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1

抑制剂 & 化合物

36

天然产物

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Cat. No. Product Name Target Signaling Pathways
TN2258 Tartrazine

酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23

Others Others
Tartrazine (Acid Yellow 23) 是偶氮型酸性染料,是橙黄色粉末,溶于水中呈黄色,常用作食品着色的合成柠檬黄色偶氮染料。

化合物

Tartrazine
Cat.No: TN2258
Synonym: 酒石黄,FD&C Yellow No. 5,Acid Yellow 23,酸性黄 23
Target: Others
Cat. No. Product Name Target Signaling Pathways
T3018 Protocatechualdehyde

Protocatechuic aldehyde,3,4-Dihydroxybenzaldehyde,Rancinamycin IV,Catechaldehyde,原儿茶醛

Reactive Oxygen Species; Antibacterial Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
Protocatechualdehyde (3,4-Dihydroxybenzaldehyde),源自丹参根的天然多酚化合物,展现多样生物活性,并作为抗氧化剂、抗衰老剂、抗菌剂和抗炎剂在医药领域广泛应用。
T3871 Daucosterol

Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷

Glucosidase Metabolism
Daucosterol (Sitogluside) 是天然的甾醇体类化合物。
T3375 Verbascoside

毛蕊花苷,麦角甾苷,Kusaginin,Acteoside,TJC160

Apoptosis; PARP; Antibacterial; PKC; p53; HSV Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; Microbiology/Virology
Verbascoside (Kusaginin) 是从Lantana camara 中得到的糖苷类物质,是具有ATP 竞争性的PKC 抑制剂,IC50值为 25 µM,它还有抗炎,抗肿瘤,抗神经性疼痛等作用。
T4795 Pimelic acid

Pileric acid,1,7-Heptanedioic acid,庚二酸,1,5-Pentanedicarboxylic acid

Others; Endogenous Metabolite Metabolism; Others
Pimelic acid (1,5-Pentanedicarboxylic acid) 的衍生物能够参与赖氨酸的生物合成。
T2981 Xanthoxylin

Brevifolin,Xanthoxyline,花椒素,2'-Hydroxy-4',6'-dimethoxyacetophenone

Others; Antifungal Microbiology/Virology; Others
Xanthoxylin (Brevifolin)e 是从Zanthoxylum simulans 中分离出来的是一种冰片和樟脑味化合物,有抗真菌和抗癫痫作用。
T8116 Azulene

甘菊蓝,奥苷菊环,Bicyclo[5.3.0]Decapentaene

Others; HIV Protease Microbiology/Virology; Others; Proteases/Proteasome
Azulene (Bicyclo[5.3.0]Decapentaene) 是萘的异构体,具有高抗HIV 活性。它是从洋甘菊精油中分离出来的一种化学支架。
T5308 2-Hydroxyphenylacetic acid

Ortho-Hydroxyphenylacetic acid,邻羟基苯乙酸,2-HPAA,2-Hydroxybenzeneacetic Acid

Others; Endogenous Metabolite Metabolism; Others
2-Hydroxyphenylacetic acid (Ortho-Hydroxyphenylacetic acid) 是一种食物的潜在生物标记,被发现和苯丙酮尿症(PKU)相关。
T5278 5-Hydroxymethyl-2-furancarboxylic acid

Sumiki's acid,5-羟甲基-2-呋喃甲酸,5-(Hydroxymethyl)-2-furoic acid

Others; Endogenous Metabolite Metabolism; Others
5-Hydroxymethyl-2-furancarboxylic acid (5-(Hydroxymethyl)-2-furoic acid) 是一种人内源性代谢物,主要由 5-羟甲基-2-糠醛代谢产生,并在肾脏中被消除。
T5S1988 Isorhamnetin-3-O-glucoside

Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷

Others Others
Isorhamnetin-3-O-glucoside (Isorhamnetin-3-O-beta-D-Glucoside) 是一种天然化合物,广泛存在于蔬菜和水稻中,经消化后可在肠道菌群中代谢。
T1407 (-)-Menthol

L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor

Opioid Receptor; Endogenous Metabolite; TRP/TRPV Channel Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel; Metabolism; Neuroscience
(-)-Menthol (Levomenthol) 分离自薄荷油,L-Menthol 是瞬时受体电位 M8 (TRPM8)的激活剂,TRPM8 是 Ca2+-可渗透的非选择性阳离子通道,并增加 [Ca2+]i。L-Menthol 具有抗肿瘤活性。
T3740 Isovanillin

3-羟基-4-甲氧基苯甲醛,3-Hydroxy-p-anisaldehyde,3-Hydroxy-4-methoxybenzaldehyde,5-Formylguaiacol

