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Search Results for " azone "

100

抑制剂 & 化合物

3

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T19781	Clomazone Gamit,FMC 57020,Command,异恶草松,Dimethazone,Magister	Others	Others
	Clomazone (Magister) 是一种能够用于控制棉花，豌豆，南瓜，大豆，地瓜，烟草的一年生草和阔叶杂草的广谱抗菌剂。
T7770	Ethylhexyl Triazone Octyl triazone,乙基己基三嗪酮	Others	Others
	Ethylhexyl Triazone (Octyl triazone) 是一种紫外线-B 化学过滤剂，可用作商业防晒剂。
T1622	Rosiglitazone maleate BRL 49653C,BRL 49653,马来酸罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone maleate (BRL 49653) 是一种选择性PPARγ激活剂，具有抗糖尿病特性和潜在抗肿瘤活性。它也是TRP 通道调节剂，可抑制 TRPM2、TRPM3 的活性，激活 TRPC5。
T22708	Darglitazone CP-86325	PPAR	DNA Damage/DNA Repair; Metabolism
	Darglitazone (CP-86325) 是一种噻唑烷二酮，是口服有效的PPAR-γ选择性激动剂。Darglitazone 可以有效控制血糖和脂质代谢，在 II 型糖尿病中有研究价值。
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T27841	Lobeglitazone Sulfate CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD	Immunology/Inflammation; NF-κB
	Lobeglitazone Sulfate（CKD-501 Sulfate）是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。
T7877	Thiacetazone 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil	Others; Antibacterial; Antibiotic	Microbiology/Virology; Others
	Thiacetazone (Diazam) 是一种氨基硫脲抗结核剂，也是一种具有口服活性抗生素。它具有抗菌作用，可抑制结核分枝杆菌 H37Rv 的生长，MIC 值为 0.1 μg/mL。
T5010	Propyphenazone Isopropylantipyrine,Propyphenazone (4-Isopropylantipyrine),异丙安替比林,Isopropylphenazone,4-Isopropylantipyrine,Isopropyrine	COX	Immunology/Inflammation; Neuroscience
	Propyphenazone (4-Isopropylantipyrine) 是吡唑啉酮衍生物，具有消炎、止痛和解热活性。基于 Propyphenazone 的类似物可作为前药和选择性 cyclooxygenase-2 抑制剂。
T9132	Emorfazone 依莫法宗,PH011085	Others	Others
	Emorfazone (PH011085) 具有抗伤害作用。
T19710	Ciglitazone Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878	Apoptosis; p38 MAPK; PPAR	Apoptosis; DNA Damage/DNA Repair; MAPK; Metabolism
	Ciglitazone (ADD 3878) 是一种强效和选择性的PPARγ激动剂(EC50：3μM)和口服降糖药。Ciglitazone 抑制th17细胞的增殖和分化，降低胰岛素水平、血管内皮生长因子的产生和血压，诱导胃癌细胞的细胞周期停止。Ciglitazone 能诱导负鼠肾上皮细胞的凋亡，激活p38 MAPK 和凋亡诱导因子(AIF)的核转位。 Ciglitazone 在肥胖症和高血糖症的动物模型中表现出降血糖活性。
T67743	4-Pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone, [C(E)]-	Others	Others
	4-Pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone, [C(E)]-是混合配体配位聚合物[Zn4(bdc)4(ppmh)2(H2O)]n 的配体。
T0214	Pioglitazone U 72107,吡格列酮,匹格列酮	Ferroptosis; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Pioglitazone (U 72107) 是一种胰岛素增敏剂和噻唑烷二酮，适用于治疗 2 型糖尿病。它是一种选择性PPARγ激动剂，高亲和力结合到 PPARγ 配体结合域，作用于人和鼠 PPARγ的EC50分别为 0.93 和 0.99 μM。
T4639	Azemiglitazone MSDC 0602	Mitochondrial Metabolism; mTOR	Metabolism; PI3K/Akt/mTOR signaling
	Azemiglitazone (MSDC 0602) 是一种 PPARγ 保留的噻唑烷二酮类药物 (TZD)，与能够线粒体丙酮酸载体 (MPC) 相互作用并抑制其活性，降低 pparγ 介导的副作用的风险，有用于 2 型糖尿病研究的潜能。
T0435	Sulfinpyrazone (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925	COX	Immunology/Inflammation; Neuroscience
	Sulfinpyrazone (NSC-75925) 是一种口服有效的尿酸剂，具有抗血栓和血小板抑制作用。它可作用于慢性和间歇性痛风性关节炎。
