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Search Results for " thromboxane "

106

抑制剂 & 化合物

9

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T36220	2,3-dinor Thromboxane B1 2,3-dinor Thromboxane B1
	Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2. In rats and rabbits, 2,3-dinor TXB1 has been identified as another urinary metabolite of TXB2. However in human urine, only trace amounts of 2,3-dinor TXB1 have been identified. In rats, 2,3-dinor TXB1 is excreted at a much higher rate than 2,3-dinor TXB2 (19.2 ± 4.9 ng/24 hr and 1.6 ± 0.3 ng/24 hr, respectively). Therefore, urinary 2,3-...
T36208	15(R)-Pinane Thromboxane A2 15(R)-Pinane Thromboxane A2
	15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2 . 15(R)-PTA2 does not inhibit collagen-induced platelet aggregation (IC50s = 120-130 μM). It does not affect gastric tone in isolated rat gastric fundus when used at concentrations of 0.5 or 1.5 μg/ml and is less effective than PTA2 at inhibiting prostaglandin-induced contraction of isolated rat stomach muscle.
T41246	Thromboxane B2
	Thromboxane B2 是一种在过敏反应期间释放的前列腺素衍生物。Thromboxane B2 诱导动脉收缩和血小板聚集。
T36548	Carbocyclic Thromboxane A2
	Carbocyclic Thromboxane A2 可用于生命科学领域的相关研究。其产品编号为 T36548，CAS号为 74034-56-3。
T34862	Thromboxane A2 Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2
	Thromboxane A2, as an unstable intermediate between the prostaglandin endoperoxides and thromboxane B2, is a potent inducer of platelet aggregation and causes vasoconstriction.
T73855	Thromboxane B1
	Thromboxane B1 (TXB1) 是TXB家族中的一员，属于类花生酸脂质家族。该家族因参与血栓形成而得名。
T12268	NTP42	Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism
	NTP42 是血栓素 A2 (TXA2) 受体的拮抗剂，IC50为 3.278 nM，可用于肺动脉高压的相关研究。
T6236	Ozagrel 奥扎格雷,OKY-046,Domenan	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel (Domenan) 是血栓烷 A2(TXA2) 合酶抑制剂，可抑制哮喘。它也是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T6625	Ozagrel hydrochloride Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl	Thrombin; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome
	Ozagrel hydrochloride (OKY-046 HCl) 是一种选择性血栓素 A(2) 合成酶抑制剂，用于改善术后脑血管收缩和伴随的脑缺血。它是一种抗血小板剂，可选择性抑制人血小板聚集，IC50为 53.12 μM。
T11339	Furegrelate sodium U-63557A	PPAR	DNA Damage/DNA Repair; Metabolism
	Furegrelate sodium (U-63557A) 是口服有效的、血栓素合酶选择性抑制剂，抑制人血小板微粒体血栓素 A2 (TxA2) 合酶的 IC50为 15 nM。它正在开发作为抗血小板药物。
T17039	Terbogrel BIBV 308SE	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Terbogrel 是一种可口服的、具有选择性 thromboxane A2 受体拮抗剂（IC50 约为 10 nM），是一种 thromboxane A2 synthase 抑制剂（IC50 约为 10 nM）。Terbogrel 是一种抗血小板化合物，可抑制血小板聚集，是预防血栓的潜在化合物。