Others Others
Isovanillin (5-Formylguaiacol) 是一种醛氧化酶抑制剂,具有解痉挛和止泻活性。
TQ0089 Juglanin

Apoptosis; JNK; Autophagy Apoptosis; Autophagy; MAPK
Juglanin 是来自金鸡脚的一种黄酮类天然产物,是一种 JNK 的激活剂,能诱导人乳腺癌细胞的凋亡和自噬,具有炎症和抗肿瘤活性。
TN1468 (-)-Carvone

Others Others
(-)-Carvone 是一种可能具有抗氧化和抗炎能力的天然产品。
TN1916 Matairesinol

罗汉松树脂酚

ATPase; p38 MAPK; ROS Immunology/Inflammation; MAPK; Membrane transporter/Ion channel
Matairesinol has radical and superoxide scavenging activities,; it also has anti-angiogenic activity by suppressing mROS signaling , can decrease hypoxia-inducible factor-1α± in hypoxic HeLa cells.
T3391 Corosolic acid

Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid

FAK; Autophagy Angiogenesis; Autophagy; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors
Corosolic acid (Colosic acid) 是从大花紫薇中提取的一种天然产物,具有抗肿瘤活性。
T2881 Crustecdysone

Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素

Others; Caspase; Endogenous Metabolite; Autophagy Apoptosis; Autophagy; Metabolism; Others; Proteases/Proteasome
Crustecdysone (Hydroxyecdysone) 是来源于露水草的一种蜕皮激素,可调节昆虫的蜕皮或蜕皮过程。它是 Ecdysone 的活性代谢物,通过 20E 核受体复合物 EcR-USP 抑制半胱天冬酶活性并诱导自噬,在心血管系统中具有调节或保护作用。
T4884 alpha-D-glucose

α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose

Others; Endogenous Metabolite Metabolism; Others
alpha-D-glucose (α-Dextrose) 是内源性代谢产物的一种。
T4S0295 Apigenin 7-glucoside

波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin

Reactive Oxygen Species; HIV Protease Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome
Apigenin 7-glucoside (Cosmosiin) 是一种 ROS 清除剂,具有抗增殖、抗氧化作用。
TN1296 5-Feruloylquinic acid

5-O-Feruloylquinic acid,5-FQA,5-O-阿魏酰奎尼酸

Tyrosinase; Sirtuin Chromatin/Epigenetic; DNA Damage/DNA Repair; Proteases/Proteasome
5-Feruloylquinic acid (5-FQA) 表现出抗氧化作用和酪氨酸酶抑制作用。
T3772 Maslinic acid

2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid

NF-κB; HIV Protease; DNA/RNA Synthesis; Antibacterial Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology; NF-κB; Proteases/Proteasome
Maslinic acid (Crategolic acid) 是一种 DNA 聚合酶 B 抑制剂,抑制 NF-κB p65的 DNA 结合活性并消除 IκB-α磷酸化。
T34529 Sarcostin

Sarcostin is a pregnane ester glycoside isolated from the aerial parts of Stapelia variegata.
TN1877 Lonicerin

忍冬苦苷,金银花

Apoptosis; Antibacterial Apoptosis; Microbiology/Virology
Lonicerin 是一种抗藻酸盐分泌蛋白的黄酮类化合物,对铜绿假单胞菌有抑制作用。它可预防脂多糖诱导的急性肺损伤的炎症和细胞凋亡。
T3741 (-)-borneol

L-Borneol,冰片

GABA Receptor Membrane transporter/Ion channel; Neuroscience
(-)-borneol (L-Borneol) 对 GABA 受体具有高效的正向调节作用,EC50 为 237 μM。
TN1261 3-O-Caffeoylquinic acid methyl ester

Others Others
3-O-Caffeoylquinic acid methyl ester 是 Pyrrosia calvata 的成分之一。
T2967 Stigmasterol

Stigmasterin,beta-Stigmasterol,豆甾醇

MMP; Endogenous Metabolite Metabolism; Proteases/Proteasome
Stigmasterol (Stigmasterin) 是一种植物性甾醇,具有抑制胆固醇的特性,此外在风湿性疾病的研究中被评价为抗硬化因子。
T2A2497 L-Glutamic acid

谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol

Apoptosis; Ferroptosis; Endogenous Metabolite; iGluR Apoptosis; Membrane transporter/Ion channel; Metabolism; Neuroscience
L-Glutamic acid (Glutaminol) 作为一种兴奋性氨基酸神经递质,为谷氨酸盐受体所有亚型的激动剂,对多巴胺从神经末梢释放的过程有激动作用。
T3S0237 Precyasterone

