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56

抑制剂 & 化合物

4

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T64771	Amido Black 10B Amido Black Staining Solution 2X,Naphthol Blue Black
	Amido Black 10B (Naphthol Blue Black) 是一种给蛋白质染色的剧毒偶氮染料，常用于给聚丙烯酰胺凝胶、琼脂糖凝胶上蛋白质的染色。
T9750	Cetyldimethylethylammonium Bromide	Others	Others
	Cetyldimethylethylammonium Bromide 可用于诱导细胞外分泌 β-半乳糖苷酶。
T23173	Ponceau S Acid Red 112	Others	Others
	Ponceau S (Acid Red 112) 是一种偶氮类蛋白染料，常用作蛋白定量的斑点印迹测定法的染色剂。
TD0098	Direct Red 80 Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80	Others	Others
	Direct Red 80 (Sirius Red) 是一种聚偶氮染料，在降解时不会释放联苯胺，比许多传统的直接染料更安全，主要用于胶原蛋白和淀粉样蛋白的染色方法。
T19067	Thionin acetate 硫堇(劳氏紫),Thionine acetate	Others	Others
	Thionin acetate (Thionine acetate) 是一种异染阳离子组织学染料，普遍用于生物学染色。
T19027	Methyl Blue	Others	Others
	Methyl blue 是一种三氨基三苯甲烷染料。它在多色染色法中被广泛用作抗菌染料，并能够应用于组织学和微生物学染色溶液。它已被用作研究各种催化剂对染料光降解影响的模型。
T20913	Light Green SF Yellowish Acid Green 5,C.I. Acid Green 5,C.I. 42095
	Light Green SF Yellowish (Acid Green 5) 是一种碱性染色剂，可用于动物组织染色，可用于植物组织学中作细胞质和纤维染色。
T19011L	Hoechst 34580 xHCl(23555-00-2(free base) HOE 34580 xHCl	Beta Amyloid	Neuroscience
	Hoechst 34580 xHCl(23555-00-2(free base) 是一种可渗透细胞的荧光染料，用于染色 DNA 和细胞核。
T19071	TMB BM blue,3,3',5,5'-四甲基联苯胺,Sure Blue TMB	Others	Others
	TMB (BM blue) 是一种免疫组化及 ELISA 的显色底物。
T18994	Fuchsine base monohydrochloride 碱性品红,Magenta base monohydrochloride,Rosaniline Base monohydrochloride,Basic Fuchsin monohydrochloride	Others	Others
	Fuchsine base monohydrochloride (Rosaniline Base monohydrochloride) 是品红染料，可用作石碳酸-品红的抗酸染色。
T19512	Phalloidin	Others	Others
	Phalloidin 是一种在鹅膏菌中发现的双环七肽，参与 F-肌动蛋白染色。 Phalloidin 是一种肌动蛋白不可逆聚合成微丝的化合物。Phalloidin 可干扰细胞的运动和生长，可用于标记脑血管。
TD0093	Oil Red O	Others	Others
	Oil Red O 用于制备染色溶液，可用于检测组织学冷冻切片中的脂质。
T19937	Pyronine B NSC44690,NSC-44690,NSC 44690	Autophagy	Autophagy
	Pyronine B (NSC 44690) 是一种相对荧光团亮度较低的荧光团，也是小型疏水性 (SH) 蛋白通道抑制剂，可用于细菌和霉菌的染色，参与分光光度法测定超痕量钌。
T19069	TMB dihydrochloride 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride	Others	Others
	TMB dihydrochloride (Sure Blue TMB dihydrochloride) 是一种免疫组化和 ELISA 的显色底物。
T19057	Solvent Blue 35 Sudan Blue II,溶剂蓝35,溶剂蓝 35,Oil Blue 35	Others	Others
	Solvent Blue 35 (Sudan Blue II) 是一种可用于着色醇类和烃基溶剂的染料。它能够作用于染色动物组织中的甘油三酯。
T19084	1-Naphthyl acetate	AChE	Neuroscience
	1-Naphthyl acetate 是一种有吸引力的生色底物，用于检测红细胞乙酰胆碱酯酶的活性。它具有检测有机磷农药中毒的潜力。
T19032	Nitro blue tetrazolium chloride NBT,氯化硝基四氮唑兰	NO Synthase	Immunology/Inflammation
	Nitro blue tetrazolium chloride (NBT) 是一种脱氢酶底物，能够与碱性磷酸酶底物 BCIP 一起用于 western blotting 和免疫组化染色。
T2130	Propidium Iodide PI,碘化丙啶,碘化丙啶（PI）	Others	Others
	Propidium Iodide (PI) 是一种可用于细胞染色的红色荧光染料，适用于荧光显微镜、共聚焦显微镜、流式细胞仪以及荧光计分析。在水溶液中，Propidium Iodide 的 Ex/Em 为 493/636 nm；与核酸结合后，PI-核酸的 Ex/Em 变为 535/617 nm，同时荧光信号增强 20-30 倍。
T34625	Setocyanine NSC57698,NSC-57698,NSC 57698	Others	Others
	Setocyanine can be used in the staining DNA.
T10810	Chromomycin A3	Others	Others
	Chromomycin A3 is an aureolic acid-type antitumor antibiotic. Chromomycin A3 has a variety of utilities as a staining agent for human sperm chromatin, autophagy inducing agent, and apoptosis inhibitor.
T20752	Biebrich scarlet NSC-79710,NSC79710,NSC 79710
	Biebrich scarlet is a scarlet dye, it has been used in Masson’s trichrome stain for the staining of collagen. It has also been used for the staining of eosinophil.