T1432	Phenylbutazone Butazolidine,保泰松	COX	Immunology/Inflammation; Neuroscience
	Phenylbutazone (Butazolidine) 是是非甾体类抗炎药，前列腺素 H 合酶过氧化物酶的还原辅助因子，可诱导肌肉盲样蛋白 1 表达，有用于强直性脊柱炎的研究潜力。
T0980	Nifenazone 尼芬那宗,Niapyrin,Nicodone,烟酰氨基比林,Nicazane	COX	Immunology/Inflammation; Neuroscience
	Nifenazone (Nicodone) 是吡唑类试剂，可用于研究各种风湿性疾病。
T5314	pyridoxal isonicotinoyl hydrazone 吡哆醛异烟酰肼,PIH	Others	Others
	pyridoxal isonicotinoyl hydrazone (PIH) 是亲脂的三价铁螯合剂，具有高铁螯合特性。
T0897	Nitrofurazone NFZ,呋喃西林,Nitrofural,Furacilin	Dehydrogenase; Antibacterial; Glutathione reductase; Antibiotic	Metabolism; Microbiology/Virology; oxidation-reduction
	Nitrofurazone (Furacilin) 是一种抗生素。
T26613L	Ambazone Ambazon,Primal,安巴腙	Others	Others
	Ambazone (Primal) 被发现对小鼠和大鼠的各种可移植肿瘤具有活性。
T35617	Mitoguazone MGBG,Methyl-GAG	Apoptosis; HIV Protease	Apoptosis; Microbiology/Virology; Proteases/Proteasome
	Mitoguazone (Methyl-GAG) 是一种可透过血脑屏障的选择性的 S-腺苷-蛋氨酸脱羧酶 (S-adenosyl-methionine decarboxylase) 抑制剂，可破坏多胺的生物合成。Mitoguazone 是一种具有抗肿瘤活性的合成多羰基衍生物，可抑制 HIV DNA 整合到单核细胞和巨噬细胞中的细胞 DNA 中，诱导细胞凋亡 (apoptosis)。Mitoguazone 具可用于预防急性白血病，霍奇金淋巴瘤和非霍奇金淋巴瘤。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T6437	Cefoperazone 头孢哌酮,Cefob,Medocef	Antibacterial; Antibiotic	Microbiology/Virology
	Cefoperazone (Medocef) 是一种半合成的头孢菌素，有抗菌活性。
T1650	Chlorzoxazone Paraflex,Chlorzoxazon,氯唑沙宗	P450; Potassium Channel	Membrane transporter/Ion channel; Metabolism
	Chlorzoxazone (Chlorzoxazon) 是作用于中枢的肌肉松弛剂, 可用于肌肉痉挛的研究。
T3170	Troglitazone CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay,曲格列酮	Apoptosis; Ferroptosis; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Metabolism
	Troglitazone (Romglizone) 是一种 PPARγ 激动剂，具有抗炎和抗肿瘤活性。
T0214L	Pioglitazone hydrochloride U-72107E,AD 4833,U 72107A,Pioglitazone HCl,匹格列酮盐酸盐	Ferroptosis; PPAR	Apoptosis; DNA Damage/DNA Repair; Metabolism
	Pioglitazone hydrochloride (AD 4833) 是一种选择性PPARγ激动剂，高亲和力结合到 PPARγ 配体结合域。作用于人和鼠 PPARγ，EC50分别为 0.93 和 0.99 μM。它是一种口服活性噻唑烷二酮的盐酸盐，具有抗糖尿病特性和潜在的抗肿瘤活性。
T7722	Feprazone Prenazone,非普拉宗,DA 2370,DA2370,DA-2370	Others	Others
	Feprazone (DA-2370) 具有抗炎和抗脂肪生成特性。 Feprazone 可用于治疗关节和肌肉疼痛的研究。
T15581	Inolitazone RS5444,Efatutazone,CS-7017,伊诺他酮	PPAR	DNA Damage/DNA Repair; Metabolism
	Inolitazone (RS5444) 是一种高亲和力PPARγ激动剂。在体外，Inotazone 显示生长抑制的IC50约为0.8 nM。
T28454	Proquazone Proquazona,Arthrex,Proquazonum,Biarison,普罗喹宗	Others	Others
	Proquazone (Arthrex) 是一种非甾体抗炎药。
T1218	Cefoperazone sodium salt CP 52640-2,头孢哌酮钠,Cefoperazone sodium	Antibacterial; Antibiotic	Microbiology/Virology
	Cefoperazone sodium salt (CP 52640-2) 是一种半合成的头孢菌素，具有广谱抗菌活性。
T68046	Ciproquazone	Others	Others
	Ciproquazone 具有镇痛活性，可用于治疗脊柱炎。
T60272	Isatin-β-thiosemicarbazone IBT	HSV	Microbiology/Virology
	Isatin-β-thiosemicarbazone 是一种有效的单纯疱疹病毒 (HSV) 抑制剂。Isatin-β-thiosemicarbazone 在对 HSV-1 和 HSV-2 都具有抑制作用，表现出抗病毒活性。Isatin-β-thiosemicarbazone 是一种有效的抗痘病毒剂 (anti-poxvirus）可用用于治疗猴痘病毒、正痘病毒和牛痘病毒。
T7710	MOFEBUTAZONE	Others	Others
	Mofebutazone 抑制前列腺素和白三烯的免疫释放。
T26613	Ambazone hydrate
