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51

抑制剂 & 化合物

6

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Cat. No. Product Name Target Signaling Pathways
T19508 Peroxidase

Others Others
Peroxidase 来自辣根,在先天免疫、氧化活性氧、激素生物合成和多种疾病的发病机制等方面具有重要作用。
T80056 Glutathione Peroxidase

GSH-Px,EC 1.11.1.9

Glutathione Peroxidase Metabolism
Glutathione Peroxidase (GSH-Px; EC 1.11.1.9),是一种关键的抗氧化酶,能催化GSH与过氧化氢或脂质过氧化物反应,生成GSSG和H2O,从而减缓氧化应激。此酶在生化研究中具有重要应用。
T83780 GPX4 24

Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24

GPX4 24是(1S,3R)-RSL3的衍生物,具有抑制谷胱甘肽过氧化物酶4(GPX4)的作用。它能够在浓度依赖的方式中与4T1小鼠乳腺癌细胞中的GPX4形成共价结合。在GPX4依赖的HT-1080成纤维细胞中,GPX4 24诱导铁死亡(EC50 = 0.16 µM)。当以200 mg/kg剂量给予小鼠时,它能够增加小鼠肾脏和血浆中丙二醛(MDA)的水平。
T37314 JKE-1674

GPX oxidation-reduction
JKE-1674 是口服有效的谷胱甘肽过氧化物酶 4 (GPX4)抑制剂,是ML-210的活性代谢物,ML-210也是GPX4抑制剂。它可转换成丁腈氧化物 JKE-1777。它用与 ML-210 相同的方式杀死 LOX-IMVI 细胞,并被ferroptosis 抑制剂完全挽救。
T5340 MPO-IN-28

Glutathione Peroxidase Metabolism
MPO-IN-28 是髓过氧化物酶 (MPO) 抑制剂,IC50=44 nM。
T14379 AZD5904

Glutathione Peroxidase Metabolism
AZD5904 是一种不可逆的人髓过氧化物酶选择性抑制剂,其IC50=140 nM,在小鼠和大鼠中也具有相似的效力。
T8375 ML-210

CID 49766530

Ferroptosis; GPX; Glutathione Peroxidase; Ras Apoptosis; GPCR/G Protein; MAPK; Metabolism; oxidation-reduction
ML-210 (CID 49766530) 是一种共价的选择性谷胱甘肽过氧化物酶 4 (GPX4) 抑制剂,EC50为 30 nM。它与 GPX4 硒代半胱氨酸残基结合,具有抗癌活性。
T4090 PF-06282999

Glutathione Peroxidase Metabolism
PF06282999 是选择性的髓过氧物酶 (myeloperoxidase) 抑制剂,用于研究心血管疾病。
T12189 NBDHEX

Apoptosis; Glutathione Peroxidase; Autophagy Apoptosis; Autophagy; Metabolism
NBDHEX 是一种谷胱甘肽 S-转移酶 P1-1 抑制剂,也是晚期自噬抑制剂。它诱导肿瘤细胞凋亡,通过抑制 GST 的催化活性,避免抑制剂被特异性泵从细胞中排出,以及破坏 GSTP1-1和关键信号传导因子之间的相互作用,从而起到抗癌的作用。
T5463 Verdiperstat

AZD3241,AZD 3241

Glutathione Peroxidase Metabolism
Verdiperstat (AZD 3241) 是一种不可逆的、选择性的、口服具有活力的髓过氧化物酶 (myeloperoxidase) 抑制剂,IC50=630 nM,可用于研究大脑神经退行性疾病。
T8970 ML162

Ferroptosis; GPX; Glutathione Peroxidase Apoptosis; Metabolism; oxidation-reduction
ML162 是一种共价谷胱甘肽过氧化物酶 4 抑制剂。它选择性抑制表达突变 RAS 癌基因的细胞系。
T3646 RSL3