T25741	Linotroban HN 11500,CL-871502	PPAR	DNA Damage/DNA Repair; Metabolism
	Linotroban（CL-871502）是一种有效的选择性血栓素（TXA2）受体拮抗剂，具有抗血栓活性。
T67958	Pirmagrel	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	pirmagrel 是一种强效的血栓素合酶抑制剂。
T15049	Daltroban BM-13505,SKF 96148	PPAR	DNA Damage/DNA Repair; Metabolism
	Daltroban (SKF 96148) (BM-13505) 是选择性和特异性的血栓素 A2 (TXA2) 受体拮抗剂。Daltroban 可以增加血管平滑肌细胞内钙。Daltroban 显示对再灌注损伤的保护作用。
T5505	Terutroban	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Terutroban 是有效的血栓素-前列腺素受体拮抗剂。
T7968	Dazoxiben UK-37248,达唑氧苯	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Dazoxiben (UK-37248) 是口服具有活性的血栓烷合酶抑制剂。
T31213	Dazmegrel UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485	PPAR	DNA Damage/DNA Repair; Metabolism
	Dazmegrel (UK 38,485) 是一种强效特异性血栓素 A2（TXA2）合成酶抑制剂，可用于预防正常妊娠中全血小板聚集增加。
T24542	NP-313 NP 313,NSC 4264,NSC-4264,NSC4264
	NP-313 (NSC-4264) 是一种有效的抗血栓剂，对血栓素 A 2 合成和选择性抑制由 SOCC 介导的 Ca 2+ 内流有抑制作用，可以抑制血小板的聚集和活化。
T11339L	Furegrelate	PPAR	DNA Damage/DNA Repair; Metabolism
	FUREGRELATE 是一种血栓素 A2 (TxA2) 合酶抑制剂，可减缓新生仔猪肺动脉高压的发展。
T15577	Indobufen Ibustrin,吲哚布芬	COX	Immunology/Inflammation; Neuroscience
	Indobufen (Ibustrin) 是一种血小板聚集抑制剂，是下调单核细胞中的组织因子，可逆抑制血小板环氧合酶 (Cox) 的活性和血栓素 A2 (TxA2) 的合成。
T27630	Isbogrel CV4151,CV-4151,CV 4151	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Isbogrel (CV4151)是一种小分子血栓素A2合成酶(TXA2 synthase)抑制剂，可用来研究心律失常、短暂性脑缺血发作和血栓形成。
T68022L	Sulotroban potassium BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)	PPAR	DNA Damage/DNA Repair; Metabolism
	Sulotroban potassium 是一种小分子血栓素A2受体（TXA2R）拮抗剂，可用于研究心肌梗塞和血栓形成。
T0839	Ketoprofen 酮基布洛芬,RP-19583,酮洛芬	Apoptosis; COX; MRP	Apoptosis; Immunology/Inflammation; Neuroscience
	Ketoprofen (RP-19583) 是一种非甾体抗炎剂，能够有效地抑制COX 的活性，在人血单核细胞中，对 COX-1 和 COX-2 的IC50值分别为 2 nM 和 26 nM。
T11825	LCB-2853	PPAR	DNA Damage/DNA Repair; Metabolism
	LCB-2853 是一种有效的血栓素 A2/前列腺素 H2 （TXA2/PGH2）受体拮抗剂，具有抗血小板聚集、抗血管痉挛和抗血栓作用。
T0212	Seratrodast 塞曲司特,AA 2414,ABT-001	COX; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; Metabolism; Neuroscience
	Seratrodast (ABT-001) 是一种血栓素 A2 受体 (TP) 拮抗剂，用于治疗哮喘。
T2396	Ramatroban BAY u3405,雷马曲班	GPR; Prostaglandin Receptor; PPAR	DNA Damage/DNA Repair; Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Metabolism
	Ramatroban (BAY u3405) 是一种血栓素 A(2) (TxA(2)) 拮抗剂，IC50为 14 nM。它还通过抑制PGD2结合从而拮抗CRTH2，IC50为113 nM。它用于治疗过敏性鼻炎，可用于治疗哮喘的研究。
TQ0145	(R)-(+)-Bay-K-8644 (R)-(+)-Bay K 8644	Calcium Channel; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	(R)-(+)-Bay-K-8644 是一种 Ca2+ 通道激动剂，是二氢吡啶激动剂，抑制 Ba2+电流 (IBa)，诱导猫的中枢性呼吸抑制，通过竞争性拮抗血栓素 A2-前列腺素 H2 受体抑制血小板活化。