Others Others
Precyasterone 是一种天然产物,分离自 Cyathula capitata 干燥的根中。
T20447 L-Linalool

p-Linalool

L-Linalool is the jasmine tea, spruce essential oil, and young leaves of Litchi chinensis Sonn key volatile compound.
TN1235 3,4,5-Tricaffeoylquinic acid

TNF; Akt; HIV Protease Apoptosis; Cytoskeletal Signaling; Microbiology/Virology; PI3K/Akt/mTOR signaling; Proteases/Proteasome
3,4,5-Tricaffeoylquinic acid may attenuate the TNF-α±- and LPS-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor 4 expression-mediated activation of the Akt, ERK and NF-κB pathways, it may exert an inhibitory effect against the pro-inflammatory mediator-induced skin disease.
TN5942 Dammarenediol II

达玛烯二醇II,Dammar-24-ene-3,20-diol

Dammarenediol II may have the ability to prevent diabetic microvascular complications, including diabetic retinopathy, it can inhibit vascular endothelial growth factor (VEGF)-induced intracellular reactive oxygen species generation and stress fiber forma
TN3062 4'-O-Methylnyasol

Histamine Receptor GPCR/G Protein; Immunology/Inflammation; Neuroscience
4'-O-Methylnyasol may have potential to be developed as medicines for the treatment of allergies by inhibiting the activation of mast cells.
TN3248 7-Oxo-beta-sitosterol

Others Others
7-Oxo-beta-sitosterol是一种天然产物,属于茜草科红芽大戟属,其产品编号为 TN3248,CAS号为 2034-74-4。7-Oxo-beta-sitosterol可用作对照参考。
TN3134 5-O-Methylhierochin D

Others Others
5-O-Methylhierochin D 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN3134,CAS号为 155836-29-6。
T37272 9(S),12(S),13(S)-TriHOME

9(S),12(S),13(S)-TriHOME is a linoleic acid-derived oxylipin that has diverse biological activities.1,2,3,4It has been found in various plants and is produced in human eosinophils in a 15-lipoxygenase-dependent, soluble epoxide hydrolase-independent manner.1,59(S),12(S)13(S)-TriHOME inhibits antigen-induced β-hexosaminidase release from RBL-2H3 mast cells (IC50= 28.7 μg/ml).2It inhibits LPS-induced nitric oxide (NO) production in BV-2 microglia (IC50= 40.95 μM).3In vivo, 9(S),12(S),13(S)-TriHOME...
TN1194 16beta,17-Dihydroxy-ent-kaurane-19-oic acid

HIV Protease Microbiology/Virology; Proteases/Proteasome
16beta,17-Dihydroxy-ent-kaurane-19-oic acid as an anti-HIV principle, it showed significant activity against HIV replication in H9 lymphocyte cells with an EC50 value of 0.8 microgram/mL. It also possesses the activities of decompression and blood viscosi
TMA1799 alpha-Spinasterol glucoside

Others Others
alpha-Spinasterol glucoside 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TMA1799,CAS号为 1745-36-4。