RSL3 1S,1S,3R-RSL3

Ferroptosis; GPX; Glutathione Peroxidase Apoptosis; Metabolism; oxidation-reduction
RSL3 (RSL3 1S) 是一种 GPX4 的抑制剂,抑制阻断 GSH 合成的 system xc- (IC50=100 nM)。RSL3 是一种不依赖 VDAC 的铁死亡激活剂,对携带致癌 RAS 的肿瘤细胞具有选择性。
T4313 Tinoridine hydrochloride

盐酸替诺立定,Nonflamin,Y-3642 hydrochloride

COX; Glutathione Peroxidase Immunology/Inflammation; Metabolism; Neuroscience
Tinoridine hydrochloride (Y-3642 hydrochloride) 是非甾体抗炎药,具有显著的自由基清除和抗过氧化物特性。
T26389 4-POBN

NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH

Glutathione Peroxidase Metabolism
4-POBN (Myeloperoxidase Inhibitor 1) 是一种有效且不可逆的髓过氧化物酶抑制剂 (IC50 = 0.3 µM)。 4-POBN 可用于亚急性中风的研究。
T0825 Ebselen

SPI-1005,PZ-51,依布硒,CCG-39161

Phosphatase; Virus Protease; Calcium Channel; COX; HIV Protease Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience; Proteases/Proteasome
Ebselen (CCG-39161) 是一种谷胱甘肽过氧化物酶模拟物,是电压依赖性钙通道阻断剂。它抑制Mpro 和COVID-19病毒,是HIV-1衣壳 CTD 二聚化的抑制剂,具有抗炎、抗癌和抗氧化活性。
T1374 2-Pyridinecarbohydrazide

2-吡啶甲酰肼,2-Picolinyl hydrazide

Dehydrogenase; CAT Metabolism; oxidation-reduction
2-Pyridinecarbohydrazide (2-Picolinyl hydrazide) 是 Catalase-peroxidase-NAPDH 的有效抑制剂。它普遍用于各种合成领域的砌块。
T0050 Ampyrone

Minoazophene,Aminoantipyrin,NSC 60242,4-Aminoantipyrine,4-氨基安替比林,Solnapyrin-A

COX; Drug Metabolite Immunology/Inflammation; Metabolism; Neuroscience
Ampyrone (4-Aminoantipyrine) 是一种检测试剂,在过氧化物酶与苯酚存在时,用于葡萄糖测定。
T18908 ABTS diammonium salt

2,2'-联氮双(3-乙基苯并噻唑啉-6-磺酸)二铵盐,AzBTS-(NH4)2

Others Others
ABTS diammonium salt (AzBTS-(NH4)2) 是辣根过氧化物酶的底物。
T18912 ADHP

10-乙酰基-3,7-二羟基吩嗪,10-Acetyl-3,7-dihydroxyphenoxazine

Others Others
ADHP (10-Acetyl-3,7-dihydroxyphenoxazine) 是荧光过氧化物酶底物,其λex=530 nm,λem=590 nm。
T9416 Dansylglycine

Others Others
Dansylglycine 是一种荧光探针,用于特异性测定髓过氧化物酶和嗜酸性粒细胞过氧化物酶的卤化活性。
Fr16629 4-(Imidazol-1-yl)phenol

4-(Imidazol-1-yl)phenol 是一种高效信号增强剂,用于辣根过氧化物酶(HRP)-鲁米诺化学发光(CL)免疫测定。
T9734 InhA-IN-2

CDK Cell Cycle/Checkpoint
InhA-IN-2直接抑制 InhA,不需要过氧化氢酶过氧化物酶 KatG 的激活。
T1309 Propylthiouracil

丙硫氧嘧啶,Pseudocapsaicin,NSC 6498,丙基硫氧嘧啶,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil

Thyroid hormone receptor(THR) Endocrinology/Hormones
Propylthiouracil (6-n-Propylthiouracil) 是一种甲状腺过氧化物酶抑制剂,也是一种5'-脱碘酶抑制剂。
T19069 TMB dihydrochloride

