抑制剂。 | |||
T6079 |
NVP-ADW742
ADW742,ADW,GSK 552602A |
Apoptosis; IGF-1R | Apoptosis; Tyrosine Kinase/Adaptors |
NVP-ADW742 (ADW) 是一种具有口服活性,选择性的IGF-1R 酪氨酸激酶抑制剂,IC50为 0.17 μM。它抑制胰岛素受体,IC50为 2.8 μM,在肿瘤细胞中诱导多效性抗增殖/促凋亡。 | |||
T22540L |
Ac-Endothelin-1 (16-21), human acetate
|
Others | Others |
Ac-Endothelin-1 (16-21), human acetate 是内皮素家族的主要肽,已被证明在血管和非血管组织中具有多种生物活性。 C-末端片段是 ET 家族肽中高度保守的序列,已显示可区分称为 ETA 和 ETB 的两种 ET 受体亚型,因为它仅激活后者。 | |||
T8411 |
C-215
|
Others | Others |
C-215 是MmpL3抑制剂。它在 HTS 中被鉴定为对结核分枝杆菌具有独立的甘油活性,对哺乳动物细胞的非特异性毒性较低,对结核分枝杆菌的IC90=16 μM,并且能够有效抑制在巨噬细胞中生长的结核分枝杆菌。 | |||
TP1604L |
Thioredoxin reductase peptide acetate
Thioredoxin reductase peptide acetate(950890-23-0 free base) |
Others | Others |
Thioredoxin reductase peptide acetate(950890-23-0 free base) 对应于硫氧还蛋白还原酶 (TrxR) 中的 53–67 位残基,用于硫氧还蛋白还原酶研究。哺乳动物硫氧还蛋白还原酶 (TR) 催化硫氧还蛋白 (Trx) 的氧化还原活性二硫键的还原,并且在结构和谷胱甘肽还原酶的作用机制,除了 C 末端的 16 个氨基酸延伸部分含有一个罕见的连位硒硫键。 | |||
T3157 |
COH29
RNR Inhibitor COH29 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
COH29 (RNR Inhibitor COH29) 是一种口服可用的芳香族取代噻唑,是人类核糖核苷酸还原酶 (RNR) 的抑制剂,具有潜在的抗肿瘤活性。它抑制核糖核苷酸还原酶的IC50为 16 μM。 | |||
T33784 |
Oidiolactone B
LL Z1271,NSC180975 PR 1387,NSC 180975,NSC-180975,LL-Z1271 |
||
Oidiolactone B is a C(16) terpenoid lactone metabolite from Acrostalagmus. | |||
T36764 |
PAF C-18:1
|
||
PAF C-18:1 is a naturally occurring phospholipid produced by cells upon stimulation and plays a role in the establishment and maintenance of the inflammatory response. It is less potent than PAF C-16 and PAF C-18 in the induction of neutrophil chemotaxis, but is equipotent to PAF C-16 and PAF C-18 in promoting eosinophil migration. PAF C-18:1 activates the PAF receptor and has been used in antibody binding experiments to determine the importance of an acyl linkage at the sn-2 position for recogn... | |||
T36763 |
PAF C-18
|
||
PAF C-18 is a naturally occurring phospholipid produced upon stimulation through two distinct pathways known as the remodeling" and 'de novo' pathways. It is less potent than PAF C-16 in the induction of platelet aggregation | |||
TF0102 |
C-HEGA-11
|
||
C-HEGA-11 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 TF0102,CAS号为 864434-16-2。 | |||
T37935 |
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide
16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide |
||
The actions of many clinical F-series prostaglandins (PGs), including those used for estrous synchronization and for reduction of intraocular pressure (IOP), are mediated through the PGF2α (FP) receptor. 16-phenoxy tetranor Prostaglandin F2α cyclopropyl methyl amide (16-phenoxy tetranor PGF2α cyclopropyl methyl amide) is an analog of PGF2α containing a 16-phenoxy group on the lower (ω) side chain and a cyclopropyl methyl amide at the C-1 position. There are no published reports on the biological... | |||
T76666 |
β-Amyloid peptide(16-20)
|
||
β-Amyloid peptide(16-20),即 Amyloid-β(Abeta) 的氨基酸序列(KLVFF)部分,有效抑制 Abeta 原纤维形成,通过在 N 和 C 末端添加 RG-/-GR-NH2 残基增强其溶解性。 | |||
T63590 |
c-Met-IN-10
|
||
c-Met-IN-10 是高效的 c-Met 激酶抑制剂 (IC50: 16 nM)。c-Met-IN-10 能够抑制癌细胞 A549、H460 和 HT-29 的活性,通过抑制 HT-29 细胞集落形成,进而诱导 HT-29 和 A549 细胞凋亡 apoptosis,抑制 A549 细胞移动。c-Met-IN-10 能够用于抗癌研究。 | |||
T76516 |
HCV-1 e2 Protein (484-499)
|
||
HCV-1 e2 蛋白 (484-499) 是由 16 个氨基酸组成的肽。 HCV-1 e2 蛋白 (484-499) 来源于具有 HCV 抗体的个体血清中丙型肝炎病毒的包膜 2 蛋白。 | |||
T74460 | c-Myc inhibitor 5 | ||
c-Myc inhibitor5 (DA3) 是一种荧光长链桥双嘌呤,可选择性靶向 c-MYCG-四链体(KD16 μM)。c-Myc inhibitor5 显示对 c-MYC 表达的抑制作用,而不是其他 G4 驱动的癌基因。 | |||
T82805 |
Butaprost free acid
|
||
