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Search Results for " phosphodiesterase 3 "

48

抑制剂 & 化合物

8

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T21389	Enprofylline Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱	Others	Others
	Enprofylline (Enprofilina) 是具有选择性的 A2B 受体竞争性拮抗剂 (Ki:7 μM) ，也是磷酸二酯酶抑制剂。它可用于研究哮喘、慢性阻塞性肺疾病。
T5956	VP3.15 dihydrobromide	GSK-3; PDE	Metabolism; PI3K/Akt/mTOR signaling; Stem Cells
	VP3.15 dihydrobromide 是一种口服具有活力的、高效的、CNS 可渗透的PDE7-GSK3双重抑制剂，对 PDE7 和 GSK3 作用的IC50值分别为 1.59 μM 和 0.88 μM。它具有神经保护和神经修复作用，可用于研究多发性硬化症 (MS) 潜在的抗炎和促髓鞘再生联合。
T3465	Vesnarinone 维司力农,OPC-8212,Arkin,Piteranometozine	HIV Protease; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Vesnarinone (Arkin) 是一种喹啉酮衍生物，可抑制磷酸二酯酶III 活性，增加钙通量和减小钾通量。
T1713	IBMX IBMX,3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine	PDE	Metabolism
	IBMX (Methylisobutylxanthine) 是一种广谱的磷酸二酯酶 (PDE) 抑制剂，对 PDE3、PDE4 和 PDE5 均有抑制活性 (IC50=6.5/26.3/31.7 μM)。IBMX 可以增强细胞内 cAMP 水平。
T16164	MY-5445 N-(3-chlorophenyl)-4-phenylphthalazin-1-amine	PDE	Metabolism
	MY-5445 (N-(3-chlorophenyl)-4-phenylphthalazin-1-amine) 是特异性的 cGMP 磷酸二酯酶 PDE5抑制剂，其 Ki=1.3 μM。它是一种 ABCG2转运蛋白调节剂，具有抗增殖活性。它能抑制人血小板凝集。
T19706	Ro 20-1724 Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724	PDE	Metabolism
	Ro 20-1724 (4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone) 是 cAMP 特异性磷酸二酯酶抑制剂 b>(PDE4/PDE IV)，其 Ki=1930 nM，具有神经保护作用。
T1096	Milrinone Win 47203,米力农	PDE	Metabolism
	Milrinone (Win 47203) 是一种 PDE3抑制剂，也是一种强心药、血管舒张药。
T0462	Cilostazol 西洛他唑,OPC 21,OPC 13013	PDE; Autophagy	Autophagy; Metabolism
	Cilostazol (OPC 21) 是一种选择性的心血管系统中磷酸二酯酶 3 亚型PDE 3A 的抑制剂，IC50值为 0.2 μM。
T19865	GEBR-7b 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde	PDE	Metabolism
	GEBR-7b (3-(Cyclopentyloxy)-4-methoxybenzaldehyde) 是一种磷酸二酯酶 4 (PDE4) 抑制剂。
T12267	NSP-805	PDE	Metabolism
	NSP-805 是一种强心剂，是一种选择性的 phosphodiesterase 3 抑制剂，具有舒张血管的作用。
T6644	Rolipram SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram	HIV Protease; Antibacterial; PDE	Metabolism; Microbiology/Virology; Proteases/Proteasome
	Rolipram (SB 95952) 是一种磷酸二酯酶 PDE4的选择性抑制剂，抑制 PDE4A，PDE4B 和 PDE4D 的 IC50分别为 3 nM，130 nM 和 240 nM。
T1265	Amrinone Inamrinone,Inocor,氨力农,Wincoram	TNF; PDE	Apoptosis; Metabolism
	Amrinone (Inocor) 是一种正性肌力血管扩张剂，是一种具有口服活性的，非糖苷和非儿茶酚胺的强心剂，也是一种选择性磷酸二酯酶 III (phosphodiesterase III) 抑制剂，能够防止环磷酸腺苷分解，从而增加环磷酸腺苷水平。
T3465L	Vesnarinone HCl Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)	Potassium Channel; Calcium Channel; PDE	Membrane transporter/Ion channel; Metabolism
	Vesnarinone HCl (OPC-8212 HCl) 是一种具有口服活性的 phosphodiesterase 3 (PDE3) 抑制剂。Vesnarinone HCl 可对钙离子和钾离子进行调节，增加钙通量，减少钾通量。Vesnarinone HCl 是一种新的正性肌力化合物，可增强心肌收缩力，可用于心力衰竭的研究。
T5033	Olprinone 奥普力农,Loprinone	PDE	Metabolism