	Ambazone hydrate has anti-cancer activity.
T69083	Nitraquazone
	Nitraquazone is a phosphodiesterase inhibitor
T20669	Bentazone 苯达松,BAS 351-07H,EPA Pesticide Chemical Code 275200
	Paicaotan is a heterocyclic herbicide. It can removal broadleaf weeds and sedge in the soybean field.
T15580	Inolitazone dihydrochloride RS5444 dihydrochloride,CS-7017 dihydrochloride,Efatutazone dihydrochloride	PPAR	DNA Damage/DNA Repair; Metabolism
	Inolitazone dihydrochloride 一种有效的、高亲和力的 PPARγ 激动剂，其生物活性的体现依赖于 PPARγ（IC50：0.8 nM），对细胞生长具有抑制作用。Inolitazone dihydrochloride 加强细胞周期激酶抑制剂p21 WAF1/CIP1的作用。
T72177	Oxyphenbutazone monohydrate 羟布宗一水合物
	Oxyphenbutazone monohydrate 是一种保泰松 (Phenylbutazone) 代谢物，具有抗炎作用。Oxyphenbutazone monohydrate 是一种具有口服活性的非选择性 COX 抑制剂。Oxyphenbutazone monohydrate 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。
T40874	2-Nitrobenzaldehyde semicarbazone 13C,15N2 2-Nitrobenzaldehyde semicarbazone 13C,15N2
	2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.
T39152	4-Hydroxyphenylbutazone
	4-Hydroxyphenylbutazone, a metabolite of Phenylbutazone, functions as an effective reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) known for its efficiency in this role.
T37852	Chlorzoxazone N-Glucuronide
	Chlorzoxazone N-glucuronide is a phase II metabolite of the skeletal muscle relaxant chlorzoxazone . Chlorzoxazone N-glucuronide is formed via glucuronidation of chlorzoxazone by the UDP-glucuronosyltransferase (UGT) isoform UGT1A9.
T30946	Cintazone NSC-102825,NSC 102825,NSC102825
	Cintazone is a biochemical.
T19894	Phenylbutazone sodium Sodium phenylbutazone,Sodium butazolidine,Phenylbutazone sodium salt
	Phenylbutazone sodium shows the effect of anti-inflammatory.
T19643	Cefbuperazone Sodium T 1982,BMY25182,BMY 25182,T-1982,BMY-25182,T1982
	Cefbuperazone Sodium is a penicillin-binding protein inhibitor. It is used as antibacterials.
T71298	Ipenoxazone HCl
	Ipenoxazone HCl is a glutamate receptor antagonist potentially for the treatment of Alzheimer's disease.
T30324	Benzaldehyde, m-hydroxy-, (5-nitro-2-pyridyl)hydrazone
	Benzaldehyde, m-hydroxy-, (5-nitro-2-pyridyl)hydrazone is a bioactive chemical.
T29966	Ametohepazone Ametohepazon
	Ametohepazone is a biochemical with radiosensitizing action.
T25431	Fluproquazone Tormosyl,46 790,46-790
	Fluproquazone is a quinazolinone derivative with potent antipyretic, analgesic, and anti-inflammatory effects. However, it was withdrawn during development due to liver toxicity.
T19896	Phenylbutazone calcium DA 241,P 241,DA-241,Phenylbutazone calcium salt,DA241
	Phenylbutazone calcium is a calcium derivative of phenylbutazone that has anti-inflammatory effects.
T26003	Pyrazinobutazone DB139,Carudol,DB-139,Ranoroc,DB 139
	Pyrazinobutazone is an antipyrene derivative which possesses anti-inflammatory properties.
T34846	Thiazolinobutazone LAS-11871,LAS 11871,LAS11871,TZB
	Thiazolinobutazone is the 2-amino-2-thiazoline salt of phenylbutazone.

