43
7
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4542 |
Clonixin
Clonixic acid,氯尼辛 |
Others | Others |
Clonixin (Clonixic acid) 是一种非甾体抗炎药,具有口服活性。 | |||
T16240 |
N,N'-Diacetyl-L-cystine
(Ac-Cys-OH)2,DiNAC |
Others | Others |
N,N'-Diacetyl-L-cystine (DiNAC) 是一种具有免疫调节特性的 N-乙酰基半胱氨酸的二硫二聚体。它在高脂血症兔中也具有抗动脉粥样硬化的作用。它是啮齿类动物中接触敏感/迟发型超敏反应的有效口服活性调节剂。 | |||
T24121 |
GW438014A
GW 438014 A,GW-438014-A |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
GW438014A 是一种有效且具有选择性的 NPY-Y5 受体拮抗剂。GW438014A 对食物摄入并减少肥胖啮齿动物的体重增加具有抑制作用。 | |||
T4351 |
DAMGO
Dagol,DAGO,RX-783006 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
DAMGO (DAGO) 是一种阿片受体激动剂,Kd 值为 3.46 nM。它能够影响啮齿动物的运动活动,可作为镇痛剂。 | |||
T16816 |
S 18986
|
GluR | Neuroscience |
S 18986 is a selective, orally active, brain penetrant positive allosteric modulator of AMPA-type receptors, showcasing cognitive-enhancing properties in rodents. It induces the release of noradrenaline and acetylcholine in the rat hippocampus, leading to enhanced object-recognition memory. | |||
T21380 |
Pravadoline
WIN 48098-6,WIN48098-6,普拉朵林,WIN-48098-6 |
Cannabinoid Receptor | GPCR/G Protein |
Pravadoline (WIN48098-6) 是一种 cannabinoid 受体激动剂。 Pravadoline 抑制小鼠大脑中的 PGs 合成,并在受到各种热、化学和机械伤害性刺激的啮齿动物中显示出镇痛活性。 | |||
T60221 |
Tabernanthalog
TBG |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Tabernanthalog (TBG) 是一种5-HT2A 激动剂。在啮齿类动物中,Tabernanthalog 已被发现可促进结构神经可塑性并产生抗抑郁作用。 | |||
T28531 |
Facinicline hydrochloride
RG3487 |
5-HT Receptor; AChR | GPCR/G Protein; Neuroscience |
Facinicline hydrochloride (RG3487) 是一种口服有效的烟碱α7 receptor 部分激动剂,对人 nAChR 的 Ki 值为 6 nM。它可改善啮齿类动物的认知和感觉运动门控。它与5-HT3受体结合的 Ki 为 1.2 nM。 | |||
T8862 |
ML 254
|
GluR | Neuroscience |
是一种化学合成中的砌块 | |||
T21556 |
Hydroxytacrine maleate
Velnacrine maleate,HP 029 maleate |
AChE | Neuroscience |
Hydroxytacrine maleate (Velnacrine maleate) 是一种胆碱酯酶(cholinesterase) 抑制剂,可增强啮齿动物的记忆力,可用于研究阿尔茨海默型老年性痴呆(SDAT)。 | |||
T13318 |
VU0650786
|
GluR | Neuroscience |
VU0650786 是能透过中枢神经系统的,选择性谷氨酸受体亚型 3 的一种负变构调节剂,IC50值为 392 nM,有抗抑郁和抗焦虑活性。 | |||
T7720 |
CGP 37849
CGP-37849,CGP37849 |
NMDAR; iGluR | Membrane transporter/Ion channel; Neuroscience |
CGP 37849 是一种竞争性口服活性 N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂((Ki = 35 nM)),具有有效性。CGP 37849 是啮齿动物的抗惊厥药,也具有抗抑郁和抗焦虑的特性。 | |||
T25672 |
Lesopitron
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Lesopitron 是一种具有突触前和突触后5-HT1A 激动剂活性的抗焦虑剂,在大鼠社会交往和狨猴焦虑模型中比5-HT1A 激动剂更有效。Lesopitron 能对抗苯二氮卓类药物戒断引起的啮齿动物的焦虑且急性毒性很低,不会增强酒精或巴比妥类药物的作用。 | |||
T67955 |
Ensaculin
Anseculin |
||
Ensaculin (Anseculin) 是一种用哌嗪部分取代的新型苯并吡喃酮,在正常和人工遗忘啮齿动物的被动和条件回避范式中显示出记忆增强作用。它在NMDA 毒性模型中表现出神经保护活性,在原代培养的大鼠脑细胞中表现出神经营养作用。Ensaculin 可用于治疗痴呆。 | |||
T8720 |
PRX-07034 hydrochloride
PRX-07034 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
PRX-07034 hydrochloride 是一种有效的高度选择性5-HT6受体拮抗剂,Ki 为 4-8 nM,IC50为 19 nM,可用于增强工作记忆和认知灵活性的研究。 | |||
TF0106 |
Cholesteryl Hemisuccinate Tris Salt
|
Apoptosis | Apoptosis |