	Olprinone (Loprinone) 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM，具有抗炎活性。它具有正性肌力和血管扩张作用，可用于心力衰竭的研究。
T0160	Anagrelide Anagrelida,Xagrid,Anagrelidum,阿那格雷	PDE	Metabolism
	Anagrelide (Xagrid) 是III 型磷酸二酯酶(PDEIII)抑制剂 (IC50=36 nM)，是咪唑喹唑啉衍生物。它能够抑制血小板生成，以及抗血栓形成作用，可用作血小板聚集抑制剂。
T10667	Calmidazolium chloride R 24571,钙调蛋白抑制剂	CaMK; Autophagy	Autophagy; Neuroscience
	Calmidazolium chloride (R 24571) 是一种钙调蛋白拮抗剂，对CaM 依赖性磷酸二酯酶和钙调蛋白诱导的红细胞Ca2+转运ATP 酶活化有拮抗作用，IC50分别为0.15和0.35 μM。Calmidazolium chloride 结合CaMK 的Kd 值为3 nM。Calmidazolium chloride 在抗癌领域有研究的价值。
T1024	Roflumilast 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217	PDE; RSV	Metabolism; Microbiology/Virology
	Roflumilast (APTA 2217) 是一种口服的长效 4 型磷酸二酯酶抑制剂 (PDE4)，具有抗炎和潜在的抗肿瘤活性，作用于PDE4A1，PDEA4，PDEB1和PDEB2，IC50分别为 0.7，0.9，0.7 和 0.2 nM。
T12391	PDE1-IN-3	Others	Others
	PDE1-IN-3 is a selective inhibitor of human phosphodiesterase 1 (PDE1).
T25463	Griseolic acid
	Griseolic acid is a cyclic adenosine 3',5'-monophosphate phosphodiesterase II inhibitor.
T69159	AY-22,252
	AY-22,252 is an inhibitor of beef heart & rat brain nucleoside-3',5'- monophosphate phosphodiesterase.
T15714	LAS-31180	Others	Others
	LAS-31180 is a phosphodiesterase 3 inhibitor. It also has positive inotropic and vasodilator properties.
T12392	PDE12-IN-3	Others	Others
	PDE12-IN-3 is an inhibitor of phosphodiesterase 12 (PDE12) (pXC50 of 7.68),with antiviral activity.
T26767	Benafentrine dimaleate Benafentrine
	Benafentrine dimaleate is a platelet activating factor receptor (PAFR) antagonists and phosphodiesterase (PDE) 3/4 inhibitors.
T68716	AY 17,605
	AY 17,605 is an inhibitor of bovine heart and rat brain nucleoside-3',5'- monophosphate phosphodiesterase.
T13310	VP3.15	Others	Others
	VP3.15 is an orally bioavailable and CNS-penetrant dual inhibitor of phosphodiesterase (PDE)7- GSK3 (IC50s: 1.59 μM and 0.88 μM for PDE7 and GSK-3).
T15640	K134 OPC33509	PDE	Metabolism
	K134 is an inhibitor of phosphodiesterase 3. The IC50s of K134 for PDE3A, PDE3B, PDE5, PDE2 and PDE4 are 0.1, 0.28, 12.1, >300 and >300 μM, respectively.
T32348	K 259-3 K2593
	K 259-3 是 K 259-2 的甲酯，是钙调素依赖性环核苷酸磷酸二酯酶的抑制剂。
T69593	Sildenafil nitrate
	Sildenafil nitrate is a selective inhibitor of PDE5 (type 5 cGMP phosphodiesterase) which catalyzes the hydrolysis of 3',5'-cyclic guanosine monophosphate (cGMP).
T61208	PDE4-IN-11
	PDE4-IN-11 is a potent phosphodiesterase isoenzyme 4 (PDE4) inhibitor, exhibiting remarkable bronchodilatory and anti-inflammatory characteristics. It is specifically designed for studying obstructive or inflammatory airway diseases [1] [2] [3].
T40356	PDE4-IN-3 PDE4-IN-3
	PDE4-IN-3 is a newly developed oral compound that acts as a potent inhibitor of the enzyme phosphodiesterase 4 (PDE4), displaying a high affinity for inhibition with an IC50 value of 4.2 nM.