T1002	Etodolac Ultradol,AY-24236,依托度酸,Etodolic acid,Lodine	Retinoid Receptor; COX	Immunology/Inflammation; Metabolism; Neuroscience
	Etodolac (AY-24236) 是一种吡喃羧酸和非甾体抗炎药，具有解热和镇痛活性，对 COX 的 IC50为53.5 nM。
T68086	Imitrodast	Thrombin	Proteases/Proteasome
	Imitrodast是一种小分子血栓素A2合成酶（TXA2 synthase）抑制剂，可用于治疗免疫系统疾病、呼吸系统疾病和心血管疾病，可用于研究动脉血栓形成、哮喘和冠状血管痉挛。
T68130	Pobilukast SKF 104353 Z2,SKF 104353	Leukotriene Receptor	GPCR/G Protein
	Pobilukast (SKF 104353) 是一种选择性半胱氨酰白三烯受体拮抗剂，可阻断磷脂酰肌醇代谢和白三烯D诱导的血栓素合成，可用于研究过度心肌再灌注损伤（MI/R）大鼠限制心肌损伤。
T67959	Pirodomast	Thrombin; Serine Protease	Proteases/Proteasome
	Pirodomast 是血栓素 A（TXA2）合成酶抑制剂。Pirodomast 能抑制白三烯（LT）D4、C4、E4 的形成和血栓素 B2（TXB2）的活性，但对组胺、甲氧胆碱、血清素、LTC4 或血小板活化因子诱导的豚鼠支气管痉挛的拮抗作用较弱或无效。Pirodomast 在体外对豚鼠气管只有微弱的松弛活性。Pirodomast 是一种潜在的抗过敏化合物，在体外可抑制胰蛋白酶的蛋白水解活性，在体内可阻止抗原诱发过敏绵羊的即时和晚期哮喘反应，抑制抗原诱导的过敏绵羊对组胺和卡巴胆碱的气道高反应性。
T34986	UK 14819 UK-14819,UK14819
	UK 14819 is a selective thromboxane inhibitor.
T70936	CGS 22652
	CGS 22652 has thromboxane receptor antagonism combined with thromboxane synthase inhibition.
T24298	L 641953 L-641953,L641953
	L 641953 is an antagonist of the thromboxane receptor.
T22896	L-655,240	Others	Others
	L-655,240 is a thromboxane A2/prostaglandin endoperoxide receptor antagonist.
T68199	Nafagrel
	Nafagrel is a thromboxane A2 synthetase inhibitor.
T68754	N.0096
	N.0096 is a thromboxane synthesis inhibitor.
T71027	KDI-792 hydrochloride
	KDI-792 hydrochloride is a thromboxane dual blocker.
T70541	IS-145
	IS-145 is a thromboxane A2 receptor antagonist.
T71511	ICI-185282
	ICI-185282 is a potent thromboxane receptor antagonist.
T23670	AH 22921 AH22921,AH-22921
	AH 22921 is an antagonist of thromboxane A2.
T68287	Indobufen sodium
	Indobufen sodium is a Thromboxane A2 antagonist and Cyclooxygenase inhibitor.
T15252	Etersalate Etherylate,Eterylate	Others	Others
	Etersalate inhibits platelet function. It also reduces thromboxane A2 (TXA2) levels.
T25710	LG 82-4-01 LG-82-4-01,L82401,Lg-82401,LG82-4-01
	LG 82-4-01 is an inhibitor of thromboxane (TX) synthetase.
T70871	Mipitroban
	Mipitroban is a thromboxane A2/prostaglandin H2 antagonist.
T70966	GR-36246
	GR-36246 is a Thromboxane A2-receptor blocker.
T28176	Nizofenone Y9179,Y-9179,Ekonal,Y 9179
	Nizofenone, a thromboxane A2 (TXA2) biosynthesis inhibitor, is used as a neuroprotective drug and used to treat stroke.
T70561	FCE-24265
	FCE-24265 is a calcium & thromboxane A2 synthase inhibitor.
T70737	HN 11500
	HN 11500 is an antithrombotic agent and thromboxane A2 receptor antagonist.
T71568	Wy 27569
	Wy 27569 is is a combined calcium channel blocker and thromboxane synthetase inhibitor.

