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35

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T7656	Apelin-13
	Apelin-13 是存在于中枢和外周神经系统由13个氨基酸组成的多肽序列，是 G 蛋白偶联受体angiotensin II protein J (APJ) 的内源性配体，对 APJ 的 EC50 值为 0.37 nM。Apelin-13 具有扩张血管和降压活性，可用于研究 2 型糖尿病综合征。
T0075	Nicorandil SG-75,尼可地尔	Potassium Channel	Membrane transporter/Ion channel
	Nicorandil (SG-75) 是一种有效的钾通道激活剂，靶向血管核苷二磷酸依赖性 K+通道和心脏 ATP 敏感 K+通道 (KATP)。Nicorandil 是一种烟酰胺酯，具有血管舒张和心脏保护作用，并具有治疗心绞痛和缺血性心脏病的潜力。
T1410	Torsemide AC-4464,JDL-464,托拉塞米,Torasemide	Na-K-Cl cotransporter	Membrane transporter/Ion channel
	Torsemide (AC-4464) 是具有口服活性的亨氏环利尿剂，也具有抗醛固酮和血管舒张活性。它可用于研究心力衰竭、肾脏疾病、肝硬化。
T3518	GSK269962A GSK269962B,GSK 269962,GSK269962A HCl	ROCK; S6 Kinase	Cell Cycle/Checkpoint; Cytoskeletal Signaling; MAPK; PI3K/Akt/mTOR signaling; Stem Cells
	GSK269962A (GSK269962A HCl) 是一种有效的ROCK 抑制剂，具有抗炎和血管舒张作用。它作用于重组人ROCK1和ROCK2，IC50分别为 1.6 和 4 nM。
T15471	Hepronicate Megrin	Others	Others
	Hepronicate（Megrin）是一种具有降血脂和血管扩张活性的小分子化合物。
T68083L	dl-Ibuterol hydrochloride dl-Ibuterol hydrochloride (53034-85-8 Free base),dl-Ibuterol HCl,Ibuterol HCl	Others	Others
	dl-Ibuterol hydrochloride (Ibuterol HCl) 具有血管扩张活性，可用于研究哮喘和支气管痉挛。
T27323	FK-453 FK453,FK 453	Adenosine Receptor	GPCR/G Protein; Neuroscience
	FK-453 是一种有效的非黄嘌呤腺苷 A1 受体拮抗剂，具有利尿和肾血管扩张活性。
T8135	Minoxidil sulfate Minoxidil sulphate,U-58838,米诺地尔硫酸盐	Potassium Channel	Membrane transporter/Ion channel
	Minoxidil sulfate (U-58838) 是米诺地尔的硫酸代谢物，是ATP 敏感的 K+通道激动剂。它被认为是血管扩张试剂，在动物实验模型中，促进头发生长。
T14064	8-Bromo-cGMP sodium	Calcium Channel; PKA	Membrane transporter/Ion channel; Metabolism; Tyrosine Kinase/Adaptors
	8-Bromo-cGMP sodium 是一种 PKG 激活剂，是 cGMP 的膜渗透性类似物。8-Bromo-cGMP sodium 具有缓解疼痛和血管舒张作用，可显着抑制 Ca2+ 宏观电流，抑制高 K+ 刺激的胰岛素释放。
T13684	Equilin 7-Dehydroestrone	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Equilin (7-Dehydroestrone) 是神经营养性雌激素类固醇，具有血管扩张活性，通过 NF-κB 信号传导增加单核细胞-内皮粘附。Equilin 通过阻断Ca（2+）进入平滑肌来同样放松肠系膜动脉的阻力。
T1398	Tadalafil Cialis,他达那非,IC-351,西力士	Apoptosis; PDE	Apoptosis; Metabolism
	Tadalafil (IC-351) 是一种PDE5抑制剂，IC50为 1.8 nM。
T0370	Pheniramine maleate Daneral,Inhiston,Trimetose,马来酸非尼拉敏	5-HT Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Pheniramine maleate (Trimetose) 是一种具有抗组胺和血管扩张特性的烷基胺衍生物，可与组胺 H1 受体结合，从而抑制磷脂酶 A2 和内皮源性松弛因子一氧化氮的产生。
T36033	DETA NONOate NOC-18,Diethylamine NONOate	NO Synthase	Immunology/Inflammation
	DETA NONOate (NOC 18)是外源性一氧化氮 (NO) 供体，具有血管舒张和抗抑郁活性。DETA NONOate 可用于激活神经元中的内向电流，可加速MRSA感染伤口的愈合。
T1158	Phenoxybenzamine hydrochloride 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl	CaMK; Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Phenoxybenzamine hydrochloride (NCI-c01661) 是一种选择性的 α-adrenoceptor 和 calmodulin 的抑制剂，是常用的抗高血压药。
T68138	Saterinone	Adrenergic Receptor; PDE	GPCR/G Protein; Metabolism; Neuroscience
	Saterinone 是一种强效且具有选择性的磷酸二酯酶III 抑制剂，是血管α - 1-肾上腺素受体的有效拮抗剂。Saterinone 具有血管舒张作用，可用于慢性心力衰竭的急性治疗。Saterinone 对豚鼠右心室匀浆中粗cAMP 磷酸二酯酶(PDE)活性具有抑制作用，ic50值为2.3 × 10(-5) mol/l。
T69142	NSC-2888
	NSC-2888 is a Novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T69123	NSC-2488
	NSC-2488 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T69132	NSC-4231
	NSC-4231 is a novel Rho-Kinase-II Inhibitor with Vasodilatory Activity.
T71377	Oberadilol
	Oberadilol is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action
T71376	Tzc 5665
	Tzc 5665 is a pyridazinone derivative with vasodilatory and beta-adrenergic blocking activities and type III phosphodiesterase inhibitory action.
T82932	Auriculin B Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)
	Auriculin B (ANP (126-150) (Rat)) 是源自大鼠的心房钠尿肽，具备显著的血管舒张与利尿作用。
T37459	Lipoxin A5