Cholesteryl Hemisuccinate Tris Salt 是一种具有保肝和抗癌活性的酸性胆固醇酯,是一种含有柴胡皂苷-d的二棕榈酰磷脂酰胆碱脂质体中的膜稳定剂,可增强顺铂的抗癌功效。Cholesteryl hemisuccinate 具有抗肿瘤活性,抑制肿瘤生长,抑制对乙酰氨基酚 (AAP) 的肝毒性,预防 AAP 诱导的肝细胞凋亡。Cholesteryl hemisuccinate 可保护啮齿动物免受对乙酰氨基酚、阿霉素、四氯化碳、氯仿和半乳糖胺的毒性作用。 | |||
T27948 |
LY-368975
LY 368975,(R)-Thionisoxetine |
||
LY-368975 is a potent and selective inhibitor of the norepinephrine (NE) reuptake site. LY-368975 reduces food consumption in rodents. | |||
T13371 | YM-53601 free base | AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
YM-53601 free base is an inhibitor of squalene synthetase which suppresses lipogenic biosynthesis and lipid secretion in rodents. | |||
T28926 |
TASP0390325
TASP-0390325,TASP 0390325 |
||
TASP0390325, a potent and orally active V1B receptor antagonist, has antidepressant and anxiolytic activities in rodents. | |||
T68676 |
Ciladopa (free base)
|
||
Ciladopa (free base) is a dopamine agonist with a similar chemical structure to dopamine. It was under investigation as an antiparkinsonian agent but was discontinued due to concerns of tumorogenesis in rodents. | |||
T29979 |
Amidantel hydrochloride
BAY-d 8815,BAY d 8815 |
||
Amidantel hydrochloride is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundw | |||
T74285 |
EDMPC
|
||
EDMPC,一种阳离子脂质,有效递送DNA至肺组织,亦用于向啮齿动物叶内递送DNA。 | |||
T81626 |
Obestatin(11-23)mouse, rat
|
||
Obestatin(11-23)mouse, rat 是多肽,涉及能量平衡调节,抑制摄食。该化合物能使啮齿类动物食量减少、体重降低、及空肠收缩。 | |||
T37416 |
Tauro-α-muricholic Acid (sodium salt)
|
||
Tauro-α-muricholic acid (TαMCA) is an antagonist of the farnesoid X receptor (FXR; IC50 = 28 μM) and a taurine-conjugated form of the murine-specific primary bile acid α-muricholic acid . TαMCA is common in rodents but has also been found in small amounts in human serum. | |||
T29979L |
Amidantel free base
BAYd 8815,BAY d8815,BAYd-8815,Amidantel,BAY d-8815,BAY d 8815 |
||
Amidantel free base is a new aminophenylamidine with an interesting anthelminthic spectrum. In rodents the compound is active against nematodes, filariae and cestodes. Of special interest is the high efficacy in dogs against hookworms and large roundworms | |||
T81336 |
PZ-1190
|
Dopamine Receptor | GPCR/G Protein; Neuroscience |
PZ-1190是一种多靶点配体,针对啮齿动物的serotonin和dopamine受体,展现出潜在的抗精神病活性。 | |||
T13691 |
Etifoxine
HOE 36-801 |
Others | Others |
Etifoxine preferentially acts on β2 or β3 subunit-containing GABAA receptors. GABAA receptor Etifoxine exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Etifoxine acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration. Etifoxine(HOE 36-801) is potentiator of GABAA receptor function in cultured neurons. | |||
T62919 | CDK9-IN-13 | ||
CDK9-IN-13 是一种有效的、选择性的 CDK 抑制剂 (IC50<3 nM)。CDK9-IN-13 在啮齿动物中的半衰期很短。 | |||
T38959 |
BMS-604992 dihydrochloride
EX-1314 dihydrochloride,BMS-604992 dihydrochloride |
||
BMS-604992 (EX-1314) dihydrochloride is a selective and orally active small-molecule agonist of the growth hormone secretagogue receptor (GHSR). It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM). Furthermore, BMS-604992 dihydrochloride has been shown to stimulate food intake in rodents. | |||