化合物

2,3-dinor Thromboxane B1

Cat.No: T36220

Synonym: 2,3-dinor Thromboxane B1

15(R)-Pinane Thromboxane A2

Cat.No: T36208

Synonym: 15(R)-Pinane Thromboxane A2

Thromboxane B2

Cat.No: T41246

Carbocyclic Thromboxane A2

Cat.No: T36548

Thromboxane A2

Cat.No: T34862

Synonym: Rabbit aorta contracting substance,TXA-2,TXA2,TXA 2

Thromboxane B1

Cat.No: T73855

Cat.No: T12268

Target: Prostaglandin Receptor, PPAR

Cat.No: T6236

Synonym: 奥扎格雷,OKY-046,Domenan

Target: Thrombin, Prostaglandin Receptor

Ozagrel hydrochloride

Cat.No: T6625

Synonym: Ozagrel HCl,盐酸奥扎格雷,OKY-046 HCl

Target: Thrombin, Prostaglandin Receptor

Furegrelate sodium

Cat.No: T11339

Synonym: U-63557A

Target: PPAR

Cat.No: T17039

Synonym: BIBV 308SE

Target: Prostaglandin Receptor

Cat.No: T25741

Synonym: HN 11500,CL-871502

Target: PPAR

Cat.No: T67958

Target: Prostaglandin Receptor

Cat.No: T15049

Synonym: BM-13505,SKF 96148

Target: PPAR

Cat.No: T5505

Target: Prostaglandin Receptor

Cat.No: T7968

Synonym: UK-37248,达唑氧苯

Target: Prostaglandin Receptor

Cat.No: T31213

Synonym: UK-38,485,UK 38485,UK 38,485,UK38,485,UK-38485

Target: PPAR

Cat.No: T24542

Synonym: NP 313,NSC 4264,NSC-4264,NSC4264

Cat.No: T11339L

Target: PPAR

Cat.No: T15577

Synonym: Ibustrin,吲哚布芬

Target: COX

Cat.No: T27630

Synonym: CV4151,CV-4151,CV 4151

Target: Prostaglandin Receptor

Sulotroban potassium

Cat.No: T68022L

Synonym: BM 13177 potassium,Sulotroban potassium(72131-33-0 Free base)