	Lipoxin A5 (LXA5) is produced by enzymatic transformation of EPA by leukocytes. LXA5 slowly contracts pulmonary parenchymal strips from guinea pig with similar potency to that of LXA4 and LXB4. However, LXA5 does not exert the vasodilatory effects on aortic smooth muscle exhibited by LXA4 and LXB4.
T39519	GSK269962A hydrochloride GSK 269962 hydrochloride
	GSK269962A hydrochloride (GSK 269962 hydrochloride) is a highly potent inhibitor of ROCK1 and ROCK2, with IC50 values of 1.6 nM and 4 nM, respectively, for recombinant human isoforms. This compound exhibits both anti-inflammatory and vasodilatory properties.
T14967	Cimlanod BMS-986231,CXL-1427	Others	Others
	Cimlanod is a second-generation Nitroxyl (HNO) donor for heart failure with positive lusitropic and inotropic as well as vasodilatory effects. Cimlanod delivers HNO via pH-dependent chemical breakdown when exposed to the neutral pH environment of the bloo
T28391	PF-9404C PF9404C
	PF-9404C is the S-S diesteroisomer of a beta adrenergic receptors blocker with vasodilatory properties. PF9404C increased the formation of cyclic GMP from 3 pmol mg−1 protein in basal conditions, to 53 pmol mg−1 protein in 10 μM in rat aorta smooth muscle
T76189	Phyllomedusin
	Phyllomedusin，一种速激肽十肽，是一种NK1受体激动剂。Phyllomedusin 具有血管舒张活性并引起幽门收缩。
T36566	Amauromine
	Amauromine is a neutral antagonist of the cannabinoid (CB) receptor CB1 that is selective for CB1 (Ki = 178 nM; Kb = 66.6 nM) over CB2, with no activity at CB2 receptors at concentrations up to 10 μM. It is also an antagonist of GPR18 (IC50 = 3.74 μM). Amauromine has vasodilatory activity.
T82217	Helospectin I
	Helospectin I属于血管活性肠肽(VIP)家族的一种神经肽，能够引起血管扩张，具有抗高血压效果，可用于降低血压。该化合物最早是从Heloderma suspectum蜥蜴的唾液腺毒液中分离得到。
T62004	(Rac)-Nebivolol
	(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种选择性的β1 肾上腺素能受体拮抗剂（IC50= 0.8 nM）。Nebivolol 显示血管舒张活性。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。
T82216	Helospectin II
	Helospectin II，一种属于血管活性肠肽（VIP）家族的神经肽，具备血管扩张作用及抗高血压活性，能够降低血压。该化合物最初从蜥蜴Heloderma suspectum的唾液腺毒液中分离得到。
T83164	Adrenomedullin (porcine)
	Adrenomedullin(porcine)是一種多肽，具有调节血管舒张的功能。它在内皮依赖性条件下能诱导大鼠主动脉舒张，IC50为2.4 nM；在内皮非依赖性条件下则能诱导猪冠状动脉舒张，IC50为27.6 nM。
T73083	Nipradolol KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351
	Nipradolol (KT-210; K-351) 是一种有效的 α-1-肾上腺素能受体的阻滞剂。Nipradolol 还抑制白化兔模型中 Phenylephrine 诱导的眼压升高 (IOP)。Nipradolol 抑制去甲肾上腺素 (NA) 引起的肌肉收缩，对犬冠状动脉也有血管扩张剂活性。
TP2000	MM 07
	Apelin biased agonist; exhibits bias for the G protein pathway. Stimulates endothelial NOS phosphorylation and expression, promotes proliferation, and attenuates apoptosis of human pulmonary arterial endothelial cells in vitro. Shows positive inotropic an
T36405	Pro-Adrenomedullin (153-185), human Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH
	Pro-Adrenomedullin(153-185),human, (C143H224N42O43), a peptide with the sequence H2N-SLPEAGPGRTLVSSKPQAHGAPAPPSGSAPHFL-OH, MW= 3219.6. Adrenomedullin (AM) is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 19931. AM was initially identified as a vasodilator, some have cited this as the most potent endogenous vasodilatory peptide found in the body2. Differences in opinion regarding the ability of AM to relax vascular tone arises from the differences in the model system...
T35876	Chlorthalidone Impurity G
	Chlorthalidone impurity G is a potential impurity found in commercial preparations of chlorthalidone that has moderate antihypertensive effects. Chlorthalidone is a thiazide-like diuretic that inhibits the Na+/Cl- cotransporter in the distal convoluted tubule of the kidney, which prevents reabsorption of sodium and chloride leading to a reduction in plasma volume and cardiac output. It also inhibits carbonic anhydrase (CA), including the isoforms CAVB, VII, IX, XII, and XIII (Kis = 2.8-23 nM) an...