T19013	Hoechst 34580 tetrahydrochloride Hoechst 34580 tetrahydrochloride (23555-00-2 free base),HOE 34580 tetrahydrochloride	Beta Amyloid	Neuroscience
	Hoechst 34580 tetrahydrochloride, a cell-permeable fluorescent dye, is used for staining DNA and nuclei.
T40644	DL-Leucyl-DL-phenylalanine	Others	Others
	DL-Leucyl-DL-phenylalanine, a dipeptide, serves as a substrate for detecting two distinct regions of dipeptidase staining on gels in both Drosophila simulans and Drosophila melanogaster.
T19070	TMB monosulfate Sure Blue TMB monosulfate,BM blue monosulfate	Others	Others
	TMB monosulfate (BM blue monosulfate) is a chromogenic substrate used in staining procedures in immunohistochemistry and a visualizing reagent used in ELISA.
T22412	Quinacrine hydrochloride hydrate Mepacrine Dihydrochloride Dihydrate,米帕林盐酸盐,Quinacrine Dihydrochloride Dihydrate	Others	Others
	Quinacrine, a dye of the acridine family, has been widely used as staining agents for DNA and model compounds for intercalators in numerous biophysical studies. It is also an antimalarial drug.
T19011	Hoechst 34580 HOE 34580	Beta Amyloid	Neuroscience
	Hoechst 34580 (HOE 34580) 是细胞渗透性荧光染料，可用于 DNA 和核染色。
T18952	Cy7 DiC18	Others	Others
	Cy7 DiC18 is a near-infrared, lipophilic fluorescent dye used for staining membranes.
T35151	X-34 X 34
	X-34 is a highly fluorescent amyloid-specific dye, exhibiting inclusion bodies that were amyloid-like aggregates by virtue of their staining.
T32091	Hofman's Violet
	Hoffman's violet is specific stains for animal chromosomes. Iodinated alcohol after staining can be substituted with various acids, both organic as well as inorganic, all of which act as trapping agent preventing leaching of the dye that binds with the ch
T29840	Alcian blue
	Alcian blue is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
T30662	C.I. 74240 NSC 324570,NSC-324570,NSC324570
	C.I. 74240 is a copper-containing dye used as a gelling agent for lubricants, for staining of bacteria and for the dyeing of histiocytes and fibroblasts in vivo.
T19034	Nile Blue A sulfate Nile blue sulfate	Others	Others
	Nile Blue A (Nile blue sulfate) is used as the differentiation of melanins and lipofuscins. It is also useful for staining fats and the preparation of an amperometric glucose sensor.
T82620	DAB tetrahydrochloride dihydrate 3,3-Diaminobenzidine tetrahydrochloride dihydrate
	3,3-Diaminobenzidine tetrahydrochloride dehydrate 作为染料，在组织化学（HC）及免疫组织化学（IHC）中应用广泛。该化合物主要用于过氧化物酶体染色和线粒体细胞色素c氧化酶活性的检测。
TD0080	Super Texas Red,SE
	Texas Red is a Red fluorescent dye, purple-red powder, more stable.Texas Red is also a derivative of Rhodamine, which also includes Rhodamine red-x (RRX), TRITC, etc.As a Red dye, Texas Red can be used in the histochemical staining of cell samples, which
T82726	Chromotrope 2R
	Chromotrope 2R 是一种用于蛋白质定量的显色分析探针，其特征在于能够将碱性蛋白染成红色，吸收光谱在pH调整下呈现从501.6nm向567nm的红移特性。
T82016	Janelia Fluor® 526, SE JF526, SE,JF526, NHS
	Janelia Fluor 526, SE (JF526,SE) 是带有 NHS 酯基的黄色荧光染料，作为荧光配体的多功能平台，适用于遗传编码的自标记蛋白以及内源性结构染色。
T18948	Cy5-DBCO DBCO-Sulfo-Cy5	Others	Others
	Cy5-DBCO (DBCO-Sulfo-Cy5) is a near-infrared (NIR) red fluorescent dye (λabs: 646 nm, λem: 670 nm). Cy5-DBCO is not suitable for staining intracellular components of the permeabilized cells because it may exhibit a high background.
TD0002	CelRed nucleic acid gel stain 10,000× concentrate in water
