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Search Results for " akt-in-9 "

10

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T62771	AKT-IN-9
	AKT-IN-9 是一种 AKT 的有效抑制剂。其中蛋白激酶 B (PKB，也称为 AKT) 是细胞中 PI3K/AKT/mTOR 信号传导的核心，在细胞生长、存活、分化和代谢中发挥着重要用处。AKT-IN-9 具有潜力进行乳腺癌和前列腺癌的研究。
T16750	Rigosertib ON-01910,瑞格色替	Apoptosis; FLT; PLK; PI3K; Bcr-Abl; CDK; PDGFR; Src	Angiogenesis; Apoptosis; Cell Cycle/Checkpoint; Cytoskeletal Signaling; PI3K/Akt/mTOR signaling; Tyrosine Kinase/Adaptors
	Rigosertib (ON-01910) 是一种多激酶抑制剂和选择性抗癌剂，通过抑制 PI3K/Akt 途径诱导细胞凋亡，促进组蛋白 H2AX 的磷酸化并诱导细胞周期中的 G2/M 期停滞。它是一种选择性的非 ATP 竞争性PLK1抑制剂，IC50值为 9 nM。
T6070	(E/Z)-Rigosertib sodium N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐,(E/Z) ON-01910 sodium	PLK	Cell Cycle/Checkpoint
	ON-01910 是一种非 ATP 竞争性 PLK1 抑制剂（IC50 为 9 nM，在无细胞试验中）。它对 Plk2 的选择性高出 30 倍，对 Plk3 没有活性。 Rigosertib 抑制 PI3K/Akt 通路并激活氧化应激信号。 Rigosertib 可诱导多种癌细胞凋亡。它是一种合成的苄基苯乙烯基砜类似物，具有潜在的抗肿瘤活性。
T63155	MMP-9-IN-3
	MMP-9-IN-3 是一种 MMP-9 抑制剂 (IC50: 5.56 nM)，可与 MMP-9 形成氢键。MMP-9-IN-3 对 AKT 的活性具有抑制作用 (IC50: 2.11 nM)。MMP-9-IN-3 具有细胞毒性，能够诱导细胞凋亡。MMP-9-IN-3 能够用于研究癌症。
T64083	MMP-9-IN-5
	MMP-9-IN-5 是一种 MMP-9 抑制剂，其 IC50 值为 4.49 nM，能够与 MMP-9 形成氢键。MMP-9-IN-5 也抑制 AKT 活性，其 IC50 值为 1.34 nM。MMP-9-IN-5 表现出细胞毒性，可诱导细胞凋亡 (apoptosis)，能够用于研究癌症。
T63994	MMP-9-IN-4
	MMP-9-IN-4 是 MMP-9 抑制剂，能够与 MMP-9 形成 H-π 相互作用，IC50 值为 7.46 nM。MMP-9-IN-4 还能够抑制 AKT 活性，其 IC50 值为 8.82 nM。MMP-9-IN-4 能够诱导细胞凋亡 (apoptosis)，显示出细胞毒性，能够用于研究癌症。
T17346	9-Decyn-1-ol	Others	Others
	9-Decyn-1-ol is an alkyl/ether-based PROTAC linker suitable for synthesizing PROTACs. It serves as a conjugation agent to combine GDC-0068 and Lenalidomide, resulting in the formation of INY-03-041. INY-03-041 is a potent and highly selective pan-Akt degrader that operates through the PROTAC mechanism. It effectively inhibits Akt1, Akt2, and Akt3 with IC50 values of 2.0 nM, 6.8 nM, and 3.5 nM, respectively[1].
T79560	22-(4′-py)-JA 22-(4′-Pyridinecarbonyl) jorunnamycin A	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	22-(4′-py)-JA是久那霉素A的半合成衍生物，源自泰国蓝海绵（Xestospongia sp.）。该化合物显示出抗转移活性，能抑制AKT/mTOR/p70S6K信号通路，并阻断人脐静脉内皮细胞（HUVEC）中肿瘤细胞侵袭及管形成作用。它通过下调金属蛋白酶（MMP-2和MMP-9）、缺氧诱导因子1α（HIF-1α）和血管内皮生长因子（VEGF）来发挥作用。此外，22-(4′-py)-JA对非小细胞肺癌（NSCLC）显示出显著的抗癌效果。
T36648	Tucatinib hemiethanolate
	Tucatinib (Irbinitinib) hemiethanolate is a potent, orally active and selective HER2 inhibitor with an IC50 of 8 nM. Tucatinib hemiethanolate has nanomolar activity against purified HER2 enzyme and is approximately 500-fold selective for HER2 versus EGFR in cell-based assays. Tucatinib selectively inhibits the receptor tyrosine kinase HER2 relative to EGFR[1].Tucatinib blocks proliferation and the phosphorylation of HER2 and its downstream effector, Akt in HER2 overexpressing cell lines. In the ...
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...

化合物

Cat.No: T62771

Cat.No: T16750

Synonym: ON-01910,瑞格色替

Target: Apoptosis, FLT, PLK, PI3K, Bcr-Abl, CDK, PDGFR, Src

(E/Z)-Rigosertib sodium

Cat.No: T6070

Synonym: N-[2-甲氧基-5-[[[2-(2,4,6-三甲氧基苯基)乙烯基]磺酰]甲基]苯基]甘氨酸钠盐,(E/Z) ON-01910 sodium

Target: PLK

Cat.No: T63155

Cat.No: T64083

Cat.No: T63994

Cat.No: T17346

Target: Others

22-(4′-py)-JA

Cat.No: T79560

Synonym: 22-(4′-Pyridinecarbonyl) jorunnamycin A

Target: Akt

Tucatinib hemiethanolate

Cat.No: T36648

Cat.No: T35897

Cat. No.	Product Name	Target	Signaling Pathways
T3729	Ethyl gallate Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯	MMP; NF-κB; Akt; Antibacterial	Cytoskeletal Signaling; Microbiology/Virology; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome
	Ethyl gallate (gallic acid ethyl ester) 是一种非类黄酮酚过氧化氢清除剂。
T4S21320	ISOGINKGETIN 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮	MMP; Others	Others; Proteases/Proteasome
	ISOGINKGETIN (4',4'''-Dimethylamentoflavone) 是一种MMP9抑制剂，也是一种Pre-mRNA Splicing 抑制剂。
T6S1699	Shogaol [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol	Lipoxygenase; Autophagy	Autophagy; Metabolism
	6-Shogaol (6-Shogaol) 是从生姜中分离的一种天然产物，具有抗癌、抗炎和抗氧化的多种生物活性。
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...

天然产物

Cat.No: T3729

Synonym: Nipagallin A,Phyllemblin,gallic acid ethyl ester,没食子酸乙酯

Target: MMP, NF-κB, Akt, Antibacterial

Cat.No: T4S21320

Synonym: 异银杏素,4',4'''-Dimethylamentoflavone,异银杏双黄酮

Target: MMP, Others

Cat.No: T6S1699

Synonym: [6]-Shogaol,姜烯酚,6-姜烯酚,6-Shogaol

Target: Lipoxygenase, Autophagy

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

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