化合物

Cat.No: T7656

Cat.No: T0075

Synonym: SG-75,尼可地尔

Target: Potassium Channel

Cat.No: T1410

Synonym: AC-4464,JDL-464,托拉塞米,Torasemide

Target: Na-K-Cl cotransporter

Cat.No: T3518

Synonym: GSK269962B,GSK 269962,GSK269962A HCl

Target: ROCK, S6 Kinase

Cat.No: T15471

Synonym: Megrin

Target: Others

dl-Ibuterol hydrochloride

Cat.No: T68083L

Synonym: dl-Ibuterol hydrochloride (53034-85-8 Free base),dl-Ibuterol HCl,Ibuterol HCl

Target: Others

Cat.No: T27323

Synonym: FK453,FK 453

Target: Adenosine Receptor

Minoxidil sulfate

Cat.No: T8135

Synonym: Minoxidil sulphate,U-58838,米诺地尔硫酸盐

Target: Potassium Channel

8-Bromo-cGMP sodium

Cat.No: T14064

Target: Calcium Channel, PKA

Cat.No: T13684

Synonym: 7-Dehydroestrone

Target: Calcium Channel

Cat.No: T1398

Synonym: Cialis,他达那非,IC-351,西力士

Target: Apoptosis, PDE

Pheniramine maleate

Cat.No: T0370

Synonym: Daneral,Inhiston,Trimetose,马来酸非尼拉敏

Target: 5-HT Receptor, Histamine Receptor

Cat.No: T36033

Synonym: NOC-18,Diethylamine NONOate

Target: NO Synthase

Phenoxybenzamine hydrochloride

Cat.No: T1158

Synonym: 苯氧苯札明,NCI-c01661,NSC 37448,盐酸酚苄明,Phenoxybenzamine HCl

Target: CaMK, Adrenergic Receptor

Cat.No: T68138

Target: Adrenergic Receptor, PDE

Cat.No: T69142

Cat.No: T69123

Cat.No: T69132

Cat.No: T71377

Cat.No: T71376

Cat.No: T82932

Synonym: Atrial natriuretic peptide(126-150)(rat),ANP (126-150) (Rat)

Cat.No: T37459

GSK269962A hydrochloride

Cat.No: T39519

Synonym: GSK 269962 hydrochloride

Cat.No: T14967

Synonym: BMS-986231,CXL-1427

Target: Others

Cat.No: T28391

Synonym: PF9404C

Cat.No: T76189

Cat.No: T36566

Cat.No: T82217

(Rac)-Nebivolol

Cat.No: T62004

Cat.No: T82216

Adrenomedullin (porcine)

Cat.No: T83164

Cat.No: T73083

Synonym: KT 210 ; K 351 ; Hypadil,Hypadil,KT 210,K 351

Cat.No: TP2000

Pro-Adrenomedullin (153-185), human

Cat.No: T36405

Synonym: Pro-Adrenomedullin (153-185), human,H2N-Ser-Leu-Pro-Glu-Ala-Gly-Pro-Gly-Arg-Thr-Leu-Val-Ser-Ser-Lys-Pro-Gln-Ala-His-Gly-Ala-Pro-Ala-Pro-Pro-Ser-Gly-Ser-Ala-Pro-His-Phe-Leu-OH