T60417	Fenspiride
	Fenspiride 是 H1-组胺受体的拮抗剂。 Fenspiride 是一种具有口服活性的非甾体类抗炎药，可用于治疗呼吸道感染和中耳炎。 Fenspiride 抑制磷酸二酯酶 4 和磷酸二酯酶 3 的活性，-logIC50 值分别为 4.16+/-0.09 和 3.44+/-0.12。磷酸二酯酶 5 活性也受到抑制，-logIC50 值约为 3.8。
T32156	Indimilast
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
T69491	(E/Z)-Ensifentrine
	(E/Z)-Ensifentrine is a potent and selective PDE3/4 inhibitor. (E/Z)-Ensifentrine acts as a long-acting inhibitor of the phosphodiesterase enzymes PDE-3 and PDE-4, producing both bronchodilator and antiinflammatory effects. It is being developed by Verona Pharma as a potential treatment for asthma and hay fever, and is currently in clinical trials.
T78559	PDE7-IN-3
	PDE7-IN-3（例2）是一种具有潜在镇痛活性的PDE7磷酸二酯酶抑制剂，可用于探究炎性、神经性、内脏性及伤害性疼痛。
T69262	ABE171
	ABE171, also known as NVP-ABE171, is a potent and novel phosphodiesterase 4 inhibitor with anti-inflammatory activities. NVP-ABE171 inhibited the activity of phosphodiesterase 4A, 4B, 4C, and 4D with respective IC(50) values of 602, 34, 1230, and 1.5 nM. In human cells, NVP-ABE171 inhibited the eosinophil and neutrophil oxidative burst, the release of cytokines by T cells, and the tumor necrosis factor-alpha release from monocytes, in the nanomolar range. NVP-ABE171 inhibited the airway neutrop...
T36133	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)
	3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one) is a non-nucleotide inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; Ki = 50 μM).1,2 It also inhibits urease (IC50 = 84.53 μM for the Jack bean enzyme).3 \|1. Choudhary, M.I., Fatima, N., Khan, K.M., et al. New biscoumarin derivatives-cytotoxicity and enzyme inhibitory activities. Bioorg. Med. Chem. 14(23), 8066-8072 (2006).\|2. Onyedibe, K.I., Wang, M., and Sintim, H.O. ENPP1, an old enzyme with new functions, ...
T36547	Quazinone
	Quazinone is a selective inhibitor of phosphodiesterase 3 (PDE3) with positive inotropic and vasodilating properties.1,2 It induces relaxation of precontracted isolated human cavernous smooth muscle (IC50 = 4.2 μM).1 Quazinone (10-300 μg/kg) increases myocardial contractile force in anesthetized open-chest dogs in a dose-dependent manner, as well as decreases systolic and diastolic blood pressure.2 It also inhibits DNA synthesis induced by the PDGF isoform PDGF-BB in bovine coronary artery smoot...
T76138	Phosphodiesterase
	Phosphodiesterase(PDE) 是一种可以催化环核苷酸3 '环磷酸键水解的酶，常用于生化研究。Phosphodiesterase 可作为第二信使分子 cAMP 和 cGMP 介导的信号转导的重要调节因子。根据其对环核苷酸的特异性也可以分别不同类型，如 PDE1-PDE11，在多种疾病方面也具有一定的潜力。
T82989	AP-C6
	AP-C6 是一种有效的 cGMP 依赖性蛋白激酶 II (cGKII) 抑制剂，其 pIC50 值为 6.5。该化合物能够在体外浓度依赖性地抑制人 cGKII 的活性，并能够通过抑制 PDE 来增强 cAMP 信号传导。
T5033L	Olprinone Hydrochloride