3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride

Others Others
TMB dihydrochloride (Sure Blue TMB dihydrochloride) 是一种免疫组化和 ELISA 的显色底物。
T18972 DHBS

DCHBS

Others Others
DHBS (DCHBS) 与 4-氨基安替比林和过氧化氢联合使用,能够用于偶联酶促反应中过氧化物酶的显色定量。它是 Trinder 试剂的组分,能够与过氧化物酶一起测量过氧化氢的产生。
T9423 Alkyne tyramide

Others Others
Alkyne tyramide 是抗坏血酸过氧化物酶 2 探针。它有助于鉴定 APEX 标记位点,明确线粒体蛋白的膜拓扑的分配。它显著提高了完整酵母细胞的 APEX 标记效率,比 APEX2 底物生物素苯酚具有更大的细胞壁渗透性。
T0664 Nicotinic acid hydrazide

Others Others
Nicotinic acid hydrazide(NAH)是烟酸的酰肼衍生物,一种杂环有机物,是过氧化物酶抑制剂,可以形成具有较强生物活性的固态金属配合物。
T36935 PKUMDL-LC-101-D04

GPX4-Activator-1d4,PKUMDL-LC-101-D04

GPX oxidation-reduction
PKUMDL-LC-101-D04是一种高效的谷胱甘肽过氧化物酶4(GPX4)的异位激活剂,是一种铁死亡的调节剂。 当在无细胞试验中使用浓度为20 μM 时,GPX4活性增加到对照水平的150%;在野生型而非Gpx4-/-小鼠胚胎成纤维细胞(MEF)提取物中使用浓度为61 μM 时,GPX4活性增加到对照水平的150%。PKUMDL-LC-101-D04(200 μM)能减少胆固醇过氧化氢诱导的MEF 死亡。
T38010 PPHP

PPHP is a substrate for the measurement of peroxidase enzymes. PPHP has been used to quantitate the peroxidase activity of COX-1 and COX-2.
T39152 4-Hydroxyphenylbutazone

4-Hydroxyphenylbutazone, a metabolite of Phenylbutazone, functions as an effective reducing cofactor for the peroxidase activity of prostaglandin H synthase (PHS). Phenylbutazone is a nonsteroidal anti-inflammatory drug (NSAID) known for its efficiency in this role.
T38914 MPO-IN-3

MPO-IN-3, a powerful inhibitor of myeloperoxidase (MPO), is described as such in example 191 of WO2013068875A1. MPO, a heme-containing enzyme, is classified under the peroxidase superfamily.
T39686 1-Methoxynaphthalene

1-Methoxynaphthalene is employed as a substrate for scrutinizing the enzymatic activity of cytochrome c peroxidase (CcP). Additionally, 1-Methoxynaphthalene can serve as a precursor for the synthesis of prenyl naphthalen-ols.
T39181 Cyanine 3 Tyramide

Cyanine 3 Tyramide,Tyramide-Cy3

Cyanine 3 Tyramide (Tyramide-Cy3), an orange fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition for signal amplification in immunoassays and in situ nucleic acid hybridization.
T38902 Cyanine 5 Tyramide

Tyramide-Cy5

Cyanine 5 Tyramide (Tyramide-Cy5), a red fluorescent dye, serves as a reporter fluorescent substrate in horseradish peroxidase (HRP)-catalyzed deposition, a signal amplification method employed in immunoassays and in situ hybridization of nucleic acids.
TP1096 Elamipretide TFA

SS-31 (TFA),MTP-131 (TFA),RX-31 (TFA)

Others Others
Elamipretide TFA (RX-31 TFA) 是一种心磷脂过氧化物酶抑制剂和线粒体靶向肽[。
T40137 MPO-IN-1

MPO-IN-1 is a powerful and orally bioavailable indole-containing inhibitor that acts irrevocably on myeloperoxidase (MPO). With IC50 values of 2.6 μM and 5.3 μM for MPO and thyroid peroxidase (TPO), respectively, MPO-IN-1 effectively inhibits both enzymes. Furthermore, it exhibits remarkable MPO inhibitory activity in an acute inflammation mouse model.
T81340 Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone

PCNPH

Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone (PCNPH) 作为一种过氧化物酶显色底物,能与过氧化物酶及过氧化物反应生成紫色吲哚染料。
T37805 JKE-1716

JKE-1716 is an inhibitor of glutathione peroxidase 4 (GPX4) and a derivative of the GPX4 inhibitor ML-210 .1JKE-1716 reduces viability of LOX-IMVI cancer cells in a concentration-dependent manner and in a panel of additional cancer cell lines, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 . 1.Eaton, J.K., Furst, L., Ruberto, R.A., et al.Selective covalent targeting of GPX4 using masked nitrile-oxide electrophilesNat. Chem. Biol.16(5)497-506(2020)
T67498 3-Amino-1,2,4-triazole

Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B

Reactive Oxygen Species Immunology/Inflammation; Metabolism; NF-κB
3-Amino-1,2,4-triazole (Trapidil impurity B) 是一种过氧化氢酶抑制剂,能够诱导过氧化氢解毒的补偿机制。 该机制涉及增加谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。
T38099 APF

APF is an aromatic amino-fluorescein derivative and fluorescent probe for highly reactive radicals. It has low intrinsic fluorescence, however, upon oxidation by hydroxyl radical, hypochlorite ion, and certain peroxidase intermediates, it is converted to the highly fluorescent molecule fluorescein, facilitating the detection of highly reactive biological radicals. APF is not oxidized by nitric oxide (NO), hydrogen peroxide (H2O2), or other oxidants. Fluorescein displays excitation/emission maxim...
T36516 RC574

RC574

RC574 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It inhibits glutamate-induced cell death in HT22 cells (IC50= 276.2 nM) and mouse primary cortical neurons when used at a concentration of 3 μM. RC574 (3 μM) increases glutathione peroxidase 1 (GPX1) levels and GPX activity, as well as inhibits glutamate-induced mitochondrial superoxide anion production, in HT22 cells. It completely inhibits ferroptosis induced by the GPX4 inhibitor ...
T36515 RC363

RC363 is an inhibitor of ferroptosis and a derivative of the antioxidant and hypocholesterolemic agent probucol .1It reduces 2,2-diphenyl-1-picrylhydrazyl radicals by approximately 40% in a cell-free assay when used at a concentration of 25 μM. RC363 prevents glutamate-induced toxicity in HT22 cultured hippocampal cells (IC50= 234.5 nM) but does not reduce oxidant levels in these cells. It increases the levels of glutathione peroxidase 1 (GPX1) and the activity of GPX in glutamate-challenged HT2...
T11357 Gamma-glutamylcysteine TFA

γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)

IL Receptor Immunology/Inflammation
Gamma-glutamylcysteine (TFA) also upregulates the level of the anti-inflammatory cytokine IL-10 and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) and attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes. Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA)), an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx).
T63729 GPX4-IN-3

GPX4-IN-3 (26a) 作为一种有效的谷胱甘肽过氧化物酶4 (GPX4) 抑制剂,其能选择性诱导铁死亡(ferroptosis)。在1 μM浓度下,该化合物能抑制GPX4活性达71.7%。
T60281 MPO-IN-4

MPO-IN-4 (compound 12) 是一种有效的选择性髓过氧化物酶 (MPO) 抑制剂,IC50为 25 nM。MPO-IN-4对甲状腺过氧化物酶(TPO)也显示抑制作用,IC50为2.2 μM。MPO-IN-4 对甲基鸟嘌呤甲基转移酶 (MGMT) 没有影响。
T78406 Cyanine 3 Tyramide methyl indole

Cyanine 3 Tyramidemethyl indole为Cyanine 3 Tyramide(Tyramide-Cy3)的衍生物,后者作为一种橙色荧光染料,在免疫测定和核酸原位杂交技术中,用作辣根过氧化物酶(HRP)催化沉积的报告荧光底物,用于信号放大。
T71288 Phenylbutazone-d9