化合物

Cat.No: T19781

Synonym: Gamit,FMC 57020,Command,异恶草松,Dimethazone,Magister

Target: Others

Ethylhexyl Triazone

Cat.No: T7770

Synonym: Octyl triazone,乙基己基三嗪酮

Target: Others

Rosiglitazone maleate

Cat.No: T1622

Synonym: BRL 49653C,BRL 49653,马来酸罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T22708

Synonym: CP-86325

Target: PPAR

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Lobeglitazone Sulfate

Cat.No: T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: NOD

Cat.No: T7877

Synonym: 氨硫脲,Diazam,Thioacetazone,Neustab,Neotibil

Target: Others, Antibacterial, Antibiotic

Cat.No: T5010

Synonym: Isopropylantipyrine,Propyphenazone (4-Isopropylantipyrine),异丙安替比林,Isopropylphenazone,4-Isopropylantipyrine,Isopropyrine

Target: COX

Cat.No: T9132

Synonym: 依莫法宗,PH011085

Target: Others

Cat.No: T19710

Synonym: Ciglitazona,U 63287,ADD3878,ADD-3878,U-63287,ADD 3878

Target: Apoptosis, p38 MAPK, PPAR

4-Pyridinecarboxaldehyde, 2-(2-pyridinyl)hydrazone, [C(E)]-

Cat.No: T67743

Target: Others

Cat.No: T0214

Synonym: U 72107,吡格列酮,匹格列酮

Target: Ferroptosis, PPAR

Cat.No: T4639

Synonym: MSDC 0602

Target: Mitochondrial Metabolism, mTOR

Cat.No: T0435

Synonym: (+/-)-Sulfinpyrazone,G-28315,苯磺保泰松,NSC 75925

Target: COX

Cat.No: T1432

Synonym: Butazolidine,保泰松

Target: COX

Cat.No: T0980

Synonym: 尼芬那宗,Niapyrin,Nicodone,烟酰氨基比林,Nicazane

Target: COX

pyridoxal isonicotinoyl hydrazone

Cat.No: T5314

Synonym: 吡哆醛异烟酰肼,PIH

Target: Others

Cat.No: T0897

Synonym: NFZ,呋喃西林,Nitrofural,Furacilin

Target: Dehydrogenase, Antibacterial, Glutathione reductase, Antibiotic

Cat.No: T26613L

Synonym: Ambazon,Primal,安巴腙

Target: Others

Cat.No: T35617

Synonym: MGBG,Methyl-GAG

Target: Apoptosis, HIV Protease

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Cat.No: T6437

Synonym: 头孢哌酮,Cefob,Medocef

Target: Antibacterial, Antibiotic

Cat.No: T1650

Synonym: Paraflex,Chlorzoxazon,氯唑沙宗

Target: P450, Potassium Channel

Cat.No: T3170

Synonym: CS-045,Romozin,Rezulin,Romglizone,Noscal,Prelay,曲格列酮

Target: Apoptosis, Ferroptosis, PPAR, Autophagy

Pioglitazone hydrochloride

Cat.No: T0214L

Synonym: U-72107E,AD 4833,U 72107A,Pioglitazone HCl,匹格列酮盐酸盐

Target: Ferroptosis, PPAR

Cat.No: T7722

Synonym: Prenazone,非普拉宗,DA 2370,DA2370,DA-2370

Target: Others

Cat.No: T15581