	Olprinone (Loprinone) Hydrochloride 是一种有效的磷酸二酯酶(PDE) 3抑制剂，对 PDE1，PDE2，PDE3，PDE4 的IC50分别为 150、100、0.35 和 14 μM。Olprinone Hydrochloride 由于具有正性肌力和血管扩张作用而被用于心力衰竭的研究。Olprinone Hydrochloride 具有抗炎活性。
T75790	CALP2 TFA
	CALP2 TFA 是一种钙调蛋白 (CaM) 拮抗剂 (Kd 为 7.9 µM)，以亲和力结合CaMEF-hand/Ca2+结合位点。CALP2 TFA 抑制CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性并增加细胞内 Ca2+浓度。CALP2 TFA 有效抑制粘附和脱粒。CALP2 TFA 还是肺泡巨噬细胞的强激活剂。
T73708	Sp-cAMPS triethylamine
	Sp-cAMPS triethylamine，一种 cAMP 类似物，是一种依赖 cAMP 的PKAI 和PKAII 的有效激活剂。Sp-cAMPS triethylamine 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 µM。Sp-cAMPS triethylamine 以EC50为 40 μM 来结合PDE10GAF 域。
T75791	CALP1 TFA
	CALP1 TFA 是一种钙调蛋白 (CaM) 激动剂 (Kd 为 88 µM)，与 CaMEF-hand/Ca2+结合位点结合。CALP1 TFA 通过抑制钙通道 (calcium channel) 的开放来阻止钙的流入和凋亡 (IC50为 44.78 µM)。CALP1 TFA 阻止谷氨酸受体 (glutamate receptor channels) 通道，并阻止存储操作的非选择性阳离子通道。CALP1 TFA 激活 CaM 依赖性磷酸二酯酶 (phosphodiesterase) 活性。
T63776	PDE1-IN-4
	PDE1-IN-4 是有效的、选择性的 PDE1 (磷酸二酯酶 -1) 抑制剂，能够作用于 PDE1C (IC50: 10 nM)、PDE1A (IC50: 145 nM) 和 PDE1B (IC50: 354 nM)。PDE1-IN-4 能够调控 cAMP (3′,5′- 环磷酸腺苷) 和 cGMP (3′,5′- 环磷酸鸟苷)，表现出抗纤维化效果。PDE1-IN-4 能够抑制 TGF-β1 诱导的人肺成纤维细胞分化。PDE1-IN-4 能够用于研究特发性肺纤维化 (IPF)。
T21697	Sp-Cyclic AMPS (sodium salt)
	Sp-cAMPS sodium salt 作为 cAMP 类似物，是一种依赖 cAMP 的PKA I 和PKA II 的有效激活剂。Sp-cAMPS sodium salt 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂，Ki 为 47.6 μM。Sp-cAMPS sodium salt 结合PDE10 GAF 结构域，EC50为 40 μM 。
T37832	CAY10761 CAY10761
	CAY10761 is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1; IC50s = 467 and 429 μM for the human and snake venom enzymes, respectively).1,2 It also inhibits mushroom tyrosinase (Ki = 1.9 μM) and urease from jack bean, P. mirabilis, and B. pasteurii (IC50s = 0.093, <0.125, and 0.089 mM, respectively, at pH 8.2).3,4 \|1. Khan, K.M., Fatima, N., Rasheed, M., et al. 1,3,4-Oxadiazole-2(3H)-thione and its analogues: A new class of non-competitive nucleotide pyrophosphatases/p...
T35929	O-Demethyl Apremilast
	O-Demethyl apremilast is an active metabolite of the phosphodiesterase 4 (PDE4) inhibitor apremilast .1It inhibits the activity of PDE4 isolated from U937 cells and LPS-induced TNF-α production in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 8.3 and 5.6 μM, respectively). O-Demethyl apremilast is also an oxidative degradation product of apremilast.2,3 1.Hoffmann, M., Kumar, G., Schafer, P., et al.Disposition, metabolism and mass balance of [14C]apremilast following oral admi...
T60511	Theophylline sodium glycinate
	Theophylline (1,3-Dimethylxanthine) sodium glycinate 是一种有效的磷酸二酯酶 (PDE) 抑制剂，可抑制 PDE3 活性以松弛气道平滑肌。Theophylline sodium glycinate 可用于研究哮喘和慢性阻塞性肺疾病 (COPD) 。Theophylline sodium glycinate 也是一种腺苷受体拮抗剂和组蛋白脱乙酰酶 (HDAC) 激活剂。 Theophylline sodium glycinate 通过增加 IL-10 和抑制 NF-κB 的核输入而具有抗炎活性。Theophyllin sodium glycinate 可诱导细胞凋亡。