T40876 |
BMS-604992 free base
BMS-604992 free base,EX-1314 free base |
||
BMS-604992 (EX-1314) free base is a selective, orally active small-molecule growth hormone secretagogue receptor (GHSR) agonist. It exhibits high-affinity binding (k i = 2.3 nM) and potent functional activity (EC 50 = 0.4 nM). Moreover, BMS-604992 free base has the ability to stimulate food intake in rodents. | |||
T70718 |
CR-6086
|
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CR6086 is a novel, potent EP4 antagonist showing favourable immunomodulatory properties, striking DMARD effects in rodents, and anti-inflammatory activity targeted to immune-mediated inflammatory diseases and distinct from the general effects of cyclooxygenase inhibitors. CR6086 showed selectivity and high affinity for the human EP4 receptor (Ki = 16.6 nM) and functioned as a pure antagonist (half-maximal inhibitory concentration, 22 nM) on PGE2-stimulated cAMP production. | |||
T27269 |
Ensaculin HCl
KA 672,KA672,Ensaculin,Anseculin Hydrochloride,KA-672 HCl |
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Ensaculin is a NMDA antagonist and a 5HT1A agonist potentially for the treatment of Alzheimer's disease (AD). Ensaculin showed memory-enhancing effects in paradigms of passive and conditioned avoidance in both normal and artificially amnesic rodents. It e | |||
T78460 |
1-Methylpyrene
|
||
1-Methylpyrene是一种环境污染物和已知的啮齿动物致癌物,它的诱变活性依赖于CYP和磺酰转移酶(SULT)系列酶的连续活化。该化合物可诱导染色体缺失和有丝分裂障碍,可能机制为对有丝分裂纺锤体和中心粒的干扰。 | |||
T62848 |
AMG 837 hemicalcium
|
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AMG 837 hemicalcium 是一种有效的、口服具有活力的 GPR40/FFA1部分激动剂。AMG 837 hemicalcium 能够抑制 [3H]AMG 837 与人类 FFA1受体的特异性结合 (pIC50: 8.13)。AMG 837 hemicalcium 能够提高啮齿动物的胰岛素分泌,减少葡萄糖水平。 | |||
T76655 |
Prokineticin 2 Isoform 2 (human)
|
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Prokineticin 2 Isoform 2 (human) 为一下丘脑神经肽,能减少食物摄入,并在啮齿动物的体温调节与能量代谢中发挥作用。此外,Prokineticin 2 对高血糖、代谢综合征 (MetS) 及肥胖研究具有潜在价值。 | |||
T14215 | AMG 837 sodium salt | Others | Others |
AMG 837 sodium salt is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents. IC50 value: 13 nM (EC50) [1] Target: GPR40 agonist AMG 837 displayed the expected t | |||
T28685 |
SB236057
SB-236057,SB 236057 |
||
SB236057 is a potent and selective inverse agonist for the 5-HT receptor, acting especially at 5-HT autoreceptors on nerve terminals. It produces a rapid increase in 5-HT levels in the brain. SB236057 also acts as a potent teratogen, producing severe musc | |||
T80287 |
KLTWQELYQLKYKGI
|
VEGFR | Angiogenesis; Tyrosine Kinase/Adaptors |
KLTWQELYQLKYKGI (QK) 是一种与VEGF受体结合并同VEGF竞争的VEGF模拟肽。在口服或全身给药时,该化合物对啮齿类动物胃溃疡的愈合展现了活性。此外,KLTWQELYQLKYKGI 在体外具有诱导毛细血管形成和组织的能力。 | |||
T79475 |
GPR119 agonist 2
|
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GPR119 agonist2(化合物43)是一种口服活性的GPR119激动剂。在啮齿动物中表现出优良的药代动力学特性,并能有效提高小鼠和大鼠的葡萄糖耐受性。GPR119 agonist2有望用于研究II型糖尿病。 | |||
T17231 |
Vicagrel
|
Others | Others |
Vicagrel 是一种有效的、具有口服活性抗血小板化合物,通过不可逆地抑制 P2Y12 受体,降低代谢失活,增强了阿司匹林对啮齿类动物血小板聚集和血栓形成起抑制作用。Viagrel 可用于治疗冠状动脉疾病、外周血管疾病和脑血管疾病中血栓。 | |||