	1) Non-toxicity: The unique oiliness and high molecular weight characteristics of CelRed prevent it from penetrating cell membranes into cells, and Ames test results also show that the mutagenicity of CelRed dye is much less than EB. 2) High sensitivity:
T15790	Lucifer Yellow CH dilithium salt
	Lucifer Yellow CH dilithium salt 是一种荧光染料，可常用于选择性染色和研究光动力破坏真核细胞和亚细胞结构。
T78459	Leishman's stain
	Leishman's stain为外周血和骨髓涂片染色的关键试剂，染色结果呈淡蓝灰色至深蓝色（在油镜下观察）。
T39531	RAD16-I hydrochloride RAD16-I hydrochloride
	RAD16-I hydrochloride is a self-assembling peptide with nanofibrous morphology that provides an optimal microenvironment for the proliferation and differentiation of human mesenchymal stem cells (hMSC) into chondrocytes. This peptide, known as RAD16-I, has been extensively studied and serves as a model to assess the amyloid-like staining properties of self-assembling peptide nanofibers (SAPNFs).
T75365	FIM-1
	FIM-1，一种荧光PKC（蛋白激酶C）探针，专用于线粒体染色，兼具ATP竞争催化位点抑制剂的功能，有效抑制PKC。
T40132	Insulin β Chain Peptide (15-23)
	Insulin β Chain Peptide (15-23), also referred to as INS, is an insulin-derived peptide that is specifically recognized by islet-associated T cells. The tetramer of Insulin β Chain Peptide (15-23) effectively stained the INS-reactive CTL clone G9C8; however, neither this tetramer nor the negative control tetramer (TUM) exhibited staining on the splenic CD8+ T cells obtained from NOD or 8.3-TCRαβ transgenic NOD mice.
TD0005	SYBR GREEN II SUPER Green II RNA gel stain 10,000× concentrate in DMSO (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）
	1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity. 2) High sensitivity: at least 100pg ssDNA or RNA can be detected, which is 25 ~ 100 times higher than EB staining. 3) High SIGNal-to-noise ratio: the sample fluorescence signal is strong, while the background signal is low. 4) Simple operation: like EB, the dye does not degrade in the prefabricated gel and electrophoresis process;The dyeing process after electrophoresis takes only 30 minutes without decolor...
T71287	CDKI-83	Others	Others
	CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be devel...
T37756	Phloxine B
	Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 μg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro. Phloxine B has also been shown to modulate channel activity of wild-type cystic fibrosis transmembrane conductance regulator chloride channels (CFTR; Ki = 38 μM) and mutant delta F508 CFTR ...
T73604	Methyl Green zinc chloride
	Methyl Green zinc chloride为高效荧光染料，主要用于细胞DNA及电泳凝胶染色。该化合物能直接通过显微镜及流式细胞术进行活性测定，其活性峰值位于633至677 nm。储存应避光。
T78446	Phenosafranine
	Phenosafranine是一种吩嗪染料，具有较高的三链RNA结合亲和力，相较于双链RNA。该染料通过嵌入机制与这两种RNA结合。Phenosafranine用途包括植物细胞染色，以及血红蛋白、多巴胺、血清素等的检测。
T78463	Calconcarboxylic acid
	Calconcarboxylic acid是一种偶氮染料，用作银离子敏化剂，对SDS-PAGE凝胶中的蛋白质条带进行染色。该染料通过与银形成银-染料复合物，促进银与蛋白质的结合，并与甲醛反应增强银离子还原为金属银的过程。
T69196	AG-012986	Others	Others
	AG-012986 is a multitargeted cyclin-dependent kinase (CDK) inhibitor active against CDK1, CDK2, CDK4/6, CDK5, and CDK9, with selectivity over a diverse panel of non-CDK kinases. AG-012986 showed antiproliferative activities in vitro with IC(50)s of <100 nmol/L in 14 of 18 tumor cell lines. In vivo, significant antitumor efficacy induced by AG-012986 was seen (tumor growth inhibition, >83.1%) in 10 of 11 human xenograft tumor models. AG-012986 also showed dose-dependent retinoblastoma Ser(795) hy...