Phenylbutazone-d9 is intended for use as an internal standard for the quantification of phenylbutazone by GC- or LC-MS. Phenylbutazone is a non-steroidal anti-inflammatory drug and an inhibitor of the peroxidase activity of COX (IC50 = ~100 µM in the presence of hydrogen peroxide). It also inhibits prostaglandin I synthase (IC50 = ~25 µM in the presence of hydrogen peroxide). Phenylbutazone (2 mg/kg) reduces increases in type II collagen levels in the inflamed joints of an equine model of LPS-in...
T74073 Cyanine 5 Tyramide methyl indole

Cyanine 5 Tyramide (Tyramide-Cy5) methyl indole 为红色荧光染料,用于HRP催化沉积报告中作为荧光底物,应用于免疫测定及核酸原位杂交信号放大。储存须避光。
T75028 TMV-IN-4

TMV-IN-4(compound 3)是一种针对烟草花叶病毒(TMV)的抑制剂。该化合物通过与TMV解旋酶交互作用,能够诱导植物产生抗性并提高对TMV感染的耐受性。TMV-IN-4还可增强过氧化物酶和超氧化物歧化酶活性,从而提升烟草的TMV抗性。
T36610 (E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine

(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine (CSTMP) is a stilbene derivative with antioxidant and anticancer activities. It stimulates proliferation of hydrogen peroxide-damaged ECV-304 cells (EC50 = 24.9 nM). CSTMP reduces hydrogen peroxide-induced release of lactate dehydrogenase (LDH) in and increases viability of human umbilical vein endothelial cells (HUVECs) in a concentration-dependent manner via inhibition of apoptosis. It reverses hydrogen peroxide-induced release of malondialdehyde ...