Synonym: RS5444,Efatutazone,CS-7017,伊诺他酮

Target: PPAR

Cat.No: T28454

Synonym: Proquazona,Arthrex,Proquazonum,Biarison,普罗喹宗

Target: Others

Cefoperazone sodium salt

Cat.No: T1218

Synonym: CP 52640-2,头孢哌酮钠,Cefoperazone sodium

Target: Antibacterial, Antibiotic

Cat.No: T68046

Target: Others

Isatin-β-thiosemicarbazone

Cat.No: T60272

Synonym: IBT

Target: HSV

Cat.No: T7710

Target: Others

Ambazone hydrate

Cat.No: T26613

Cat.No: T69083

Cat.No: T20669

Synonym: 苯达松,BAS 351-07H,EPA Pesticide Chemical Code 275200

Inolitazone dihydrochloride

Cat.No: T15580

Synonym: RS5444 dihydrochloride,CS-7017 dihydrochloride,Efatutazone dihydrochloride

Target: PPAR

Oxyphenbutazone monohydrate

Cat.No: T72177

Synonym: 羟布宗一水合物

2-Nitrobenzaldehyde semicarbazone 13C,15N2

Cat.No: T40874

Synonym: 2-Nitrobenzaldehyde semicarbazone 13C,15N2

4-Hydroxyphenylbutazone

Cat.No: T39152

Chlorzoxazone N-Glucuronide

Cat.No: T37852

Cat.No: T30946

Synonym: NSC-102825,NSC 102825,NSC102825

Phenylbutazone sodium

Cat.No: T19894

Synonym: Sodium phenylbutazone,Sodium butazolidine,Phenylbutazone sodium salt

Cefbuperazone Sodium

Cat.No: T19643

Synonym: T 1982,BMY25182,BMY 25182,T-1982,BMY-25182,T1982

Ipenoxazone HCl

Cat.No: T71298

Benzaldehyde, m-hydroxy-, (5-nitro-2-pyridyl)hydrazone

Cat.No: T30324

Cat.No: T29966

Synonym: Ametohepazon

Cat.No: T25431

Synonym: Tormosyl,46 790,46-790

Phenylbutazone calcium

Cat.No: T19896

Synonym: DA 241,P 241,DA-241,Phenylbutazone calcium salt,DA241

Pyrazinobutazone

Cat.No: T26003

Synonym: DB139,Carudol,DB-139,Ranoroc,DB 139

Thiazolinobutazone

Cat.No: T34846

Synonym: LAS-11871,LAS 11871,LAS11871,TZB

Cat. No.	Product Name	Target	Signaling Pathways
T2A2509	Laurocapram 月桂氮酮,Tranzone,Azone,N-Lauryl caprolactam,N-0252,月桂氮卓酮,N-Dodecylcaprolactam	Others	Others
	Laurocapram (N-Lauryl caprolactam) 是吸收促进剂，对于亲脂性和亲水性物质都是一种最有效的吸收剂。
T21164	Sulfentrazone 甲磺草胺,FP-846	Others	Others
	Sulfentrazone (FP-846) 是苯基三唑啉酮除草剂，能够抑制原卟啉原氧化酶，导致脂质细胞膜破裂，可用于控制某些阔叶和禾本科杂草。
TN2312	Xanthiazone	Others	Others
	Xanthiazone is a natural product

天然产物

Cat.No: T2A2509

Synonym: 月桂氮酮,Tranzone,Azone,N-Lauryl caprolactam,N-0252,月桂氮卓酮,N-Dodecylcaprolactam

Target: Others

Cat.No: T21164

Synonym: 甲磺草胺,FP-846

Target: Others

Cat.No: TN2312

Target: Others

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