化合物

Amido Black 10B

Cat.No: T64771

Synonym: Amido Black Staining Solution 2X,Naphthol Blue Black

Cetyldimethylethylammonium Bromide

Cat.No: T9750

Target: Others

Cat.No: T23173

Synonym: Acid Red 112

Target: Others

Cat.No: TD0098

Synonym: Sirius Red,天狼猩红,Sirius Red F 3BA,C.I. direct red 80

Target: Others

Thionin acetate

Cat.No: T19067

Synonym: 硫堇(劳氏紫),Thionine acetate

Target: Others

Cat.No: T19027

Target: Others

Light Green SF Yellowish

Cat.No: T20913

Synonym: Acid Green 5,C.I. Acid Green 5,C.I. 42095

Hoechst 34580 xHCl(23555-00-2(free base)

Cat.No: T19011L

Synonym: HOE 34580 xHCl

Target: Beta Amyloid

Cat.No: T19071

Synonym: BM blue,3,3',5,5'-四甲基联苯胺,Sure Blue TMB

Target: Others

Fuchsine base monohydrochloride

Cat.No: T18994

Synonym: 碱性品红,Magenta base monohydrochloride,Rosaniline Base monohydrochloride,Basic Fuchsin monohydrochloride

Target: Others

Cat.No: T19512

Target: Others

Cat.No: TD0093

Target: Others

Cat.No: T19937

Synonym: NSC44690,NSC-44690,NSC 44690

Target: Autophagy

TMB dihydrochloride

Cat.No: T19069

Synonym: 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride

Target: Others

Solvent Blue 35

Cat.No: T19057

Synonym: Sudan Blue II,溶剂蓝35,溶剂蓝 35,Oil Blue 35

Target: Others

1-Naphthyl acetate

Cat.No: T19084

Target: AChE

Nitro blue tetrazolium chloride

Cat.No: T19032

Synonym: NBT,氯化硝基四氮唑兰

Target: NO Synthase

Propidium Iodide

Cat.No: T2130

Synonym: PI,碘化丙啶,碘化丙啶（PI）

Target: Others

Cat.No: T34625

Synonym: NSC57698,NSC-57698,NSC 57698

Target: Others

Cat.No: T10810

Target: Others

Biebrich scarlet

Cat.No: T20752

Synonym: NSC-79710,NSC79710,NSC 79710

Hoechst 34580 tetrahydrochloride

Cat.No: T19013

Synonym: Hoechst 34580 tetrahydrochloride (23555-00-2 free base),HOE 34580 tetrahydrochloride

Target: Beta Amyloid

DL-Leucyl-DL-phenylalanine

Cat.No: T40644

Target: Others

TMB monosulfate

Cat.No: T19070

Synonym: Sure Blue TMB monosulfate,BM blue monosulfate

Target: Others

Quinacrine hydrochloride hydrate

Cat.No: T22412

Synonym: Mepacrine Dihydrochloride Dihydrate,米帕林盐酸盐,Quinacrine Dihydrochloride Dihydrate