Chlorthalidone Impurity G

Cat.No: T35876

Cat. No.	Product Name	Target	Signaling Pathways
T7437	3-(3-Hydroxyphenyl)propionic Acid m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸	Others; Endogenous Metabolite	Metabolism; Others
	3-(3-Hydroxyphenyl)propionic Acid (m-Hydroxyphenylpropionic acid) 是一种黄酮类代谢产物，由人体微生物区系形成，具有舒张血管的特性。
T0853	Adenosine 腺苷,D-Adenosine,Adenine riboside	Apoptosis; Nucleoside Antimetabolite/Analog; Endogenous Metabolite; Autophagy	Apoptosis; Autophagy; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism
	Adenosine (D-Adenosine) 是一种核糖核苷，由与核糖结合的腺嘌呤组成，具有血管扩张、抗心律失常和镇痛作用。
T3904	Gomisin J	Calcium Channel; AMPK	Chromatin/Epigenetic; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling
	Gomisin J 是在五味子中发现的小分子量木脂素，具有血管舒张活性，在非酒精性脂肪性肝病方面有研究潜力。它通过激活 AMPK、LKB1 和 Ca2+/钙调蛋白依赖性蛋白激酶 II 以及抑制 HepG2 细胞中的胎球蛋白 A 来调节脂肪生成酶和脂肪分解酶以及炎症分子的表达，从而抑制脂质积累。
TN1393	(-)-Anonaine 番荔枝碱	Apoptosis; Antioxidant; Parasite; Antifungal	Apoptosis; Microbiology/Virology; oxidation-reduction
	(-)-Anonaine 可从木兰科和安妮科的几个物种中提取出来，具有抗疟、抗菌、抗真菌、抗氧化、抗癌、抗抑郁和血管舒张的活性。(-)-Anonaine 通过 Bax 和 caspase 依赖性途径诱导人类宫颈癌（HeLa）细胞的凋亡，诱导 DNA 损伤并抑制人类肺癌 h1299细胞的生长和迁移。
T3011	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸	Others; Endogenous Metabolite	Metabolism; Others
	2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid (3-Anthraniloylalanine) 是一种酮类和氨基酸衍生物，具有多种生物功能，包括血管舒张、免疫调节和神经调节活性。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 是烟酸的前体。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 的异常产生与神经系统疾病相关的认知缺陷和抑郁症状有关。2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid 在某些类型的癌细胞中过度表达，可能被用作评估癌症风险的生物标志物。
T3794	Pentagalloylglucose Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖	Influenza Virus	Microbiology/Virology
	1,2,3,4,6-O-Pentagalloylglucose (Penta-O-galloyl-β-D-glucose) 存在于多种植物中，具有重要的药理作用。Pentagalloylglucose 表现出显著的抗狂犬病病毒 (RABV) 活性。
T78468	Yohimbic acid hydrate
	Yohimbic acid hydrate，一种Yohimbine的两性脱甲基衍生物，具有血管舒张效果，且在骨关节炎（OA）研究中展现出潜在应用价值。
TN2533	1-Hydroxy-2,3,4,7-tetramethoxyxanthone	5-HT Receptor	GPCR/G Protein; Neuroscience
	1-Hydroxy-2,3,4,7-tetramethoxy-xanthone has vasodilatory action, it can cause vasodilation in the coronary artery pre-contracted with 1uM 5-hydroxytryptamine (5-HT), with the EC 50 value of 6.6±1.4 uM. 1-Hydroxy-2,3,4,7-tetramethoxyxanthone can effectivel

天然产物

3-(3-Hydroxyphenyl)propionic Acid

Cat.No: T7437

Synonym: m-Hydroxyphenylpropionic acid,3-Hydroxyhydrocinnamic acid,3-(3-羟基苯基)丙酸

Target: Others, Endogenous Metabolite

Cat.No: T0853

Synonym: 腺苷,D-Adenosine,Adenine riboside

Target: Apoptosis, Nucleoside Antimetabolite/Analog, Endogenous Metabolite, Autophagy

Cat.No: T3904

Target: Calcium Channel, AMPK

Cat.No: TN1393

Synonym: 番荔枝碱

Target: Apoptosis, Antioxidant, Parasite, Antifungal

2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

Cat.No: T3011

Synonym: Kynurenine,Dl-Kynurenine,Kynurenin,3-Anthraniloylalanine,犬尿氨酸

Target: Others, Endogenous Metabolite

Pentagalloylglucose

Cat.No: T3794

Synonym: Penta-O-galloyl-β-D-glucose,1,2,3,4,6-O-Pentagalloylglucose,1,2,3,4,6-Penta-O-galloyl-beta-D-glucopyranose,1,2,3,4,6-五没食子酰葡萄糖

Target: Influenza Virus

Yohimbic acid hydrate

Cat.No: T78468

1-Hydroxy-2,3,4,7-tetramethoxyxanthone

Cat.No: TN2533

Target: 5-HT Receptor

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