(R)-Butaprost (free acid) 是PGE2的一个结构类似物,特异性地对EP2受体亚型有选择性。该化合物用于药理学研究,以确定不同人类及动物组织和细胞中EP受体的分布。去除甲酯基团并恢复C-1自然羧酸后,增强了(R)-butaprost与前列腺素受体的结合亲和力,通常情况下,游离酸形式的亲和力是相应酯形式的10到100倍。尽管(R)-butaprost作为C-16的较低活性差向异构体,其药理作用未经充分研究,但在1986年Gardiner的论文中提到的TR 4979即布他前列素,结构中的差向异构体错误表达为16(R),实际为16(S),该错误直至1990年代后期才被美国和日本的研究纠正。 | |||
T36590 |
9-PAHSA
|
||
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to a hydroxylated C-16 or C-18 lipid. 9-PAHSA is a FAHFA in which palmitic acid is esterified to 9-hydroxy stearic acid. PAHSAs are the most abundant forms of FAHFA in serum as well as whi... | |||
T79467 |
Antifungal agent 60
|
||
Antifungalagent 60(compound 16)是一种抑制麦角甾醇生物合成的广谱抗真菌剂。它能够有效抑制包括7种人类致病真菌、2种耐氟康唑的白色念珠菌分离株以及2种多重耐药的耳念珠菌分离株。 | |||
T36586 |
12-PAHSA
|
||
Branched fatty acid esters of hydroxy fatty acids (FAHFAs) are newly identified endogenous lipids regulated by fasting and high-fat feeding and associated with insulin sensitivity. Structurally, these esters are comprised of a C-16 or C-18 fatty acid (e.g., palmitoleic, palmitic, oleic, or stearic acid) linked to either a C-16 or C-18 hydroxy substituent. 12-PAHSA is a FAHFA in which palmitic acid is esterified at the 12th carbon of hydroxy stearic acid. Among the FAHFA family members, PAHSAs ar... | |||
T35533 |
6-Hydroxypyridin-3-ylboronic Acid
|
||
6-Hydroxypyridin-3-ylboronic acid is a heterocyclic building block.1,2It has been used in the synthesis of non-nucleoside inhibitors of hepatitis C virus (HCV) RNA-dependent RNA polymerase nonstructural protein 5B (NS5B).16-Hydroxypyridin-3-ylboronic acid has also been used in the synthesis of mammalian target of rapamycin (mTOR) inhibitors.2 1.Hendricks, R.T., Spencer, S.R., Blake, J.F., et al.3-Hydroxyisoquinolines as inhibitors of HCV NS5b RNA-dependent RNA polymeraseBioorg. Med. Chem. Lett.1... | |||
T70798 |
Benastatin B
|
||
Benastatin B is a polyketide synthase-derived benastatin that has been found in Streptomyces and has diverse biological activities. It inhibits glutathione S-transferase (GST; Ki = 3.7 µM for the rat liver enzyme).2 Benastatin B also inhibits the transglycosylase activity of A. baumannii, C. difficile, E. coli, and S. aureus recombinant penicillin-binding proteins (PBPs; IC50s = 16, 53.3, 30.7, and 31.6 µM, respectively).3 It is active against several bacteria, including methicillin-resistant S.... | |||
TP1604 |
Thioredoxin reductase peptide
|
||
Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfide bond of thioredoxin (Trx) and is | |||
T35902 |
Milbemycin A4 oxime
|
||
Milbemycin A4 oxime is a derivative of milbemycin A4 and a component of milbemycin oxime , compounds that both have insecticidal and nematocidal activity. Milbemycin A4 oxime (0.05 mg/kg) reduces the number of microfilariae of the heartworm D. immitis in naturally infested dogs. It inhibits the growth of clinical isolates of C. glabrata with MIC80 values ranging from 16 to greater than 32 μg/ml. Milbemycin A4 oxime (2.5 μg/ml) blocks efflux of fluconazole from a clinical isolate of C. glabrata, ... | |||
T71382 |
KRC-108
|
||
KRC-108 is a multiple kinase inhibitor. KRC-108 is a potent inhibitor of Ron, Flt3 and TrkA as well as c-Met. KRC-108 inhibited oncogenic c-Met M1250T and Y1230D more strongly than wild type c-Met. The anti-proliferative activity of KRC-108 was measured by performing a cytotoxicity assay on a panel of cancer cell lines. The GI(50) values (i.e., 50% inhibition of cell growth) for KRC-108 ranged from 0.01 to 4.22 μM for these cancer cell lines. KRC-108 was also effective for the inhibition of tumo... | |||
T35988 |
CAY10564
|
||