化合物

Peroxidase
Cat.No: T19508
Synonym:
Target: Others
Glutathione Peroxidase
Cat.No: T80056
Synonym: GSH-Px,EC 1.11.1.9
Target: Glutathione Peroxidase
GPX4 24
Cat.No: T83780
Synonym: Phospholipid Hydroperoxide Glutathione Peroxidase 24,PHGPx 24,Glutathione Peroxidase 4 24
Target:
JKE-1674
Cat.No: T37314
Synonym:
Target: GPX
MPO-IN-28
Cat.No: T5340
Synonym:
Target: Glutathione Peroxidase
AZD5904
Cat.No: T14379
Synonym:
Target: Glutathione Peroxidase
ML-210
Cat.No: T8375
Synonym: CID 49766530
Target: Ferroptosis, GPX, Glutathione Peroxidase, Ras
PF-06282999
Cat.No: T4090
Synonym:
Target: Glutathione Peroxidase
NBDHEX
Cat.No: T12189
Synonym:
Target: Apoptosis, Glutathione Peroxidase, Autophagy
Verdiperstat
Cat.No: T5463
Synonym: AZD3241,AZD 3241
Target: Glutathione Peroxidase
ML162
Cat.No: T8970
Synonym:
Target: Ferroptosis, GPX, Glutathione Peroxidase
RSL3
Cat.No: T3646
Synonym: RSL3 1S,1S,3R-RSL3
Target: Ferroptosis, GPX, Glutathione Peroxidase
Tinoridine hydrochloride
Cat.No: T4313
Synonym: 盐酸替诺立定,Nonflamin,Y-3642 hydrochloride
Target: COX, Glutathione Peroxidase
4-POBN
Cat.No: T26389
Synonym: NSC-640,NSC640,4-Aminobenzohydrazide,4-氨基苯甲酰肼,NSC 640,Myeloperoxidase Inhibitor 1,4-ABAH
Target: Glutathione Peroxidase
Ebselen
Cat.No: T0825
Synonym: SPI-1005,PZ-51,依布硒,CCG-39161
Target: Phosphatase, Virus Protease, Calcium Channel, COX, HIV Protease
2-Pyridinecarbohydrazide
Cat.No: T1374
Synonym: 2-吡啶甲酰肼,2-Picolinyl hydrazide
Target: Dehydrogenase, CAT
Ampyrone
Cat.No: T0050
Synonym: Minoazophene,Aminoantipyrin,NSC 60242,4-Aminoantipyrine,4-氨基安替比林,Solnapyrin-A
Target: COX, Drug Metabolite
ABTS diammonium salt
Cat.No: T18908
Synonym: 2,2'-联氮双(3-乙基苯并噻唑啉-6-磺酸)二铵盐,AzBTS-(NH4)2
Target: Others
ADHP
Cat.No: T18912
Synonym: 10-乙酰基-3,7-二羟基吩嗪,10-Acetyl-3,7-dihydroxyphenoxazine
Target: Others
Dansylglycine
Cat.No: T9416
Synonym:
Target: Others
4-(Imidazol-1-yl)phenol
Cat.No: Fr16629
Synonym:
Target:
InhA-IN-2
Cat.No: T9734
Synonym:
Target: CDK
Propylthiouracil
Cat.No: T1309
Synonym: 丙硫氧嘧啶,Pseudocapsaicin,NSC 6498,丙基硫氧嘧啶,NSC 70461,6-n-Propylthiouracil,6-Propyl-2-thiouracil
Target: Thyroid hormone receptor(THR)
TMB dihydrochloride
Cat.No: T19069
Synonym: 3,3',5,5'-四甲基联苯胺盐酸盐,BM blue dihydrochloride,Sure Blue TMB dihydrochloride,3,3',5,5'-Tetramethylbenzidine dihydrochloride
Target: Others
DHBS
Cat.No: T18972
Synonym: DCHBS
Target: Others
Alkyne tyramide
Cat.No: T9423
Synonym:
Target: Others
Nicotinic acid hydrazide
Cat.No: T0664
Synonym:
Target: Others
PKUMDL-LC-101-D04
Cat.No: T36935
Synonym: GPX4-Activator-1d4,PKUMDL-LC-101-D04
Target: GPX
PPHP
Cat.No: T38010
Synonym:
Target:
4-Hydroxyphenylbutazone
Cat.No: T39152
Synonym:
Target:
MPO-IN-3
Cat.No: T38914
Synonym:
Target:
1-Methoxynaphthalene
Cat.No: T39686
Synonym:
Target:
Cyanine 3 Tyramide
Cat.No: T39181
Synonym: Cyanine 3 Tyramide,Tyramide-Cy3
Target:
Cyanine 5 Tyramide
Cat.No: T38902
Synonym: Tyramide-Cy5
Target:
Elamipretide TFA
Cat.No: TP1096
Synonym: SS-31 (TFA),MTP-131 (TFA),RX-31 (TFA)
Target: Others
MPO-IN-1
Cat.No: T40137
Synonym:
Target:
Pyridine-2-carboxaldehyde 4-nitrophenylhydrazone
Cat.No: T81340
Synonym: PCNPH
Target:
JKE-1716
Cat.No: T37805
Synonym:
Target:
3-Amino-1,2,4-triazole
Cat.No: T67498
Synonym: Amitrole,3-AT,1H-1,2,4-Triazol-5-amine,Trapidil impurity B
Target: Reactive Oxygen Species
APF
Cat.No: T38099
Synonym:
Target:
RC574
Cat.No: T36516
Synonym: RC574
Target:
RC363
Cat.No: T36515
Synonym:
Target:
Gamma-glutamylcysteine TFA
Cat.No: T11357
Synonym: γ-glutamylcysteine (TFA),Gamma-glutamylcysteine (TFA)
Target: IL Receptor
GPX4-IN-3
Cat.No: T63729
Synonym:
Target:
MPO-IN-4
Cat.No: T60281
Synonym:
Target:
Cyanine 3 Tyramide methyl indole
Cat.No: T78406
Synonym:
Target:
Phenylbutazone-d9
Cat.No: T71288
Synonym:
Target:
Cyanine 5 Tyramide methyl indole
Cat.No: T74073
Synonym:
Target:
TMV-IN-4
Cat.No: T75028
Synonym:
Target:
(E)-2-(2-Chlorostyryl)-3,5,6-trimethylpyrazine
Cat.No: T36610
Synonym:
Target:
Cat. No. Product Name Target Signaling Pathways
T5372 L-SelenoMethionine