Target: Others

Cat.No: T19011

Synonym: HOE 34580

Target: Beta Amyloid

Cat.No: T18952

Target: Others

Cat.No: T35151

Synonym: X 34

Hofman's Violet

Cat.No: T32091

Cat.No: T29840

Cat.No: T30662

Synonym: NSC 324570,NSC-324570,NSC324570

Nile Blue A sulfate

Cat.No: T19034

Synonym: Nile blue sulfate

Target: Others

DAB tetrahydrochloride dihydrate

Cat.No: T82620

Synonym: 3,3-Diaminobenzidine tetrahydrochloride dihydrate

Super Texas Red,SE

Cat.No: TD0080

Cat.No: T82726

Janelia Fluor® 526, SE

Cat.No: T82016

Synonym: JF526, SE,JF526, NHS

Cat.No: T18948

Synonym: DBCO-Sulfo-Cy5

Target: Others

CelRed nucleic acid gel stain *10,000× concentrate in water*

Cat.No: TD0002

Lucifer Yellow CH dilithium salt

Cat.No: T15790

Leishman's stain

Cat.No: T78459

RAD16-I hydrochloride

Cat.No: T39531

Synonym: RAD16-I hydrochloride

Cat.No: T75365

Insulin β Chain Peptide (15-23)

Cat.No: T40132

Cat.No: TD0005

Synonym: SUPER Green II RNA gel stain *10,000× concentrate in DMSO* (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）

Cat.No: T71287

Target: Others

Cat.No: T37756

Methyl Green zinc chloride

Cat.No: T73604

Cat.No: T78446

Calconcarboxylic acid

Cat.No: T78463

Cat.No: T69196

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN2364	Sudan IV 苏丹红Ⅳ,Solvent Red 24,C.I. 26105	Others	Others
	Sudan IV (Solvent Red 24) 是脂溶性重氮染料，可用于冰冻或石蜡切片上，能够将脂类、甘油三酯和脂蛋白染色。
TN6926	Paeonoside	Others	Others
	Paeonoside 发现与P. suffruticosa 中，具有生物活性，可以促进成骨细胞分化过程中的伤口愈合和迁移。Paeonoside 具有一定的抗糖尿病活性，可防止脓毒症和败血症引起的死亡。Paeonoside 对 MC3T3-E1细胞的前成骨细胞没有细胞毒性作用，以剂量依赖性的方式显著恢复伤口区域并促进细胞迁移和促进碱性磷酸酶（ALP）染色及其活性。
T4S0797	Berberine 小檗碱,Berberin,Umbellatine,黄连素	Reactive Oxygen Species; Topoisomerase; Endogenous Metabolite; Antibacterial; Antibiotic; Autophagy	Autophagy; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB
	Berberine (Umbellatine) 属于生物碱类天然产物，可以激活 AMPK、抑制 DNA 拓扑异构酶、诱导 ROS 生成。Berberine 具有抗肿瘤、抗菌、降血糖、降血脂等生物学活性。
TN4046	Excisanin A	MMP; FAK; PARP; GSK-3; NF-κB; Wnt/beta-catenin; Akt; Caspase; PI3K; Prostaglandin Receptor; JNK	Angiogenesis; Apoptosis; Chromatin/Epigenetic; Cytoskeletal Signaling; DNA Damage/DNA Repair; GPCR/G Protein; Immunology/Inflammation; MAPK; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Stem Cells; Tyrosine Kinase/Adaptors
	ExcisaninA may be a potent inhibitor of AKT signaling pathway in tumor cells, it can inhibit invasion by suppressing MMP-2 and MMP-9 expression, it may be a potential anti-metastatic chemotherapeutic agent for the treatment of breast cancer. Excisanin A shows comparable inhibitory effects on the LPS-induced production of NO and PGE2, and activation of NF-kappaB without affecting cell viability.Excisanin A induces apoptosis in colon cancer cell line SW620 as determined by Annexin V staining, the ...

天然产物

Cat.No: TN2364

Synonym: 苏丹红Ⅳ,Solvent Red 24,C.I. 26105

Target: Others

Cat.No: TN6926

Target: Others

Cat.No: T4S0797

Synonym: 小檗碱,Berberin,Umbellatine,黄连素

Target: Reactive Oxygen Species, Topoisomerase, Endogenous Metabolite, Antibacterial, Antibiotic, Autophagy

Cat.No: TN4046

Target: MMP, FAK, PARP, GSK-3, NF-κB, Wnt/beta-catenin, Akt, Caspase, PI3K, Prostaglandin Receptor, JNK

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