Target: PPAR

Cat.No: T0839

Synonym: 酮基布洛芬,RP-19583,酮洛芬

Target: Apoptosis, COX, MRP

Cat.No: T11825

Target: PPAR

Cat.No: T0212

Synonym: 塞曲司特,AA 2414,ABT-001

Target: COX, Prostaglandin Receptor, PPAR

Cat.No: T2396

Synonym: BAY u3405,雷马曲班

Target: GPR, Prostaglandin Receptor, PPAR

(R)-(+)-Bay-K-8644

Cat.No: TQ0145

Synonym: (R)-(+)-Bay K 8644

Target: Calcium Channel, PPAR

Cat.No: T1002

Synonym: Ultradol,AY-24236,依托度酸,Etodolic acid,Lodine

Target: Retinoid Receptor, COX

Cat.No: T68086

Target: Thrombin

Cat.No: T68130

Synonym: SKF 104353 Z2,SKF 104353

Target: Leukotriene Receptor

Cat.No: T67959

Target: Thrombin, Serine Protease

Cat.No: T34986

Synonym: UK-14819,UK14819

Cat.No: T70936

Cat.No: T24298

Synonym: L-641953,L641953

Cat.No: T22896

Target: Others

Cat.No: T68199

Cat.No: T68754

KDI-792 hydrochloride

Cat.No: T71027

Cat.No: T70541

Cat.No: T71511

Cat.No: T23670

Synonym: AH22921,AH-22921

Indobufen sodium

Cat.No: T68287

Cat.No: T15252

Synonym: Etherylate,Eterylate

Target: Others

Cat.No: T25710

Synonym: LG-82-4-01,L82401,Lg-82401,LG82-4-01

Cat.No: T70871

Cat.No: T70966

Cat.No: T28176

Synonym: Y9179,Y-9179,Ekonal,Y 9179

Cat.No: T70561

Cat.No: T70737

Cat.No: T71568

Cat. No.	Product Name	Target	Signaling Pathways
T2964	2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside 芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols	Others	Others
	2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside (Astragalus polyphenols) 是分离自蓼属植物物种的根中，对5-HETE、HHT、thromboxane B2的形成具有抑制作用。
TN1957	Mulberrofuran Q MulberrofuranQ
	Mulberrofuran Q是一种有活性的化合物，可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成，可保护神经细胞免受缺氧-缺糖（OGD）诱导的氧化应激的影响。
T7053	p-Hydroxycinnamic acid p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260	Thrombin; Endogenous Metabolite; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	p-Hydroxycinnamic acid (NSC-59260) 是常见的食用酚，可抑制血小板活性，对血栓素 B2 和前列腺素 E2 的 IC50值分别为 371 和 126 μM。
T4740	Elaidic acid 反油酸,trans-Oleic Acid	Endogenous Metabolite	Metabolism
	Elaidic acid (trans-Oleic Acid) 是在氢化植物油中发现的主要反式脂肪，能够被用作药物溶剂。在与花生四烯酸孵育的人类血小板中，反油酸抑制 HHT 和 HETE 的形成，同时诱导前列腺素和血栓素的合成。
T36831	9-Oxononanoic Acid 9-ONA	Phospholipase; CPT	Metabolism
	9-Oxononanoic Acid是一种氧化脂肪酸，由亚油酸自氧化形成，它能提高磷脂酶 A2（PLA2）的活性，并增加离体人体血浆中血栓素 B2 的生成。9-Oxononanoic Acid 能减少肝脏新脂肪酸的合成，并提高大鼠肝脏肉碱棕榈酰转移酶（β-氧化的标志物）的活性。
TN5939	Glutinone 赤杨酮,5-Glutinen-3-one
	Glutinone (IC50=24 microM) shows a significant effect on thromboxane B2 (TXB2)-release induced by calcium ionophore in human platelets.
TN2040	Panaxynol	BCL; Caspase; HIF	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Proteases/Proteasome
	Panaxynol is the most potent antiplatelet agent in ginseng and its mechanism of action is chiefly due to the inhibition of thromboxane formation.
TMA1944	Protopine hydrochloride	EGFR; cAMP	Angiogenesis; GPCR/G Protein; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Protopine has antiplatelet effects,which is due to inhibition on thromboxane formation and phosphoinositides breakdown and then lead to the decrease of intracellular calcium concentration.Protopine seems to inhibit the heterotypic cell adhesion between MD
TN4586	Mulberrofuran A	COX	Immunology/Inflammation; Neuroscience
	Mulberrofuran A can inhibit the formations of 12-hydroxy-, 8, 10-heptadecatrienoic acid (HHT) and thromboxane B2, but it can increase the formation of 12-hydroxy-5, 8, 10, 14-eicosatetraenoic acid (12-HETE).

天然产物

2,3,5,4'-Tetrahydroxystilbene 2-O-β-D-glucoside

Cat.No: T2964

Synonym: 芪多酚,2,3,4',5-Tetrahydroxystilbene 2-O-D-glucoside,2,3,5,4'-Tetrahydroxystilbene-2-O-b-D-glucopyranoside,Astragalus polyphenols

Target: Others

Mulberrofuran Q

Cat.No: TN1957

Synonym: MulberrofuranQ

p-Hydroxycinnamic acid

Cat.No: T7053

Synonym: p-Coumaric acid,p-Cumaric acid,p-Hydroxy-cinnamic acid,对羟基肉桂酸,NSC 59260

Target: Thrombin, Endogenous Metabolite, Prostaglandin Receptor

Cat.No: T4740

Synonym: 反油酸,trans-Oleic Acid

Target: Endogenous Metabolite

9-Oxononanoic Acid

Cat.No: T36831

Synonym: 9-ONA

Target: Phospholipase, CPT

Cat.No: TN5939

Synonym: 赤杨酮,5-Glutinen-3-one

Cat.No: TN2040

Target: BCL, Caspase, HIF

Protopine hydrochloride

Cat.No: TMA1944

Target: EGFR, cAMP

Mulberrofuran A

Cat.No: TN4586

Target: COX

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