L-(+)-Selenomethionine,L-硒代蛋氨酸

Apoptosis; Amino Acids and Derivatives; Endogenous Metabolite Apoptosis; Metabolism
L-SelenoMethionine (L-(+)-Selenomethionine) 是 Selenomethionine 的 L-异构体,是硒的主要天然食物形式。它是一种癌症化学预防剂,可以增加谷胱甘肽过氧化物酶的表达,还可以通过饮食补充降低癌症的发生率并诱导癌细胞凋亡。
TJS0338 4-Methylesculetin

4-Methyl-6,7-dihydroxycoumarin,6,7-二羟基-4-甲基香豆素,Methylesculetin,4-甲基七叶亭

Antioxidant; Glutathione Peroxidase Metabolism; oxidation-reduction
4-Methylesculetin (Methylesculetin) 是口服具有活力的天然香豆素衍生物,有抗氧化、抗炎特性。它可抑制myeloperoxidase 的特性,抑制 IL-6 的水平
TL0009 coniferin

Coniferoside,松柏苷,Abietin

Others; Antifungal Microbiology/Virology; Others
Coniferin (Abietin) 是一种松柏醇中的葡萄糖苷。它抑制真菌生长和黑化反应,具有 ATP 依赖性转运活性并具有抗氧化作用。
T19117 3-Deoxyglucosone

3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

GPX; Glucagon Receptor GPCR/G Protein; oxidation-reduction
3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活,可与低葡萄糖协同作用以增强 GLP-1 分泌,可以作为糖尿病生物学检测的标志物。
T13753 (±)-Licarin A

(±)-trans-Dehydrodiisoeugenol

Others Others
(±)-Licarin A ((±)-trans-Dehydrodiisoeugenol) is a dihydrobenzofuran neolignan, the resultant of an oxidative coupling reaction of isoeugenol and horseradish peroxidase (HRP) enzyme. (±)-Licarin A shows 100% parasites mortality at 200 μM.
T73465 Goitrin

L-5-Vinyl-2-thiooxazolidone,(S)-Goitrin,(S)-Goitrin ; L-5-Vinyl-2-thiooxazolidone

Goitrin ((S)-Goitrin) 为芥子油苷-黑芥子酶反应产物,有效抑制甲状腺过氧化物酶并阻碍碘在甲状腺的利用。此外,该化合物亦展现出对抗流感病毒(H1N1)的活性。

天然产物

L-SelenoMethionine
Cat.No: T5372
Synonym: L-(+)-Selenomethionine,L-硒代蛋氨酸
Target: Apoptosis, Amino Acids and Derivatives, Endogenous Metabolite
4-Methylesculetin
Cat.No: TJS0338
Synonym: 4-Methyl-6,7-dihydroxycoumarin,6,7-二羟基-4-甲基香豆素,Methylesculetin,4-甲基七叶亭
Target: Antioxidant, Glutathione Peroxidase
coniferin
Cat.No: TL0009
Synonym: Coniferoside,松柏苷,Abietin
Target: Others, Antifungal
3-Deoxyglucosone
Cat.No: T19117
Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose
Target: GPX, Glucagon Receptor
(±)-Licarin A
Cat.No: T13753
Synonym: (±)-trans-Dehydrodiisoeugenol
Target: Others
Goitrin
Cat.No: T73465
Synonym: L-5-Vinyl-2-thiooxazolidone,(S)-Goitrin,(S)-Goitrin ; L-5-Vinyl-2-thiooxazolidone
Target:
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