S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10564 is a member of a new class of S-nitrosothiol species that act as NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.0, ... | |||
T35987 |
CAY10563
CAY10563 |
||
S-Nitrosothiols (RSNOs) are a class of molecules that function as exogenous and endogenous nitric oxide (NO) donors. RSNOs found in vivo include proteins such as S-nitrosohemoglobin and S-nitrosoalbumin, as well as low molecular weight species such as S-nitrosoglutathione (GSNO) and S-nitrosocysteine (CysNO). CAY10563 is a member of a new class of S-nitrosothiol species that act as an NO donors under acidic conditions. It decomposes with a half-life of one minute in 0.1 M phosphate buffer, pH 5.... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T38179 |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)
C16 3'-sulfo Galactosylceramide (d18:1/16:0) |
Others | Others |
C16 3'-sulfo Galactosylceramide (d18:1/16:0)是硫酸盐类糖脂的一种。C16 3'-sulfo Galactosylceramide (d18:1/16:0)是在猪脑和血浆中发现的一种比较丰富的硫化物,在小鼠的整个发育过程中会有所减少。C16 3'-sulfo Galactosylceramide (d18:1/16:0)在体外可抑制视网膜神经节细胞生长。C16 3'-sulfo Galactosylceramide (d18:1/16:0)已被用作量化大鼠小脑和多发性硬化症患者分离的白质中的硫化物的参照物。 | |||
T1272 |
Cytarabine
阿糖胞苷,Ara-C,Cytosine Arabinoside,Cytosine β-D-arabinofuranoside,Arabinocytidine |
Apoptosis; Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite; Autophagy; HSV | Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Microbiology/Virology |
Cytarabine (Ara-C) 是一种核苷类似物,一种 DNA 合成抑制剂 (IC50=16 nM)。Cytarabine 可以抑制 DNA 聚合酶,诱导细胞周期阻滞、细胞自噬和凋亡。Cytarabine 具有抗肿瘤活性。 | |||
TN4861 | Pueroside C | Others | Others |
Pueroside C 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN4861,CAS号为 112343-16-5。 | |||
TN6142 |
Chrysosplenol C
|
||
Chrysosplenol C 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6142,CAS号为 23370-16-3。 | |||
T82572 |
D-Glucosyl-β-1,1′-N-palmitoylsphingosine
C16 Glucosyl(β) Ceramide (d18:1/16:0) |
||
D-Glucosyl-β-1,1′-N-palmitoylsphingosine (C16 Glucosyl(β) Ceramide (d18:1/16:0)) 是内源性Mincle配体,具免疫刺激活性。 | |||
TN4410 | Lappaol C | P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol C has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol C also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
T37712 | Fumiquinazoline D | ||
Fumiquinazoline D is a fungal metabolite originally isolated from A. fumigatus that has activity against Gram-positive and Gram-negative bacteria (MICs = 8-16 μg/ml) as well as F. solani and C. albicans fungi (MICs = 32 and 64 μg/ml, respectively). | |||
TN1072 |
Lappaol A
|
P-gp; JNK | MAPK; Membrane transporter/Ion channel; Neuroscience |
Lappaol A has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. Lappaol A also has potential chemosensitizing activity, it may be candidates for developing novel adjuvant an | |||
TN4411 |
Lappaol F
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CDK; P-gp; JNK | Cell Cycle/Checkpoint; MAPK; Membrane transporter/Ion channel; Neuroscience |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. Lappaol F has potential chemosensitizing activity, it may be candidates for developing novel adju | |||
T35779 |
Oosporein
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Oosporein is a mycotoxin that has been found inBeauveriaand has diverse biological activities.1,2It is cytotoxic to Sf9 and Sf21 insect cells with 50% cytotoxic concentration (CC50) values of 4.23 and 10.43 μM, respectively.3Oosporin induces lethality in day-old cockerels (LD50= 6.12 mg/kg).4It inhibits Na+/K+-, Ca2+-, and Mg2+-ATPase activities by 27, 52, and 100%, respectively, in equine erythrocyte ghosts when used at a concentration of 200 μg/ml.2Oosporein inhibits herpes simplex 1 (HSV-1), ... |