首页工具

登录

搜索结果

Search Results for " tetracyclic "

15

抑制剂 & 化合物

12

天然产物

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name	Target	Signaling Pathways
T0172	Maprotiline hydrochloride Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil	5-HT Receptor; Adrenergic Receptor; AChR; Norepinephrine; Autophagy; Histamine Receptor	Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Maprotiline hydrochloride (Psymion) 是一种桥环四环类抗抑郁药，是去甲肾上腺素重吸收抑制剂。
T21428	Mianserin Lantanon,Lumin,Norval,Lerivon,Depnon	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mianserin 是H1受体反向激动剂，是四环抗抑郁药(TeCA)治疗家族中的一种精神活性化合物，具有抗抑郁、抗焦虑、止吐、促氧、催眠和抗组胺作用，可作为去甲肾上腺素和特定的血清素联合用药能治疗抑郁症。
T0137	Mirtazapine 米氮平,6-Azamianserin,Org3770	Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mirtazapine (6-Azamianserin) 是一种有效的具有口服活性的去甲肾上腺素能和特异性血清素能抗抑郁剂 (NaSSA)。它也是一种5-HT2、5-HT3、组胺 H1 受体和 α2-肾上腺素受体拮抗剂，pKi 值分别为 8.05、8.1、9.3 和 6.95。
T33215	Masticadienediol
	Masticadienediol is a tetracyclic triterpene.
T26415	A 31472 A31472,A-31472
	A 31472 is a tetracyclic spiro amine that has affinity for dopamine D-2 receptors.
T28666	Savoxepin mesylate CGP-19486A,CGP 19486A,Savoxepin mesilate
	Savoxepin mesylate, a tetracyclic cyano-dibenzoxepino-azepine derivative, has potent antidopaminergic activity.
T32365	Kaurene
	Kaurene is a tetracyclic diterpene.
T30108	Aptazapine maleate CGS7525A,CGS-7525A,CGS 7525A
	Aptazapine (CGS 7525A) is a tetracyclic antidepressant (TECA) that is a potent α2-adrenergic receptor antagonist and has also been shown to act as a 5-HT2 receptor antagonist and an H1 receptor reverse agonist, both for serotonin reuptake or norepinephrin
T26472	A23887 A-23887,A 23887
	A23887 is a potentially neuroleptic tetracyclic spiro amine that has affinity for dopamine D-2 receptors.
T11744	KB-5246	Ras	GPCR/G Protein; MAPK
	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
T68924	Citatepine
	Citatepine is a tetracyclic dopamine antagonist acting strongly antidopaminergic opposed to antiserotonergic. Some anticholinergic activity.
T37161	8-hydroxy Amoxapine
	8-hydroxy Amoxapine is a metabolite of the tetracyclic antidepressant amoxapine .1,2 1.Johnson, S.M., Nygard, G., and Khalil, S.K.Isocratic liquid chromatographic method for the determination of amoxapine and its metabolitesJ. Pharm. Sci.73(5)696-699(1984) 2.Tasset, J.J., and Pesce, A.J.Amoxapine in human overdoseJ. Anal. Toxicol.8(3)124-128(1984)
T63931	Lp-PLA2-IN-9
	Lp-PLA2-IN-9 (compound 17) 是一种四环嘧啶酮化合物，一种有效的Lp-PLA2抑制剂，能够作用于 rhLp-PLA2 (pIC50: 10.1)。Lp-PLA2-IN-9 对神经退行性疾病表现出研究潜力。
T63633	Lp-PLA2-IN-6
	Lp-PLA2-IN-6 是四环嘧啶酮化合物，是 Lp-PLA2 的有效抑制剂，能够作用于 rhLp-PLA2 (pIC50: 10.0)。Lp-PLA2-IN-6 对神经退行性疾病表现出研究潜力。
T83019	Antiproliferative agent-38
	Antiproliferative agent-38（com 18）是一个多环化合物，其中最关键的环氮部分（可能为喹啉）不能进行N-烷基化反应。此化合物不具备抗疟疾活性，也不具有抗癌细胞增殖活性。

化合物

Maprotiline hydrochloride

Cat.No: T0172

Synonym: Maprotiline HCl,盐酸马普替林,Psymion,Deprilept,Ludiomil

Target: 5-HT Receptor, Adrenergic Receptor, AChR, Norepinephrine, Autophagy, Histamine Receptor