化合物

Cat.No: T21389

Synonym: Enprofilina,3-propylxanthine,3-n-Propylxanthine,Enprofyllinum,恩丙茶碱

Target: Others

VP3.15 dihydrobromide

Cat.No: T5956

Target: GSK-3, PDE

Cat.No: T3465

Synonym: 维司力农,OPC-8212,Arkin,Piteranometozine

Target: HIV Protease, PDE

Cat.No: T1713

Synonym: IBMX,3-异丁基-1-甲基黄嘌呤,3-Isobutyl-1-methylxanthine,1-Methyl-3-Isobutylxanthine,Methylisobutylxanthine,Isobutylmethylxanthine

Target: PDE

Cat.No: T16164

Synonym: N-(3-chlorophenyl)-4-phenylphthalazin-1-amine

Target: PDE

Cat.No: T19706

Synonym: Ro-20-1724,4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone,Ro20-1724

Target: PDE

Cat.No: T1096

Synonym: Win 47203,米力农

Target: PDE

Cat.No: T0462

Synonym: 西洛他唑,OPC 21,OPC 13013

Target: PDE, Autophagy

Cat.No: T19865

Synonym: 3-环戊氧-4-甲氧基苯甲醛,3-(Cyclopentyloxy)-4-methoxybenzaldehyde

Target: PDE

Cat.No: T12267

Target: PDE

Cat.No: T6644

Synonym: SB 95952,ZK 62711,咯利普兰,(R,S)-Rolipram

Target: HIV Protease, Antibacterial, PDE

Cat.No: T1265

Synonym: Inamrinone,Inocor,氨力农,Wincoram

Target: TNF, PDE

Vesnarinone HCl

Cat.No: T3465L

Synonym: Synonym 2,OPC-8212 HCl,Vesnarinone HCl(81840-15-5 Free base)

Target: Potassium Channel, Calcium Channel, PDE

Cat.No: T5033

Synonym: 奥普力农,Loprinone

Target: PDE

Cat.No: T0160

Synonym: Anagrelida,Xagrid,Anagrelidum,阿那格雷

Target: PDE

Calmidazolium chloride

Cat.No: T10667

Synonym: R 24571,钙调蛋白抑制剂

Target: CaMK, Autophagy

Cat.No: T1024

Synonym: 罗氟司特,B9302-107,BYK 20869,APTA 2217,BY 217

Target: PDE, RSV

Cat.No: T12391

Target: Others

Cat.No: T25463

Cat.No: T69159

Cat.No: T15714

Target: Others

Cat.No: T12392

Target: Others

Benafentrine dimaleate

Cat.No: T26767

Synonym: Benafentrine

Cat.No: T68716

Cat.No: T13310

Target: Others

Cat.No: T15640

Synonym: OPC33509

Target: PDE

Cat.No: T32348

Synonym: K2593

Sildenafil nitrate

Cat.No: T69593

Cat.No: T61208

Cat.No: T40356

Synonym: PDE4-IN-3

Cat.No: T60417

Cat.No: T32156

(E/Z)-Ensifentrine

Cat.No: T69491

Cat.No: T78559

Cat.No: T69262

3,3'-((2-Chlorophenyl)methylene)bis(4-hydroxy-2H-chromen-2-one)

Cat.No: T36133

Cat.No: T36547

Phosphodiesterase

Cat.No: T76138

Cat.No: T82989

Olprinone Hydrochloride

Cat.No: T5033L

Cat.No: T75790

Sp-cAMPS triethylamine

Cat.No: T73708

Cat.No: T75791

Cat.No: T63776

Sp-Cyclic AMPS (sodium salt)