天然产物

Protocatechualdehyde
Cat.No: T3018
Synonym: Protocatechuic aldehyde,3,4-Dihydroxybenzaldehyde,Rancinamycin IV,Catechaldehyde,原儿茶醛
Target: Reactive Oxygen Species, Antibacterial
Daucosterol
Cat.No: T3871
Synonym: Alexandrin,Sitogluside,β-Sitosterol β-D-glucoside,Eleutheroside A,西托糖苷
Target: Glucosidase
Verbascoside
Cat.No: T3375
Synonym: 毛蕊花苷,麦角甾苷,Kusaginin,Acteoside,TJC160
Target: Apoptosis, PARP, Antibacterial, PKC, p53, HSV
Pimelic acid
Cat.No: T4795
Synonym: Pileric acid,1,7-Heptanedioic acid,庚二酸,1,5-Pentanedicarboxylic acid
Target: Others, Endogenous Metabolite
Xanthoxylin
Cat.No: T2981
Synonym: Brevifolin,Xanthoxyline,花椒素,2'-Hydroxy-4',6'-dimethoxyacetophenone
Target: Others, Antifungal
Azulene
Cat.No: T8116
Synonym: 甘菊蓝,奥苷菊环,Bicyclo[5.3.0]Decapentaene
Target: Others, HIV Protease
2-Hydroxyphenylacetic acid
Cat.No: T5308
Synonym: Ortho-Hydroxyphenylacetic acid,邻羟基苯乙酸,2-HPAA,2-Hydroxybenzeneacetic Acid
Target: Others, Endogenous Metabolite
5-Hydroxymethyl-2-furancarboxylic acid
Cat.No: T5278
Synonym: Sumiki's acid,5-羟甲基-2-呋喃甲酸,5-(Hydroxymethyl)-2-furoic acid
Target: Others, Endogenous Metabolite
Isorhamnetin-3-O-glucoside
Cat.No: T5S1988
Synonym: Isorhamnetin-3-O-beta-D-Glucoside,异鼠李素-3-O-葡萄糖苷
Target: Others
(-)-Menthol
Cat.No: T1407
Synonym: L-Menthol,Levomenthol,(-)-薄荷醇,薄荷冰,Menthomenthol,Menthacamphor
Target: Opioid Receptor, Endogenous Metabolite, TRP/TRPV Channel
Isovanillin
Cat.No: T3740
Synonym: 3-羟基-4-甲氧基苯甲醛,3-Hydroxy-p-anisaldehyde,3-Hydroxy-4-methoxybenzaldehyde,5-Formylguaiacol
Target: Others
Juglanin
Cat.No: TQ0089
Synonym:
Target: Apoptosis, JNK, Autophagy
(-)-Carvone
Cat.No: TN1468
Synonym:
Target: Others
Matairesinol
Cat.No: TN1916
Synonym: 罗汉松树脂酚
Target: ATPase, p38 MAPK, ROS
Corosolic acid
Cat.No: T3391
Synonym: Corsolic acid,2α-Hydroxyursolic acid,科罗索酸,Glucosol,Colosolic acid,Colosic acid
Target: FAK, Autophagy
Crustecdysone
Cat.No: T2881
Synonym: Commisterone,B-ecdysone,Commisterone,20-Hydroxyecdysone,Ecdysterone,B-ecdysone,β-蜕皮甾酮,Hydroxyecdysone,羟基蜕皮激素
Target: Others, Caspase, Endogenous Metabolite, Autophagy
alpha-D-glucose
Cat.No: T4884
Synonym: α-D-Glucose,α-葡萄糖,alpha-Glucose,α-Dextrose
Target: Others, Endogenous Metabolite
Apigenin 7-glucoside
Cat.No: T4S0295
Synonym: 波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin
Target: Reactive Oxygen Species, HIV Protease
5-Feruloylquinic acid
Cat.No: TN1296
Synonym: 5-O-Feruloylquinic acid,5-FQA,5-O-阿魏酰奎尼酸
Target: Tyrosinase, Sirtuin
Maslinic acid
Cat.No: T3772
Synonym: 2α-Hydroxyoleanoic Acid,山楂酸,2α-Hydroxyoleanolic acid,Crategolic acid
Target: NF-κB, HIV Protease, DNA/RNA Synthesis, Antibacterial
Sarcostin
Cat.No: T34529
Synonym:
Target:
Lonicerin
Cat.No: TN1877
Synonym: 忍冬苦苷,金银花
Target: Apoptosis, Antibacterial
(-)-borneol
Cat.No: T3741
Synonym: L-Borneol,冰片
Target: GABA Receptor
3-O-Caffeoylquinic acid methyl ester
Cat.No: TN1261
Synonym:
Target: Others
Stigmasterol
Cat.No: T2967
Synonym: Stigmasterin,beta-Stigmasterol,豆甾醇
Target: MMP, Endogenous Metabolite
L-Glutamic acid
Cat.No: T2A2497
Synonym: 谷氨酸,(S)-Glutamic acid,glutamic acid,(+)-L-Glutamic acid,Aciglut,L-谷氨酸,glutacid,Glutaminol
Target: Apoptosis, Ferroptosis, Endogenous Metabolite, iGluR
Precyasterone
Cat.No: T3S0237
Synonym:
Target: Others
L-Linalool
Cat.No: T20447
Synonym: p-Linalool
Target:
3,4,5-Tricaffeoylquinic acid
Cat.No: TN1235
Synonym:
Target: TNF, Akt, HIV Protease
Dammarenediol II
Cat.No: TN5942
Synonym: 达玛烯二醇II,Dammar-24-ene-3,20-diol
Target:
4'-O-Methylnyasol
Cat.No: TN3062
Synonym:
Target: Histamine Receptor
7-Oxo-beta-sitosterol
Cat.No: TN3248
Synonym:
Target: Others
5-O-Methylhierochin D
Cat.No: TN3134
Synonym:
Target: Others
9(S),12(S),13(S)-TriHOME
Cat.No: T37272
Synonym:
Target:
16beta,17-Dihydroxy-ent-kaurane-19-oic acid
Cat.No: TN1194
Synonym:
Target: HIV Protease
alpha-Spinasterol glucoside
Cat.No: TMA1799
Synonym:
Target: Others
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