Cat.No: T21428

Synonym: Lantanon,Lumin,Norval,Lerivon,Depnon

Target: Histamine Receptor

Cat.No: T0137

Synonym: 米氮平,6-Azamianserin,Org3770

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Masticadienediol

Cat.No: T33215

Cat.No: T26415

Synonym: A31472,A-31472

Savoxepin mesylate

Cat.No: T28666

Synonym: CGP-19486A,CGP 19486A,Savoxepin mesilate

Cat.No: T32365

Aptazapine maleate

Cat.No: T30108

Synonym: CGS7525A,CGS-7525A,CGS 7525A

Cat.No: T26472

Synonym: A-23887,A 23887

Cat.No: T11744

Target: Ras

Cat.No: T68924

8-hydroxy Amoxapine

Cat.No: T37161

Cat.No: T63931

Cat.No: T63633

Antiproliferative agent-38

Cat.No: T83019

Cat. No.	Product Name	Target	Signaling Pathways
TN1006	Tirucallol	NOS; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	Tirucallol 是一种四环三萜，分离自Euphorbia lacteal 乳胶。它能够抑制小鼠模型中的耳部水肿，并阻碍脂多糖刺激的巨噬细胞中亚硝酸盐的产生，具有局部消炎作用。
T5S0658	Corynoxine 柯诺辛,柯诺辛碱	Autophagy	Autophagy
	Corynoxine 是从大叶钩藤中分离出的一种四环羟吲哚生物碱。它是一种自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。
T5S1133	Ganoderic acid D 灵芝酸D,灵芝酸 D	Apoptosis; Sirtuin	Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair
	Ganoderic acid D 是高度氧化的四环三萜，是灵芝的主要活性成分，可诱导 HeLa 人宫颈癌细胞凋亡。它上调 SIRT3的蛋白质表达并通过 SIRT3 诱导脱乙酰化的亲环蛋白 D 。它抑制结肠癌细胞的能量重编程，包括结肠癌细胞中的葡萄糖摄取，乳酸、丙酮酸和乙酰辅酶的产生。
TN2341	Cucurbitacin Q1 葫芦素F-25-乙酸酯,葫芦素Q1	Others	Others
	Cucurbitacin Q1 是一种天然的四环三萜，来源于Cucumis prophetarum。
T4970	LANOSTEROL 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol	Endogenous Metabolite	Metabolism
	Lanosterol (3β-Hydroxy-8,24-lanostadiene) 是胆固醇合成的中间产物，能够诱导胆固醇合成的速率控制酶 HMG-CoA 还原酶的泛素化和降解。Lanosterol 可以抑制神经退行性疾病相关错误折叠蛋白的聚集和细胞毒性。
T0783	Mianserin hydrochloride Mianserin HCl,Org GB 94,盐酸米安色林,ORG GB-94 HCl	Dopamine Receptor; 5-HT Receptor; Opioid Receptor; Adrenergic Receptor; Histamine Receptor	Endocrinology/Hormones; GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Mianserin hydrochloride (Org GB 94) 是一种有抗抑郁活性的 H1 受体反向激动剂。
T5737	euphol	Others; Lipase; Endogenous Metabolite	Metabolism; Others
	Euphol 是从Euphorbia tirucalli 的汁液中分离出来的四环三萜醇，具有抗炎和免疫调节作用，口服具有活力。它通过能够逆机制抑制单酰基甘油脂肪酶 (MGL) 的特性，IC50=315 nM。外周 MGL 抑制能够调节内源性大麻素系统从而阻止炎症性疼痛的发展。
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T31910	Ganoderiol A (+)-Ganoderiol A
	Ganoderiol A is a tetracyclic triterpene extracted from Ganoderma amboinense.
T12517	Polyketomycin	Others	Others
	Polyketomycin is a tetracyclic quinone glycoside antibiotic isolated from Streptomyces sp. or Streptomyces diastatochromogenes, has antibacterial, anticancer, antimalarial activities.
T75438	Corynoxine hydrochloride
	Corynoxine hydrochloride 是一种从Uncaria macrophylla 中分离出的四环羟吲哚生物碱。Corynoxine hydrochloride 是一种天然的自噬增强剂，可通过Akt/mTOR 途径促进 α-突触核蛋白的清除。
T72533	4-Deoxy-4α-phorbol
	4-Deoxy-4α-phorbol 是在 E. desmondi 中发现的一种四环二萜类物质。4-Deoxy-4α-phorbol 可用于半合成 HIV-1诱导的 MT-4 细胞的细胞病理学效应抑制剂和 4α-山梨醇酯。

天然产物

Cat.No: TN1006

Target: NOS, NO Synthase, Prostaglandin Receptor

Cat.No: T5S0658

Synonym: 柯诺辛,柯诺辛碱

Target: Autophagy

Ganoderic acid D

Cat.No: T5S1133

Synonym: 灵芝酸D,灵芝酸 D

Target: Apoptosis, Sirtuin

Cucurbitacin Q1

Cat.No: TN2341

Synonym: 葫芦素F-25-乙酸酯,葫芦素Q1

Target: Others

Cat.No: T4970

Synonym: 羊毛甾醇,3β-Hydroxy-8,24-lanostadiene,8,24-Lanostadien-3β-ol

Target: Endogenous Metabolite

Mianserin hydrochloride

Cat.No: T0783

Synonym: Mianserin HCl,Org GB 94,盐酸米安色林,ORG GB-94 HCl

Target: Dopamine Receptor, 5-HT Receptor, Opioid Receptor, Adrenergic Receptor, Histamine Receptor

Cat.No: T5737

Target: Others, Lipase, Endogenous Metabolite

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Cat.No: T31910

Synonym: (+)-Ganoderiol A

Cat.No: T12517

Target: Others

Corynoxine hydrochloride

Cat.No: T75438

4-Deoxy-4α-phorbol

Cat.No: T72533

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