T14216 |
AMG 837
|
Others | Others |
AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. Overall, AMG 837 was both highly potent and selective in vitro. AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a sup | |||
T36618 |
Rupatadine
|
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Rupatadine (UR-12592) is a potent dual PAF/H1 antagonist with Ki of 0.55/0.1 uM(rabbit platelet membranes/guinea pig cerebellum membranes).IC50 value:Target: PAF/H1 antagonistin vitro: Rupatadine competitively inhibited histamine-induced guinea pig ileum contraction (pA2 = 9.29 +/- 0.06) without affecting contraction induced by ACh, serotonin or leukotriene D4 (LTD4). It also competitively inhibited PAF-induced platelet aggregation in washed rabbit platelets (WRP) (pA2 = 6.68 +/- 0.08) and in hu... | |||
T35560 |
SAR502250
|
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SAR502250 is a potent, selective, ATP competitive, orally active and brain-penetrant inhibitor of GSK3, with an IC50 of 12 nM for human GSK-3β. SAR502250 displays antidepressant-like activity. SAR502250 can be used for the research of Alzheimer’s disease (AD)[1][2]. SAR502250 (0.01-1 μM; 36 h) attenuates the Aβ25-35-induced cell death in rat embryonic hippocampal neurons[2]. SAR502250 (1-100 mg/kg; a single p.o,) attenuates tau hyperphosphorylation in the cortex and spinal cord of transgenic mic... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5573 |
Coenzyme Q9
辅酶Q9,Ubiquinone Q9,Ubiquinone 9,CoQ9 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Coenzyme Q9 (Ubiquinone 9) 是啮齿类动物泛醌的主要形式,是电子传递链中的一种双亲分子组分,具有内源性抗氧化剂的作用。它可减轻糖尿病引起的抗氧化防御机制的下降,改善左心室功能,减少心肌梗死面积和心肌细胞凋亡。 | |||
T8141 |
L-Cysteine hydrochloride
L-Cysteine HCl,L-半胱氨酸盐酸盐,L-半胱氨酸盐酸盐(无水物) |
Others; Endogenous Metabolite | Metabolism; Others |
L-Cysteine hydrochloride (L-Cysteine HCl) 是一种条件必需氨基酸,是硫化氢 (H2S)、牛磺酸谷胱甘肽和等生物特性分子的前体。它能抑制胃饥饿素,抑制啮齿动物和人类的食欲。 | |||
TN5283 |
L-Cysteine hydrochloride hydrate
L-Cysteine hydrochloride monohydrate,L-半胱氨酸盐酸盐一水物,L-半胱氨酸盐酸盐 一水合物 |
Others; Endogenous Metabolite | Metabolism; Others |
L-Cysteine hydrochloride hydrate (L-Cysteine hydrochloride monohydrate) 是条件必需氨基酸,是硫化氢、谷胱甘肽和牛磺酸等生物活性分子的前体。它可以抑制胃饥饿素,抑制啮齿动物和人类的食欲。 | |||
T19623 |
α-Muricholic acid
|
AChR | Neuroscience |
α-Muricholic acid is the most abundant primary bile acid in rodents. | |||
T40584 |
Corymbiferin
|
||
Corymbiferin, a chemical compound, exhibits significant anti-diabetic properties by enhancing antioxidant capacity and carbohydrate metabolism in diabetic rodents. In addition, Corymbiferin promotes the improvement of histopathology in both the liver and pancreatic β cells. | |||
T1208 |
Citicoline sodium
Citicoline sodium salt,CDP-choline,胞磷胆碱钠 |
Apoptosis; Others; Endogenous Metabolite | Apoptosis; Metabolism; Others |
Citicoline sodium (CDP-choline) 是一种合成细胞膜组分磷脂酰胆碱的中间体,有神经保护作用。 | |||
T36563 |
(E)-Guggulsterone
|
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Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy... |