Cat.No: T21697

Cat.No: T37832

Synonym: CAY10761

O-Demethyl Apremilast

Cat.No: T35929

Theophylline sodium glycinate

Cat.No: T60511

Cat. No.	Product Name	Target	Signaling Pathways
TN1266	3-O-Methylquercetin	IL Receptor; cAMP; PDE	GPCR/G Protein; Immunology/Inflammation; Metabolism
	3-O-Methylquercetin 是分离自植物Rhamnus nakaharai 的天然产物，可抑制总 cAMP 和cGMP-phosphodiesterase (PDE)。它对PDE1、PDE5、PDE 和PDE4的IC50分别是31.9 μM、86.9 μM、18.6 μM 和1.6 μM。
T17199	Udenafil 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非	PDE	Metabolism
	Udenafil 是一种选择性的，有效的，具有口服活性的 5 型磷酸二酯酶 (PDE5) 抑制剂。它能够抑制 cGMP 水解，可用于研究勃起功能障碍的。
T1083	Theophylline Theo-24,1,3-Dimethylxanthine,茶碱	Endogenous Metabolite; HDAC; PDE; Adenosine Receptor; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Theophylline (1,3-Dimethylxanthine) 是茶中的甲基黄嘌呤衍生物，具有利尿、平滑肌松弛、支气管扩张、心脏和中枢神经系统兴奋作用。
T8787	Drotaverine hydrochloride	PDE	Metabolism
	Drotaverine hydrochloride 是磷酸二酯酶 4 (PDE4)的抑制剂，也是 L 型电压依赖钙通道(L-VDCC)的阻滞剂，可阻断3',5'-环腺苷单磷酸的降解。它在体内有抗痉挛效果，但无抗胆碱能的效果。
TN2974	3-O-Methylquercetin tetraacetate	IL Receptor; TNF; PDE	Apoptosis; Immunology/Inflammation; Metabolism
	Quercetin 3-O-methyl ether is a potent phosphodiesterase (PDE)3/4 inhibitor, it has potential for treating asthma against ovalbumin-induced airway hyperresponsiveness.
TN1841	Kushenol A 苦参新醇 A,Leachianone E	cAMP	GPCR/G Protein
	Kushenol A is a kind of Adenosine 3', 5'-cyclic monophosphate(cAMP)phosphodiesterase inhibitiors, it shows selective alpha-glucosidase inhibitory activity. Kushenol A and kushenol C exhibit inhibitory activity against Sodium-dependent glucose cotransporter 2(SGLT2).
TN4886	Quinovic acid 3-O-alpha-L-rhamnopyranoside	Others	Others
	Quinovic acid 3-O-alpha-L-rhamnopyranoside shows significant inhibitory activity against snake venom phosphodiesterase-I.
TN4433	Licoarylcoumarin	cAMP; HIV Protease; Antifection	GPCR/G Protein; Microbiology/Virology; Proteases/Proteasome
	Licoarylcoumarin is a strong inhibitor of adenosine 3',5'-cyclic monophosphate (cAMP) phosphodiesterase. Licoarylcoumarin has antibacterial effects on the VRE strains; it has anti-HIV activity, and it has inhibitory effects on xanthine oxidase.

天然产物

3-O-Methylquercetin

Cat.No: TN1266

Target: IL Receptor, cAMP, PDE

Cat.No: T17199

Synonym: 3-(6,7-二氢-1-甲基-7-氧代-3-丙基-1H-吡唑并[4,3-D]嘧啶-5-基)-N-[2-(1-甲基-2-吡咯烷基)乙基]-4-丙氧基苯磺酰胺,乌地那非

Target: PDE

Cat.No: T1083

Synonym: Theo-24,1,3-Dimethylxanthine,茶碱

Target: Endogenous Metabolite, HDAC, PDE, Adenosine Receptor, Autophagy

Drotaverine hydrochloride

Cat.No: T8787

Target: PDE

3-O-Methylquercetin tetraacetate

Cat.No: TN2974

Target: IL Receptor, TNF, PDE

Cat.No: TN1841

Synonym: 苦参新醇 A,Leachianone E

Target: cAMP

Quinovic acid 3-O-alpha-L-rhamnopyranoside

Cat.No: TN4886

Target: Others

Licoarylcoumarin

Cat.No: TN4433

Target: cAMP, HIV Protease, Antifection

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